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Q9VLP9

- PORED_DROME

UniProt

Q9VLP9 - PORED_DROME

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Protein

Polyprenol reductase

Gene
CG7840
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism By similarity.

Catalytic activityi

Ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH.

Pathwayi

GO - Molecular functioni

  1. oxidoreductase activity, acting on the CH-CH group of donors Source: InterPro

GO - Biological processi

  1. dolichol-linked oligosaccharide biosynthetic process Source: UniProtKB
  2. dolichol metabolic process Source: UniProtKB
  3. polyprenol catabolic process Source: UniProtKB
  4. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiREACT_181992. Synthesis of Dolichyl-phosphate.
UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyprenol reductase (EC:1.3.1.94)
Gene namesi
ORF Names:CG7840
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0032014. CG7840.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621Helical; Reviewed predictionAdd
BLAST
Transmembranei84 – 10421Helical; Reviewed predictionAdd
BLAST
Transmembranei167 – 18721Helical; Reviewed predictionAdd
BLAST
Transmembranei212 – 23221Helical; Reviewed predictionAdd
BLAST
Transmembranei256 – 27621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Polyprenol reductasePRO_0000398654Add
BLAST

Proteomic databases

PaxDbiQ9VLP9.
PRIDEiQ9VLP9.

Expressioni

Gene expression databases

BgeeiQ9VLP9.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
unc-119Q9XYQ21EBI-88569,EBI-127298

Protein-protein interaction databases

BioGridi60262. 1 interaction.
IntActiQ9VLP9. 1 interaction.
MINTiMINT-313018.
STRINGi7227.FBpp0079218.

Structurei

3D structure databases

ProteinModelPortaliQ9VLP9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG330066.
GeneTreeiENSGT00500000044920.
InParanoidiQ9VLP9.
KOiK12345.
OMAiSSPHMFF.
OrthoDBiEOG72ZCFT.
PhylomeDBiQ9VLP9.

Family and domain databases

InterProiIPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamiPF02544. Steroid_dh. 1 hit.
[Graphical view]
PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VLP9-1 [UniParc]FASTAAdd to Basket

« Hide

MAPPENGILE VLENLLDRYK INLLQMMFGT FIATIVFFGG LMTFVEKYLP    50
NSIRQSFRYG KHSFKGETDP LVAWLEVPKS WFKHFYTFAL FWSWLAFYVL 100
VSTVREQKEA PEYVLQFLDI MGGGRSHRKV EIDSTTACVG AFMLTLQCTR 150
RFYETNFVQI FSKKSKINLS HYAVGYVHYF GAVIALLSNT SGFVRGSKPM 200
EFSLDKLTSQ QILYLGVFFL AWQQQYASNM ILVNLRKDPR TGSVKTEKHL 250
LPKGGLFNLL SSPHMFLEVV MYFCIADLYM PVRIWRLIFL WVASNQTINA 300
LLTHKWYQET FREYPKNRRA IIPFLL 326
Length:326
Mass (Da):38,034
Last modified:May 1, 2000 - v1
Checksum:iB1DF380F2631AD90
GO

Sequence cautioni

The sequence AAM52687.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91L → P in strain: ZBMEL95 and ZBMEL157.
Natural varianti96 – 961A → V in strain: MEL11, ZBMEL145, ZBMEL131, ZBMEL229 and ZBMEL384.
Natural varianti125 – 1251R → H in strain: MEL01, MEL02, MEL12, MEL13, MEL14, MEL15, MEL16, MEL17, MEL18, MEL19, MEL20, ZBMEL84, ZBMEL95, ZBMEL131, ZBMEL157, ZBMEL191, ZBMEL377 and ZBMEL398.
Natural varianti239 – 2391P → R in strain: ZBMEL186.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM294298 Genomic DNA. Translation: CAL26216.1.
AM294299 Genomic DNA. Translation: CAL26217.1.
AM294300 Genomic DNA. Translation: CAL26218.1.
AM294301 Genomic DNA. Translation: CAL26219.1.
AM294302 Genomic DNA. Translation: CAL26220.1.
AM294303 Genomic DNA. Translation: CAL26221.1.
AM294304 Genomic DNA. Translation: CAL26230.1.
AM294305 Genomic DNA. Translation: CAL26235.1.
AM294306 Genomic DNA. Translation: CAL26236.1.
AM294307 Genomic DNA. Translation: CAL26237.1.
AM294308 Genomic DNA. Translation: CAL26238.1.
FM245364 Genomic DNA. Translation: CAR93290.1.
FM245365 Genomic DNA. Translation: CAR93291.1.
FM245366 Genomic DNA. Translation: CAR93292.1.
FM245367 Genomic DNA. Translation: CAR93293.1.
FM245368 Genomic DNA. Translation: CAR93294.1.
FM245369 Genomic DNA. Translation: CAR93295.1.
FM245370 Genomic DNA. Translation: CAR93296.1.
FM245371 Genomic DNA. Translation: CAR93297.1.
FM245372 Genomic DNA. Translation: CAR93298.1.
FM245373 Genomic DNA. Translation: CAR93299.1.
FM245374 Genomic DNA. Translation: CAR93300.1.
FM245375 Genomic DNA. Translation: CAR93301.1.
AE014134 Genomic DNA. Translation: AAF52635.1.
AY122175 mRNA. Translation: AAM52687.1. Different initiation.
RefSeqiNP_609203.1. NM_135359.3.
UniGeneiDm.23194.

Genome annotation databases

EnsemblMetazoaiFBtr0079598; FBpp0079218; FBgn0032014.
GeneIDi34136.
KEGGidme:Dmel_CG7840.
UCSCiCG7840-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM294298 Genomic DNA. Translation: CAL26216.1 .
AM294299 Genomic DNA. Translation: CAL26217.1 .
AM294300 Genomic DNA. Translation: CAL26218.1 .
AM294301 Genomic DNA. Translation: CAL26219.1 .
AM294302 Genomic DNA. Translation: CAL26220.1 .
AM294303 Genomic DNA. Translation: CAL26221.1 .
AM294304 Genomic DNA. Translation: CAL26230.1 .
AM294305 Genomic DNA. Translation: CAL26235.1 .
AM294306 Genomic DNA. Translation: CAL26236.1 .
AM294307 Genomic DNA. Translation: CAL26237.1 .
AM294308 Genomic DNA. Translation: CAL26238.1 .
FM245364 Genomic DNA. Translation: CAR93290.1 .
FM245365 Genomic DNA. Translation: CAR93291.1 .
FM245366 Genomic DNA. Translation: CAR93292.1 .
FM245367 Genomic DNA. Translation: CAR93293.1 .
FM245368 Genomic DNA. Translation: CAR93294.1 .
FM245369 Genomic DNA. Translation: CAR93295.1 .
FM245370 Genomic DNA. Translation: CAR93296.1 .
FM245371 Genomic DNA. Translation: CAR93297.1 .
FM245372 Genomic DNA. Translation: CAR93298.1 .
FM245373 Genomic DNA. Translation: CAR93299.1 .
FM245374 Genomic DNA. Translation: CAR93300.1 .
FM245375 Genomic DNA. Translation: CAR93301.1 .
AE014134 Genomic DNA. Translation: AAF52635.1 .
AY122175 mRNA. Translation: AAM52687.1 . Different initiation.
RefSeqi NP_609203.1. NM_135359.3.
UniGenei Dm.23194.

3D structure databases

ProteinModelPortali Q9VLP9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 60262. 1 interaction.
IntActi Q9VLP9. 1 interaction.
MINTi MINT-313018.
STRINGi 7227.FBpp0079218.

Proteomic databases

PaxDbi Q9VLP9.
PRIDEi Q9VLP9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0079598 ; FBpp0079218 ; FBgn0032014 .
GeneIDi 34136.
KEGGi dme:Dmel_CG7840.
UCSCi CG7840-RA. d. melanogaster.

Organism-specific databases

FlyBasei FBgn0032014. CG7840.

Phylogenomic databases

eggNOGi NOG330066.
GeneTreei ENSGT00500000044920.
InParanoidi Q9VLP9.
KOi K12345.
OMAi SSPHMFF.
OrthoDBi EOG72ZCFT.
PhylomeDBi Q9VLP9.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_181992. Synthesis of Dolichyl-phosphate.

Miscellaneous databases

GenomeRNAii 34136.
NextBioi 787042.
PROi Q9VLP9.

Gene expression databases

Bgeei Q9VLP9.

Family and domain databases

InterProi IPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view ]
Pfami PF02544. Steroid_dh. 1 hit.
[Graphical view ]
PROSITEi PS50244. S5A_REDUCTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Widespread adaptive evolution of Drosophila genes with sex-biased expression."
    Proeschel M., Zhang Z., Parsch J.
    Genetics 174:893-900(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ZBMEL131, ZBMEL145, ZBMEL157, ZBMEL186, ZBMEL191, ZBMEL229, ZBMEL377, ZBMEL384, ZBMEL398, ZBMEL84 and ZBMEL95.
  2. "The influence of demography and weak selection on the McDonald-Kreitman test: an empirical study in Drosophila."
    Parsch J., Zhang Z., Baines J.F.
    Mol. Biol. Evol. 26:691-698(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MEL01, MEL02, MEL11, MEL12, MEL13, MEL14, MEL15, MEL16, MEL17, MEL18, MEL19 and MEL20.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiPORED_DROME
AccessioniPrimary (citable) accession number: Q9VLP9
Secondary accession number(s): A0ANR0
, A0ANR1, A0ANR2, A0ANR3, A0ANR5, Q8MR21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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