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Q9VL32

- SUR_DROME

UniProt

Q9VL32 - SUR_DROME

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Protein

ATP-binding cassette sub-family C member Sur

Gene
Sur, CG5772
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May function as regulatory subunit of ATP-sensitive potassium channels (KATP) and form KATP channels with a member of the ATP-sensitive inward rectifier potassium channel family By similarity. May also have channel activity by itself (in vitro). May protect the heart during hypoxia. May protect against heart failure under conditions of tachycardic stress.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi822 – 8298ATP 1 Reviewed prediction
Nucleotide bindingi1964 – 19718ATP 2 Reviewed prediction

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. heart development Source: FlyBase
  2. response to hypoxia Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Receptor

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_205321. Regulation of insulin secretion.
REACT_223044. ATP sensitive Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family C member Sur
Alternative name(s):
Sulfonylurea receptor
Short name:
Dsur
Gene namesi
Name:Sur
ORF Names:CG5772
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0028675. Sur.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636Extracellular Reviewed predictionAdd
BLAST
Transmembranei37 – 5721Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini58 – 7114Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei72 – 9221Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini93 – 11220Extracellular Reviewed predictionAdd
BLAST
Transmembranei113 – 13321Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini134 – 14512Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei146 – 16621Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini167 – 18216Extracellular Reviewed predictionAdd
BLAST
Transmembranei183 – 20321Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini204 – 22421Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei225 – 24521Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini246 – 29954Extracellular Reviewed predictionAdd
BLAST
Transmembranei300 – 32021Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini321 – 447127Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei448 – 46821Helical; Name=8; Reviewed predictionAdd
BLAST
Topological domaini469 – 4746Extracellular Reviewed prediction
Transmembranei475 – 49521Helical; Name=9; Reviewed predictionAdd
BLAST
Topological domaini496 – 56267Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei563 – 58321Helical; Name=10; Reviewed predictionAdd
BLAST
Topological domaini584 – 60017Extracellular Reviewed predictionAdd
BLAST
Transmembranei601 – 62121Helical; Name=11; Reviewed predictionAdd
BLAST
Topological domaini622 – 1409788Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1410 – 143021Helical; Name=12; Reviewed predictionAdd
BLAST
Topological domaini1431 – 146838Extracellular Reviewed predictionAdd
BLAST
Transmembranei1469 – 148921Helical; Name=13; Reviewed predictionAdd
BLAST
Topological domaini1490 – 155869Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1559 – 157921Helical; Name=14; Reviewed predictionAdd
BLAST
Topological domaini1580 – 165576Extracellular Reviewed predictionAdd
BLAST
Transmembranei1656 – 167621Helical; Name=15; Reviewed predictionAdd
BLAST
Topological domaini1677 – 171842Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1719 – 173921Helical; Name=16; Reviewed predictionAdd
BLAST
Topological domaini1740 – 2171432Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21712171ATP-binding cassette sub-family C member SurPRO_0000415415Add
BLAST

Expressioni

Tissue specificityi

Highly expressed in adult heart. Detected at lower levels in head and abdomen.1 Publication

Developmental stagei

Detected in embryonic myocardial cells and in the developing heart tube. Detected in embryonic dorsal vessels and tracheal system.2 Publications

Gene expression databases

BgeeiQ9VL32.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0288707.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini344 – 622279ABC transmembrane type-1 1Add
BLAST
Domaini785 – 1014230ABC transporter 1Add
BLAST
Domaini1421 – 1715295ABC transmembrane type-1 2Add
BLAST
Domaini1930 – 2165236ABC transporter 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00750000117379.
InParanoidiQ9VL32.
OMAiTARERWK.
OrthoDBiEOG7C8GGC.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VL32-1 [UniParc]FASTAAdd to Basket

« Hide

MKQLFNIIHC DHLNGHVRSI YDNLNTDICG IDRVRRVFTF FSIFLLLFGL     50
MFVCSRYKKC HKTLLTFHNG RAAISLLLLA LNSFDLARIF LPHQNVRNLN 100
RLFQSSPRDL NYLVVIGSGE LWNALFSTLL TLMLMLYHRM VERKKATVFL 150
YASTAVEALT FALLSNELFE LVRYEDFLEL QTCLVAMSAM CMVSLAMLDG 200
LTVYKECYHD DYLDDYGKIG YKHSMATFYS KSCFWWLTPL LWLGYKEPLE 250
LEDLGQMKLE DSARSHYDHF LYIYTEKKKK SNSSPSLWYC YIKNSWQMFA 300
LGGILKLAGD LFALIGPLAI QKIVEYIEQL YAQASEPPAK SPGNEVANVL 350
LSTSRILGTE FDEVFGTNID KGLIYRKSLL LNADGGCDSS DSAGQVQSTS 400
STSDEKQKND DSMATPEHVD NPSEPNISHD IGSITNHMTE DTRNIMEFFL 450
IIHYAWAIPF KIAVVIYLLY MNLGISAVIG SIACIVIMTP LQFFIGNAMS 500
KNAEVIAGYT DERLKRIHDT LVGIKVIKLN AWDEVFLKKI QEARRKELKY 550
LNKDATFWTL MAVLTHIATV LITFVTLGVY VWLHRDQEFD LNASRLFSSL 600
ALFQQLTVPL LIFPITVPII IAARVSTRRL ERFLKSSEIQ KQFEGIRNMA 650
RILSKSDASL DMYETQEKSN MTMRTAQAEN RLNEKRLAQK SQTPELATNS 700
TPLLQNAEES AEDISPSTVQ ELGHNKLVQQ RRELLRNTPY VAIRPPKMRG 750
SVMERPVEFS VIRARNTDSW RRDSLLLKMP DDIAVSINDG LFTWQPQSQM 800
PVVQLHVPGI IVPKGKLTIV VGKNGSGKTS LLSALLMEMP LLAGNMFWHK 850
TCTISYVSQQ PWLLNDTIRE NILFGESFRP KRYDFVLEAC ALKPDIELMP 900
RGDLSIIGER GINISGGQRQ RIAIARAIYS SANVVIMDDP LASLDNEVGE 950
HIFQHCIREM LQKSNRTFIL VTQQLHRIKE AEYLIAIKDG RVEACGSYAD 1000
IELMQPRITA EWNAIIAMAK AKNDNPSQNP GEKTAGERWK LLKNVSKLGL 1050
QRSISVTMDA NVACHADAID GSGCISVANM QSNVVEEDDQ VSVSYPIGNA 1100
SCGGFNLQRK RSSIYGSRHL MYDVPLPIDE CQGDDVIMRP RRRHTLGRRG 1150
SRNTNSSHRL SGLSTLTATS ESSSISGDVL SRSVLATSCS SYAESSVDGG 1200
DLATAAPEPR VQSWQPPQHV THHQPLSRNA SSPPAMEVAN PDVKKSEEAR 1250
RSNTSSESPL DDHVRGSFQQ FLRRMSMRRS NKPKNHHHPL SATNSILSIS 1300
EESPPVVHFP ASILATDGNK NETQSEEKPK KCVNIDSKET TINCDDNCYS 1350
ASDKELRANV TSSPADQEQH NERHVLAEVA GESGRESMPL ARLAIDTERK 1400
YGKISDDIYL MYIRAAGLPI ITIFFITALI WQCLRVYTDI WLQQWSNVHG 1450
RVASKGHVVL HPSEQDHEVT YYFRMYAAIS CVCIIMALVS TPAGQYAGCN 1500
ARRNLHDKLL QTILHKTLHF FQVTPLGRIV NRFSNDMAVI DKKIAATGQR 1550
LLQFTLLCLS AILINVTITP WILVLTLPIC GAYYLIQKFY RCSARELQRI 1600
ENATNSPVIS HLSETIQGVT TIRAFNQQTR FTEILFKRLE ANTIAYALLN 1650
TSHRWLGVSL DYLGGCIVFV ATVTALTAAS VSCRRHYEAT TSPSASASPS 1700
PFETYAVTKS PSELRPSPSL VGLAINYTLL VPIYLNWVVK LLADMEMYAG 1750
SVERIAHYAQ GQDADADADA DADADVDADL DHEPSSNEDV SAEVDRSSQS 1800
DAGDKVYPGA TTAAGDVDED GDQQRIGGAR GGGGDCGYRQ GHENGAEANA 1850
DKLNAGNVTG DGNHLNFHHP PATAGDKVEQ ATTKTSVIKD KQLPPQQDDK 1900
DKKVVLPNEP ARKLERYQSV PISWPQRGDI HFDNVSLRYE GQKQNVISNL 1950
TLKIPAGQRI GICGRTGSGK SSLGLSLFGV LQTTRGHIYI DDVDIQRIRP 2000
DELRTRLSII PQDVHLFNAT IRENLDPHGY FQDLQLWNCL ELAQLKEFVN 2050
GHLPLGLDTV ICDGGLNLSA GHRQLLCLAR AILRGSVCLV LDEATSVLDS 2100
STESALLKAA DLAFRGRTII TIAHRLTTIL DYDRLIVLDQ GRIVEDGNPR 2150
ELQQLEGSVF RGLLEKGASK W 2171
Length:2,171
Mass (Da):242,375
Last modified:March 3, 2009 - v4
Checksum:i5BA7802AD742B6D2
GO

Sequence cautioni

The sequence AAF06736.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 352VR → CA in AAF06736. 1 Publication
Sequence conflicti54 – 541C → Y in AAF06736. 1 Publication
Sequence conflicti77 – 771L → I in AAF06736. 1 Publication
Sequence conflicti85 – 851D → E in AAF06736. 1 Publication
Sequence conflicti413 – 4131M → V in AAF06736. 1 Publication
Sequence conflicti433 – 4331S → G in AAF06736. 1 Publication
Sequence conflicti444 – 4441N → S in AAF06736. 1 Publication
Sequence conflicti731 – 7311R → G in AAF06736. 1 Publication
Sequence conflicti1022 – 10221K → E in AAF06736. 1 Publication
Sequence conflicti1603 – 16031A → T in AAF06736. 1 Publication
Sequence conflicti1757 – 17571H → Q in AAF06736. 1 Publication
Sequence conflicti1763 – 17664Missing in AAF06736. 1 Publication
Sequence conflicti1772 – 17721A → T in AAF06736. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF167431 mRNA. Translation: AAF06736.1. Different initiation.
AE014134 Genomic DNA. Translation: AAF52866.4.
RefSeqiNP_477472.2. NM_058124.3.
UniGeneiDm.382.

Genome annotation databases

EnsemblMetazoaiFBtr0290268; FBpp0288707; FBgn0028675.
GeneIDi34350.
KEGGidme:Dmel_CG5772.

Cross-referencesi

Web resourcesi

Protein Spotlight

On The Other Side - Issue 139 of June 2012

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF167431 mRNA. Translation: AAF06736.1 . Different initiation.
AE014134 Genomic DNA. Translation: AAF52866.4 .
RefSeqi NP_477472.2. NM_058124.3.
UniGenei Dm.382.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7227.FBpp0288707.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0290268 ; FBpp0288707 ; FBgn0028675 .
GeneIDi 34350.
KEGGi dme:Dmel_CG5772.

Organism-specific databases

CTDi 34350.
FlyBasei FBgn0028675. Sur.

Phylogenomic databases

GeneTreei ENSGT00750000117379.
InParanoidi Q9VL32.
OMAi TARERWK.
OrthoDBi EOG7C8GGC.

Enzyme and pathway databases

Reactomei REACT_205321. Regulation of insulin secretion.
REACT_223044. ATP sensitive Potassium channels.

Miscellaneous databases

ChiTaRSi SUR. drosophila.
GenomeRNAii 34350.
NextBioi 788061.

Gene expression databases

Bgeei Q9VL32.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel sulfonylurea receptor family member expressed in the embryonic Drosophila dorsal vessel and tracheal system."
    Nasonkin I., Alikasifoglu A., Ambrose C., Cahill P., Cheng M., Sarniak A., Egan M., Thomas P.M.
    J. Biol. Chem. 274:29420-29425(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. "The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman."
    Akasaka T., Klinedinst S., Ocorr K., Bustamante E.L., Kim S.K., Bodmer R.
    Proc. Natl. Acad. Sci. U.S.A. 103:11999-12004(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
  5. Cited for: POSSIBLE FUNCTION IN REGULATION OF SLEEP PATTERN.

Entry informationi

Entry nameiSUR_DROME
AccessioniPrimary (citable) accession number: Q9VL32
Secondary accession number(s): Q9U6Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 111 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Miscellaneous

Drosophila is predominantly active around dawn and dusk, and has large sleep periods during the day and during night. Knockdown of Sur reduces sleep duration during the first half of the night, but has little effect on sleep during the day (1 Publication).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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