Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9VL32 (SUR_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-binding cassette sub-family C member Sur
Alternative name(s):
Sulfonylurea receptor
Short name=Dsur
Gene names
Name:Sur
ORF Names:CG5772
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length2171 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function as regulatory subunit of ATP-sensitive potassium channels (KATP) and form KATP channels with a member of the ATP-sensitive inward rectifier potassium channel family By similarity. May also have channel activity by itself (in vitro). May protect the heart during hypoxia. May protect against heart failure under conditions of tachycardic stress. Ref.1 Ref.4 Ref.5

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Tissue specificity

Highly expressed in adult heart. Detected at lower levels in head and abdomen. Ref.4

Developmental stage

Detected in embryonic myocardial cells and in the developing heart tube. Detected in embryonic dorsal vessels and tracheal system. Ref.1 Ref.4

Miscellaneous

Drosophila is predominantly active around dawn and dusk, and has large sleep periods during the day and during night. Knockdown of Sur reduces sleep duration during the first half of the night, but has little effect on sleep during the day (Ref.5).

Sequence similarities

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

Sequence caution

The sequence AAF06736.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 21712171ATP-binding cassette sub-family C member Sur
PRO_0000415415

Regions

Topological domain1 – 3636Extracellular Potential
Transmembrane37 – 5721Helical; Name=1; Potential
Topological domain58 – 7114Cytoplasmic Potential
Transmembrane72 – 9221Helical; Name=2; Potential
Topological domain93 – 11220Extracellular Potential
Transmembrane113 – 13321Helical; Name=3; Potential
Topological domain134 – 14512Cytoplasmic Potential
Transmembrane146 – 16621Helical; Name=4; Potential
Topological domain167 – 18216Extracellular Potential
Transmembrane183 – 20321Helical; Name=5; Potential
Topological domain204 – 22421Cytoplasmic Potential
Transmembrane225 – 24521Helical; Name=6; Potential
Topological domain246 – 29954Extracellular Potential
Transmembrane300 – 32021Helical; Name=7; Potential
Topological domain321 – 447127Cytoplasmic Potential
Transmembrane448 – 46821Helical; Name=8; Potential
Topological domain469 – 4746Extracellular Potential
Transmembrane475 – 49521Helical; Name=9; Potential
Topological domain496 – 56267Cytoplasmic Potential
Transmembrane563 – 58321Helical; Name=10; Potential
Topological domain584 – 60017Extracellular Potential
Transmembrane601 – 62121Helical; Name=11; Potential
Topological domain622 – 1409788Cytoplasmic Potential
Transmembrane1410 – 143021Helical; Name=12; Potential
Topological domain1431 – 146838Extracellular Potential
Transmembrane1469 – 148921Helical; Name=13; Potential
Topological domain1490 – 155869Cytoplasmic Potential
Transmembrane1559 – 157921Helical; Name=14; Potential
Topological domain1580 – 165576Extracellular Potential
Transmembrane1656 – 167621Helical; Name=15; Potential
Topological domain1677 – 171842Cytoplasmic Potential
Transmembrane1719 – 173921Helical; Name=16; Potential
Topological domain1740 – 2171432Extracellular Potential
Domain344 – 622279ABC transmembrane type-1 1
Domain785 – 1014230ABC transporter 1
Domain1421 – 1715295ABC transmembrane type-1 2
Domain1930 – 2165236ABC transporter 2
Nucleotide binding822 – 8298ATP 1 Potential
Nucleotide binding1964 – 19718ATP 2 Potential

Experimental info

Sequence conflict34 – 352VR → CA in AAF06736. Ref.1
Sequence conflict541C → Y in AAF06736. Ref.1
Sequence conflict771L → I in AAF06736. Ref.1
Sequence conflict851D → E in AAF06736. Ref.1
Sequence conflict4131M → V in AAF06736. Ref.1
Sequence conflict4331S → G in AAF06736. Ref.1
Sequence conflict4441N → S in AAF06736. Ref.1
Sequence conflict7311R → G in AAF06736. Ref.1
Sequence conflict10221K → E in AAF06736. Ref.1
Sequence conflict16031A → T in AAF06736. Ref.1
Sequence conflict17571H → Q in AAF06736. Ref.1
Sequence conflict1763 – 17664Missing in AAF06736. Ref.1
Sequence conflict17721A → T in AAF06736. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9VL32 [UniParc].

Last modified March 3, 2009. Version 4.
Checksum: 5BA7802AD742B6D2

FASTA2,171242,375
        10         20         30         40         50         60 
MKQLFNIIHC DHLNGHVRSI YDNLNTDICG IDRVRRVFTF FSIFLLLFGL MFVCSRYKKC 

        70         80         90        100        110        120 
HKTLLTFHNG RAAISLLLLA LNSFDLARIF LPHQNVRNLN RLFQSSPRDL NYLVVIGSGE 

       130        140        150        160        170        180 
LWNALFSTLL TLMLMLYHRM VERKKATVFL YASTAVEALT FALLSNELFE LVRYEDFLEL 

       190        200        210        220        230        240 
QTCLVAMSAM CMVSLAMLDG LTVYKECYHD DYLDDYGKIG YKHSMATFYS KSCFWWLTPL 

       250        260        270        280        290        300 
LWLGYKEPLE LEDLGQMKLE DSARSHYDHF LYIYTEKKKK SNSSPSLWYC YIKNSWQMFA 

       310        320        330        340        350        360 
LGGILKLAGD LFALIGPLAI QKIVEYIEQL YAQASEPPAK SPGNEVANVL LSTSRILGTE 

       370        380        390        400        410        420 
FDEVFGTNID KGLIYRKSLL LNADGGCDSS DSAGQVQSTS STSDEKQKND DSMATPEHVD 

       430        440        450        460        470        480 
NPSEPNISHD IGSITNHMTE DTRNIMEFFL IIHYAWAIPF KIAVVIYLLY MNLGISAVIG 

       490        500        510        520        530        540 
SIACIVIMTP LQFFIGNAMS KNAEVIAGYT DERLKRIHDT LVGIKVIKLN AWDEVFLKKI 

       550        560        570        580        590        600 
QEARRKELKY LNKDATFWTL MAVLTHIATV LITFVTLGVY VWLHRDQEFD LNASRLFSSL 

       610        620        630        640        650        660 
ALFQQLTVPL LIFPITVPII IAARVSTRRL ERFLKSSEIQ KQFEGIRNMA RILSKSDASL 

       670        680        690        700        710        720 
DMYETQEKSN MTMRTAQAEN RLNEKRLAQK SQTPELATNS TPLLQNAEES AEDISPSTVQ 

       730        740        750        760        770        780 
ELGHNKLVQQ RRELLRNTPY VAIRPPKMRG SVMERPVEFS VIRARNTDSW RRDSLLLKMP 

       790        800        810        820        830        840 
DDIAVSINDG LFTWQPQSQM PVVQLHVPGI IVPKGKLTIV VGKNGSGKTS LLSALLMEMP 

       850        860        870        880        890        900 
LLAGNMFWHK TCTISYVSQQ PWLLNDTIRE NILFGESFRP KRYDFVLEAC ALKPDIELMP 

       910        920        930        940        950        960 
RGDLSIIGER GINISGGQRQ RIAIARAIYS SANVVIMDDP LASLDNEVGE HIFQHCIREM 

       970        980        990       1000       1010       1020 
LQKSNRTFIL VTQQLHRIKE AEYLIAIKDG RVEACGSYAD IELMQPRITA EWNAIIAMAK 

      1030       1040       1050       1060       1070       1080 
AKNDNPSQNP GEKTAGERWK LLKNVSKLGL QRSISVTMDA NVACHADAID GSGCISVANM 

      1090       1100       1110       1120       1130       1140 
QSNVVEEDDQ VSVSYPIGNA SCGGFNLQRK RSSIYGSRHL MYDVPLPIDE CQGDDVIMRP 

      1150       1160       1170       1180       1190       1200 
RRRHTLGRRG SRNTNSSHRL SGLSTLTATS ESSSISGDVL SRSVLATSCS SYAESSVDGG 

      1210       1220       1230       1240       1250       1260 
DLATAAPEPR VQSWQPPQHV THHQPLSRNA SSPPAMEVAN PDVKKSEEAR RSNTSSESPL 

      1270       1280       1290       1300       1310       1320 
DDHVRGSFQQ FLRRMSMRRS NKPKNHHHPL SATNSILSIS EESPPVVHFP ASILATDGNK 

      1330       1340       1350       1360       1370       1380 
NETQSEEKPK KCVNIDSKET TINCDDNCYS ASDKELRANV TSSPADQEQH NERHVLAEVA 

      1390       1400       1410       1420       1430       1440 
GESGRESMPL ARLAIDTERK YGKISDDIYL MYIRAAGLPI ITIFFITALI WQCLRVYTDI 

      1450       1460       1470       1480       1490       1500 
WLQQWSNVHG RVASKGHVVL HPSEQDHEVT YYFRMYAAIS CVCIIMALVS TPAGQYAGCN 

      1510       1520       1530       1540       1550       1560 
ARRNLHDKLL QTILHKTLHF FQVTPLGRIV NRFSNDMAVI DKKIAATGQR LLQFTLLCLS 

      1570       1580       1590       1600       1610       1620 
AILINVTITP WILVLTLPIC GAYYLIQKFY RCSARELQRI ENATNSPVIS HLSETIQGVT 

      1630       1640       1650       1660       1670       1680 
TIRAFNQQTR FTEILFKRLE ANTIAYALLN TSHRWLGVSL DYLGGCIVFV ATVTALTAAS 

      1690       1700       1710       1720       1730       1740 
VSCRRHYEAT TSPSASASPS PFETYAVTKS PSELRPSPSL VGLAINYTLL VPIYLNWVVK 

      1750       1760       1770       1780       1790       1800 
LLADMEMYAG SVERIAHYAQ GQDADADADA DADADVDADL DHEPSSNEDV SAEVDRSSQS 

      1810       1820       1830       1840       1850       1860 
DAGDKVYPGA TTAAGDVDED GDQQRIGGAR GGGGDCGYRQ GHENGAEANA DKLNAGNVTG 

      1870       1880       1890       1900       1910       1920 
DGNHLNFHHP PATAGDKVEQ ATTKTSVIKD KQLPPQQDDK DKKVVLPNEP ARKLERYQSV 

      1930       1940       1950       1960       1970       1980 
PISWPQRGDI HFDNVSLRYE GQKQNVISNL TLKIPAGQRI GICGRTGSGK SSLGLSLFGV 

      1990       2000       2010       2020       2030       2040 
LQTTRGHIYI DDVDIQRIRP DELRTRLSII PQDVHLFNAT IRENLDPHGY FQDLQLWNCL 

      2050       2060       2070       2080       2090       2100 
ELAQLKEFVN GHLPLGLDTV ICDGGLNLSA GHRQLLCLAR AILRGSVCLV LDEATSVLDS 

      2110       2120       2130       2140       2150       2160 
STESALLKAA DLAFRGRTII TIAHRLTTIL DYDRLIVLDQ GRIVEDGNPR ELQQLEGSVF 

      2170 
RGLLEKGASK W 

« Hide

References

« Hide 'large scale' references
[1]"A novel sulfonylurea receptor family member expressed in the embryonic Drosophila dorsal vessel and tracheal system."
Nasonkin I., Alikasifoglu A., Ambrose C., Cahill P., Cheng M., Sarniak A., Egan M., Thomas P.M.
J. Biol. Chem. 274:29420-29425(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman."
Akasaka T., Klinedinst S., Ocorr K., Bustamante E.L., Kim S.K., Bodmer R.
Proc. Natl. Acad. Sci. U.S.A. 103:11999-12004(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
[5]"A K(ATP) channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila."
Allebrandt K.V., Amin N., Muller-Myhsok B., Esko T., Teder-Laving M., Azevedo R.V., Hayward C., van Mill J., Vogelzangs N., Green E.W., Melville S.A., Lichtner P., Wichmann H.E., Oostra B.A., Janssens A.C., Campbell H., Wilson J.F., Hicks A.A. expand/collapse author list , Pramstaller P.P., Dogas Z., Rudan I., Merrow M., Penninx B., Kyriacou C.P., Metspalu A., van Duijn C.M., Meitinger T., Roenneberg T.
Mol. Psychiatry 18:122-132(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE FUNCTION IN REGULATION OF SLEEP PATTERN.
+Additional computationally mapped references.

Web resources

Protein Spotlight

On The Other Side - Issue 139 of June 2012

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF167431 mRNA. Translation: AAF06736.1. Different initiation.
AE014134 Genomic DNA. Translation: AAF52866.4.
RefSeqNP_477472.2. NM_058124.3.
UniGeneDm.382.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7227.FBpp0288707.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0290268; FBpp0288707; FBgn0028675.
GeneID34350.
KEGGdme:Dmel_CG5772.

Organism-specific databases

CTD34350.
FlyBaseFBgn0028675. Sur.

Phylogenomic databases

GeneTreeENSGT00750000117379.
InParanoidQ9VL32.
OMATARERWK.
OrthoDBEOG7C8GGC.

Gene expression databases

BgeeQ9VL32.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSUR. drosophila.
GenomeRNAi34350.
NextBio788061.

Entry information

Entry nameSUR_DROME
AccessionPrimary (citable) accession number: Q9VL32
Secondary accession number(s): Q9U6Z2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: March 3, 2009
Last modified: July 9, 2014
This is version 110 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase