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UniProtKB - Q9VL32 (SUR_DROME)

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Protein

ATP-binding cassette sub-family C member Sur

Gene

Sur

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as regulatory subunit of ATP-sensitive potassium channels (KATP) and form KATP channels with a member of the ATP-sensitive inward rectifier potassium channel family (By similarity). May also have channel activity by itself (in vitro). May protect the heart during hypoxia. May protect against heart failure under conditions of tachycardic stress.By similarity2 Publications

Miscellaneous

Drosophila is predominantly active around dawn and dusk, and has large sleep periods during the day and during night. Knockdown of Sur reduces sleep duration during the first half of the night, but has little effect on sleep during the day (PubMed:22105623).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi822 – 829ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1964 – 1971ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • heart development Source: FlyBase
  • response to hypoxia Source: FlyBase
  • transmembrane transport Source: GO_Central
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHydrolase, Receptor
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-1296025. ATP sensitive Potassium channels.
R-DME-382556. ABC-family proteins mediated transport.
R-DME-422356. Regulation of insulin secretion.
R-DME-5578775. Ion homeostasis.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family C member Sur
Alternative name(s):
Sulfonylurea receptor
Short name:
Dsur
Gene namesi
Name:Sur
ORF Names:CG5772
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0028675. Sur.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36ExtracellularSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini58 – 71CytoplasmicSequence analysisAdd BLAST14
Transmembranei72 – 92Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini93 – 112ExtracellularSequence analysisAdd BLAST20
Transmembranei113 – 133Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini134 – 145CytoplasmicSequence analysisAdd BLAST12
Transmembranei146 – 166Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini167 – 182ExtracellularSequence analysisAdd BLAST16
Transmembranei183 – 203Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini204 – 224CytoplasmicSequence analysisAdd BLAST21
Transmembranei225 – 245Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini246 – 299ExtracellularSequence analysisAdd BLAST54
Transmembranei300 – 320Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini321 – 447CytoplasmicSequence analysisAdd BLAST127
Transmembranei448 – 468Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini469 – 474ExtracellularSequence analysis6
Transmembranei475 – 495Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini496 – 562CytoplasmicSequence analysisAdd BLAST67
Transmembranei563 – 583Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini584 – 600ExtracellularSequence analysisAdd BLAST17
Transmembranei601 – 621Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini622 – 1409CytoplasmicSequence analysisAdd BLAST788
Transmembranei1410 – 1430Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini1431 – 1468ExtracellularSequence analysisAdd BLAST38
Transmembranei1469 – 1489Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1490 – 1558CytoplasmicSequence analysisAdd BLAST69
Transmembranei1559 – 1579Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1580 – 1655ExtracellularSequence analysisAdd BLAST76
Transmembranei1656 – 1676Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1677 – 1718CytoplasmicSequence analysisAdd BLAST42
Transmembranei1719 – 1739Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1740 – 2171ExtracellularSequence analysisAdd BLAST432

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004154151 – 2171ATP-binding cassette sub-family C member SurAdd BLAST2171

Proteomic databases

PaxDbiQ9VL32.
PRIDEiQ9VL32.

Expressioni

Tissue specificityi

Highly expressed in adult heart. Detected at lower levels in head and abdomen.1 Publication

Developmental stagei

Detected in embryonic myocardial cells and in the developing heart tube. Detected in embryonic dorsal vessels and tracheal system.2 Publications

Gene expression databases

BgeeiFBgn0028675.
ExpressionAtlasiQ9VL32. differential.
GenevisibleiQ9VL32. DM.

Interactioni

Protein-protein interaction databases

BioGridi60441. 1 interactor.
IntActiQ9VL32. 3 interactors.
STRINGi7227.FBpp0288707.

Structurei

3D structure databases

SMRiQ9VL32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini344 – 622ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST279
Domaini785 – 1014ABC transporter 1PROSITE-ProRule annotationAdd BLAST230
Domaini1421 – 1715ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST295
Domaini1930 – 2165ABC transporter 2PROSITE-ProRule annotationAdd BLAST236

Sequence similaritiesi

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
InParanoidiQ9VL32.
OMAiCTISYVS.
OrthoDBiEOG091G00AA.

Family and domain databases

Gene3Di1.20.1560.10. 2 hits.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9VL32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQLFNIIHC DHLNGHVRSI YDNLNTDICG IDRVRRVFTF FSIFLLLFGL 
        60         70         80         90        100
MFVCSRYKKC HKTLLTFHNG RAAISLLLLA LNSFDLARIF LPHQNVRNLN 
       110        120        130        140        150
RLFQSSPRDL NYLVVIGSGE LWNALFSTLL TLMLMLYHRM VERKKATVFL 
       160        170        180        190        200
YASTAVEALT FALLSNELFE LVRYEDFLEL QTCLVAMSAM CMVSLAMLDG 
       210        220        230        240        250
LTVYKECYHD DYLDDYGKIG YKHSMATFYS KSCFWWLTPL LWLGYKEPLE 
       260        270        280        290        300
LEDLGQMKLE DSARSHYDHF LYIYTEKKKK SNSSPSLWYC YIKNSWQMFA 
       310        320        330        340        350
LGGILKLAGD LFALIGPLAI QKIVEYIEQL YAQASEPPAK SPGNEVANVL 
       360        370        380        390        400
LSTSRILGTE FDEVFGTNID KGLIYRKSLL LNADGGCDSS DSAGQVQSTS 
       410        420        430        440        450
STSDEKQKND DSMATPEHVD NPSEPNISHD IGSITNHMTE DTRNIMEFFL 
       460        470        480        490        500
IIHYAWAIPF KIAVVIYLLY MNLGISAVIG SIACIVIMTP LQFFIGNAMS 
       510        520        530        540        550
KNAEVIAGYT DERLKRIHDT LVGIKVIKLN AWDEVFLKKI QEARRKELKY 
       560        570        580        590        600
LNKDATFWTL MAVLTHIATV LITFVTLGVY VWLHRDQEFD LNASRLFSSL 
       610        620        630        640        650
ALFQQLTVPL LIFPITVPII IAARVSTRRL ERFLKSSEIQ KQFEGIRNMA 
       660        670        680        690        700
RILSKSDASL DMYETQEKSN MTMRTAQAEN RLNEKRLAQK SQTPELATNS 
       710        720        730        740        750
TPLLQNAEES AEDISPSTVQ ELGHNKLVQQ RRELLRNTPY VAIRPPKMRG 
       760        770        780        790        800
SVMERPVEFS VIRARNTDSW RRDSLLLKMP DDIAVSINDG LFTWQPQSQM 
       810        820        830        840        850
PVVQLHVPGI IVPKGKLTIV VGKNGSGKTS LLSALLMEMP LLAGNMFWHK 
       860        870        880        890        900
TCTISYVSQQ PWLLNDTIRE NILFGESFRP KRYDFVLEAC ALKPDIELMP 
       910        920        930        940        950
RGDLSIIGER GINISGGQRQ RIAIARAIYS SANVVIMDDP LASLDNEVGE 
       960        970        980        990       1000
HIFQHCIREM LQKSNRTFIL VTQQLHRIKE AEYLIAIKDG RVEACGSYAD 
      1010       1020       1030       1040       1050
IELMQPRITA EWNAIIAMAK AKNDNPSQNP GEKTAGERWK LLKNVSKLGL 
      1060       1070       1080       1090       1100
QRSISVTMDA NVACHADAID GSGCISVANM QSNVVEEDDQ VSVSYPIGNA 
      1110       1120       1130       1140       1150
SCGGFNLQRK RSSIYGSRHL MYDVPLPIDE CQGDDVIMRP RRRHTLGRRG 
      1160       1170       1180       1190       1200
SRNTNSSHRL SGLSTLTATS ESSSISGDVL SRSVLATSCS SYAESSVDGG 
      1210       1220       1230       1240       1250
DLATAAPEPR VQSWQPPQHV THHQPLSRNA SSPPAMEVAN PDVKKSEEAR 
      1260       1270       1280       1290       1300
RSNTSSESPL DDHVRGSFQQ FLRRMSMRRS NKPKNHHHPL SATNSILSIS 
      1310       1320       1330       1340       1350
EESPPVVHFP ASILATDGNK NETQSEEKPK KCVNIDSKET TINCDDNCYS 
      1360       1370       1380       1390       1400
ASDKELRANV TSSPADQEQH NERHVLAEVA GESGRESMPL ARLAIDTERK 
      1410       1420       1430       1440       1450
YGKISDDIYL MYIRAAGLPI ITIFFITALI WQCLRVYTDI WLQQWSNVHG 
      1460       1470       1480       1490       1500
RVASKGHVVL HPSEQDHEVT YYFRMYAAIS CVCIIMALVS TPAGQYAGCN 
      1510       1520       1530       1540       1550
ARRNLHDKLL QTILHKTLHF FQVTPLGRIV NRFSNDMAVI DKKIAATGQR 
      1560       1570       1580       1590       1600
LLQFTLLCLS AILINVTITP WILVLTLPIC GAYYLIQKFY RCSARELQRI 
      1610       1620       1630       1640       1650
ENATNSPVIS HLSETIQGVT TIRAFNQQTR FTEILFKRLE ANTIAYALLN 
      1660       1670       1680       1690       1700
TSHRWLGVSL DYLGGCIVFV ATVTALTAAS VSCRRHYEAT TSPSASASPS 
      1710       1720       1730       1740       1750
PFETYAVTKS PSELRPSPSL VGLAINYTLL VPIYLNWVVK LLADMEMYAG 
      1760       1770       1780       1790       1800
SVERIAHYAQ GQDADADADA DADADVDADL DHEPSSNEDV SAEVDRSSQS 
      1810       1820       1830       1840       1850
DAGDKVYPGA TTAAGDVDED GDQQRIGGAR GGGGDCGYRQ GHENGAEANA 
      1860       1870       1880       1890       1900
DKLNAGNVTG DGNHLNFHHP PATAGDKVEQ ATTKTSVIKD KQLPPQQDDK 
      1910       1920       1930       1940       1950
DKKVVLPNEP ARKLERYQSV PISWPQRGDI HFDNVSLRYE GQKQNVISNL 
      1960       1970       1980       1990       2000
TLKIPAGQRI GICGRTGSGK SSLGLSLFGV LQTTRGHIYI DDVDIQRIRP 
      2010       2020       2030       2040       2050
DELRTRLSII PQDVHLFNAT IRENLDPHGY FQDLQLWNCL ELAQLKEFVN 
      2060       2070       2080       2090       2100
GHLPLGLDTV ICDGGLNLSA GHRQLLCLAR AILRGSVCLV LDEATSVLDS 
      2110       2120       2130       2140       2150
STESALLKAA DLAFRGRTII TIAHRLTTIL DYDRLIVLDQ GRIVEDGNPR 
      2160       2170 
ELQQLEGSVF RGLLEKGASK W
Length:2,171
Mass (Da):242,375
Last modified:March 3, 2009 - v4
Checksum:i5BA7802AD742B6D2
GO

Sequence cautioni

The sequence AAF06736 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34 – 35VR → CA in AAF06736 (PubMed:10506204).Curated2
Sequence conflicti54C → Y in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti77L → I in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti85D → E in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti413M → V in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti433S → G in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti444N → S in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti731R → G in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti1022K → E in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti1603A → T in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti1757H → Q in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti1763 – 1766Missing in AAF06736 (PubMed:10506204).Curated4
Sequence conflicti1772A → T in AAF06736 (PubMed:10506204).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167431 mRNA. Translation: AAF06736.1. Different initiation.
AE014134 Genomic DNA. Translation: AAF52866.4.

Similar proteinsi

Entry informationi

Entry nameiSUR_DROME
AccessioniPrimary (citable) accession number: Q9VL32
Secondary accession number(s): Q9U6Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: March 3, 2009
Last modified: March 28, 2018
This is version 143 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome