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Protein

ATP-binding cassette sub-family C member Sur

Gene

Sur

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as regulatory subunit of ATP-sensitive potassium channels (KATP) and form KATP channels with a member of the ATP-sensitive inward rectifier potassium channel family (By similarity). May also have channel activity by itself (in vitro). May protect the heart during hypoxia. May protect against heart failure under conditions of tachycardic stress.By similarity2 Publications

Miscellaneous

Drosophila is predominantly active around dawn and dusk, and has large sleep periods during the day and during night. Knockdown of Sur reduces sleep duration during the first half of the night, but has little effect on sleep during the day (PubMed:22105623).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi822 – 829ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1964 – 1971ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • heart development Source: FlyBase
  • response to hypoxia Source: FlyBase
  • transmembrane transport Source: GO_Central

Keywordsi

Molecular functionHydrolase, Receptor
Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family C member Sur
Alternative name(s):
Sulfonylurea receptor
Short name:
Dsur
Gene namesi
Name:Sur
ORF Names:CG5772
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0028675. Sur.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36ExtracellularSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini58 – 71CytoplasmicSequence analysisAdd BLAST14
Transmembranei72 – 92Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini93 – 112ExtracellularSequence analysisAdd BLAST20
Transmembranei113 – 133Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini134 – 145CytoplasmicSequence analysisAdd BLAST12
Transmembranei146 – 166Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini167 – 182ExtracellularSequence analysisAdd BLAST16
Transmembranei183 – 203Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini204 – 224CytoplasmicSequence analysisAdd BLAST21
Transmembranei225 – 245Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini246 – 299ExtracellularSequence analysisAdd BLAST54
Transmembranei300 – 320Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini321 – 447CytoplasmicSequence analysisAdd BLAST127
Transmembranei448 – 468Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini469 – 474ExtracellularSequence analysis6
Transmembranei475 – 495Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini496 – 562CytoplasmicSequence analysisAdd BLAST67
Transmembranei563 – 583Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini584 – 600ExtracellularSequence analysisAdd BLAST17
Transmembranei601 – 621Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini622 – 1409CytoplasmicSequence analysisAdd BLAST788
Transmembranei1410 – 1430Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini1431 – 1468ExtracellularSequence analysisAdd BLAST38
Transmembranei1469 – 1489Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1490 – 1558CytoplasmicSequence analysisAdd BLAST69
Transmembranei1559 – 1579Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1580 – 1655ExtracellularSequence analysisAdd BLAST76
Transmembranei1656 – 1676Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1677 – 1718CytoplasmicSequence analysisAdd BLAST42
Transmembranei1719 – 1739Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1740 – 2171ExtracellularSequence analysisAdd BLAST432

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004154151 – 2171ATP-binding cassette sub-family C member SurAdd BLAST2171

Proteomic databases

PaxDbiQ9VL32.
PRIDEiQ9VL32.

Expressioni

Tissue specificityi

Highly expressed in adult heart. Detected at lower levels in head and abdomen.1 Publication

Developmental stagei

Detected in embryonic myocardial cells and in the developing heart tube. Detected in embryonic dorsal vessels and tracheal system.2 Publications

Gene expression databases

BgeeiFBgn0028675.
GenevisibleiQ9VL32. DM.

Interactioni

Protein-protein interaction databases

BioGridi60441. 1 interactor.
IntActiQ9VL32. 3 interactors.
STRINGi7227.FBpp0288707.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini344 – 622ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST279
Domaini785 – 1014ABC transporter 1PROSITE-ProRule annotationAdd BLAST230
Domaini1421 – 1715ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST295
Domaini1930 – 2165ABC transporter 2PROSITE-ProRule annotationAdd BLAST236

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00880000138026.
InParanoidiQ9VL32.
OMAiHMTEDTL.
OrthoDBiEOG091G00AA.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9VL32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQLFNIIHC DHLNGHVRSI YDNLNTDICG IDRVRRVFTF FSIFLLLFGL
60 70 80 90 100
MFVCSRYKKC HKTLLTFHNG RAAISLLLLA LNSFDLARIF LPHQNVRNLN
110 120 130 140 150
RLFQSSPRDL NYLVVIGSGE LWNALFSTLL TLMLMLYHRM VERKKATVFL
160 170 180 190 200
YASTAVEALT FALLSNELFE LVRYEDFLEL QTCLVAMSAM CMVSLAMLDG
210 220 230 240 250
LTVYKECYHD DYLDDYGKIG YKHSMATFYS KSCFWWLTPL LWLGYKEPLE
260 270 280 290 300
LEDLGQMKLE DSARSHYDHF LYIYTEKKKK SNSSPSLWYC YIKNSWQMFA
310 320 330 340 350
LGGILKLAGD LFALIGPLAI QKIVEYIEQL YAQASEPPAK SPGNEVANVL
360 370 380 390 400
LSTSRILGTE FDEVFGTNID KGLIYRKSLL LNADGGCDSS DSAGQVQSTS
410 420 430 440 450
STSDEKQKND DSMATPEHVD NPSEPNISHD IGSITNHMTE DTRNIMEFFL
460 470 480 490 500
IIHYAWAIPF KIAVVIYLLY MNLGISAVIG SIACIVIMTP LQFFIGNAMS
510 520 530 540 550
KNAEVIAGYT DERLKRIHDT LVGIKVIKLN AWDEVFLKKI QEARRKELKY
560 570 580 590 600
LNKDATFWTL MAVLTHIATV LITFVTLGVY VWLHRDQEFD LNASRLFSSL
610 620 630 640 650
ALFQQLTVPL LIFPITVPII IAARVSTRRL ERFLKSSEIQ KQFEGIRNMA
660 670 680 690 700
RILSKSDASL DMYETQEKSN MTMRTAQAEN RLNEKRLAQK SQTPELATNS
710 720 730 740 750
TPLLQNAEES AEDISPSTVQ ELGHNKLVQQ RRELLRNTPY VAIRPPKMRG
760 770 780 790 800
SVMERPVEFS VIRARNTDSW RRDSLLLKMP DDIAVSINDG LFTWQPQSQM
810 820 830 840 850
PVVQLHVPGI IVPKGKLTIV VGKNGSGKTS LLSALLMEMP LLAGNMFWHK
860 870 880 890 900
TCTISYVSQQ PWLLNDTIRE NILFGESFRP KRYDFVLEAC ALKPDIELMP
910 920 930 940 950
RGDLSIIGER GINISGGQRQ RIAIARAIYS SANVVIMDDP LASLDNEVGE
960 970 980 990 1000
HIFQHCIREM LQKSNRTFIL VTQQLHRIKE AEYLIAIKDG RVEACGSYAD
1010 1020 1030 1040 1050
IELMQPRITA EWNAIIAMAK AKNDNPSQNP GEKTAGERWK LLKNVSKLGL
1060 1070 1080 1090 1100
QRSISVTMDA NVACHADAID GSGCISVANM QSNVVEEDDQ VSVSYPIGNA
1110 1120 1130 1140 1150
SCGGFNLQRK RSSIYGSRHL MYDVPLPIDE CQGDDVIMRP RRRHTLGRRG
1160 1170 1180 1190 1200
SRNTNSSHRL SGLSTLTATS ESSSISGDVL SRSVLATSCS SYAESSVDGG
1210 1220 1230 1240 1250
DLATAAPEPR VQSWQPPQHV THHQPLSRNA SSPPAMEVAN PDVKKSEEAR
1260 1270 1280 1290 1300
RSNTSSESPL DDHVRGSFQQ FLRRMSMRRS NKPKNHHHPL SATNSILSIS
1310 1320 1330 1340 1350
EESPPVVHFP ASILATDGNK NETQSEEKPK KCVNIDSKET TINCDDNCYS
1360 1370 1380 1390 1400
ASDKELRANV TSSPADQEQH NERHVLAEVA GESGRESMPL ARLAIDTERK
1410 1420 1430 1440 1450
YGKISDDIYL MYIRAAGLPI ITIFFITALI WQCLRVYTDI WLQQWSNVHG
1460 1470 1480 1490 1500
RVASKGHVVL HPSEQDHEVT YYFRMYAAIS CVCIIMALVS TPAGQYAGCN
1510 1520 1530 1540 1550
ARRNLHDKLL QTILHKTLHF FQVTPLGRIV NRFSNDMAVI DKKIAATGQR
1560 1570 1580 1590 1600
LLQFTLLCLS AILINVTITP WILVLTLPIC GAYYLIQKFY RCSARELQRI
1610 1620 1630 1640 1650
ENATNSPVIS HLSETIQGVT TIRAFNQQTR FTEILFKRLE ANTIAYALLN
1660 1670 1680 1690 1700
TSHRWLGVSL DYLGGCIVFV ATVTALTAAS VSCRRHYEAT TSPSASASPS
1710 1720 1730 1740 1750
PFETYAVTKS PSELRPSPSL VGLAINYTLL VPIYLNWVVK LLADMEMYAG
1760 1770 1780 1790 1800
SVERIAHYAQ GQDADADADA DADADVDADL DHEPSSNEDV SAEVDRSSQS
1810 1820 1830 1840 1850
DAGDKVYPGA TTAAGDVDED GDQQRIGGAR GGGGDCGYRQ GHENGAEANA
1860 1870 1880 1890 1900
DKLNAGNVTG DGNHLNFHHP PATAGDKVEQ ATTKTSVIKD KQLPPQQDDK
1910 1920 1930 1940 1950
DKKVVLPNEP ARKLERYQSV PISWPQRGDI HFDNVSLRYE GQKQNVISNL
1960 1970 1980 1990 2000
TLKIPAGQRI GICGRTGSGK SSLGLSLFGV LQTTRGHIYI DDVDIQRIRP
2010 2020 2030 2040 2050
DELRTRLSII PQDVHLFNAT IRENLDPHGY FQDLQLWNCL ELAQLKEFVN
2060 2070 2080 2090 2100
GHLPLGLDTV ICDGGLNLSA GHRQLLCLAR AILRGSVCLV LDEATSVLDS
2110 2120 2130 2140 2150
STESALLKAA DLAFRGRTII TIAHRLTTIL DYDRLIVLDQ GRIVEDGNPR
2160 2170
ELQQLEGSVF RGLLEKGASK W
Length:2,171
Mass (Da):242,375
Last modified:March 3, 2009 - v4
Checksum:i5BA7802AD742B6D2
GO

Sequence cautioni

The sequence AAF06736 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34 – 35VR → CA in AAF06736 (PubMed:10506204).Curated2
Sequence conflicti54C → Y in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti77L → I in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti85D → E in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti413M → V in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti433S → G in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti444N → S in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti731R → G in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti1022K → E in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti1603A → T in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti1757H → Q in AAF06736 (PubMed:10506204).Curated1
Sequence conflicti1763 – 1766Missing in AAF06736 (PubMed:10506204).Curated4
Sequence conflicti1772A → T in AAF06736 (PubMed:10506204).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167431 mRNA. Translation: AAF06736.1. Different initiation.
AE014134 Genomic DNA. Translation: AAF52866.4.

Genome annotation databases

EnsemblMetazoaiFBtr0290268; FBpp0288707; FBgn0028675.

Cross-referencesi

Web resourcesi

Protein Spotlight

On The Other Side - Issue 139 of June 2012

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167431 mRNA. Translation: AAF06736.1. Different initiation.
AE014134 Genomic DNA. Translation: AAF52866.4.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi60441. 1 interactor.
IntActiQ9VL32. 3 interactors.
STRINGi7227.FBpp0288707.

Proteomic databases

PaxDbiQ9VL32.
PRIDEiQ9VL32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0290268; FBpp0288707; FBgn0028675.

Organism-specific databases

CTDi34350.
FlyBaseiFBgn0028675. Sur.

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00880000138026.
InParanoidiQ9VL32.
OMAiHMTEDTL.
OrthoDBiEOG091G00AA.

Miscellaneous databases

ChiTaRSiSur. fly.
GenomeRNAii34350.
PROiPR:Q9VL32.

Gene expression databases

BgeeiFBgn0028675.
GenevisibleiQ9VL32. DM.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSUR_DROME
AccessioniPrimary (citable) accession number: Q9VL32
Secondary accession number(s): Q9U6Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: March 3, 2009
Last modified: June 7, 2017
This is version 136 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.