ATP-binding cassette sub-family C member Sur

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
• ATP binding Source: UniProtKB-KW

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• heart development Source: FlyBase <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 12027431
• response to hypoxia Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 16882722
• transmembrane transport Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componentⁱ

• integral component of plasma membrane Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression"><span class="caps">P92958</span></a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression"><span class="caps">Q8TDN4</span></a>, <a href="http://www.uniprot.org/uniprot/O14734#expression"><span class="caps">O14734</span></a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the ‘Sequence’ section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MKQLFNIIHC DHLNGHVRSI YDNLNTDICG IDRVRRVFTF FSIFLLLFGL 
        60         70         80         90        100
MFVCSRYKKC HKTLLTFHNG RAAISLLLLA LNSFDLARIF LPHQNVRNLN 
       110        120        130        140        150
RLFQSSPRDL NYLVVIGSGE LWNALFSTLL TLMLMLYHRM VERKKATVFL 
       160        170        180        190        200
YASTAVEALT FALLSNELFE LVRYEDFLEL QTCLVAMSAM CMVSLAMLDG 
       210        220        230        240        250
LTVYKECYHD DYLDDYGKIG YKHSMATFYS KSCFWWLTPL LWLGYKEPLE 
       260        270        280        290        300
LEDLGQMKLE DSARSHYDHF LYIYTEKKKK SNSSPSLWYC YIKNSWQMFA 
       310        320        330        340        350
LGGILKLAGD LFALIGPLAI QKIVEYIEQL YAQASEPPAK SPGNEVANVL 
       360        370        380        390        400
LSTSRILGTE FDEVFGTNID KGLIYRKSLL LNADGGCDSS DSAGQVQSTS 
       410        420        430        440        450
STSDEKQKND DSMATPEHVD NPSEPNISHD IGSITNHMTE DTRNIMEFFL 
       460        470        480        490        500
IIHYAWAIPF KIAVVIYLLY MNLGISAVIG SIACIVIMTP LQFFIGNAMS 
       510        520        530        540        550
KNAEVIAGYT DERLKRIHDT LVGIKVIKLN AWDEVFLKKI QEARRKELKY 
       560        570        580        590        600
LNKDATFWTL MAVLTHIATV LITFVTLGVY VWLHRDQEFD LNASRLFSSL 
       610        620        630        640        650
ALFQQLTVPL LIFPITVPII IAARVSTRRL ERFLKSSEIQ KQFEGIRNMA 
       660        670        680        690        700
RILSKSDASL DMYETQEKSN MTMRTAQAEN RLNEKRLAQK SQTPELATNS 
       710        720        730        740        750
TPLLQNAEES AEDISPSTVQ ELGHNKLVQQ RRELLRNTPY VAIRPPKMRG 
       760        770        780        790        800
SVMERPVEFS VIRARNTDSW RRDSLLLKMP DDIAVSINDG LFTWQPQSQM 
       810        820        830        840        850
PVVQLHVPGI IVPKGKLTIV VGKNGSGKTS LLSALLMEMP LLAGNMFWHK 
       860        870        880        890        900
TCTISYVSQQ PWLLNDTIRE NILFGESFRP KRYDFVLEAC ALKPDIELMP 
       910        920        930        940        950
RGDLSIIGER GINISGGQRQ RIAIARAIYS SANVVIMDDP LASLDNEVGE 
       960        970        980        990       1000
HIFQHCIREM LQKSNRTFIL VTQQLHRIKE AEYLIAIKDG RVEACGSYAD 
      1010       1020       1030       1040       1050
IELMQPRITA EWNAIIAMAK AKNDNPSQNP GEKTAGERWK LLKNVSKLGL 
      1060       1070       1080       1090       1100
QRSISVTMDA NVACHADAID GSGCISVANM QSNVVEEDDQ VSVSYPIGNA 
      1110       1120       1130       1140       1150
SCGGFNLQRK RSSIYGSRHL MYDVPLPIDE CQGDDVIMRP RRRHTLGRRG 
      1160       1170       1180       1190       1200
SRNTNSSHRL SGLSTLTATS ESSSISGDVL SRSVLATSCS SYAESSVDGG 
      1210       1220       1230       1240       1250
DLATAAPEPR VQSWQPPQHV THHQPLSRNA SSPPAMEVAN PDVKKSEEAR 
      1260       1270       1280       1290       1300
RSNTSSESPL DDHVRGSFQQ FLRRMSMRRS NKPKNHHHPL SATNSILSIS 
      1310       1320       1330       1340       1350
EESPPVVHFP ASILATDGNK NETQSEEKPK KCVNIDSKET TINCDDNCYS 
      1360       1370       1380       1390       1400
ASDKELRANV TSSPADQEQH NERHVLAEVA GESGRESMPL ARLAIDTERK 
      1410       1420       1430       1440       1450
YGKISDDIYL MYIRAAGLPI ITIFFITALI WQCLRVYTDI WLQQWSNVHG 
      1460       1470       1480       1490       1500
RVASKGHVVL HPSEQDHEVT YYFRMYAAIS CVCIIMALVS TPAGQYAGCN 
      1510       1520       1530       1540       1550
ARRNLHDKLL QTILHKTLHF FQVTPLGRIV NRFSNDMAVI DKKIAATGQR 
      1560       1570       1580       1590       1600
LLQFTLLCLS AILINVTITP WILVLTLPIC GAYYLIQKFY RCSARELQRI 
      1610       1620       1630       1640       1650
ENATNSPVIS HLSETIQGVT TIRAFNQQTR FTEILFKRLE ANTIAYALLN 
      1660       1670       1680       1690       1700
TSHRWLGVSL DYLGGCIVFV ATVTALTAAS VSCRRHYEAT TSPSASASPS 
      1710       1720       1730       1740       1750
PFETYAVTKS PSELRPSPSL VGLAINYTLL VPIYLNWVVK LLADMEMYAG 
      1760       1770       1780       1790       1800
SVERIAHYAQ GQDADADADA DADADVDADL DHEPSSNEDV SAEVDRSSQS 
      1810       1820       1830       1840       1850
DAGDKVYPGA TTAAGDVDED GDQQRIGGAR GGGGDCGYRQ GHENGAEANA 
      1860       1870       1880       1890       1900
DKLNAGNVTG DGNHLNFHHP PATAGDKVEQ ATTKTSVIKD KQLPPQQDDK 
      1910       1920       1930       1940       1950
DKKVVLPNEP ARKLERYQSV PISWPQRGDI HFDNVSLRYE GQKQNVISNL 
      1960       1970       1980       1990       2000
TLKIPAGQRI GICGRTGSGK SSLGLSLFGV LQTTRGHIYI DDVDIQRIRP 
      2010       2020       2030       2040       2050
DELRTRLSII PQDVHLFNAT IRENLDPHGY FQDLQLWNCL ELAQLKEFVN 
      2060       2070       2080       2090       2100
GHLPLGLDTV ICDGGLNLSA GHRQLLCLAR AILRGSVCLV LDEATSVLDS 
      2110       2120       2130       2140       2150
STESALLKAA DLAFRGRTII TIAHRLTTIL DYDRLIVLDQ GRIVEDGNPR 
      2160       2170 
ELQQLEGSVF RGLLEKGASK W                       

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase
2. Protein Spotlight
   Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
3. SIMILARITY comments
   Index of protein domains and families