UniProtKB - Q9VL32 (SUR_DROME)
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Protein
ATP-binding cassette sub-family C member Sur
Gene
Sur
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
May function as regulatory subunit of ATP-sensitive potassium channels (KATP) and form KATP channels with a member of the ATP-sensitive inward rectifier potassium channel family (By similarity). May also have channel activity by itself (in vitro). May protect the heart during hypoxia. May protect against heart failure under conditions of tachycardic stress.By similarity2 Publications
Miscellaneous
Drosophila is predominantly active around dawn and dusk, and has large sleep periods during the day and during night. Knockdown of Sur reduces sleep duration during the first half of the night, but has little effect on sleep during the day (PubMed:22105623).1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 822 – 829 | ATP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1964 – 1971 | ATP 2PROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- heart development Source: FlyBase
- response to hypoxia Source: FlyBase
- transmembrane transport Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Receptor |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-DME-1296025. ATP sensitive Potassium channels. R-DME-382556. ABC-family proteins mediated transport. R-DME-422356. Regulation of insulin secretion. R-DME-5578775. Ion homeostasis. |
Names & Taxonomyi
Protein namesi | Recommended name: ATP-binding cassette sub-family C member SurAlternative name(s): Sulfonylurea receptor Short name: Dsur |
Gene namesi | Name:Sur ORF Names:CG5772 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0028675. Sur. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 36 | ExtracellularSequence analysisAdd BLAST | 36 | |
Transmembranei | 37 – 57 | Helical; Name=1PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 58 – 71 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 72 – 92 | Helical; Name=2PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 93 – 112 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 113 – 133 | Helical; Name=3PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 134 – 145 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 146 – 166 | Helical; Name=4PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 167 – 182 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 183 – 203 | Helical; Name=5PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 204 – 224 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 225 – 245 | Helical; Name=6PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 246 – 299 | ExtracellularSequence analysisAdd BLAST | 54 | |
Transmembranei | 300 – 320 | Helical; Name=7PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 321 – 447 | CytoplasmicSequence analysisAdd BLAST | 127 | |
Transmembranei | 448 – 468 | Helical; Name=8PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 469 – 474 | ExtracellularSequence analysis | 6 | |
Transmembranei | 475 – 495 | Helical; Name=9PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 496 – 562 | CytoplasmicSequence analysisAdd BLAST | 67 | |
Transmembranei | 563 – 583 | Helical; Name=10PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 584 – 600 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 601 – 621 | Helical; Name=11PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 622 – 1409 | CytoplasmicSequence analysisAdd BLAST | 788 | |
Transmembranei | 1410 – 1430 | Helical; Name=12PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1431 – 1468 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 1469 – 1489 | Helical; Name=13PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1490 – 1558 | CytoplasmicSequence analysisAdd BLAST | 69 | |
Transmembranei | 1559 – 1579 | Helical; Name=14PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1580 – 1655 | ExtracellularSequence analysisAdd BLAST | 76 | |
Transmembranei | 1656 – 1676 | Helical; Name=15PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1677 – 1718 | CytoplasmicSequence analysisAdd BLAST | 42 | |
Transmembranei | 1719 – 1739 | Helical; Name=16PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1740 – 2171 | ExtracellularSequence analysisAdd BLAST | 432 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000415415 | 1 – 2171 | ATP-binding cassette sub-family C member SurAdd BLAST | 2171 |
Proteomic databases
PaxDbi | Q9VL32. |
PRIDEi | Q9VL32. |
Expressioni
Tissue specificityi
Highly expressed in adult heart. Detected at lower levels in head and abdomen.1 Publication
Developmental stagei
Detected in embryonic myocardial cells and in the developing heart tube. Detected in embryonic dorsal vessels and tracheal system.2 Publications
Gene expression databases
Bgeei | FBgn0028675. |
ExpressionAtlasi | Q9VL32. differential. |
Genevisiblei | Q9VL32. DM. |
Interactioni
Protein-protein interaction databases
BioGridi | 60441. 1 interactor. |
IntActi | Q9VL32. 3 interactors. |
STRINGi | 7227.FBpp0288707. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 344 – 622 | ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST | 279 | |
Domaini | 785 – 1014 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 230 | |
Domaini | 1421 – 1715 | ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST | 295 | |
Domaini | 1930 – 2165 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 236 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0054. Eukaryota. COG1132. LUCA. |
InParanoidi | Q9VL32. |
OMAi | CTISYVS. |
OrthoDBi | EOG091G00AA. |
Family and domain databases
Gene3Di | 1.20.1560.10. 2 hits. |
InterProi | View protein in InterPro IPR003593. AAA+_ATPase. IPR011527. ABC1_TM_dom. IPR036640. ABC1_TM_sf. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR027417. P-loop_NTPase. |
Pfami | View protein in Pfam PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. |
SMARTi | View protein in SMART SM00382. AAA. 2 hits. |
SUPFAMi | SSF52540. SSF52540. 2 hits. SSF90123. SSF90123. 3 hits. |
PROSITEi | View protein in PROSITE PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. |
i Sequence
Sequence statusi: Complete.
Q9VL32-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKQLFNIIHC DHLNGHVRSI YDNLNTDICG IDRVRRVFTF FSIFLLLFGL
60 70 80 90 100
MFVCSRYKKC HKTLLTFHNG RAAISLLLLA LNSFDLARIF LPHQNVRNLN
110 120 130 140 150
RLFQSSPRDL NYLVVIGSGE LWNALFSTLL TLMLMLYHRM VERKKATVFL
160 170 180 190 200
YASTAVEALT FALLSNELFE LVRYEDFLEL QTCLVAMSAM CMVSLAMLDG
210 220 230 240 250
LTVYKECYHD DYLDDYGKIG YKHSMATFYS KSCFWWLTPL LWLGYKEPLE
260 270 280 290 300
LEDLGQMKLE DSARSHYDHF LYIYTEKKKK SNSSPSLWYC YIKNSWQMFA
310 320 330 340 350
LGGILKLAGD LFALIGPLAI QKIVEYIEQL YAQASEPPAK SPGNEVANVL
360 370 380 390 400
LSTSRILGTE FDEVFGTNID KGLIYRKSLL LNADGGCDSS DSAGQVQSTS
410 420 430 440 450
STSDEKQKND DSMATPEHVD NPSEPNISHD IGSITNHMTE DTRNIMEFFL
460 470 480 490 500
IIHYAWAIPF KIAVVIYLLY MNLGISAVIG SIACIVIMTP LQFFIGNAMS
510 520 530 540 550
KNAEVIAGYT DERLKRIHDT LVGIKVIKLN AWDEVFLKKI QEARRKELKY
560 570 580 590 600
LNKDATFWTL MAVLTHIATV LITFVTLGVY VWLHRDQEFD LNASRLFSSL
610 620 630 640 650
ALFQQLTVPL LIFPITVPII IAARVSTRRL ERFLKSSEIQ KQFEGIRNMA
660 670 680 690 700
RILSKSDASL DMYETQEKSN MTMRTAQAEN RLNEKRLAQK SQTPELATNS
710 720 730 740 750
TPLLQNAEES AEDISPSTVQ ELGHNKLVQQ RRELLRNTPY VAIRPPKMRG
760 770 780 790 800
SVMERPVEFS VIRARNTDSW RRDSLLLKMP DDIAVSINDG LFTWQPQSQM
810 820 830 840 850
PVVQLHVPGI IVPKGKLTIV VGKNGSGKTS LLSALLMEMP LLAGNMFWHK
860 870 880 890 900
TCTISYVSQQ PWLLNDTIRE NILFGESFRP KRYDFVLEAC ALKPDIELMP
910 920 930 940 950
RGDLSIIGER GINISGGQRQ RIAIARAIYS SANVVIMDDP LASLDNEVGE
960 970 980 990 1000
HIFQHCIREM LQKSNRTFIL VTQQLHRIKE AEYLIAIKDG RVEACGSYAD
1010 1020 1030 1040 1050
IELMQPRITA EWNAIIAMAK AKNDNPSQNP GEKTAGERWK LLKNVSKLGL
1060 1070 1080 1090 1100
QRSISVTMDA NVACHADAID GSGCISVANM QSNVVEEDDQ VSVSYPIGNA
1110 1120 1130 1140 1150
SCGGFNLQRK RSSIYGSRHL MYDVPLPIDE CQGDDVIMRP RRRHTLGRRG
1160 1170 1180 1190 1200
SRNTNSSHRL SGLSTLTATS ESSSISGDVL SRSVLATSCS SYAESSVDGG
1210 1220 1230 1240 1250
DLATAAPEPR VQSWQPPQHV THHQPLSRNA SSPPAMEVAN PDVKKSEEAR
1260 1270 1280 1290 1300
RSNTSSESPL DDHVRGSFQQ FLRRMSMRRS NKPKNHHHPL SATNSILSIS
1310 1320 1330 1340 1350
EESPPVVHFP ASILATDGNK NETQSEEKPK KCVNIDSKET TINCDDNCYS
1360 1370 1380 1390 1400
ASDKELRANV TSSPADQEQH NERHVLAEVA GESGRESMPL ARLAIDTERK
1410 1420 1430 1440 1450
YGKISDDIYL MYIRAAGLPI ITIFFITALI WQCLRVYTDI WLQQWSNVHG
1460 1470 1480 1490 1500
RVASKGHVVL HPSEQDHEVT YYFRMYAAIS CVCIIMALVS TPAGQYAGCN
1510 1520 1530 1540 1550
ARRNLHDKLL QTILHKTLHF FQVTPLGRIV NRFSNDMAVI DKKIAATGQR
1560 1570 1580 1590 1600
LLQFTLLCLS AILINVTITP WILVLTLPIC GAYYLIQKFY RCSARELQRI
1610 1620 1630 1640 1650
ENATNSPVIS HLSETIQGVT TIRAFNQQTR FTEILFKRLE ANTIAYALLN
1660 1670 1680 1690 1700
TSHRWLGVSL DYLGGCIVFV ATVTALTAAS VSCRRHYEAT TSPSASASPS
1710 1720 1730 1740 1750
PFETYAVTKS PSELRPSPSL VGLAINYTLL VPIYLNWVVK LLADMEMYAG
1760 1770 1780 1790 1800
SVERIAHYAQ GQDADADADA DADADVDADL DHEPSSNEDV SAEVDRSSQS
1810 1820 1830 1840 1850
DAGDKVYPGA TTAAGDVDED GDQQRIGGAR GGGGDCGYRQ GHENGAEANA
1860 1870 1880 1890 1900
DKLNAGNVTG DGNHLNFHHP PATAGDKVEQ ATTKTSVIKD KQLPPQQDDK
1910 1920 1930 1940 1950
DKKVVLPNEP ARKLERYQSV PISWPQRGDI HFDNVSLRYE GQKQNVISNL
1960 1970 1980 1990 2000
TLKIPAGQRI GICGRTGSGK SSLGLSLFGV LQTTRGHIYI DDVDIQRIRP
2010 2020 2030 2040 2050
DELRTRLSII PQDVHLFNAT IRENLDPHGY FQDLQLWNCL ELAQLKEFVN
2060 2070 2080 2090 2100
GHLPLGLDTV ICDGGLNLSA GHRQLLCLAR AILRGSVCLV LDEATSVLDS
2110 2120 2130 2140 2150
STESALLKAA DLAFRGRTII TIAHRLTTIL DYDRLIVLDQ GRIVEDGNPR
2160 2170
ELQQLEGSVF RGLLEKGASK W
Sequence cautioni
The sequence AAF06736 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 34 – 35 | VR → CA in AAF06736 (PubMed:10506204).Curated | 2 | |
Sequence conflicti | 54 | C → Y in AAF06736 (PubMed:10506204).Curated | 1 | |
Sequence conflicti | 77 | L → I in AAF06736 (PubMed:10506204).Curated | 1 | |
Sequence conflicti | 85 | D → E in AAF06736 (PubMed:10506204).Curated | 1 | |
Sequence conflicti | 413 | M → V in AAF06736 (PubMed:10506204).Curated | 1 | |
Sequence conflicti | 433 | S → G in AAF06736 (PubMed:10506204).Curated | 1 | |
Sequence conflicti | 444 | N → S in AAF06736 (PubMed:10506204).Curated | 1 | |
Sequence conflicti | 731 | R → G in AAF06736 (PubMed:10506204).Curated | 1 | |
Sequence conflicti | 1022 | K → E in AAF06736 (PubMed:10506204).Curated | 1 | |
Sequence conflicti | 1603 | A → T in AAF06736 (PubMed:10506204).Curated | 1 | |
Sequence conflicti | 1757 | H → Q in AAF06736 (PubMed:10506204).Curated | 1 | |
Sequence conflicti | 1763 – 1766 | Missing in AAF06736 (PubMed:10506204).Curated | 4 | |
Sequence conflicti | 1772 | A → T in AAF06736 (PubMed:10506204).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF167431 mRNA. Translation: AAF06736.1. Different initiation. AE014134 Genomic DNA. Translation: AAF52866.4. |
Similar proteinsi
Entry informationi
Entry namei | SUR_DROME | |
Accessioni | Q9VL32Primary (citable) accession number: Q9VL32 Secondary accession number(s): Q9U6Z2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 22, 2012 |
Last sequence update: | March 3, 2009 | |
Last modified: | March 28, 2018 | |
This is version 143 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |