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Q9VKZ1

- Q9VKZ1_DROME

UniProt

Q9VKZ1 - Q9VKZ1_DROME

Protein

Protoheme IX farnesyltransferase, mitochondrial

Gene

CG5037

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Converts protoheme IX and farnesyl diphosphate to heme O.UniRule annotation

    GO - Molecular functioni

    1. protoheme IX farnesyltransferase activity Source: InterPro

    GO - Biological processi

    1. heme O biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    TransferaseUniRule annotationImported

    Keywords - Biological processi

    Heme biosynthesisUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protoheme IX farnesyltransferase, mitochondrialUniRule annotation (EC:2.5.1.-UniRule annotation)
    Alternative name(s):
    Heme O synthaseUniRule annotation
    Gene namesi
    ORF Names:CG5037Imported, Dmel_CG5037Imported
    OrganismiDrosophila melanogaster (Fruit fly)Imported
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0032222. CG5037.

    Subcellular locationi

    Mitochondrion membrane UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: InterPro
    2. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    MembraneUniRule annotation, MitochondrionUniRule annotation

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-872940.
    STRINGi7227.FBpp0079582.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiA prenyltransferase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0109.
    GeneTreeiENSGT00390000008408.
    InParanoidiQ9VKZ1.
    KOiK02257.
    OMAiPFDSQMS.
    OrthoDBiEOG7SFHX1.

    Family and domain databases

    HAMAPiMF_00154. CyoE_CtaB.
    InterProiIPR006369. Protohaem_IX_farnesylTrfase.
    IPR016315. Protohaem_IX_farnesylTrfase_mt.
    IPR000537. UbiA_prenyltransferase.
    [Graphical view]
    PfamiPF01040. UbiA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001773. COX10. 1 hit.
    TIGRFAMsiTIGR01473. cyoE_ctaB. 1 hit.
    PROSITEiPS00943. UBIA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9VKZ1-1 [UniParc]FASTAAdd to Basket

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    MILFKGIRRV QSQLRTPVDL VLIRYSTAAT IASQDDKGVT TASPVSQAGK    50
    VQHLPDSQIT WMPSPYTMPG KTLSQYKKLS KFRLTSLVVI TTMGGYAMAP 100
    AAFDPTTFAM CTLGTGLVSA AANAINQYHE VPFDSQMSRT KNRVLVTGQM 150
    TPLHAVTFAA VSATAGLSML YFGVNGLTAA LGAGNLFLYT TIYTPMKRIS 200
    IVNTWVGSIV GAIPPLMGWA GCAATLDAGA MILAGVLYAW QFPHFNALSW 250
    NLRPDYSRAG YRMMAVTNPG LCRRTALRYS VAIVGLSAMA PVLDVTNYWF 300
    ALETLPLNAY FAYLAYKFHE KSDSGSSRKL FRFSLIHLPA LMLLFLTNKK 350
    EWYFSKPAGE ENKKESTYSA IKHSASSLGN VLPVAVAEGP R 391
    Length:391
    Mass (Da):42,562
    Last modified:May 1, 2000 - v1
    Checksum:i826FB24E5D4EECD0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF52915.1.
    AY058639 mRNA. Translation: AAL13868.1.
    RefSeqiNP_609382.1. NM_135538.3.
    UniGeneiDm.386.

    Genome annotation databases

    EnsemblMetazoaiFBtr0079992; FBpp0079582; FBgn0032222.
    GeneIDi34394.
    KEGGidme:Dmel_CG5037.
    UCSCiCG5037-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF52915.1 .
    AY058639 mRNA. Translation: AAL13868.1 .
    RefSeqi NP_609382.1. NM_135538.3.
    UniGenei Dm.386.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-872940.
    STRINGi 7227.FBpp0079582.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0079992 ; FBpp0079582 ; FBgn0032222 .
    GeneIDi 34394.
    KEGGi dme:Dmel_CG5037.
    UCSCi CG5037-RA. d. melanogaster.

    Organism-specific databases

    FlyBasei FBgn0032222. CG5037.

    Phylogenomic databases

    eggNOGi COG0109.
    GeneTreei ENSGT00390000008408.
    InParanoidi Q9VKZ1.
    KOi K02257.
    OMAi PFDSQMS.
    OrthoDBi EOG7SFHX1.

    Miscellaneous databases

    GenomeRNAii 34394.
    NextBioi 788285.
    PROi Q9VKZ1.

    Family and domain databases

    HAMAPi MF_00154. CyoE_CtaB.
    InterProi IPR006369. Protohaem_IX_farnesylTrfase.
    IPR016315. Protohaem_IX_farnesylTrfase_mt.
    IPR000537. UbiA_prenyltransferase.
    [Graphical view ]
    Pfami PF01040. UbiA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001773. COX10. 1 hit.
    TIGRFAMsi TIGR01473. cyoE_ctaB. 1 hit.
    PROSITEi PS00943. UBIA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BerkeleyImported.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    4. Cited for: GENOME REANNOTATION.
      Strain: BerkeleyImported.
    5. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
      Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
      Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    6. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
      Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
      Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    7. "Combined evidence annotation of transposable elements in genome sequences."
      Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
      PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    8. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    9. "Drosophila melanogaster release 4 sequence."
      Berkeley Drosophila Genome Project
      Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    10. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
      Smith C.D., Shu S., Mungall C.J., Karpen G.H.
      Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    12. FlyBase
      Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9VKZ1_DROME
    AccessioniPrimary (citable) accession number: Q9VKZ1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3