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Protein

Protoheme IX farnesyltransferase, mitochondrial

Gene

Dmel\CG5037

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Converts protoheme IX and farnesyl diphosphate to heme O.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseImported, TransferaseUniRule annotationImported
Biological processHeme biosynthesisUniRule annotation

Enzyme and pathway databases

ReactomeiR-DME-189451 Heme biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protoheme IX farnesyltransferase, mitochondrialUniRule annotation (EC:2.5.1.-UniRule annotation)
Alternative name(s):
Heme O synthaseUniRule annotation
Gene namesi
Name:Dmel\CG5037Imported
Synonyms:COXXImported
ORF Names:CG5037Imported, Dmel_CG5037Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0032222 CG5037

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei84 – 103HelicalSequence analysisAdd BLAST20
Transmembranei276 – 293HelicalSequence analysisAdd BLAST18
Transmembranei330 – 347HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, MitochondrionUniRule annotation

Expressioni

Gene expression databases

BgeeiFBgn0032222

Interactioni

Protein-protein interaction databases

IntActiQ9VKZ1 1 interactor.
STRINGi7227.FBpp0079582

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiA prenyltransferase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1380 Eukaryota
COG0109 LUCA
GeneTreeiENSGT00390000008408
KOiK02257
OMAiWQFPHFW
OrthoDBiEOG091G0F6B

Family and domain databases

CDDicd13957 PT_UbiA_Cox10, 1 hit
HAMAPiMF_00154 CyoE_CtaB, 1 hit
InterProiView protein in InterPro
IPR006369 Protohaem_IX_farnesylTrfase
IPR016315 Protohaem_IX_farnesylTrfase_mt
IPR000537 UbiA_prenyltransferase
IPR030470 UbiA_prenylTrfase_CS
PANTHERiPTHR43448 PTHR43448, 1 hit
PfamiView protein in Pfam
PF01040 UbiA, 1 hit
PIRSFiPIRSF001773 COX10, 1 hit
TIGRFAMsiTIGR01473 cyoE_ctaB, 1 hit
PROSITEiView protein in PROSITE
PS00943 UBIA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VKZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILFKGIRRV QSQLRTPVDL VLIRYSTAAT IASQDDKGVT TASPVSQAGK
60 70 80 90 100
VQHLPDSQIT WMPSPYTMPG KTLSQYKKLS KFRLTSLVVI TTMGGYAMAP
110 120 130 140 150
AAFDPTTFAM CTLGTGLVSA AANAINQYHE VPFDSQMSRT KNRVLVTGQM
160 170 180 190 200
TPLHAVTFAA VSATAGLSML YFGVNGLTAA LGAGNLFLYT TIYTPMKRIS
210 220 230 240 250
IVNTWVGSIV GAIPPLMGWA GCAATLDAGA MILAGVLYAW QFPHFNALSW
260 270 280 290 300
NLRPDYSRAG YRMMAVTNPG LCRRTALRYS VAIVGLSAMA PVLDVTNYWF
310 320 330 340 350
ALETLPLNAY FAYLAYKFHE KSDSGSSRKL FRFSLIHLPA LMLLFLTNKK
360 370 380 390
EWYFSKPAGE ENKKESTYSA IKHSASSLGN VLPVAVAEGP R
Length:391
Mass (Da):42,562
Last modified:May 1, 2000 - v1
Checksum:i826FB24E5D4EECD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF52915.1
AY058639 mRNA Translation: AAL13868.1
RefSeqiNP_609382.1, NM_135538.3
UniGeneiDm.386

Genome annotation databases

EnsemblMetazoaiFBtr0079992; FBpp0079582; FBgn0032222
GeneIDi34394
KEGGidme:Dmel_CG5037
UCSCiCG5037-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9VKZ1_DROME
AccessioniPrimary (citable) accession number: Q9VKZ1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported