Q9VKX2 (Q9VKX2_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Malate dehydrogenase RuleBase RU003405
EC=1.1.1.37 RuleBase RU003405

Gene names

Name:	Mdh1 FlyBase FBgn0262782
Synonyms:	CG5362-RA EMBL AEK87152.1
ORF Names:	CG5362 FlyBase FBgn0032237, Dmel_CG5362 EMBL AAF52935.2

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	(S)-malate + NAD+ = oxaloacetate + NADH. RuleBase RU003405
Sequence similarities	Belongs to the LDH/MDH superfamily. MDH type 2 family. RuleBase RU000421

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle RuleBase RU003405
Ligand	NAD RuleBase RU003405
Molecular function	Oxidoreductase RuleBase RU003405 EMBL AAF52935.2
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro malate metabolic process Inferred from electronic annotation. Source: InterPro tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-malate dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9VKX2 [UniParc]. Last modified October 1, 2002. Version 2. Checksum: 56E6D4E708B04A89	FASTA	337	36,059
	10 20 30 40 50 60 MAEPIRVVVT GAAGQIAYSL LYMIARGEVF GKDQPIVLHL LDIPPMVGVL EGVVMELADC 70 80 90 100 110 120 ALPLLVEVVP TTDPAVGFKD VSAAFLVGAM PRKEGMERKD LLSANVKIFR TQGQALDKFA 130 140 150 160 170 180 KKDVKVLVVG NPANTNALVC SSYAPSIPRE NFSAMTRLDQ NRATSQIAAK LGVPISAVKN 190 200 210 220 230 240 IIIWGNHSST QYPDAGQAKV TANGTVKSVV DAINDNGYLQ GSFVETVQKR GAAVIAARKM 250 260 270 280 290 300 SSAMSAAKAA CDHMHDWWNG TAPGQFVSMG VFSDGSYDSP KDVIFSFPVE IKNKQWKIVS 310 320 330 GLTLSDFAKT KLSVTGKELQ EEKDEALSVL DSNVSNL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[3]	Carlson J., Booth B., Frise E., Sandler J., Wan K., Yu C., Celniker S. Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014134 Genomic DNA. Translation: AAF52935.2. BT128780 mRNA. Translation: AEK87152.1.
RefSeq	NP_609394.1. NM_135550.1.
UniGene	Dm.11601.
3D structure databases
HSSP	HSSP built from PDB template 4MDH based on UniProtKB P11708.
ProteinModelPortal	Q9VKX2.
SMR	Q9VKX2. Positions 2-332.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VKX2. 2 interactions.
MINT	MINT-1559678.
STRING	Q9VKX2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0080050; FBpp0079640; FBgn0262782.
GeneID	34414.
KEGG	dme:Dmel_CG5362.
NMPDR	fig|7227.3.peg.1814.
UCSC	CG5362-RA. d. melanogaster.
Organism-specific databases
FlyBase	FBgn0262782. Mdh1.
Phylogenomic databases
GeneTree	EMGT00050000006654.
InParanoid	Q9VKX2.
OMA	NFSAMTR.
PhylomeDB	Q9VKX2.
Gene expression databases
ArrayExpress	Q9VKX2.
Bgee	Q9VKX2.
Family and domain databases
HAMAP	MF_01517. Malate_dehydrog_2. [Tree]
InterPro	IPR001557. L-lactate/malate_DH. IPR022383. Lactate/malate_DH_C. IPR001236. Lactate/malate_DH_N. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR001252. Malate_DH_AS. IPR011274. Malate_DH_NAD-dep_euk. IPR010945. Malate_DH_type2. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.90.110.10. lact_mal_DH. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00025.
PANTHER	PTHR23382. MDH_SF1. 1 hit.
Pfam	PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view]
PIRSF	PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAM	SSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMs	TIGR01759. MalateDH-SF1. 1 hit. TIGR01758. MDH_euk_cyt. 1 hit.
PROSITE	PS00068. MDH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	788384.

Entry information

Entry name

Q9VKX2_DROME

Accession

Primary (citable) accession number: Q9VKX2

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)