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Protein

Homogentisate 1,2-dioxygenase

Gene

hgo

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.

Cofactori

Fe cationBy similarity

Pathwayi: L-phenylalanine degradation

This protein is involved in step 4 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Protein henna (Hn)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Homogentisate 1,2-dioxygenase (hgo)
  5. Probable maleylacetoacetate isomerase 1 (GstZ1), Probable maleylacetoacetate isomerase 2 (GstZ2)
  6. no protein annotated in this organism
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi335IronBy similarity1
Metal bindingi341IronBy similarity1
Metal bindingi371IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPhenylalanine catabolism, Tyrosine catabolism
LigandIron, Metal-binding

Enzyme and pathway databases

ReactomeiR-DME-71182. Phenylalanine and tyrosine catabolism.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene namesi
Name:hgo
ORF Names:CG4779
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0040211. hgo.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002202421 – 439Homogentisate 1,2-dioxygenaseAdd BLAST439

Proteomic databases

PaxDbiQ9VKJ0.
PRIDEiQ9VKJ0.

Expressioni

Gene expression databases

BgeeiFBgn0040211.
GenevisibleiQ9VKJ0. DM.

Interactioni

Protein-protein interaction databases

BioGridi60614. 1 interactor.
DIPiDIP-23788N.
MINTiMINT-927986.
STRINGi7227.FBpp0079790.

Structurei

3D structure databases

ProteinModelPortaliQ9VKJ0.
SMRiQ9VKJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.Curated

Phylogenomic databases

eggNOGiKOG1417. Eukaryota.
COG3508. LUCA.
GeneTreeiENSGT00390000004601.
InParanoidiQ9VKJ0.
KOiK00451.
OMAiHGNYTPY.
OrthoDBiEOG091G11CO.
PhylomeDBiQ9VKJ0.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiView protein in InterPro
IPR005708. Homogentis_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin_sf.
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiView protein in Pfam
PF04209. HgmA. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VKJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEYKYLSGF GSHFSSEDER YPNSLPVGQN SPQVCPYKLY AEQLSGSAFT
60 70 80 90 100
APRTENMRTW LYRKLPSAAH LPFQPFKGAE YFSQNWDEQP PNPNQLRWKP
110 120 130 140 150
FDLPPKDGKN VNFVEGLHTV CGAGDPRSRH GLAIHIYSCN GSMDNSAFYN
160 170 180 190 200
SDGDFLIVPQ QGVLDITTEF GRMSVAPNEI CVIPQGIRFA VNVDSPSRGY
210 220 230 240 250
ILEVYDDHFV LPDLGPIGAN GLANPRDFET PVAWFDDRDV KDFQVISKFQ
260 270 280 290 300
GRLFVAKQNH TVFDVVAWHG NYVPFKYDLS KFMVINSVSF DHCDPSIFTV
310 320 330 340 350
LTCPSLRAGT AIADFVIFPP RWSVQEHTFR PPYYHRNCMS EFMGLILGKY
360 370 380 390 400
EAKEDGFAAG GATLHSMMTP HGPDVKCFEG ASNAKLVPER VAEGTQAFMF
410 420 430
ESSLSLAVTK WGEETCQKLD AAYYECWQAL KNNFQITKN
Length:439
Mass (Da):49,398
Last modified:July 25, 2003 - v3
Checksum:i08418138B9600FE1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96 – 106Missing in AAF36489 (Ref. 1) CuratedAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131124 Genomic DNA. Translation: AAF36489.1.
AE014134 Genomic DNA. Translation: AAF53078.2.
BT003496 mRNA. Translation: AAO39500.1.
RefSeqiNP_523544.2. NM_078820.3.
UniGeneiDm.2807.

Genome annotation databases

EnsemblMetazoaiFBtr0080201; FBpp0079790; FBgn0040211.
GeneIDi34552.
KEGGidme:Dmel_CG4779.

Similar proteinsi

Entry informationi

Entry nameiHGD_DROME
AccessioniPrimary (citable) accession number: Q9VKJ0
Secondary accession number(s): Q86P40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 25, 2003
Last modified: November 22, 2017
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families