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Q9VKJ0

- HGD_DROME

UniProt

Q9VKJ0 - HGD_DROME

Protein

Homogentisate 1,2-dioxygenase

Gene

hgo

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 3 (25 Jul 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Homogentisate + O2 = 4-maleylacetoacetate.

    Cofactori

    Iron.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi335 – 3351IronBy similarity
    Metal bindingi341 – 3411IronBy similarity
    Metal bindingi371 – 3711IronBy similarity

    GO - Molecular functioni

    1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. L-phenylalanine catabolic process Source: UniProtKB-UniPathway
    2. tyrosine catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Phenylalanine catabolism, Tyrosine catabolism

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_203229. Phenylalanine and tyrosine catabolism.
    UniPathwayiUPA00139; UER00339.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
    Alternative name(s):
    Homogentisate oxygenase
    Homogentisic acid oxidase
    Homogentisicase
    Gene namesi
    Name:hgo
    ORF Names:CG4779
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0040211. hgo.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 439439Homogentisate 1,2-dioxygenasePRO_0000220242Add
    BLAST

    Proteomic databases

    PaxDbiQ9VKJ0.

    Expressioni

    Gene expression databases

    BgeeiQ9VKJ0.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself1EBI-150349,EBI-150349

    Protein-protein interaction databases

    BioGridi60614. 1 interaction.
    DIPiDIP-23788N.
    MINTiMINT-927986.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VKJ0.
    SMRiQ9VKJ0. Positions 2-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the homogentisate dioxygenase family.Curated

    Phylogenomic databases

    eggNOGiCOG3508.
    GeneTreeiENSGT00390000004601.
    InParanoidiQ9VKJ0.
    KOiK00451.
    OMAiTTETHKL.
    OrthoDBiEOG7PP58Z.
    PhylomeDBiQ9VKJ0.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    InterProiIPR005708. Homogentis_dOase.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR11056. PTHR11056. 1 hit.
    PfamiPF04209. HgmA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR01015. hmgA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9VKJ0-1 [UniParc]FASTAAdd to Basket

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    MSEYKYLSGF GSHFSSEDER YPNSLPVGQN SPQVCPYKLY AEQLSGSAFT    50
    APRTENMRTW LYRKLPSAAH LPFQPFKGAE YFSQNWDEQP PNPNQLRWKP 100
    FDLPPKDGKN VNFVEGLHTV CGAGDPRSRH GLAIHIYSCN GSMDNSAFYN 150
    SDGDFLIVPQ QGVLDITTEF GRMSVAPNEI CVIPQGIRFA VNVDSPSRGY 200
    ILEVYDDHFV LPDLGPIGAN GLANPRDFET PVAWFDDRDV KDFQVISKFQ 250
    GRLFVAKQNH TVFDVVAWHG NYVPFKYDLS KFMVINSVSF DHCDPSIFTV 300
    LTCPSLRAGT AIADFVIFPP RWSVQEHTFR PPYYHRNCMS EFMGLILGKY 350
    EAKEDGFAAG GATLHSMMTP HGPDVKCFEG ASNAKLVPER VAEGTQAFMF 400
    ESSLSLAVTK WGEETCQKLD AAYYECWQAL KNNFQITKN 439
    Length:439
    Mass (Da):49,398
    Last modified:July 25, 2003 - v3
    Checksum:i08418138B9600FE1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti96 – 10611Missing in AAF36489. 1 PublicationCuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF131124 Genomic DNA. Translation: AAF36489.1.
    AE014134 Genomic DNA. Translation: AAF53078.2.
    BT003496 mRNA. Translation: AAO39500.1.
    RefSeqiNP_523544.2. NM_078820.2.
    UniGeneiDm.2807.

    Genome annotation databases

    EnsemblMetazoaiFBtr0080201; FBpp0079790; FBgn0040211.
    GeneIDi34552.
    KEGGidme:Dmel_CG4779.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF131124 Genomic DNA. Translation: AAF36489.1 .
    AE014134 Genomic DNA. Translation: AAF53078.2 .
    BT003496 mRNA. Translation: AAO39500.1 .
    RefSeqi NP_523544.2. NM_078820.2.
    UniGenei Dm.2807.

    3D structure databases

    ProteinModelPortali Q9VKJ0.
    SMRi Q9VKJ0. Positions 2-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 60614. 1 interaction.
    DIPi DIP-23788N.
    MINTi MINT-927986.

    Proteomic databases

    PaxDbi Q9VKJ0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0080201 ; FBpp0079790 ; FBgn0040211 .
    GeneIDi 34552.
    KEGGi dme:Dmel_CG4779.

    Organism-specific databases

    CTDi 34552.
    FlyBasei FBgn0040211. hgo.

    Phylogenomic databases

    eggNOGi COG3508.
    GeneTreei ENSGT00390000004601.
    InParanoidi Q9VKJ0.
    KOi K00451.
    OMAi TTETHKL.
    OrthoDBi EOG7PP58Z.
    PhylomeDBi Q9VKJ0.

    Enzyme and pathway databases

    UniPathwayi UPA00139 ; UER00339 .
    Reactomei REACT_203229. Phenylalanine and tyrosine catabolism.

    Miscellaneous databases

    GenomeRNAii 34552.
    NextBioi 789029.
    PROi Q9VKJ0.

    Gene expression databases

    Bgeei Q9VKJ0.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    InterProi IPR005708. Homogentis_dOase.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR11056. PTHR11056. 1 hit.
    Pfami PF04209. HgmA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR01015. hmgA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Schmidt S.R.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.

    Entry informationi

    Entry nameiHGD_DROME
    AccessioniPrimary (citable) accession number: Q9VKJ0
    Secondary accession number(s): Q86P40
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 25, 2003
    Last modified: October 1, 2014
    This is version 105 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3