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Protein

Palmitoyltransferase

Gene

Patsas

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.UniRule annotation

GO - Molecular functioni

  • protein-cysteine S-palmitoyltransferase activity Source: FlyBase

GO - Biological processi

  • protein palmitoylation Source: FlyBase

Keywordsi

Molecular functionAcyltransferaseUniRule annotationSAAS annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
PalmitoyltransferaseUniRule annotation (EC:2.3.1.225UniRule annotation)
Gene namesi
Name:PatsasImported
ORF Names:CG6618Imported, Dmel_CG6618Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0029137. Patsas.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei340 – 360HelicalUniRule annotationAdd BLAST21
Transmembranei469 – 493HelicalUniRule annotationAdd BLAST25
Transmembranei500 – 518HelicalUniRule annotationAdd BLAST19

GO - Cellular componenti

  • Golgi apparatus Source: FlyBase
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0029137.

Interactioni

Protein-protein interaction databases

IntActiQ9VKB1. 2 interactors.
MINTiMINT-929341.
STRINGi7227.FBpp0079944.

Structurei

3D structure databases

ProteinModelPortaliQ9VKB1.
SMRiQ9VKB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 308ANK_REP_REGIONInterPro annotationAdd BLAST195
Repeati120 – 148ANKPROSITE-ProRule annotationAdd BLAST29
Repeati155 – 187ANKPROSITE-ProRule annotationAdd BLAST33
Repeati188 – 220ANKPROSITE-ProRule annotationAdd BLAST33
Repeati221 – 253ANKPROSITE-ProRule annotationAdd BLAST33
Repeati254 – 274ANKPROSITE-ProRule annotationAdd BLAST21

Domaini

The DHHC domain is required for palmitoyltransferase activity.UniRule annotation

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.UniRule annotationSAAS annotation

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0509. Eukaryota.
COG0666. LUCA.
COG5273. LUCA.
GeneTreeiENSGT00530000063074.
KOiK20032.
OMAiDIDIDHR.
OrthoDBiEOG091G0CPB.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF12796. Ank_2. 2 hits.
PF13606. Ank_3. 1 hit.
PF01529. zf-DHHC. 1 hit.
SMARTiView protein in SMART
SM00248. ANK. 6 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.

Sequencei

Sequence statusi: Complete.

Q9VKB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKVHPSPG AARSVWALPL TASSSCNMVV AEEDGHAHAD DIHLDHRPHS
60 70 80 90 100
PPLTGRGTDG GHGSSGVEDH ENVLLFEGLD GATTVSLDDI FDIIKNGEVS
110 120 130 140 150
EVENLVDKFG MECLSARDRH GYTPAHWIAL NGNVQLMRYL IERTAPIDLP
160 170 180 190 200
CLGTQGPRPI HWACRKGHAS VVQVLLQAGV AVNAADFKGL TPLHLACMYG
210 220 230 240 250
RTATAAYLLG MGALNNLTDI NGDTALHWAA YKGHADLMRL LMYSGVELQK
260 270 280 290 300
TDNFGSTPLH LACLSGNMTC VRLLCEKSQL DLEPRDKNGK TPIMLAQAHQ
310 320 330 340 350
HQDVVRLLYG EVKKKSRWIP SVSESWGWLF GGAGDSKGPL FLFLFSVLLW
360 370 380 390 400
GYPMYMIRAI PITWNILRRS HYCFIYWNAV MWISWAIANR RDPGYIPLSS
410 420 430 440 450
DAYYRAIKQI PYFDKLKKRN VMLTRLCHSC RCLRPLRAKH CRVCNRCVSY
460 470 480 490 500
FDHHCPFIYN CVGLRNRMWF FLFVLSVAVN CSFTIYFACY CVMIEGFTML
510 520 530 540 550
YVLGLIEAVV FCGLGWILTC TSILHACMNL TTNEMFNYKR YPYLRDKRGR
560 570 580
YQNPFSRGPI LNLLEFFVCL PDRGDDNDLL LEDNI
Length:585
Mass (Da):65,975
Last modified:May 1, 2000 - v1
Checksum:iB1490B6466C56FD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF53165.1.
AY058389 mRNA. Translation: AAL13618.1.
RefSeqiNP_723724.1. NM_164993.2.
UniGeneiDm.23204.

Genome annotation databases

EnsemblMetazoaiFBtr0080362; FBpp0079944; FBgn0029137.
GeneIDi34634.
KEGGidme:Dmel_CG6618.
UCSCiCG6618-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF53165.1.
AY058389 mRNA. Translation: AAL13618.1.
RefSeqiNP_723724.1. NM_164993.2.
UniGeneiDm.23204.

3D structure databases

ProteinModelPortaliQ9VKB1.
SMRiQ9VKB1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9VKB1. 2 interactors.
MINTiMINT-929341.
STRINGi7227.FBpp0079944.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0080362; FBpp0079944; FBgn0029137.
GeneIDi34634.
KEGGidme:Dmel_CG6618.
UCSCiCG6618-RA. d. melanogaster.

Organism-specific databases

CTDi34634.
FlyBaseiFBgn0029137. Patsas.

Phylogenomic databases

eggNOGiKOG0509. Eukaryota.
COG0666. LUCA.
COG5273. LUCA.
GeneTreeiENSGT00530000063074.
KOiK20032.
OMAiDIDIDHR.
OrthoDBiEOG091G0CPB.

Miscellaneous databases

GenomeRNAii34634.

Gene expression databases

BgeeiFBgn0029137.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF12796. Ank_2. 2 hits.
PF13606. Ank_3. 1 hit.
PF01529. zf-DHHC. 1 hit.
SMARTiView protein in SMART
SM00248. ANK. 6 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9VKB1_DROME
AccessioniPrimary (citable) accession number: Q9VKB1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: April 12, 2017
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.