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Protein
Submitted name:

MIP30126p

Gene

Pkd2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cation transport Source: FlyBase
  • detection of mechanical stimulus Source: GO_Central
  • flagellated sperm motility Source: FlyBase
  • larval feeding behavior Source: FlyBase
  • smooth muscle contraction Source: FlyBase
  • spermatogenesis Source: FlyBase
  • sperm competition Source: FlyBase
  • sperm storage Source: FlyBase

Names & Taxonomyi

Protein namesi
Submitted name:
MIP30126pImported
Submitted name:
Polycystic kidney disease 2Imported
Submitted name:
Polycystin-2Imported
Gene namesi
Name:Pkd2Imported
Synonyms:AMOImported, AmoImported, amoImported, Dmel\CG6504Imported, Dmpkd2Imported, PKD2Imported, pkd2Imported, Pkd2-RAImported, TRPPImported, TRPP2Imported
ORF Names:CG6504Imported, Dmel_CG6504Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0041195 Pkd2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei241 – 262HelicalSequence analysisAdd BLAST22
Transmembranei586 – 604HelicalSequence analysisAdd BLAST19
Transmembranei616 – 643HelicalSequence analysisAdd BLAST28
Transmembranei664 – 693HelicalSequence analysisAdd BLAST30
Transmembranei713 – 735HelicalSequence analysisAdd BLAST23
Transmembranei774 – 796HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ9VK95

Expressioni

Gene expression databases

BgeeiFBgn0041195
ExpressionAtlasiQ9VK95 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0079947

Structurei

3D structure databases

SMRiQ9VK95
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini413 – 803PKD_channelInterPro annotationAdd BLAST391

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili887 – 914Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3599 Eukaryota
ENOG410XTGE LUCA
GeneTreeiENSGT00700000104221
KOiK04986
OMAiTHCGRKR
OrthoDBiEOG091G04JX

Family and domain databases

InterProiView protein in InterPro
IPR013122 PKD1_2_channel
PfamiView protein in Pfam
PF08016 PKD_channel, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VK95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQQGQSGRS PSGPPGPPPP RPPKTPPGAS PRGTPTADST PGDVTPARGP
60 70 80 90 100
PPPPATKRVS IGVGSTRSAP PPATDPTGPP PTAGKPVRDT GPSTSPRPSL
110 120 130 140 150
RDPGQSTSDK PSTSDKPSTS DKPSTSARTT VREPGPSSSP SRPVSTRESG
160 170 180 190 200
RITFQEAAPS TSAKVVKLAA SEPRPAKPPE KEGFSLFKRK KKSVGSSTPP
210 220 230 240 250
SPSRGHRAPS IIAASALQNR AKTNRILYTT DEEVREALVE FSVFIIFLIL
260 270 280 290 300
TSLVVLSVRH TYMFYFNDTM KKLFTNREMV VAPSVTVGFE KLITVPDWWD
310 320 330 340 350
YLKYNFLVTL HGDLTFMDDA QANLTSMPPE GSEQGSEQGS EQGSEQSPEE
360 370 380 390 400
VVGEAPEEAP EMDRLQEDFK YNGNPYIDLR GHRRAKRQSG VDGNSEDGSE
410 420 430 440 450
DVSGNYLKDD SDSIQANMSF HHLEGRVFLY ENLLLGPPRL RQIRVRKESC
460 470 480 490 500
YVNDAFIRYF NTCYAAYSSG AEDRKPMHKG SPFRTMHDLD STPIWTVLAF
510 520 530 540 550
YRTGGYTVNL DYDKDRNVKI INDLKDIHWL DRGSRLCLVE FNLFNENTDI
560 570 580 590 600
FQSIKLIAEI PPTGGVIPQA HLQTVKMYSF FTDRSMLMTV IYIFWYIMVI
610 620 630 640 650
YYTIYEITEI RKSGIKIYFC SMLNILDCAI LLGCYLALVY NIWHSFKVMS
660 670 680 690 700
LTARAHSDVT YQSLDVLCFW NIIYVDMMAI LAFLVWIKIF KFISFNKTLV
710 720 730 740 750
QFTTTLKRCS KDLAGFSLMF GIVFLAYAQL GLLLFGTKHP DFRNFITSIL
760 770 780 790 800
TMIRMILGDF QYNLIEQANR VLGPIYFLTY ILLVFFILLN MFLAIIMETY
810 820 830 840 850
NTVKGEITQG RSHLGSYIYR KLSGMLYWIT HCGRKRRHHP QASETEDKDA
860 870 880 890 900
EHDVGAAHDE THEIRKNMTP AEQQYFKDIP QGENQDMVRL NNRVGLLEEI
910 920
LEKLINNMDD ILKRVEKDYH NKKK
Length:924
Mass (Da):104,122
Last modified:October 17, 2006 - v2
Checksum:i5A36F9FD892ADC60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53183.2
AY283154 mRNA Translation: AAQ18122.1
BT126366 mRNA Translation: AEC46882.1
RefSeqiNP_609561.2, NM_135717.3
UniGeneiDm.18495

Genome annotation databases

EnsemblMetazoaiFBtr0080365; FBpp0079947; FBgn0041195
GeneIDi34651
KEGGidme:Dmel_CG6504
UCSCiCG6504-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9VK95_DROME
AccessioniPrimary (citable) accession number: Q9VK95
Secondary accession number(s): Q6WIZ8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health