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Protein
Submitted name:

MIP30126p

Gene

Pkd2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cation transport Source: FlyBase
  • detection of mechanical stimulus Source: GO_Central
  • larval feeding behavior Source: FlyBase
  • smooth muscle contraction Source: FlyBase
  • spermatogenesis Source: FlyBase
  • sperm competition Source: FlyBase
  • sperm motility Source: FlyBase
  • sperm storage Source: FlyBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
MIP30126pImported
Submitted name:
Polycystic kidney disease 2 orthologImported
Submitted name:
Polycystin-2Imported
Gene namesi
Name:Pkd2Imported
Synonyms:pkd2Imported, Pkd2-RAImported
ORF Names:CG6504Imported, Dmel_CG6504Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0041195. Pkd2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei241 – 26222HelicalSequence analysisAdd
BLAST
Transmembranei586 – 60419HelicalSequence analysisAdd
BLAST
Transmembranei616 – 64328HelicalSequence analysisAdd
BLAST
Transmembranei664 – 69330HelicalSequence analysisAdd
BLAST
Transmembranei713 – 73523HelicalSequence analysisAdd
BLAST
Transmembranei774 – 79623HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0079947.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini413 – 803391PKD_channelInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili887 – 91428Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3599. Eukaryota.
ENOG410XTGE. LUCA.
GeneTreeiENSGT00700000104221.
KOiK04986.
OMAiTHCGRKR.

Family and domain databases

InterProiIPR013122. PKD1_2_channel.
[Graphical view]
PfamiPF08016. PKD_channel. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VK95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQQGQSGRS PSGPPGPPPP RPPKTPPGAS PRGTPTADST PGDVTPARGP
60 70 80 90 100
PPPPATKRVS IGVGSTRSAP PPATDPTGPP PTAGKPVRDT GPSTSPRPSL
110 120 130 140 150
RDPGQSTSDK PSTSDKPSTS DKPSTSARTT VREPGPSSSP SRPVSTRESG
160 170 180 190 200
RITFQEAAPS TSAKVVKLAA SEPRPAKPPE KEGFSLFKRK KKSVGSSTPP
210 220 230 240 250
SPSRGHRAPS IIAASALQNR AKTNRILYTT DEEVREALVE FSVFIIFLIL
260 270 280 290 300
TSLVVLSVRH TYMFYFNDTM KKLFTNREMV VAPSVTVGFE KLITVPDWWD
310 320 330 340 350
YLKYNFLVTL HGDLTFMDDA QANLTSMPPE GSEQGSEQGS EQGSEQSPEE
360 370 380 390 400
VVGEAPEEAP EMDRLQEDFK YNGNPYIDLR GHRRAKRQSG VDGNSEDGSE
410 420 430 440 450
DVSGNYLKDD SDSIQANMSF HHLEGRVFLY ENLLLGPPRL RQIRVRKESC
460 470 480 490 500
YVNDAFIRYF NTCYAAYSSG AEDRKPMHKG SPFRTMHDLD STPIWTVLAF
510 520 530 540 550
YRTGGYTVNL DYDKDRNVKI INDLKDIHWL DRGSRLCLVE FNLFNENTDI
560 570 580 590 600
FQSIKLIAEI PPTGGVIPQA HLQTVKMYSF FTDRSMLMTV IYIFWYIMVI
610 620 630 640 650
YYTIYEITEI RKSGIKIYFC SMLNILDCAI LLGCYLALVY NIWHSFKVMS
660 670 680 690 700
LTARAHSDVT YQSLDVLCFW NIIYVDMMAI LAFLVWIKIF KFISFNKTLV
710 720 730 740 750
QFTTTLKRCS KDLAGFSLMF GIVFLAYAQL GLLLFGTKHP DFRNFITSIL
760 770 780 790 800
TMIRMILGDF QYNLIEQANR VLGPIYFLTY ILLVFFILLN MFLAIIMETY
810 820 830 840 850
NTVKGEITQG RSHLGSYIYR KLSGMLYWIT HCGRKRRHHP QASETEDKDA
860 870 880 890 900
EHDVGAAHDE THEIRKNMTP AEQQYFKDIP QGENQDMVRL NNRVGLLEEI
910 920
LEKLINNMDD ILKRVEKDYH NKKK
Length:924
Mass (Da):104,122
Last modified:October 17, 2006 - v2
Checksum:i5A36F9FD892ADC60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF53183.2.
AY283154 mRNA. Translation: AAQ18122.1.
BT126366 mRNA. Translation: AEC46882.1.
RefSeqiNP_609561.2. NM_135717.3.
UniGeneiDm.18495.

Genome annotation databases

EnsemblMetazoaiFBtr0080365; FBpp0079947; FBgn0041195.
GeneIDi34651.
KEGGidme:Dmel_CG6504.
UCSCiCG6504-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF53183.2.
AY283154 mRNA. Translation: AAQ18122.1.
BT126366 mRNA. Translation: AEC46882.1.
RefSeqiNP_609561.2. NM_135717.3.
UniGeneiDm.18495.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0079947.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0080365; FBpp0079947; FBgn0041195.
GeneIDi34651.
KEGGidme:Dmel_CG6504.
UCSCiCG6504-RA. d. melanogaster.

Organism-specific databases

CTDi5311.
FlyBaseiFBgn0041195. Pkd2.

Phylogenomic databases

eggNOGiKOG3599. Eukaryota.
ENOG410XTGE. LUCA.
GeneTreeiENSGT00700000104221.
KOiK04986.
OMAiTHCGRKR.

Miscellaneous databases

GenomeRNAii34651.

Family and domain databases

InterProiIPR013122. PKD1_2_channel.
[Graphical view]
PfamiPF08016. PKD_channel. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "PKD2 cation channel is required for directional sperm movement and male fertility."
    Gao Z., Ruden D.M., Lu X.
    Curr. Biol. 13:2175-2178(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ywImported.
  7. "Drosophila Pkd2 is haploid-insufficient for mediating optimal smooth muscle contractility."
    Gao Z., Joseph E., Ruden D.M., Lu X.
    J. Biol. Chem. 279:14225-14231(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ywImported.
  8. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  9. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  11. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  12. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  13. Carlson J., Booth B., Frise E., Sandler J., Wan K., Yu C., Celniker S.
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  14. Millard Andrew
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9VK95_DROME
AccessioniPrimary (citable) accession number: Q9VK95
Secondary accession number(s): Q6WIZ8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 17, 2006
Last modified: July 6, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.