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Q9VK71

- PDM2B_DROME

UniProt

Q9VK71 - PDM2B_DROME

Protein

POU domain protein 2, isoform B

Gene

pdm2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. May act as an octamer-dependent activator of transcription. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system.4 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi786 – 84560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: FlyBase
    3. sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. central nervous system development Source: UniProtKB
    2. ectoderm development Source: UniProtKB
    3. generation of neurons Source: FlyBase
    4. neuroblast development Source: FlyBase
    5. positive regulation of transcription from RNA polymerase II promoter Source: GOC
    6. regulation of transcription, DNA-templated Source: UniProtKB

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_208061. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_217491. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain protein 2, isoform B
    Alternative name(s):
    Miti-mere
    Pdm-2
    Protein didymous
    dOct2
    dPOU-28
    Gene namesi
    Name:pdm2Imported
    Synonyms:dim1 Publication, OCT21 Publication, pdm-21 Publication, POU-281 Publication
    ORF Names:CG12287
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0004394. pdm2.

    Subcellular locationi

    Nucleus Sequence Analysis

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 893893POU domain protein 2, isoform BPRO_0000308166Add
    BLAST

    Expressioni

    Tissue specificityi

    Initial expression in cellular blastoderm stage, then in ectodermal stripes during germband extension. Broad expression in the neuroectoderm followed by limitation to discrete subsets of CNS cells, and expression in specific PNS neurons and support cells.4 Publications

    Developmental stagei

    Expressed primarily during the first half of embryogenesis.2 Publications

    Gene expression databases

    BgeeiQ9VK71.

    Interactioni

    Protein-protein interaction databases

    BioGridi60717. 1 interaction.
    STRINGi7227.FBpp0079973.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VK71.
    SMRiQ9VK71. Positions 684-846.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini681 – 75575POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi22 – 6544Ala-richSequence AnalysisAdd
    BLAST
    Compositional biasi182 – 1898Poly-AsnSequence Analysis
    Compositional biasi388 – 45770Pro-richSequence AnalysisAdd
    BLAST
    Compositional biasi469 – 4746Poly-GluSequence Analysis

    Sequence similaritiesi

    Belongs to the POU transcription factor family. Class-2 subfamily.Sequence Analysis
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    GeneTreeiENSGT00750000117373.
    InParanoidiQ9VK71.
    KOiK09364.
    OMAiSYFGMET.
    PhylomeDBiQ9VK71.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform B1 Publication (identifier: Q9VK71-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPLLLATTLA NNSHHQHLST TATETAAAAA TAKAAATAAA AATATMLLTS    50
    PTAATHCLAA ATSAAGVNVQ ITGQGVSATL NDDQLQLPAN YAANVGHLNG 100
    FNPKDNCPPV PPTSERAFEG LLRLPQIQVK QEFMESPPER PSCHPMNHQQ 150
    APANSALATS CRGKTILNPW YLRPADGIGY HNYNSNNNNS GSGEINKDVS 200
    QQMTSACGGS DGQTCLPVSY FGMETLASVK QRQKSLPDFL IPLHEIMFQQ 250
    QHHYQQRTMG TLINSLPPGL VGYPPQKTET FKSLTPPKAL QHHQNNQNHQ 300
    IPQNHTGDHS FVRHFHERDR LIREHQLKHQ QLRDVEEVLQ EQEQDEEQEH 350
    ETLRKPHVVP SELEHNHHWH GVVCDANGHA TRLLHIAPPR AGPTPLPTHQ 400
    QPPVGEVLPP NSTSFSTIVD PPKEPSIYEQ PAPNGRHCRP ANKVMRHMSN 450
    SPTPPSPLRS LSDCGKSFEE EELELGENCE MPQNLSSKRQ ARELDSELEN 500
    EVLDLAPPPK RLAEEQEEEK VASVNPPQPV AFAPEEMHQA LQLQLHSYIE 550
    MVRQLAPEAF PNPNLATQFL LQNSLQALAQ FQALQQMKQQ QREDPLPSYS 600
    TPLAKSPLRS PSLSPVPRHS KSQQRTPPNS MTANSLGMSS AVMTPNTPSM 650
    QQQPQLQQST PKPTSGLTVA SAMAKLEQSP EETTDLEELE QFAKTFKQRR 700
    IKLGFTQGDV GLAMGKLYGN DFSQTTISRF EALNLSFKNM CKLKPLLQKW 750
    LEDADSTVAK SGGGVFNINT MTSTLSSTPE SILGRRRKKR TSIETTVRTT 800
    LEKAFLMNCK PTSEEISQLS ERLNMDKEVI RVWFCNRRQK EKRINPSLDL 850
    DSPTGTPLSS HAFGYPPQAL NMSHMQMEGG SGSFCGSSIS SGE 893

    Note: No experimental confirmation available.Curated

    Length:893
    Mass (Da):98,465
    Last modified:October 1, 2002 - v2
    Checksum:iCBA3E4A02B498EC1
    GO
    Isoform A1 Publication (identifier: P31369-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry P31369.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:498
    Mass (Da):55,463
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti618 – 6181R → G in AAQ23575. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF53208.2.
    BT010257 mRNA. Translation: AAQ23575.1.
    RefSeqiNP_723763.1. NM_165017.1. [Q9VK71-1]
    UniGeneiDm.4704.

    Genome annotation databases

    EnsemblMetazoaiFBtr0080392; FBpp0079973; FBgn0004394. [Q9VK71-1]
    GeneIDi34673.
    KEGGidme:Dmel_CG12287.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF53208.2 .
    BT010257 mRNA. Translation: AAQ23575.1 .
    RefSeqi NP_723763.1. NM_165017.1. [Q9VK71-1 ]
    UniGenei Dm.4704.

    3D structure databases

    ProteinModelPortali Q9VK71.
    SMRi Q9VK71. Positions 684-846.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 60717. 1 interaction.
    STRINGi 7227.FBpp0079973.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0080392 ; FBpp0079973 ; FBgn0004394 . [Q9VK71-1 ]
    GeneIDi 34673.
    KEGGi dme:Dmel_CG12287.

    Organism-specific databases

    CTDi 34673.
    FlyBasei FBgn0004394. pdm2.

    Phylogenomic databases

    GeneTreei ENSGT00750000117373.
    InParanoidi Q9VK71.
    KOi K09364.
    OMAi SYFGMET.
    PhylomeDBi Q9VK71.

    Enzyme and pathway databases

    Reactomei REACT_208061. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_217491. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

    Miscellaneous databases

    GenomeRNAii 34673.
    NextBioi 789620.

    Gene expression databases

    Bgeei Q9VK71.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley1 Publication.
    2. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: BerkeleyImported.
      Tissue: Embryo.
    4. "Isolation of a family of Drosophila POU domain genes expressed in early development."
      Billin A.N., Cockerill K.A., Poole S.J.
      Mech. Dev. 34:75-84(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: Oregon-R1 Publication.
      Tissue: Embryo1 Publication.
    5. "Characterization of two Drosophila POU domain genes, related to oct-1 and oct-2, and the regulation of their expression patterns."
      Lloyd A., Sakonju S.
      Mech. Dev. 36:87-102(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    6. "Two closely linked Drosophila POU domain genes are expressed in neuroblasts and sensory elements."
      Dick T., Yang X., Yeo S., Chia W.
      Proc. Natl. Acad. Sci. U.S.A. 88:7645-7649(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
      Tissue: Embryo1 Publication.
    7. "dOct2, a Drosophila Oct transcription factor that functions in yeast."
      Prakash K., Fang X.D., Engelberg D., Behal A., Parker C.S.
      Proc. Natl. Acad. Sci. U.S.A. 89:7080-7084(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
      Tissue: Embryo1 Publication.

    Entry informationi

    Entry nameiPDM2B_DROME
    AccessioniPrimary (citable) accession number: Q9VK71
    Secondary accession number(s): Q6NR25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3