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Q9VK71

- PDM2B_DROME

UniProt

Q9VK71 - PDM2B_DROME

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Protein

POU domain protein 2, isoform B

Gene

pdm2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. May act as an octamer-dependent activator of transcription. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system.4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi786 – 84560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: FlyBase
  3. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. central nervous system development Source: UniProtKB
  2. ectoderm development Source: UniProtKB
  3. generation of neurons Source: FlyBase
  4. neuroblast development Source: FlyBase
  5. positive regulation of transcription from RNA polymerase II promoter Source: GOC
  6. regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_208061. RNA Polymerase III Abortive And Retractive Initiation.
REACT_217491. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain protein 2, isoform B
Alternative name(s):
Miti-mere
Pdm-2
Protein didymous
dOct2
dPOU-28
Gene namesi
Name:pdm2Imported
Synonyms:dim1 Publication, OCT21 Publication, pdm-21 Publication, POU-281 Publication
ORF Names:CG12287
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0004394. pdm2.

Subcellular locationi

Nucleus Sequence Analysis

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 893893POU domain protein 2, isoform BPRO_0000308166Add
BLAST

Expressioni

Tissue specificityi

Initial expression in cellular blastoderm stage, then in ectodermal stripes during germband extension. Broad expression in the neuroectoderm followed by limitation to discrete subsets of CNS cells, and expression in specific PNS neurons and support cells.4 Publications

Developmental stagei

Expressed primarily during the first half of embryogenesis.2 Publications

Gene expression databases

BgeeiQ9VK71.
ExpressionAtlasiQ9VK71. differential.

Interactioni

Protein-protein interaction databases

BioGridi60717. 1 interaction.
STRINGi7227.FBpp0079973.

Structurei

3D structure databases

ProteinModelPortaliQ9VK71.
SMRiQ9VK71. Positions 684-846.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini681 – 75575POU-specificPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 6544Ala-richSequence AnalysisAdd
BLAST
Compositional biasi182 – 1898Poly-AsnSequence Analysis
Compositional biasi388 – 45770Pro-richSequence AnalysisAdd
BLAST
Compositional biasi469 – 4746Poly-GluSequence Analysis

Sequence similaritiesi

Belongs to the POU transcription factor family. Class-2 subfamily.Sequence Analysis
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00760000118935.
InParanoidiQ9VK71.
KOiK09364.
OMAiSYFGMET.
PhylomeDBiQ9VK71.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform B1 Publication (identifier: Q9VK71-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLLLATTLA NNSHHQHLST TATETAAAAA TAKAAATAAA AATATMLLTS
60 70 80 90 100
PTAATHCLAA ATSAAGVNVQ ITGQGVSATL NDDQLQLPAN YAANVGHLNG
110 120 130 140 150
FNPKDNCPPV PPTSERAFEG LLRLPQIQVK QEFMESPPER PSCHPMNHQQ
160 170 180 190 200
APANSALATS CRGKTILNPW YLRPADGIGY HNYNSNNNNS GSGEINKDVS
210 220 230 240 250
QQMTSACGGS DGQTCLPVSY FGMETLASVK QRQKSLPDFL IPLHEIMFQQ
260 270 280 290 300
QHHYQQRTMG TLINSLPPGL VGYPPQKTET FKSLTPPKAL QHHQNNQNHQ
310 320 330 340 350
IPQNHTGDHS FVRHFHERDR LIREHQLKHQ QLRDVEEVLQ EQEQDEEQEH
360 370 380 390 400
ETLRKPHVVP SELEHNHHWH GVVCDANGHA TRLLHIAPPR AGPTPLPTHQ
410 420 430 440 450
QPPVGEVLPP NSTSFSTIVD PPKEPSIYEQ PAPNGRHCRP ANKVMRHMSN
460 470 480 490 500
SPTPPSPLRS LSDCGKSFEE EELELGENCE MPQNLSSKRQ ARELDSELEN
510 520 530 540 550
EVLDLAPPPK RLAEEQEEEK VASVNPPQPV AFAPEEMHQA LQLQLHSYIE
560 570 580 590 600
MVRQLAPEAF PNPNLATQFL LQNSLQALAQ FQALQQMKQQ QREDPLPSYS
610 620 630 640 650
TPLAKSPLRS PSLSPVPRHS KSQQRTPPNS MTANSLGMSS AVMTPNTPSM
660 670 680 690 700
QQQPQLQQST PKPTSGLTVA SAMAKLEQSP EETTDLEELE QFAKTFKQRR
710 720 730 740 750
IKLGFTQGDV GLAMGKLYGN DFSQTTISRF EALNLSFKNM CKLKPLLQKW
760 770 780 790 800
LEDADSTVAK SGGGVFNINT MTSTLSSTPE SILGRRRKKR TSIETTVRTT
810 820 830 840 850
LEKAFLMNCK PTSEEISQLS ERLNMDKEVI RVWFCNRRQK EKRINPSLDL
860 870 880 890
DSPTGTPLSS HAFGYPPQAL NMSHMQMEGG SGSFCGSSIS SGE

Note: No experimental confirmation available.Curated

Length:893
Mass (Da):98,465
Last modified:October 1, 2002 - v2
Checksum:iCBA3E4A02B498EC1
GO
Isoform A1 Publication (identifier: P31369-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry P31369.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:498
Mass (Da):55,463
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti618 – 6181R → G in AAQ23575. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014134 Genomic DNA. Translation: AAF53208.2.
BT010257 mRNA. Translation: AAQ23575.1.
RefSeqiNP_723763.1. NM_165017.2. [Q9VK71-1]
UniGeneiDm.4704.

Genome annotation databases

EnsemblMetazoaiFBtr0080392; FBpp0079973; FBgn0004394. [Q9VK71-1]
GeneIDi34673.
KEGGidme:Dmel_CG12287.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014134 Genomic DNA. Translation: AAF53208.2 .
BT010257 mRNA. Translation: AAQ23575.1 .
RefSeqi NP_723763.1. NM_165017.2. [Q9VK71-1 ]
UniGenei Dm.4704.

3D structure databases

ProteinModelPortali Q9VK71.
SMRi Q9VK71. Positions 684-846.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 60717. 1 interaction.
STRINGi 7227.FBpp0079973.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0080392 ; FBpp0079973 ; FBgn0004394 . [Q9VK71-1 ]
GeneIDi 34673.
KEGGi dme:Dmel_CG12287.

Organism-specific databases

CTDi 34673.
FlyBasei FBgn0004394. pdm2.

Phylogenomic databases

GeneTreei ENSGT00760000118935.
InParanoidi Q9VK71.
KOi K09364.
OMAi SYFGMET.
PhylomeDBi Q9VK71.

Enzyme and pathway databases

Reactomei REACT_208061. RNA Polymerase III Abortive And Retractive Initiation.
REACT_217491. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Miscellaneous databases

GenomeRNAii 34673.
NextBioi 789620.

Gene expression databases

Bgeei Q9VK71.
ExpressionAtlasi Q9VK71. differential.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley1 Publication.
  2. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BerkeleyImported.
    Tissue: Embryo.
  4. "Isolation of a family of Drosophila POU domain genes expressed in early development."
    Billin A.N., Cockerill K.A., Poole S.J.
    Mech. Dev. 34:75-84(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: Oregon-R1 Publication.
    Tissue: Embryo1 Publication.
  5. "Characterization of two Drosophila POU domain genes, related to oct-1 and oct-2, and the regulation of their expression patterns."
    Lloyd A., Sakonju S.
    Mech. Dev. 36:87-102(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  6. "Two closely linked Drosophila POU domain genes are expressed in neuroblasts and sensory elements."
    Dick T., Yang X., Yeo S., Chia W.
    Proc. Natl. Acad. Sci. U.S.A. 88:7645-7649(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
    Tissue: Embryo1 Publication.
  7. "dOct2, a Drosophila Oct transcription factor that functions in yeast."
    Prakash K., Fang X.D., Engelberg D., Behal A., Parker C.S.
    Proc. Natl. Acad. Sci. U.S.A. 89:7080-7084(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
    Tissue: Embryo1 Publication.

Entry informationi

Entry nameiPDM2B_DROME
AccessioniPrimary (citable) accession number: Q9VK71
Secondary accession number(s): Q6NR25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3