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Q9VK71 (PDM2B_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain protein 2, isoform B
Alternative name(s):
Miti-mere
Pdm-2
Protein didymous
dOct2
dPOU-28
Gene names
Name:pdm2
Synonyms:dim, OCT2, pdm-2, POU-28
ORF Names:CG12287
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length893 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. May act as an octamer-dependent activator of transcription. Could also play an early role in specific ectodermal cells, and a subsequent role in the embryonic nervous system. Ref.4 Ref.5 Ref.6 Ref.7

Subcellular location

Nucleus.

Tissue specificity

Initial expression in cellular blastoderm stage, then in ectodermal stripes during germband extension. Broad expression in the neuroectoderm followed by limitation to discrete subsets of CNS cells, and expression in specific PNS neurons and support cells. Ref.4 Ref.5 Ref.6 Ref.7

Developmental stage

Expressed primarily during the first half of embryogenesis. Ref.4 Ref.5

Sequence similarities

Belongs to the POU transcription factor family. Class-2 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform B Ref.1 (identifier: Q9VK71-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform A Ref.1 (identifier: P31369-1)

The sequence of this isoform can be found in the external entry P31369.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 893893POU domain protein 2, isoform B
PRO_0000308166

Regions

Domain681 – 75575POU-specific
DNA binding786 – 84560Homeobox
Compositional bias22 – 6544Ala-rich
Compositional bias182 – 1898Poly-Asn
Compositional bias388 – 45770Pro-rich
Compositional bias469 – 4746Poly-Glu

Experimental info

Sequence conflict6181R → G in AAQ23575. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform B [UniParc].

Last modified October 1, 2002. Version 2.
Checksum: CBA3E4A02B498EC1

FASTA89398,465
        10         20         30         40         50         60 
MPLLLATTLA NNSHHQHLST TATETAAAAA TAKAAATAAA AATATMLLTS PTAATHCLAA 

        70         80         90        100        110        120 
ATSAAGVNVQ ITGQGVSATL NDDQLQLPAN YAANVGHLNG FNPKDNCPPV PPTSERAFEG 

       130        140        150        160        170        180 
LLRLPQIQVK QEFMESPPER PSCHPMNHQQ APANSALATS CRGKTILNPW YLRPADGIGY 

       190        200        210        220        230        240 
HNYNSNNNNS GSGEINKDVS QQMTSACGGS DGQTCLPVSY FGMETLASVK QRQKSLPDFL 

       250        260        270        280        290        300 
IPLHEIMFQQ QHHYQQRTMG TLINSLPPGL VGYPPQKTET FKSLTPPKAL QHHQNNQNHQ 

       310        320        330        340        350        360 
IPQNHTGDHS FVRHFHERDR LIREHQLKHQ QLRDVEEVLQ EQEQDEEQEH ETLRKPHVVP 

       370        380        390        400        410        420 
SELEHNHHWH GVVCDANGHA TRLLHIAPPR AGPTPLPTHQ QPPVGEVLPP NSTSFSTIVD 

       430        440        450        460        470        480 
PPKEPSIYEQ PAPNGRHCRP ANKVMRHMSN SPTPPSPLRS LSDCGKSFEE EELELGENCE 

       490        500        510        520        530        540 
MPQNLSSKRQ ARELDSELEN EVLDLAPPPK RLAEEQEEEK VASVNPPQPV AFAPEEMHQA 

       550        560        570        580        590        600 
LQLQLHSYIE MVRQLAPEAF PNPNLATQFL LQNSLQALAQ FQALQQMKQQ QREDPLPSYS 

       610        620        630        640        650        660 
TPLAKSPLRS PSLSPVPRHS KSQQRTPPNS MTANSLGMSS AVMTPNTPSM QQQPQLQQST 

       670        680        690        700        710        720 
PKPTSGLTVA SAMAKLEQSP EETTDLEELE QFAKTFKQRR IKLGFTQGDV GLAMGKLYGN 

       730        740        750        760        770        780 
DFSQTTISRF EALNLSFKNM CKLKPLLQKW LEDADSTVAK SGGGVFNINT MTSTLSSTPE 

       790        800        810        820        830        840 
SILGRRRKKR TSIETTVRTT LEKAFLMNCK PTSEEISQLS ERLNMDKEVI RVWFCNRRQK 

       850        860        870        880        890 
EKRINPSLDL DSPTGTPLSS HAFGYPPQAL NMSHMQMEGG SGSFCGSSIS SGE 

« Hide

Isoform A [UniParc].

See P31369.

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
Strain: Berkeley.
[3]Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A. expand/collapse author list , Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[4]"Isolation of a family of Drosophila POU domain genes expressed in early development."
Billin A.N., Cockerill K.A., Poole S.J.
Mech. Dev. 34:75-84(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Strain: Oregon-R.
Tissue: Embryo.
[5]"Characterization of two Drosophila POU domain genes, related to oct-1 and oct-2, and the regulation of their expression patterns."
Lloyd A., Sakonju S.
Mech. Dev. 36:87-102(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[6]"Two closely linked Drosophila POU domain genes are expressed in neuroblasts and sensory elements."
Dick T., Yang X., Yeo S., Chia W.
Proc. Natl. Acad. Sci. U.S.A. 88:7645-7649(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
Tissue: Embryo.
[7]"dOct2, a Drosophila Oct transcription factor that functions in yeast."
Prakash K., Fang X.D., Engelberg D., Behal A., Parker C.S.
Proc. Natl. Acad. Sci. U.S.A. 89:7080-7084(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014134 Genomic DNA. Translation: AAF53208.2.
BT010257 mRNA. Translation: AAQ23575.1.
RefSeqNP_723763.1. NM_165017.1. [Q9VK71-1]
UniGeneDm.4704.

3D structure databases

ProteinModelPortalQ9VK71.
SMRQ9VK71. Positions 684-846.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid60717. 1 interaction.
STRING7227.FBpp0079973.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0080392; FBpp0079973; FBgn0004394. [Q9VK71-1]
GeneID34673.
KEGGdme:Dmel_CG12287.

Organism-specific databases

CTD34673.
FlyBaseFBgn0004394. pdm2.

Phylogenomic databases

GeneTreeENSGT00750000117373.
InParanoidQ9VK71.
KOK09364.
OMASYFGMET.
PhylomeDBQ9VK71.

Gene expression databases

BgeeQ9VK71.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi34673.
NextBio789620.

Entry information

Entry namePDM2B_DROME
AccessionPrimary (citable) accession number: Q9VK71
Secondary accession number(s): Q6NR25
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase