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Protein

Phospholipid-transporting ATPase

Gene

P4-ATPase

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).UniRule annotationSAAS annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-UniRule
  • magnesium ion binding Source: UniProtKB-UniRule
  • phospholipid-translocating ATPase activity Source: FlyBase

GO - Biological processi

  • phospholipid translocation Source: FlyBase

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPaseUniRule annotation (EC:3.6.3.1UniRule annotation)
Gene namesi
Name:P4-ATPaseImported
Synonyms:CG31729-RAImported, DmCG31729Imported, Dmel\CG31729Imported
ORF Names:CG16823Imported, CG31729Imported, CG6263Imported, Dmel_CG31729Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0051729. CG31729.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei74 – 97HelicalUniRule annotationAdd BLAST24
Transmembranei109 – 128HelicalUniRule annotationAdd BLAST20
Transmembranei313 – 332HelicalUniRule annotationAdd BLAST20
Transmembranei338 – 358HelicalUniRule annotationAdd BLAST21
Transmembranei887 – 907HelicalUniRule annotationAdd BLAST21
Transmembranei913 – 935HelicalUniRule annotationAdd BLAST23
Transmembranei965 – 988HelicalUniRule annotationAdd BLAST24
Transmembranei994 – 1014HelicalUniRule annotationAdd BLAST21
Transmembranei1021 – 1041HelicalUniRule annotationAdd BLAST21
Transmembranei1053 – 1071HelicalUniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0051729.

Interactioni

Protein-protein interaction databases

IntActiQ9VK04. 1 interactor.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 112PhoLip_ATPase_NInterPro annotationAdd BLAST57
Domaini853 – 1080PhoLip_ATPase_CInterPro annotationAdd BLAST228

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0210. Eukaryota.
ENOG410XPYK. LUCA.
GeneTreeiENSGT00550000074723.
OrthoDBiEOG091G076A.

Family and domain databases

Gene3Di3.40.1110.10. 1 hit.
3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR030355. ATP9B.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF115. PTHR24092:SF115. 1 hit.
PfamiView protein in Pfam
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81653. SSF81653. 2 hits.
SSF81660. SSF81660. 3 hits.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VK04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDATSQNSA ATPMTRENIP LLNRQRNRWY LFSCWRKWFR PRELRARTVN
60 70 80 90 100
LGRVNTEKFP PNEIRNQKYN FITFLPLVLF EQFRFFLNLY FLLMALSQFI
110 120 130 140 150
PDIRIGYPYT YWGPLGFVLM VTICREAVDD LRRHQRDHEV NSQKYKRLSS
160 170 180 190 200
TNISGYEMVP SSKLKVGDVI IVEKNERVPA DLILLRTSDR SGSVFVRTDQ
210 220 230 240 250
LDGETDWKPR LAVPYTQKLS RDSELHSIDA SFYVEKPQND IHSFIATFCM
260 270 280 290 300
ADGSEDTGLS VENTLWANTV VAAGTATGIV IYTGCETRSV MNNSQPRSKV
310 320 330 340 350
GLLDMEINGL TKVLFCAVLG LSLVMMMLKG FGGPWYRYMF RFVLLFSYII
360 370 380 390 400
PISLRVNLDM GKAFYSWQMQ NDSNIQGTVV RSTTIPEELG RISYVLTDKT
410 420 430 440 450
GTLTQNEMVF KKIHLGIVSH DADTFHHIGQ MIQKLSGNIL QQQQGSLSSS
460 470 480 490 500
SSGGDSTKPM MFGNRMRRPE GWREWEAVRA LALCHNVTPV SDDEDNRSVS
510 520 530 540 550
TASTVTGGNN SPTKSVINIE APGSTDTEHQ YQAASPDEIA LVKWTEQVGL
560 570 580 590 600
TLIARDLNTM TLQVKTPSED NDILLHYQIL QLFPFTSESK RMGIIVRESK
610 620 630 640 650
TGQITFYLKG ADVVMSSIVQ YNDWLSEESG NMAREGLRTL VVAKKVLTEE
660 670 680 690 700
QYSDFETRYN AARLSITDRV AKVAAVTESL ERELELLCLT GVEDRLQENV
710 720 730 740 750
RPTLELLRNA GVRVWMLTGD KLETACCIAK SSQLIGRNQG LHVLRSVKTR
760 770 780 790 800
TDAHQELNSF RRKQGHALVI SGESLEVCLQ YYRPEFLELA TASPAVVCCR
810 820 830 840 850
CSPTQKAQVV ALIQKHTGKR TCAVGDGGND VSMIQQADAG VGIEGREGRQ
860 870 880 890 900
ASLAGDFSIP QFSHIAKLLL IHGRRSYKRS AALSQFVIHR GLIITTLQAV
910 920 930 940 950
FSAVFYLSSV ALYQGFLMVG YSTLYTMFPV FSLVLDQDIT SETAVTYPEL
960 970 980 990 1000
YKDLSKGRSL SYKTFFIWVL ISIYQGGVIM YGALILFVDE FIHIVAISFS
1010 1020 1030 1040 1050
ALIMTELIMV ALTVRTWHRL MVLAELFSLA LYLISLAVLH EYFDWEFIWS
1060 1070 1080
YDFLWKVSLI TLVSCLPLYI IKFLRKKCSP PSYLKLS
Length:1,087
Mass (Da):122,921
Last modified:October 1, 2002 - v2
Checksum:i1D18ACE858E1FEBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF53280.2.
BT133369 mRNA. Translation: AFH36354.1.
RefSeqiNP_723806.1. NM_165038.3.
UniGeneiDm.420.

Genome annotation databases

EnsemblMetazoaiFBtr0080462; FBpp0080041; FBgn0051729.
GeneIDi34736.
UCSCiCG31729-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ9VK04_DROME
AccessioniPrimary (citable) accession number: Q9VK04
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported