Reviewed, UniProtKB/Swiss-Prot Q9VJ79 (PDE11_DROME)

Names and origin

Protein names

Recommended name:
    Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11
    EC=3.1.4.17
    EC=3.1.4.35
Alternative name(s):
    cAMP and cGMP phosphodiesterase 11

Gene names

Name:	Pde11
ORF Names:	CG34341

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1451 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. Ref.4
Catalytic activity	Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.
Cofactor	Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.
Tissue specificity	In adults, it is enriched in Malpighian tubules. Ref.4
Sequence similarities	Belongs to the cyclic nucleotide phosphodiesterase family. Contains 2 GAF domains.
Biophysicochemical properties	Kinetic parameters: KM=18.5 µM for cAMP KM=6 µM for cGMP

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	Metal-binding cAMP cGMP
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cAMP metabolic process Ref.4 Inferred from direct assay. Source: UniProtKB cGMP metabolic process Ref.4 Inferred from direct assay. Source: UniProtKB signal transduction Inferred from electronic annotation. Source: InterPro
Molecular function	3',5'-cyclic-AMP phosphodiesterase activity Ref.4 Inferred from direct assay. Source: UniProtKB 3',5'-cyclic-GMP phosphodiesterase activity Ref.4 Inferred from direct assay. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform B (identifier: Q9VJ79-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform C (identifier: Q9VJ79-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.
     45-64: QTPSHSPQIQHHSEIIPATT → MASSPNNAAPPVLWRARRKI

Note: No experimental confirmation available.

Isoform D (identifier: Q9VJ79-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKVTQSEENT...GLTFALLAGP

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1451	1451	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11		PRO_0000247044
Regions
	Domain	419 – 572	154	GAF 1
	Domain	604 – 754	151	GAF 2
	Region	836 – 1100	265	Catalytic By similarity
	Compositional bias	1121 – 1124	4	Poly-Gln
	Compositional bias	1328 – 1436	109	His-rich
Sites
	Active site	860	1	Proton donor By similarity
	Metal binding	864	1	Divalent metal cation 1 By similarity
	Metal binding	900	1	Divalent metal cation 1 By similarity
	Metal binding	901	1	Divalent metal cation 1 By similarity
	Metal binding	901	1	Divalent metal cation 2 By similarity
	Metal binding	904	1	Divalent metal cation 2 By similarity
	Metal binding	929	1	Divalent metal cation 2 By similarity
	Metal binding	1011	1	Divalent metal cation 1 By similarity
	Binding site	1064	1	cAMP or cGMP By similarity
Natural variations
	Alternative sequence	1 – 44	44	Missing in isoform C.		VSP_030328
	Alternative sequence	1	1	M → MKVTQSEENTRNTSDRSKSV QTNRKFDNFNWLLSCGLLAA VKSTKLIPQLPRQQQPKKYN LRYAAELLKFDKIQFIKTEG LTFALLAGP in isoform D.		VSP_019906
	Alternative sequence	45 – 64	20	QTPSH…IPATT → MASSPNNAAPPVLWRARRKI in isoform C.		VSP_030329
Experimental info
	Sequence conflict	38	1	Q → QQQ in AAM52774. Ref.3
	Sequence conflict	1192	1	V → A in AAM52774. Ref.3
	Sequence conflict	1196	1	A → V in AAM52774. Ref.3
	Sequence conflict	1232	1	C → R in AAM52774. Ref.3
	Sequence conflict	1342	1	H → HNH in AAM52774. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform B [UniParc]. Last modified January 15, 2008. Version 4. Checksum: DFEC01058FB600A9	FASTA	1,451	160,930
	10 20 30 40 50 60 MGQAASMCRF RGCRYKNKNK SSKQQQQQQQ QQQQQQQQHQ QQQQQTPSHS PQIQHHSEII 70 80 90 100 110 120 PATTGLHLRS IEEPATTPLQ FQPTGRMNTE QGGTGYGGYG SSEHSLLIAT RHAGVPLPLA 130 140 150 160 170 180 QHQPLPAHYQ PLNHSGAAPP SSSNGSSSSG GGVQTSATPQ QQQQYQVQQP YQYQYQHHYH 190 200 210 220 230 240 HQANSPQHHR PYDPEHARME AWLDENQEFV QDYFIRKATR QTVDAWLVSH ATSAGNDVVS 250 260 270 280 290 300 STSPTHANGQ TSSSRGGSGA TTPVRKISAH EFERGGLLKP IVNTIDGTPT FLSIGPPMDN 310 320 330 340 350 360 GSVGGSCSNL QNVGGVVAGQ YQYNHQQHHH NHAHLHHSQH SHYQAGGAVG SSSLGSTGGA 370 380 390 400 410 420 SGAGGAPSLG GSGGAGNGHQ YPYYHCHQRP QRLSRNELKQ LDEKELIFEL VKDICNELEV 430 440 450 460 470 480 RTLCHKILQN VSILLNADRG SLFLVQGRCN GPDGLKKCLV SKLFDVCPRS TVEEMEQQDE 490 500 510 520 530 540 VRVAWGTGIA GHVAESGEPV NIPDAYQDER FNCEIDSLTG YRTKALLCMP IKDSSGDVIG 550 560 570 580 590 600 VAQVINKMNG ECFSEIDEKV FSSYLQFCGI GLRNAQLYEK SQLEIKRNQV LLDLARMIFE 610 620 630 640 650 660 EQSTIEHMVF RILTHMQSLI QCQRVQILLV HEADKGSFSR VFDFEANDLS EEEATSRTSP 670 680 690 700 710 720 YESRFPINIG ITGHVATTGE TVNVPNAYED DRFDASVDEN SCFKHRSILC MAIKNSLGQI 730 740 750 760 770 780 IGVIQLINKF NELDFTKNDE NFVEAFAIFC GMGIHNTHMY EKAIVAMAKQ SVTLEVLSYH 790 800 810 820 830 840 ASATMDEAHR LRRLRVPSAV HFRLHDFKFD DIHFEDDDTL KACLRMFLDL DFVERFHIDY 850 860 870 880 890 900 EVLCRWLLSV KKNYRNVTYH NWRHAFNVAQ MMFAILTTTQ WWKIFGEIEC LALIIGCLCH 910 920 930 940 950 960 DLDHRGTNNS FQIKASSPLA QLYSTSTMEH HHFDQCLMIL NSPGNQILAN LSSDDYCRVI 970 980 990 1000 1010 1020 RVLEDAILST DLAVYFKKRG PFLESVSQPT SYWVAEEPRA LLRAMSMTVC DLSAITKPWE 1030 1040 1050 1060 1070 1080 IEKRVADLVS SEFFEQGDME KQELNITPID IMNREKEDEL PMMQVNFIDS ICLPIYEAFA 1090 1100 1110 1120 1130 1140 TLSDKLEPLV EGVRDNRGHW IDLADVVKTK TSQDQEPEEE QQQQNVISNG DCKAMSDDDV 1150 1160 1170 1180 1190 1200 AASEAEVAVD SPSEKASVNG SNVANNSSNT NKKIAVASHP TSTQPSDDDN DVDADADDVD 1210 1220 1230 1240 1250 1260 EQAAEENGHD AEVDEASCRS NSTCSSSTAS SCLSTPPPTG EDDSTPVSPL KTLQAKLVAA 1270 1280 1290 1300 1310 1320 NLNALQRQTS NQAQTQKQRC KSCDHSRSGL QVRKTSSLRG AQELDLDSKT RNGTHAALCK 1330 1340 1350 1360 1370 1380 STPVINNHSH HHNHSHSHNH NHHHHHHHHS HHNHSQHGIG IGSASIGGSG LISLTTPLLA 1390 1400 1410 1420 1430 1440 MDSDRIPKIV GKIGNLDGLP FANGIGGPQN GHGLPFGSYQ HHHHHQHHHH LLARRHSETN 1450 SNGATAMAVE K
	Isoform C. Checksum: DC01CA40E8325C1E	FASTA	1,407	155,622
	10 20 30 40 50 60 MASSPNNAAP PVLWRARRKI GLHLRSIEEP ATTPLQFQPT GRMNTEQGGT GYGGYGSSEH 70 80 90 100 110 120 SLLIATRHAG VPLPLAQHQP LPAHYQPLNH SGAAPPSSSN GSSSSGGGVQ TSATPQQQQQ 130 140 150 160 170 180 YQVQQPYQYQ YQHHYHHQAN SPQHHRPYDP EHARMEAWLD ENQEFVQDYF IRKATRQTVD 190 200 210 220 230 240 AWLVSHATSA GNDVVSSTSP THANGQTSSS RGGSGATTPV RKISAHEFER GGLLKPIVNT 250 260 270 280 290 300 IDGTPTFLSI GPPMDNGSVG GSCSNLQNVG GVVAGQYQYN HQQHHHNHAH LHHSQHSHYQ 310 320 330 340 350 360 AGGAVGSSSL GSTGGASGAG GAPSLGGSGG AGNGHQYPYY HCHQRPQRLS RNELKQLDEK 370 380 390 400 410 420 ELIFELVKDI CNELEVRTLC HKILQNVSIL LNADRGSLFL VQGRCNGPDG LKKCLVSKLF 430 440 450 460 470 480 DVCPRSTVEE MEQQDEVRVA WGTGIAGHVA ESGEPVNIPD AYQDERFNCE IDSLTGYRTK 490 500 510 520 530 540 ALLCMPIKDS SGDVIGVAQV INKMNGECFS EIDEKVFSSY LQFCGIGLRN AQLYEKSQLE 550 560 570 580 590 600 IKRNQVLLDL ARMIFEEQST IEHMVFRILT HMQSLIQCQR VQILLVHEAD KGSFSRVFDF 610 620 630 640 650 660 EANDLSEEEA TSRTSPYESR FPINIGITGH VATTGETVNV PNAYEDDRFD ASVDENSCFK 670 680 690 700 710 720 HRSILCMAIK NSLGQIIGVI QLINKFNELD FTKNDENFVE AFAIFCGMGI HNTHMYEKAI 730 740 750 760 770 780 VAMAKQSVTL EVLSYHASAT MDEAHRLRRL RVPSAVHFRL HDFKFDDIHF EDDDTLKACL 790 800 810 820 830 840 RMFLDLDFVE RFHIDYEVLC RWLLSVKKNY RNVTYHNWRH AFNVAQMMFA ILTTTQWWKI 850 860 870 880 890 900 FGEIECLALI IGCLCHDLDH RGTNNSFQIK ASSPLAQLYS TSTMEHHHFD QCLMILNSPG 910 920 930 940 950 960 NQILANLSSD DYCRVIRVLE DAILSTDLAV YFKKRGPFLE SVSQPTSYWV AEEPRALLRA 970 980 990 1000 1010 1020 MSMTVCDLSA ITKPWEIEKR VADLVSSEFF EQGDMEKQEL NITPIDIMNR EKEDELPMMQ 1030 1040 1050 1060 1070 1080 VNFIDSICLP IYEAFATLSD KLEPLVEGVR DNRGHWIDLA DVVKTKTSQD QEPEEEQQQQ 1090 1100 1110 1120 1130 1140 NVISNGDCKA MSDDDVAASE AEVAVDSPSE KASVNGSNVA NNSSNTNKKI AVASHPTSTQ 1150 1160 1170 1180 1190 1200 PSDDDNDVDA DADDVDEQAA EENGHDAEVD EASCRSNSTC SSSTASSCLS TPPPTGEDDS 1210 1220 1230 1240 1250 1260 TPVSPLKTLQ AKLVAANLNA LQRQTSNQAQ TQKQRCKSCD HSRSGLQVRK TSSLRGAQEL 1270 1280 1290 1300 1310 1320 DLDSKTRNGT HAALCKSTPV INNHSHHHNH SHSHNHNHHH HHHHHSHHNH SQHGIGIGSA 1330 1340 1350 1360 1370 1380 SIGGSGLISL TTPLLAMDSD RIPKIVGKIG NLDGLPFANG IGGPQNGHGL PFGSYQHHHH 1390 1400 HQHHHHLLAR RHSETNSNGA TAMAVEK
	Isoform D. Checksum: E1EBAD64C5391214	FASTA	1,539	170,998
	10 20 30 40 50 60 MKVTQSEENT RNTSDRSKSV QTNRKFDNFN WLLSCGLLAA VKSTKLIPQL PRQQQPKKYN 70 80 90 100 110 120 LRYAAELLKF DKIQFIKTEG LTFALLAGPG QAASMCRFRG CRYKNKNKSS KQQQQQQQQQ 130 140 150 160 170 180 QQQQQQHQQQ QQQTPSHSPQ IQHHSEIIPA TTGLHLRSIE EPATTPLQFQ PTGRMNTEQG 190 200 210 220 230 240 GTGYGGYGSS EHSLLIATRH AGVPLPLAQH QPLPAHYQPL NHSGAAPPSS SNGSSSSGGG 250 260 270 280 290 300 VQTSATPQQQ QQYQVQQPYQ YQYQHHYHHQ ANSPQHHRPY DPEHARMEAW LDENQEFVQD 310 320 330 340 350 360 YFIRKATRQT VDAWLVSHAT SAGNDVVSST SPTHANGQTS SSRGGSGATT PVRKISAHEF 370 380 390 400 410 420 ERGGLLKPIV NTIDGTPTFL SIGPPMDNGS VGGSCSNLQN VGGVVAGQYQ YNHQQHHHNH 430 440 450 460 470 480 AHLHHSQHSH YQAGGAVGSS SLGSTGGASG AGGAPSLGGS GGAGNGHQYP YYHCHQRPQR 490 500 510 520 530 540 LSRNELKQLD EKELIFELVK DICNELEVRT LCHKILQNVS ILLNADRGSL FLVQGRCNGP 550 560 570 580 590 600 DGLKKCLVSK LFDVCPRSTV EEMEQQDEVR VAWGTGIAGH VAESGEPVNI PDAYQDERFN 610 620 630 640 650 660 CEIDSLTGYR TKALLCMPIK DSSGDVIGVA QVINKMNGEC FSEIDEKVFS SYLQFCGIGL 670 680 690 700 710 720 RNAQLYEKSQ LEIKRNQVLL DLARMIFEEQ STIEHMVFRI LTHMQSLIQC QRVQILLVHE 730 740 750 760 770 780 ADKGSFSRVF DFEANDLSEE EATSRTSPYE SRFPINIGIT GHVATTGETV NVPNAYEDDR 790 800 810 820 830 840 FDASVDENSC FKHRSILCMA IKNSLGQIIG VIQLINKFNE LDFTKNDENF VEAFAIFCGM 850 860 870 880 890 900 GIHNTHMYEK AIVAMAKQSV TLEVLSYHAS ATMDEAHRLR RLRVPSAVHF RLHDFKFDDI 910 920 930 940 950 960 HFEDDDTLKA CLRMFLDLDF VERFHIDYEV LCRWLLSVKK NYRNVTYHNW RHAFNVAQMM 970 980 990 1000 1010 1020 FAILTTTQWW KIFGEIECLA LIIGCLCHDL DHRGTNNSFQ IKASSPLAQL YSTSTMEHHH 1030 1040 1050 1060 1070 1080 FDQCLMILNS PGNQILANLS SDDYCRVIRV LEDAILSTDL AVYFKKRGPF LESVSQPTSY 1090 1100 1110 1120 1130 1140 WVAEEPRALL RAMSMTVCDL SAITKPWEIE KRVADLVSSE FFEQGDMEKQ ELNITPIDIM 1150 1160 1170 1180 1190 1200 NREKEDELPM MQVNFIDSIC LPIYEAFATL SDKLEPLVEG VRDNRGHWID LADVVKTKTS 1210 1220 1230 1240 1250 1260 QDQEPEEEQQ QQNVISNGDC KAMSDDDVAA SEAEVAVDSP SEKASVNGSN VANNSSNTNK 1270 1280 1290 1300 1310 1320 KIAVASHPTS TQPSDDDNDV DADADDVDEQ AAEENGHDAE VDEASCRSNS TCSSSTASSC 1330 1340 1350 1360 1370 1380 LSTPPPTGED DSTPVSPLKT LQAKLVAANL NALQRQTSNQ AQTQKQRCKS CDHSRSGLQV 1390 1400 1410 1420 1430 1440 RKTSSLRGAQ ELDLDSKTRN GTHAALCKST PVINNHSHHH NHSHSHNHNH HHHHHHHSHH 1450 1460 1470 1480 1490 1500 NHSQHGIGIG SASIGGSGLI SLTTPLLAMD SDRIPKIVGK IGNLDGLPFA NGIGGPQNGH 1510 1520 1530 GLPFGSYQHH HHHQHHHHLL ARRHSETNSN GATAMAVEK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM D). Strain: Berkeley. Tissue: Embryo.
[4]	"Cyclic nucleotide phosphodiesterases in Drosophila melanogaster." Day J.P., Dow J.A.T., Houslay M.D., Davies S.A. Biochem. J. 388:333-342(2005) [PubMed: 15673286] [Abstract] Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014134 Genomic DNA. Translation: AAF53675.3. AE014134 Genomic DNA. Translation: AAF53676.2. AY122262 mRNA. Translation: AAM52774.1.
RefSeq	NP_001097177.1. NP_609885.2.
UniGene	Dm.13948
3D structure databases
SMR	Q9VJ79. Positions 408-763, 787-1105.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VJ79. 6 interactions.
Genome annotation databases
Ensembl	FBtr0112544; FBpp0111456; FBgn0085370; Drosophila melanogaster. [Genome view] FBtr0112545; FBpp0111457; FBgn0085370; Drosophila melanogaster. [Genome view]
GeneID	35107.
KEGG	dme:Dmel_CG34341.
Organism-specific databases
CTD	35107.
FlyBase	FBgn0085370. Pde11.
Phylogenomic databases
eggNOG	inNOG05173.
InParanoid	Q9VJ79.
OrthoDB	EOG9MCX5S.
PhylomeDB	Q9VJ79.
Enzyme and pathway databases
BRENDA	3.1.4.17. 48. 3.1.4.35. 48.
Gene expression databases
ArrayExpress	Q9VJ79.
GermOnline	CG10231. Drosophila melanogaster.
Family and domain databases
InterPro	IPR003018. GAF. IPR003607. Metal-dep_PHydrolase_HD_dom. IPR002073. PDEase. [Graphical view]
Pfam	PF01590. GAF. 2 hits. PF00233. PDEase_I. 1 hit. [Graphical view]
PRINTS	PR00387. PDIESTERASE1.
SMART	SM00065. GAF. 2 hits. SM00471. HDc. 1 hit. [Graphical view]
PROSITE	PS00126. PDEASE_I. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	791899.

Entry information

Entry name

PDE11_DROME

Accession

Primary (citable) accession number: Q9VJ79
Secondary accession number(s): Q8MQW0, Q9VJ78

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	January 15, 2008
Last modified:	January 19, 2010
This is version 61 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project