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Q9VJ07 (PHLPP_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase PHLPP-like protein

EC=3.1.3.16
Alternative name(s):
PH domain leucine-rich repeat protein phosphatase
dPHLPP
Gene names
Name:Phlpp
ORF Names:CG10493
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length954 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protein phosphatase that specifically mediates dephosphorylation of 'Ser-586' of Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-586' of Akt1 triggers apoptosis and suppression of tumor growth. Ref.3

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Manganese By similarity.

Sequence similarities

Contains 14 LRR (leucine-rich) repeats.

Contains 1 PP2C-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 954954Protein phosphatase PHLPP-like protein
PRO_0000057787

Regions

Repeat69 – 8921LRR 1
Repeat90 – 10415LRR 2
Repeat110 – 13122LRR 3
Repeat135 – 15622LRR 4
Repeat158 – 17922LRR 5
Repeat183 – 20220LRR 6
Repeat206 – 22722LRR 7
Repeat231 – 25222LRR 8
Repeat255 – 27521LRR 9
Repeat279 – 30022LRR 10
Repeat303 – 32422LRR 11
Repeat326 – 34722LRR 12
Repeat348 – 36922LRR 13
Repeat372 – 39322LRR 14
Domain418 – 653236PP2C-like

Sequences

Sequence LengthMass (Da)Tools
Q9VJ07 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 7ADCF6F54F15957A

FASTA954107,092
        10         20         30         40         50         60 
MLKATRKQAD PYKSKLKVSA SHSGPHPLPV EVTAAEEEQA ATFGQTSPQK LSLKGSQLGG 

        70         80         90        100        110        120 
SILIGNYNYL TQLEVCENEM EVLDLSSLAQ LETLKCSRNK LMELIINGTN LQTLVADHNY 

       130        140        150        160        170        180 
LHNISTTNTH PVPLKLQRID ISHNNFSELP NWVGACASLT AINASHNRLN NVAVLLRNYR 

       190        200        210        220        230        240 
ITELVSLDLA YNDLKQLDQF PEGFSSIRSL QLQSNELPSL PDNFFAVTHA RLETLNVSCN 

       250        260        270        280        290        300 
KLSTLPRYEQ NNHAALVNLS LAGNHLNDSI FEPLHNAAKL RVLHLAYNRI GVLPAACVRN 

       310        320        330        340        350        360 
WPELEILVLS GNMLQQLPEE VATLGQLRVL RCCNNLLLCT PQLAKLAMLK VLDLSHNHLD 

       370        380        390        400        410        420 
RVNLLALVPS RNLKYLDLSG NLQLQVDEQQ FKVCQSQSQR HWSLVDVSGN NRAALPTTKI 

       430        440        450        460        470        480 
RQVSAQRNQN KTSGPWTMGF AETPGSGDCR KLSVYQLRAA NYGGSDEALY GMFEALEGRG 

       490        500        510        520        530        540 
RAAQEMSHLV PDLMKQEQMV KDSAVRDYMK FTLLAAQQQC GSVRSAALFH LTRTRAPSKV 

       550        560        570        580        590        600 
RPLKSKRYVL RMASTGGLDA YLIRRTSQLR LTKPDVIQKD QIHSMPDPHV LELILSNDDE 

       610        620        630        640        650        660 
YLVVGNAQLW SVMDIDRAAR EIRKEENSLL AAKRLVDIAQ SFAAAESLSV IVVRFRHLGT 

       670        680        690        700        710        720 
DVDHLIRELK QSVRKKPQPV SLPLSSGSVC KRTCCDRSNA CRHRAIEQEP LAGRSSPSGQ 

       730        740        750        760        770        780 
SDRDLLAKDK DDEFVLAHAR VLQEEQQLEM LDETESVSES VLSEEQFKCW EYMLEQNTQL 

       790        800        810        820        830        840 
LFDKELNTIS KSFTKQRTVP NAIMAATVLP ERNDFTSNLM RTVTNKFIST STPQLPQPIT 

       850        860        870        880        890        900 
TSVPLGSYHQ VKQAPPGHFG SALSFQQAHS YGYNLFDAKP RPKFHGGTVK RSAGPNSAYF 

       910        920        930        940        950 
GSLQRLMPYN FEYDFAVTQE RERNILDEEE HDDDDFNEHE SRMRKYWGVA TTEL 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[3]"PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth."
Gao T., Furnari F., Newton A.C.
Mol. Cell 18:13-24(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014134 Genomic DNA. Translation: AAF53751.1.
RefSeqNP_001260558.1. NM_001273629.1.
NP_609938.1. NM_136094.2.
UniGeneDm.17963.

3D structure databases

ProteinModelPortalQ9VJ07.
SMRQ9VJ07. Positions 25-429.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7227.FBpp0080693.

Proteomic databases

PRIDEQ9VJ07.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0081149; FBpp0080693; FBgn0032749.
GeneID35178.
KEGGdme:Dmel_CG10493.

Organism-specific databases

CTD35178.
FlyBaseFBgn0032749. Phlpp.

Phylogenomic databases

eggNOGNOG240924.
GeneTreeENSGT00440000037833.
InParanoidQ9VJ07.
KOK16340.
OMAVCENEME.
OrthoDBEOG7RFTGK.
PhylomeDBQ9VJ07.

Gene expression databases

BgeeQ9VJ07.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001611. Leu-rich_rpt.
IPR001932. PP2C-like_dom.
[Graphical view]
PfamPF00560. LRR_1. 2 hits.
PF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 1 hit.
PROSITEPS51450. LRR. 12 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi35178.
NextBio792238.

Entry information

Entry namePHLPP_DROME
AccessionPrimary (citable) accession number: Q9VJ07
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 1, 2000
Last modified: March 19, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase