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Q9VJ07

- PHLPP_DROME

UniProt

Q9VJ07 - PHLPP_DROME

Protein

Protein phosphatase PHLPP-like protein

Gene

Phlpp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Protein phosphatase that specifically mediates dephosphorylation of 'Ser-586' of Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-586' of Akt1 triggers apoptosis and suppression of tumor growth.1 Publication

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Manganese.By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. protein serine/threonine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. protein dephosphorylation Source: UniProtKB
    3. regulation of apoptotic process Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase PHLPP-like protein (EC:3.1.3.16)
    Alternative name(s):
    PH domain leucine-rich repeat protein phosphatase
    dPHLPP
    Gene namesi
    Name:Phlpp
    ORF Names:CG10493
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0032749. Phlpp.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 954954Protein phosphatase PHLPP-like proteinPRO_0000057787Add
    BLAST

    Proteomic databases

    PRIDEiQ9VJ07.

    Expressioni

    Gene expression databases

    BgeeiQ9VJ07.

    Interactioni

    Protein-protein interaction databases

    STRINGi7227.FBpp0080693.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VJ07.
    SMRiQ9VJ07. Positions 23-429.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati69 – 8921LRR 1Add
    BLAST
    Repeati90 – 10415LRR 2Add
    BLAST
    Repeati110 – 13122LRR 3Add
    BLAST
    Repeati135 – 15622LRR 4Add
    BLAST
    Repeati158 – 17922LRR 5Add
    BLAST
    Repeati183 – 20220LRR 6Add
    BLAST
    Repeati206 – 22722LRR 7Add
    BLAST
    Repeati231 – 25222LRR 8Add
    BLAST
    Repeati255 – 27521LRR 9Add
    BLAST
    Repeati279 – 30022LRR 10Add
    BLAST
    Repeati303 – 32422LRR 11Add
    BLAST
    Repeati326 – 34722LRR 12Add
    BLAST
    Repeati348 – 36922LRR 13Add
    BLAST
    Repeati372 – 39322LRR 14Add
    BLAST
    Domaini418 – 653236PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Contains 14 LRR (leucine-rich) repeats.Curated
    Contains 1 PP2C-like domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG240924.
    GeneTreeiENSGT00440000037833.
    InParanoidiQ9VJ07.
    KOiK16340.
    OMAiVCENEME.
    OrthoDBiEOG7RFTGK.
    PhylomeDBiQ9VJ07.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001611. Leu-rich_rpt.
    IPR001932. PP2C-like_dom.
    [Graphical view]
    PfamiPF00560. LRR_1. 2 hits.
    PF13855. LRR_8. 1 hit.
    PF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS51450. LRR. 12 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9VJ07-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKATRKQAD PYKSKLKVSA SHSGPHPLPV EVTAAEEEQA ATFGQTSPQK    50
    LSLKGSQLGG SILIGNYNYL TQLEVCENEM EVLDLSSLAQ LETLKCSRNK 100
    LMELIINGTN LQTLVADHNY LHNISTTNTH PVPLKLQRID ISHNNFSELP 150
    NWVGACASLT AINASHNRLN NVAVLLRNYR ITELVSLDLA YNDLKQLDQF 200
    PEGFSSIRSL QLQSNELPSL PDNFFAVTHA RLETLNVSCN KLSTLPRYEQ 250
    NNHAALVNLS LAGNHLNDSI FEPLHNAAKL RVLHLAYNRI GVLPAACVRN 300
    WPELEILVLS GNMLQQLPEE VATLGQLRVL RCCNNLLLCT PQLAKLAMLK 350
    VLDLSHNHLD RVNLLALVPS RNLKYLDLSG NLQLQVDEQQ FKVCQSQSQR 400
    HWSLVDVSGN NRAALPTTKI RQVSAQRNQN KTSGPWTMGF AETPGSGDCR 450
    KLSVYQLRAA NYGGSDEALY GMFEALEGRG RAAQEMSHLV PDLMKQEQMV 500
    KDSAVRDYMK FTLLAAQQQC GSVRSAALFH LTRTRAPSKV RPLKSKRYVL 550
    RMASTGGLDA YLIRRTSQLR LTKPDVIQKD QIHSMPDPHV LELILSNDDE 600
    YLVVGNAQLW SVMDIDRAAR EIRKEENSLL AAKRLVDIAQ SFAAAESLSV 650
    IVVRFRHLGT DVDHLIRELK QSVRKKPQPV SLPLSSGSVC KRTCCDRSNA 700
    CRHRAIEQEP LAGRSSPSGQ SDRDLLAKDK DDEFVLAHAR VLQEEQQLEM 750
    LDETESVSES VLSEEQFKCW EYMLEQNTQL LFDKELNTIS KSFTKQRTVP 800
    NAIMAATVLP ERNDFTSNLM RTVTNKFIST STPQLPQPIT TSVPLGSYHQ 850
    VKQAPPGHFG SALSFQQAHS YGYNLFDAKP RPKFHGGTVK RSAGPNSAYF 900
    GSLQRLMPYN FEYDFAVTQE RERNILDEEE HDDDDFNEHE SRMRKYWGVA 950
    TTEL 954
    Length:954
    Mass (Da):107,092
    Last modified:May 1, 2000 - v1
    Checksum:i7ADCF6F54F15957A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF53751.1.
    RefSeqiNP_001260558.1. NM_001273629.1.
    NP_609938.1. NM_136094.2.
    UniGeneiDm.17963.

    Genome annotation databases

    EnsemblMetazoaiFBtr0081149; FBpp0080693; FBgn0032749.
    GeneIDi35178.
    KEGGidme:Dmel_CG10493.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014134 Genomic DNA. Translation: AAF53751.1 .
    RefSeqi NP_001260558.1. NM_001273629.1.
    NP_609938.1. NM_136094.2.
    UniGenei Dm.17963.

    3D structure databases

    ProteinModelPortali Q9VJ07.
    SMRi Q9VJ07. Positions 23-429.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7227.FBpp0080693.

    Proteomic databases

    PRIDEi Q9VJ07.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0081149 ; FBpp0080693 ; FBgn0032749 .
    GeneIDi 35178.
    KEGGi dme:Dmel_CG10493.

    Organism-specific databases

    CTDi 35178.
    FlyBasei FBgn0032749. Phlpp.

    Phylogenomic databases

    eggNOGi NOG240924.
    GeneTreei ENSGT00440000037833.
    InParanoidi Q9VJ07.
    KOi K16340.
    OMAi VCENEME.
    OrthoDBi EOG7RFTGK.
    PhylomeDBi Q9VJ07.

    Miscellaneous databases

    GenomeRNAii 35178.
    NextBioi 792238.

    Gene expression databases

    Bgeei Q9VJ07.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001611. Leu-rich_rpt.
    IPR001932. PP2C-like_dom.
    [Graphical view ]
    Pfami PF00560. LRR_1. 2 hits.
    PF13855. LRR_8. 1 hit.
    PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS51450. LRR. 12 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. "PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth."
      Gao T., Furnari F., Newton A.C.
      Mol. Cell 18:13-24(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiPHLPP_DROME
    AccessioniPrimary (citable) accession number: Q9VJ07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3