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Q9VJ07

- PHLPP_DROME

UniProt

Q9VJ07 - PHLPP_DROME

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Protein
Protein phosphatase PHLPP-like protein
Gene
Phlpp, CG10493
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Protein phosphatase that specifically mediates dephosphorylation of 'Ser-586' of Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-586' of Akt1 triggers apoptosis and suppression of tumor growth.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Manganese By similarity.

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein binding Source: UniProtKB
  3. protein serine/threonine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. protein dephosphorylation Source: UniProtKB
  3. regulation of apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase PHLPP-like protein (EC:3.1.3.16)
Alternative name(s):
PH domain leucine-rich repeat protein phosphatase
dPHLPP
Gene namesi
Name:Phlpp
ORF Names:CG10493
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0032749. Phlpp.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Protein phosphatase PHLPP-like protein
PRO_0000057787Add
BLAST

Proteomic databases

PRIDEiQ9VJ07.

Expressioni

Gene expression databases

BgeeiQ9VJ07.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0080693.

Structurei

3D structure databases

ProteinModelPortaliQ9VJ07.
SMRiQ9VJ07. Positions 23-429.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati69 – 8921LRR 1
Add
BLAST
Repeati90 – 10415LRR 2
Add
BLAST
Repeati110 – 13122LRR 3
Add
BLAST
Repeati135 – 15622LRR 4
Add
BLAST
Repeati158 – 17922LRR 5
Add
BLAST
Repeati183 – 20220LRR 6
Add
BLAST
Repeati206 – 22722LRR 7
Add
BLAST
Repeati231 – 25222LRR 8
Add
BLAST
Repeati255 – 27521LRR 9
Add
BLAST
Repeati279 – 30022LRR 10
Add
BLAST
Repeati303 – 32422LRR 11
Add
BLAST
Repeati326 – 34722LRR 12
Add
BLAST
Repeati348 – 36922LRR 13
Add
BLAST
Repeati372 – 39322LRR 14
Add
BLAST
Domaini418 – 653236PP2C-like
Add
BLAST

Sequence similaritiesi

Contains 1 PP2C-like domain.

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiNOG240924.
GeneTreeiENSGT00440000037833.
InParanoidiQ9VJ07.
KOiK16340.
OMAiVCENEME.
OrthoDBiEOG7RFTGK.
PhylomeDBiQ9VJ07.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001611. Leu-rich_rpt.
IPR001932. PP2C-like_dom.
[Graphical view]
PfamiPF00560. LRR_1. 2 hits.
PF13855. LRR_8. 1 hit.
PF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VJ07-1 [UniParc]FASTAAdd to Basket

« Hide

MLKATRKQAD PYKSKLKVSA SHSGPHPLPV EVTAAEEEQA ATFGQTSPQK    50
LSLKGSQLGG SILIGNYNYL TQLEVCENEM EVLDLSSLAQ LETLKCSRNK 100
LMELIINGTN LQTLVADHNY LHNISTTNTH PVPLKLQRID ISHNNFSELP 150
NWVGACASLT AINASHNRLN NVAVLLRNYR ITELVSLDLA YNDLKQLDQF 200
PEGFSSIRSL QLQSNELPSL PDNFFAVTHA RLETLNVSCN KLSTLPRYEQ 250
NNHAALVNLS LAGNHLNDSI FEPLHNAAKL RVLHLAYNRI GVLPAACVRN 300
WPELEILVLS GNMLQQLPEE VATLGQLRVL RCCNNLLLCT PQLAKLAMLK 350
VLDLSHNHLD RVNLLALVPS RNLKYLDLSG NLQLQVDEQQ FKVCQSQSQR 400
HWSLVDVSGN NRAALPTTKI RQVSAQRNQN KTSGPWTMGF AETPGSGDCR 450
KLSVYQLRAA NYGGSDEALY GMFEALEGRG RAAQEMSHLV PDLMKQEQMV 500
KDSAVRDYMK FTLLAAQQQC GSVRSAALFH LTRTRAPSKV RPLKSKRYVL 550
RMASTGGLDA YLIRRTSQLR LTKPDVIQKD QIHSMPDPHV LELILSNDDE 600
YLVVGNAQLW SVMDIDRAAR EIRKEENSLL AAKRLVDIAQ SFAAAESLSV 650
IVVRFRHLGT DVDHLIRELK QSVRKKPQPV SLPLSSGSVC KRTCCDRSNA 700
CRHRAIEQEP LAGRSSPSGQ SDRDLLAKDK DDEFVLAHAR VLQEEQQLEM 750
LDETESVSES VLSEEQFKCW EYMLEQNTQL LFDKELNTIS KSFTKQRTVP 800
NAIMAATVLP ERNDFTSNLM RTVTNKFIST STPQLPQPIT TSVPLGSYHQ 850
VKQAPPGHFG SALSFQQAHS YGYNLFDAKP RPKFHGGTVK RSAGPNSAYF 900
GSLQRLMPYN FEYDFAVTQE RERNILDEEE HDDDDFNEHE SRMRKYWGVA 950
TTEL 954
Length:954
Mass (Da):107,092
Last modified:May 1, 2000 - v1
Checksum:i7ADCF6F54F15957A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014134 Genomic DNA. Translation: AAF53751.1.
RefSeqiNP_001260558.1. NM_001273629.1.
NP_609938.1. NM_136094.2.
UniGeneiDm.17963.

Genome annotation databases

EnsemblMetazoaiFBtr0081149; FBpp0080693; FBgn0032749.
GeneIDi35178.
KEGGidme:Dmel_CG10493.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014134 Genomic DNA. Translation: AAF53751.1 .
RefSeqi NP_001260558.1. NM_001273629.1.
NP_609938.1. NM_136094.2.
UniGenei Dm.17963.

3D structure databases

ProteinModelPortali Q9VJ07.
SMRi Q9VJ07. Positions 23-429.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7227.FBpp0080693.

Proteomic databases

PRIDEi Q9VJ07.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0081149 ; FBpp0080693 ; FBgn0032749 .
GeneIDi 35178.
KEGGi dme:Dmel_CG10493.

Organism-specific databases

CTDi 35178.
FlyBasei FBgn0032749. Phlpp.

Phylogenomic databases

eggNOGi NOG240924.
GeneTreei ENSGT00440000037833.
InParanoidi Q9VJ07.
KOi K16340.
OMAi VCENEME.
OrthoDBi EOG7RFTGK.
PhylomeDBi Q9VJ07.

Miscellaneous databases

GenomeRNAii 35178.
NextBioi 792238.

Gene expression databases

Bgeei Q9VJ07.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001611. Leu-rich_rpt.
IPR001932. PP2C-like_dom.
[Graphical view ]
Pfami PF00560. LRR_1. 2 hits.
PF13855. LRR_8. 1 hit.
PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS51450. LRR. 12 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. "PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth."
    Gao T., Furnari F., Newton A.C.
    Mol. Cell 18:13-24(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiPHLPP_DROME
AccessioniPrimary (citable) accession number: Q9VJ07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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