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Q9VIS1 (CDGAP_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTPase-activating protein CdGAPr
Alternative name(s):
d-CdGAPr
Gene names
Name:CdGAPr
ORF Names:CG10538
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1843 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably functions as a GTPase-activating protein (GAP) for RAC1 and/or CDC42. Required for optic stalk formation. Ref.6

Tissue specificity

Ubiquitously expressed. Ref.1

Developmental stage

Expressed at all developmental stages, with highest expression at the posterior pole of the early cellular blastoderm, the neuro-ectoderm prior to neuroblast delamination, rows of epidermal cells in the most posterior part of thoracic and first abdominal segments and a ring of epidermal cells at the posterior end of the embryo. Ref.1

Sequence similarities

Contains 1 Rho-GAP domain.

Contains 1 SH3 domain.

Sequence caution

The sequence AAM49910.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAT94493.1 differs from that shown. Reason: Frameshift at position 351.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 18431843GTPase-activating protein CdGAPr
PRO_0000320117

Regions

Domain295 – 36369SH3
Domain424 – 618195Rho-GAP
Coiled coil1378 – 140427 Potential
Compositional bias632 – 64211Poly-Ala
Compositional bias957 – 9604Poly-Pro
Compositional bias1041 – 10455Poly-Ser
Compositional bias1171 – 11744Poly-Gln
Compositional bias1244 – 12485Poly-Ala

Amino acid modifications

Modified residue1661Phosphoserine Ref.8
Modified residue1681Phosphoserine Ref.8
Modified residue1801Phosphoserine Ref.8
Modified residue8371Phosphoserine Ref.8
Modified residue8401Phosphoserine Ref.8
Modified residue8431Phosphothreonine Ref.8
Modified residue8511Phosphoserine Ref.8
Modified residue8611Phosphoserine Ref.8
Modified residue8721Phosphoserine Ref.8
Modified residue8761Phosphoserine Ref.8
Modified residue10291Phosphoserine Ref.8
Modified residue11181Phosphothreonine Ref.8
Modified residue11211Phosphothreonine Ref.8
Modified residue11251Phosphoserine Ref.8
Modified residue12161Phosphoserine Ref.7
Modified residue12811Phosphoserine Ref.8
Modified residue12841Phosphoserine Ref.8
Modified residue14531Phosphoserine Ref.8
Modified residue14561Phosphoserine Ref.8
Modified residue16791Phosphothreonine Ref.8

Experimental info

Sequence conflict10921Missing in AAT94493. Ref.4
Sequence conflict10921Missing in AAM49910. Ref.5
Sequence conflict1818 – 18203NNR → K in AAM49910. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q9VIS1 [UniParc].

Last modified October 1, 2002. Version 2.
Checksum: 4D5C65C637765D57

FASTA1,843204,217
        10         20         30         40         50         60 
MSDKVSTSLA AQLHSHALAS AEAGGIGGVN GGPIACHAST DKDAQAPPLQ FEMDAPAAAI 

        70         80         90        100        110        120 
SAQLNFKIVP ADSLPGLSYQ DMFASMNTSQ ISNASTESSC SPPIQGAVPP PKPSRHMAVQ 

       130        140        150        160        170        180 
PLNSKSCRFP KLEECAHFHY ERVQLGPLSV QLLDDKSEHM GSSIASQSLG GDLPHSSLRS 

       190        200        210        220        230        240 
FSPESCWFII RVCPQRCEPF LIKRSFENMQ LLDEMLHRCV YDRKISGLRN MEELAAELPS 

       250        260        270        280        290        300 
ESDVEYAVAK YLERFSKIAS DSLTCGTILT WLQLDNKGRR LPLADGETQR TINTPAVGAA 

       310        320        330        340        350        360 
YGVRRYQAQA PDEINIEVGD MISVIDMPSP AESIWWRGKK SHLQKSLYEV GFFPQSCVAT 

       370        380        390        400        410        420 
IGDKVPRNFP MPAPLVGHLD ASPTKPVLRK HGKLIAFFRS FILSRPSRRR LKQSGIYRER 

       430        440        450        460        470        480 
VFNCDLSEHL LNSGQDIPMV LRSCAEFIEN YGVIDGIYRL SGITSNIQRL RRAFDEERVP 

       490        500        510        520        530        540 
DLGNPEMKQD IHAVSSLLKM YFRELPNPLC TYQLYDNFVE AIQVKADEAD ERLRLMKETV 

       550        560        570        580        590        600 
LKLPPPHYRT LKYLAEHLYK VSQHHGRTGM TDKNLAIVWA PNLLRSPALE SGGVAALRGV 

       610        620        630        640        650        660 
GVQAVVTEYL IRNCHNIFDA LDDHPARHSM VASATAAAAN AAGGELRLES LTDCESLLVE 

       670        680        690        700        710        720 
QREQDQSLGV VERPKSLSTG GAKLISLEEA QERHSRVEGA DLKQSLPISM LTSASSNAAS 

       730        740        750        760        770        780 
NIGSYIEVGG GPSSLPDKYH TVLSAPRSWQ KRKPDKTPSW KSIFSRSQRQ GNPDPGQKIT 

       790        800        810        820        830        840 
TDVKDSVASR VSFVQASHAH ASKELTKHDK PKSIELLETT SNERDPKPMD LCIRSNSIDS 

       850        860        870        880        890        900 
LRTVGHSRSV SHDSYFDLLQ SPQRGHMTTC PSRELSELGL NFDREEPEMR IFSESESLVS 

       910        920        930        940        950        960 
SPRVGKENVP PASGSATRRI MRARPEDFSS QTNSVNPSPK KQPRLNLLSP SSARTMPPPP 

       970        980        990       1000       1010       1020 
LSAPGTASSS CGHESGGAEN CCKRYKLEDQ LCDIQFIDCG TPENVPTTQQ QFASVEVHPP 

      1030       1040       1050       1060       1070       1080 
PKPARANQSP ISSSNGASVG SSSSSTRYSY PSVQLGAKRK EQQDAKERFS YQGTFTQPGQ 

      1090       1100       1110       1120       1130       1140 
KQESSAPRPV HSTNNGATLR KPRVEPVEDG QIKLHVPTPT TPARSPRYSL LLCDTESSDN 

      1150       1160       1170       1180       1190       1200 
SSAVNTPQYD MEPLMLTSAM SGVSGVSSNV QQQQLLLGVD ASSSYLGSSH ESLGQNINNH 

      1210       1220       1230       1240       1250       1260 
HDAEQRDMNA LKRELSLDLN PLQPRLPQPA NRAATLPVKD QLQAAAAAMC SSPNNSNFTD 

      1270       1280       1290       1300       1310       1320 
NTSQSVTPSE YGYQHLQRQL SMHSLLATDE SSPVYEDFEQ TPVKMVPSPI KSTISITYKS 

      1330       1340       1350       1360       1370       1380 
PEKEKKPSAI LETNFDENTV YEQVKLFRNS VTEVNQMLHE RSSLKQIAEE EQHDGGAYKA 

      1390       1400       1410       1420       1430       1440 
AEMTQQLLQL EQEHHDHEEQ QEKEPEDEEQ SQLLYENIEL RKPKTVYENL RGEEMKFITE 

      1450       1460       1470       1480       1490       1500 
EQKPNVDRIE LDSLDSLPDN MEHEQSSPSK SPTFSVKELA NKFESSPVEQ LPNFDFSVRG 

      1510       1520       1530       1540       1550       1560 
GSMKKPNELS VPKTMPAPVP LKKLNSSAQK ITRSLDENAF VREFGGKQLQ DLSLSNKLPE 

      1570       1580       1590       1600       1610       1620 
VMSEVNSRRK SFDFTRPKTL NPPKRLPGMS ITEEICQKRV GEMEAITPTT ENRISLIQQN 

      1630       1640       1650       1660       1670       1680 
NMPKEQQSSA NQFLPPAGRK NVLTGVVLDR ERIDKIKEER RQQLTQKYYG DTLKSRSRTE 

      1690       1700       1710       1720       1730       1740 
LNSEDNFPAA ESLRIKSKSR GDMHALQKDI DMNLKQLSRV TGGGSECTLH TGLSQGNGQE 

      1750       1760       1770       1780       1790       1800 
HLGQQRVRRI SDEKNQNCDT SNGGVSGITS TSLLSVKTTA QKYGSTSKTP ANKFERSQPM 

      1810       1820       1830       1840 
PRDRLQRNSL AESNAGTNNR EKISPQFSIR DVTAMFESRS QNQ 

« Hide

References

« Hide 'large scale' references
[1]"Dynamic expression of d-CdGAPr, a novel Drosophila melanogaster gene encoding a GTPase activating protein."
Sagnier T., Grienenberger A., Mariol M.-C., Berenger H., Pradel J., Graba Y.
Mech. Dev. 94:267-270(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[5]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1062-1843.
Strain: Berkeley.
Tissue: Embryo.
[6]"Focal adhesion kinase controls morphogenesis of the Drosophila optic stalk."
Murakami S., Umetsu D., Maeyama Y., Sato M., Yoshida S., Tabata T.
Development 134:1539-1548(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
Mol. Biosyst. 3:275-286(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1216, IDENTIFICATION BY MASS SPECTROMETRY.
[8]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166; SER-168; SER-180; SER-837; SER-840; THR-843; SER-851; SER-861; SER-872; SER-876; SER-1029; THR-1118; THR-1121; SER-1125; SER-1281; SER-1284; SER-1453; SER-1456 AND THR-1679, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF218776 mRNA. Translation: AAF44627.1.
AE014134 Genomic DNA. Translation: AAF53844.2.
BT015264 mRNA. Translation: AAT94493.1. Frameshift.
AY118541 mRNA. Translation: AAM49910.1. Different initiation.
RefSeqNP_001260600.1. NM_001273671.1.
NP_610002.1. NM_136158.4.
UniGeneDm.3427.

3D structure databases

ProteinModelPortalQ9VIS1.
SMRQ9VIS1. Positions 299-359, 420-618.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid61243. 2 interactions.
MINTMINT-1558952.

Proteomic databases

PaxDbQ9VIS1.
PRIDEQ9VIS1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0081318; FBpp0080851; FBgn0032821.
FBtr0332179; FBpp0304488; FBgn0032821.
GeneID35267.
KEGGdme:Dmel_CG10538.
UCSCCG10538-RA. d. melanogaster.

Organism-specific databases

CTD35267.
FlyBaseFBgn0032821. CdGAPr.

Phylogenomic databases

eggNOGNOG311367.
GeneTreeENSGT00720000108475.
InParanoidQ9VIS1.
OMAAMFESRS.
OrthoDBEOG7WMCHV.
PhylomeDBQ9VIS1.

Gene expression databases

BgeeQ9VIS1.

Family and domain databases

Gene3D1.10.555.10. 1 hit.
InterProIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTSM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEPS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi35267.
NextBio792708.

Entry information

Entry nameCDGAP_DROME
AccessionPrimary (citable) accession number: Q9VIS1
Secondary accession number(s): Q6AWI4, Q8MSV9, Q9NCL1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase