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Q9VIS1

- CDGAP_DROME

UniProt

Q9VIS1 - CDGAP_DROME

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Protein

GTPase-activating protein CdGAPr

Gene

CdGAPr

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Probably functions as a GTPase-activating protein (GAP) for RAC1 and/or CDC42. Required for optic stalk formation.1 Publication

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW

GO - Biological processi

  1. retinal ganglion cell axon guidance Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase-activating protein CdGAPr
Alternative name(s):
d-CdGAPr
Gene namesi
Name:CdGAPr
ORF Names:CG10538
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0032821. CdGAPr.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18431843GTPase-activating protein CdGAPrPRO_0000320117Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei166 – 1661Phosphoserine1 Publication
Modified residuei168 – 1681Phosphoserine1 Publication
Modified residuei180 – 1801Phosphoserine1 Publication
Modified residuei837 – 8371Phosphoserine1 Publication
Modified residuei840 – 8401Phosphoserine1 Publication
Modified residuei843 – 8431Phosphothreonine1 Publication
Modified residuei851 – 8511Phosphoserine1 Publication
Modified residuei861 – 8611Phosphoserine1 Publication
Modified residuei872 – 8721Phosphoserine1 Publication
Modified residuei876 – 8761Phosphoserine1 Publication
Modified residuei1029 – 10291Phosphoserine1 Publication
Modified residuei1118 – 11181Phosphothreonine1 Publication
Modified residuei1121 – 11211Phosphothreonine1 Publication
Modified residuei1125 – 11251Phosphoserine1 Publication
Modified residuei1216 – 12161Phosphoserine1 Publication
Modified residuei1281 – 12811Phosphoserine1 Publication
Modified residuei1284 – 12841Phosphoserine1 Publication
Modified residuei1453 – 14531Phosphoserine1 Publication
Modified residuei1456 – 14561Phosphoserine1 Publication
Modified residuei1679 – 16791Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9VIS1.
PRIDEiQ9VIS1.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Developmental stagei

Expressed at all developmental stages, with highest expression at the posterior pole of the early cellular blastoderm, the neuro-ectoderm prior to neuroblast delamination, rows of epidermal cells in the most posterior part of thoracic and first abdominal segments and a ring of epidermal cells at the posterior end of the embryo.1 Publication

Gene expression databases

BgeeiQ9VIS1.

Interactioni

Protein-protein interaction databases

BioGridi61243. 2 interactions.
MINTiMINT-1558952.

Structurei

3D structure databases

ProteinModelPortaliQ9VIS1.
SMRiQ9VIS1. Positions 299-362, 420-618.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini295 – 36369SH3PROSITE-ProRule annotationAdd
BLAST
Domaini424 – 618195Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1378 – 140427Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi632 – 64211Poly-AlaAdd
BLAST
Compositional biasi957 – 9604Poly-Pro
Compositional biasi1041 – 10455Poly-Ser
Compositional biasi1171 – 11744Poly-Gln
Compositional biasi1244 – 12485Poly-Ala

Sequence similaritiesi

Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiNOG311367.
GeneTreeiENSGT00720000108475.
InParanoidiQ9VIS1.
OMAiAMFESRS.
OrthoDBiEOG7WMCHV.
PhylomeDBiQ9VIS1.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VIS1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDKVSTSLA AQLHSHALAS AEAGGIGGVN GGPIACHAST DKDAQAPPLQ
60 70 80 90 100
FEMDAPAAAI SAQLNFKIVP ADSLPGLSYQ DMFASMNTSQ ISNASTESSC
110 120 130 140 150
SPPIQGAVPP PKPSRHMAVQ PLNSKSCRFP KLEECAHFHY ERVQLGPLSV
160 170 180 190 200
QLLDDKSEHM GSSIASQSLG GDLPHSSLRS FSPESCWFII RVCPQRCEPF
210 220 230 240 250
LIKRSFENMQ LLDEMLHRCV YDRKISGLRN MEELAAELPS ESDVEYAVAK
260 270 280 290 300
YLERFSKIAS DSLTCGTILT WLQLDNKGRR LPLADGETQR TINTPAVGAA
310 320 330 340 350
YGVRRYQAQA PDEINIEVGD MISVIDMPSP AESIWWRGKK SHLQKSLYEV
360 370 380 390 400
GFFPQSCVAT IGDKVPRNFP MPAPLVGHLD ASPTKPVLRK HGKLIAFFRS
410 420 430 440 450
FILSRPSRRR LKQSGIYRER VFNCDLSEHL LNSGQDIPMV LRSCAEFIEN
460 470 480 490 500
YGVIDGIYRL SGITSNIQRL RRAFDEERVP DLGNPEMKQD IHAVSSLLKM
510 520 530 540 550
YFRELPNPLC TYQLYDNFVE AIQVKADEAD ERLRLMKETV LKLPPPHYRT
560 570 580 590 600
LKYLAEHLYK VSQHHGRTGM TDKNLAIVWA PNLLRSPALE SGGVAALRGV
610 620 630 640 650
GVQAVVTEYL IRNCHNIFDA LDDHPARHSM VASATAAAAN AAGGELRLES
660 670 680 690 700
LTDCESLLVE QREQDQSLGV VERPKSLSTG GAKLISLEEA QERHSRVEGA
710 720 730 740 750
DLKQSLPISM LTSASSNAAS NIGSYIEVGG GPSSLPDKYH TVLSAPRSWQ
760 770 780 790 800
KRKPDKTPSW KSIFSRSQRQ GNPDPGQKIT TDVKDSVASR VSFVQASHAH
810 820 830 840 850
ASKELTKHDK PKSIELLETT SNERDPKPMD LCIRSNSIDS LRTVGHSRSV
860 870 880 890 900
SHDSYFDLLQ SPQRGHMTTC PSRELSELGL NFDREEPEMR IFSESESLVS
910 920 930 940 950
SPRVGKENVP PASGSATRRI MRARPEDFSS QTNSVNPSPK KQPRLNLLSP
960 970 980 990 1000
SSARTMPPPP LSAPGTASSS CGHESGGAEN CCKRYKLEDQ LCDIQFIDCG
1010 1020 1030 1040 1050
TPENVPTTQQ QFASVEVHPP PKPARANQSP ISSSNGASVG SSSSSTRYSY
1060 1070 1080 1090 1100
PSVQLGAKRK EQQDAKERFS YQGTFTQPGQ KQESSAPRPV HSTNNGATLR
1110 1120 1130 1140 1150
KPRVEPVEDG QIKLHVPTPT TPARSPRYSL LLCDTESSDN SSAVNTPQYD
1160 1170 1180 1190 1200
MEPLMLTSAM SGVSGVSSNV QQQQLLLGVD ASSSYLGSSH ESLGQNINNH
1210 1220 1230 1240 1250
HDAEQRDMNA LKRELSLDLN PLQPRLPQPA NRAATLPVKD QLQAAAAAMC
1260 1270 1280 1290 1300
SSPNNSNFTD NTSQSVTPSE YGYQHLQRQL SMHSLLATDE SSPVYEDFEQ
1310 1320 1330 1340 1350
TPVKMVPSPI KSTISITYKS PEKEKKPSAI LETNFDENTV YEQVKLFRNS
1360 1370 1380 1390 1400
VTEVNQMLHE RSSLKQIAEE EQHDGGAYKA AEMTQQLLQL EQEHHDHEEQ
1410 1420 1430 1440 1450
QEKEPEDEEQ SQLLYENIEL RKPKTVYENL RGEEMKFITE EQKPNVDRIE
1460 1470 1480 1490 1500
LDSLDSLPDN MEHEQSSPSK SPTFSVKELA NKFESSPVEQ LPNFDFSVRG
1510 1520 1530 1540 1550
GSMKKPNELS VPKTMPAPVP LKKLNSSAQK ITRSLDENAF VREFGGKQLQ
1560 1570 1580 1590 1600
DLSLSNKLPE VMSEVNSRRK SFDFTRPKTL NPPKRLPGMS ITEEICQKRV
1610 1620 1630 1640 1650
GEMEAITPTT ENRISLIQQN NMPKEQQSSA NQFLPPAGRK NVLTGVVLDR
1660 1670 1680 1690 1700
ERIDKIKEER RQQLTQKYYG DTLKSRSRTE LNSEDNFPAA ESLRIKSKSR
1710 1720 1730 1740 1750
GDMHALQKDI DMNLKQLSRV TGGGSECTLH TGLSQGNGQE HLGQQRVRRI
1760 1770 1780 1790 1800
SDEKNQNCDT SNGGVSGITS TSLLSVKTTA QKYGSTSKTP ANKFERSQPM
1810 1820 1830 1840
PRDRLQRNSL AESNAGTNNR EKISPQFSIR DVTAMFESRS QNQ
Length:1,843
Mass (Da):204,217
Last modified:October 1, 2002 - v2
Checksum:i4D5C65C637765D57
GO

Sequence cautioni

The sequence AAT94493.1 differs from that shown. Reason: Frameshift at position 351.
The sequence AAM49910.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1092 – 10921Missing in AAT94493. 1 PublicationCurated
Sequence conflicti1092 – 10921Missing in AAM49910. (PubMed:12537569)Curated
Sequence conflicti1818 – 18203NNR → K in AAM49910. (PubMed:12537569)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF218776 mRNA. Translation: AAF44627.1.
AE014134 Genomic DNA. Translation: AAF53844.2.
BT015264 mRNA. Translation: AAT94493.1. Frameshift.
AY118541 mRNA. Translation: AAM49910.1. Different initiation.
RefSeqiNP_001260600.1. NM_001273671.2.
NP_610002.1. NM_136158.5.
UniGeneiDm.3427.

Genome annotation databases

EnsemblMetazoaiFBtr0081318; FBpp0080851; FBgn0032821.
FBtr0332179; FBpp0304488; FBgn0032821.
GeneIDi35267.
KEGGidme:Dmel_CG10538.
UCSCiCG10538-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF218776 mRNA. Translation: AAF44627.1 .
AE014134 Genomic DNA. Translation: AAF53844.2 .
BT015264 mRNA. Translation: AAT94493.1 . Frameshift.
AY118541 mRNA. Translation: AAM49910.1 . Different initiation.
RefSeqi NP_001260600.1. NM_001273671.2.
NP_610002.1. NM_136158.5.
UniGenei Dm.3427.

3D structure databases

ProteinModelPortali Q9VIS1.
SMRi Q9VIS1. Positions 299-362, 420-618.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 61243. 2 interactions.
MINTi MINT-1558952.

Proteomic databases

PaxDbi Q9VIS1.
PRIDEi Q9VIS1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0081318 ; FBpp0080851 ; FBgn0032821 .
FBtr0332179 ; FBpp0304488 ; FBgn0032821 .
GeneIDi 35267.
KEGGi dme:Dmel_CG10538.
UCSCi CG10538-RA. d. melanogaster.

Organism-specific databases

CTDi 35267.
FlyBasei FBgn0032821. CdGAPr.

Phylogenomic databases

eggNOGi NOG311367.
GeneTreei ENSGT00720000108475.
InParanoidi Q9VIS1.
OMAi AMFESRS.
OrthoDBi EOG7WMCHV.
PhylomeDBi Q9VIS1.

Miscellaneous databases

GenomeRNAii 35267.
NextBioi 792708.

Gene expression databases

Bgeei Q9VIS1.

Family and domain databases

Gene3Di 1.10.555.10. 1 hit.
InterProi IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00620. RhoGAP. 1 hit.
[Graphical view ]
SMARTi SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEi PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dynamic expression of d-CdGAPr, a novel Drosophila melanogaster gene encoding a GTPase activating protein."
    Sagnier T., Grienenberger A., Mariol M.-C., Berenger H., Pradel J., Graba Y.
    Mech. Dev. 94:267-270(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1062-1843.
    Strain: Berkeley.
    Tissue: Embryo.
  6. "Focal adhesion kinase controls morphogenesis of the Drosophila optic stalk."
    Murakami S., Umetsu D., Maeyama Y., Sato M., Yoshida S., Tabata T.
    Development 134:1539-1548(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
    Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
    Mol. Biosyst. 3:275-286(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1216, IDENTIFICATION BY MASS SPECTROMETRY.
  8. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166; SER-168; SER-180; SER-837; SER-840; THR-843; SER-851; SER-861; SER-872; SER-876; SER-1029; THR-1118; THR-1121; SER-1125; SER-1281; SER-1284; SER-1453; SER-1456 AND THR-1679, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiCDGAP_DROME
AccessioniPrimary (citable) accession number: Q9VIS1
Secondary accession number(s): Q6AWI4, Q8MSV9, Q9NCL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3