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Q9VIS1

- CDGAP_DROME

UniProt

Q9VIS1 - CDGAP_DROME

Protein

GTPase-activating protein CdGAPr

Gene

CdGAPr

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Probably functions as a GTPase-activating protein (GAP) for RAC1 and/or CDC42. Required for optic stalk formation.1 Publication

    GO - Molecular functioni

    1. GTPase activator activity Source: UniProtKB-KW

    GO - Biological processi

    1. retinal ganglion cell axon guidance Source: UniProtKB
    2. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Developmental protein, GTPase activation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTPase-activating protein CdGAPr
    Alternative name(s):
    d-CdGAPr
    Gene namesi
    Name:CdGAPr
    ORF Names:CG10538
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0032821. CdGAPr.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18431843GTPase-activating protein CdGAPrPRO_0000320117Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei166 – 1661Phosphoserine1 Publication
    Modified residuei168 – 1681Phosphoserine1 Publication
    Modified residuei180 – 1801Phosphoserine1 Publication
    Modified residuei837 – 8371Phosphoserine1 Publication
    Modified residuei840 – 8401Phosphoserine1 Publication
    Modified residuei843 – 8431Phosphothreonine1 Publication
    Modified residuei851 – 8511Phosphoserine1 Publication
    Modified residuei861 – 8611Phosphoserine1 Publication
    Modified residuei872 – 8721Phosphoserine1 Publication
    Modified residuei876 – 8761Phosphoserine1 Publication
    Modified residuei1029 – 10291Phosphoserine1 Publication
    Modified residuei1118 – 11181Phosphothreonine1 Publication
    Modified residuei1121 – 11211Phosphothreonine1 Publication
    Modified residuei1125 – 11251Phosphoserine1 Publication
    Modified residuei1216 – 12161Phosphoserine1 Publication
    Modified residuei1281 – 12811Phosphoserine1 Publication
    Modified residuei1284 – 12841Phosphoserine1 Publication
    Modified residuei1453 – 14531Phosphoserine1 Publication
    Modified residuei1456 – 14561Phosphoserine1 Publication
    Modified residuei1679 – 16791Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9VIS1.
    PRIDEiQ9VIS1.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Developmental stagei

    Expressed at all developmental stages, with highest expression at the posterior pole of the early cellular blastoderm, the neuro-ectoderm prior to neuroblast delamination, rows of epidermal cells in the most posterior part of thoracic and first abdominal segments and a ring of epidermal cells at the posterior end of the embryo.1 Publication

    Gene expression databases

    BgeeiQ9VIS1.

    Interactioni

    Protein-protein interaction databases

    BioGridi61243. 2 interactions.
    MINTiMINT-1558952.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VIS1.
    SMRiQ9VIS1. Positions 299-362, 420-618.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini295 – 36369SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini424 – 618195Rho-GAPPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1378 – 140427Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi632 – 64211Poly-AlaAdd
    BLAST
    Compositional biasi957 – 9604Poly-Pro
    Compositional biasi1041 – 10455Poly-Ser
    Compositional biasi1171 – 11744Poly-Gln
    Compositional biasi1244 – 12485Poly-Ala

    Sequence similaritiesi

    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, SH3 domain

    Phylogenomic databases

    eggNOGiNOG311367.
    GeneTreeiENSGT00720000108475.
    InParanoidiQ9VIS1.
    OMAiAMFESRS.
    OrthoDBiEOG7WMCHV.
    PhylomeDBiQ9VIS1.

    Family and domain databases

    Gene3Di1.10.555.10. 1 hit.
    InterProiIPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00620. RhoGAP. 1 hit.
    [Graphical view]
    SMARTiSM00324. RhoGAP. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEiPS50238. RHOGAP. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9VIS1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDKVSTSLA AQLHSHALAS AEAGGIGGVN GGPIACHAST DKDAQAPPLQ     50
    FEMDAPAAAI SAQLNFKIVP ADSLPGLSYQ DMFASMNTSQ ISNASTESSC 100
    SPPIQGAVPP PKPSRHMAVQ PLNSKSCRFP KLEECAHFHY ERVQLGPLSV 150
    QLLDDKSEHM GSSIASQSLG GDLPHSSLRS FSPESCWFII RVCPQRCEPF 200
    LIKRSFENMQ LLDEMLHRCV YDRKISGLRN MEELAAELPS ESDVEYAVAK 250
    YLERFSKIAS DSLTCGTILT WLQLDNKGRR LPLADGETQR TINTPAVGAA 300
    YGVRRYQAQA PDEINIEVGD MISVIDMPSP AESIWWRGKK SHLQKSLYEV 350
    GFFPQSCVAT IGDKVPRNFP MPAPLVGHLD ASPTKPVLRK HGKLIAFFRS 400
    FILSRPSRRR LKQSGIYRER VFNCDLSEHL LNSGQDIPMV LRSCAEFIEN 450
    YGVIDGIYRL SGITSNIQRL RRAFDEERVP DLGNPEMKQD IHAVSSLLKM 500
    YFRELPNPLC TYQLYDNFVE AIQVKADEAD ERLRLMKETV LKLPPPHYRT 550
    LKYLAEHLYK VSQHHGRTGM TDKNLAIVWA PNLLRSPALE SGGVAALRGV 600
    GVQAVVTEYL IRNCHNIFDA LDDHPARHSM VASATAAAAN AAGGELRLES 650
    LTDCESLLVE QREQDQSLGV VERPKSLSTG GAKLISLEEA QERHSRVEGA 700
    DLKQSLPISM LTSASSNAAS NIGSYIEVGG GPSSLPDKYH TVLSAPRSWQ 750
    KRKPDKTPSW KSIFSRSQRQ GNPDPGQKIT TDVKDSVASR VSFVQASHAH 800
    ASKELTKHDK PKSIELLETT SNERDPKPMD LCIRSNSIDS LRTVGHSRSV 850
    SHDSYFDLLQ SPQRGHMTTC PSRELSELGL NFDREEPEMR IFSESESLVS 900
    SPRVGKENVP PASGSATRRI MRARPEDFSS QTNSVNPSPK KQPRLNLLSP 950
    SSARTMPPPP LSAPGTASSS CGHESGGAEN CCKRYKLEDQ LCDIQFIDCG 1000
    TPENVPTTQQ QFASVEVHPP PKPARANQSP ISSSNGASVG SSSSSTRYSY 1050
    PSVQLGAKRK EQQDAKERFS YQGTFTQPGQ KQESSAPRPV HSTNNGATLR 1100
    KPRVEPVEDG QIKLHVPTPT TPARSPRYSL LLCDTESSDN SSAVNTPQYD 1150
    MEPLMLTSAM SGVSGVSSNV QQQQLLLGVD ASSSYLGSSH ESLGQNINNH 1200
    HDAEQRDMNA LKRELSLDLN PLQPRLPQPA NRAATLPVKD QLQAAAAAMC 1250
    SSPNNSNFTD NTSQSVTPSE YGYQHLQRQL SMHSLLATDE SSPVYEDFEQ 1300
    TPVKMVPSPI KSTISITYKS PEKEKKPSAI LETNFDENTV YEQVKLFRNS 1350
    VTEVNQMLHE RSSLKQIAEE EQHDGGAYKA AEMTQQLLQL EQEHHDHEEQ 1400
    QEKEPEDEEQ SQLLYENIEL RKPKTVYENL RGEEMKFITE EQKPNVDRIE 1450
    LDSLDSLPDN MEHEQSSPSK SPTFSVKELA NKFESSPVEQ LPNFDFSVRG 1500
    GSMKKPNELS VPKTMPAPVP LKKLNSSAQK ITRSLDENAF VREFGGKQLQ 1550
    DLSLSNKLPE VMSEVNSRRK SFDFTRPKTL NPPKRLPGMS ITEEICQKRV 1600
    GEMEAITPTT ENRISLIQQN NMPKEQQSSA NQFLPPAGRK NVLTGVVLDR 1650
    ERIDKIKEER RQQLTQKYYG DTLKSRSRTE LNSEDNFPAA ESLRIKSKSR 1700
    GDMHALQKDI DMNLKQLSRV TGGGSECTLH TGLSQGNGQE HLGQQRVRRI 1750
    SDEKNQNCDT SNGGVSGITS TSLLSVKTTA QKYGSTSKTP ANKFERSQPM 1800
    PRDRLQRNSL AESNAGTNNR EKISPQFSIR DVTAMFESRS QNQ 1843
    Length:1,843
    Mass (Da):204,217
    Last modified:October 1, 2002 - v2
    Checksum:i4D5C65C637765D57
    GO

    Sequence cautioni

    The sequence AAT94493.1 differs from that shown. Reason: Frameshift at position 351.
    The sequence AAM49910.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1092 – 10921Missing in AAT94493. 1 PublicationCurated
    Sequence conflicti1092 – 10921Missing in AAM49910. (PubMed:12537569)Curated
    Sequence conflicti1818 – 18203NNR → K in AAM49910. (PubMed:12537569)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF218776 mRNA. Translation: AAF44627.1.
    AE014134 Genomic DNA. Translation: AAF53844.2.
    BT015264 mRNA. Translation: AAT94493.1. Frameshift.
    AY118541 mRNA. Translation: AAM49910.1. Different initiation.
    RefSeqiNP_001260600.1. NM_001273671.1.
    NP_610002.1. NM_136158.4.
    UniGeneiDm.3427.

    Genome annotation databases

    EnsemblMetazoaiFBtr0081318; FBpp0080851; FBgn0032821.
    FBtr0332179; FBpp0304488; FBgn0032821.
    GeneIDi35267.
    KEGGidme:Dmel_CG10538.
    UCSCiCG10538-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF218776 mRNA. Translation: AAF44627.1 .
    AE014134 Genomic DNA. Translation: AAF53844.2 .
    BT015264 mRNA. Translation: AAT94493.1 . Frameshift.
    AY118541 mRNA. Translation: AAM49910.1 . Different initiation.
    RefSeqi NP_001260600.1. NM_001273671.1.
    NP_610002.1. NM_136158.4.
    UniGenei Dm.3427.

    3D structure databases

    ProteinModelPortali Q9VIS1.
    SMRi Q9VIS1. Positions 299-362, 420-618.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 61243. 2 interactions.
    MINTi MINT-1558952.

    Proteomic databases

    PaxDbi Q9VIS1.
    PRIDEi Q9VIS1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0081318 ; FBpp0080851 ; FBgn0032821 .
    FBtr0332179 ; FBpp0304488 ; FBgn0032821 .
    GeneIDi 35267.
    KEGGi dme:Dmel_CG10538.
    UCSCi CG10538-RA. d. melanogaster.

    Organism-specific databases

    CTDi 35267.
    FlyBasei FBgn0032821. CdGAPr.

    Phylogenomic databases

    eggNOGi NOG311367.
    GeneTreei ENSGT00720000108475.
    InParanoidi Q9VIS1.
    OMAi AMFESRS.
    OrthoDBi EOG7WMCHV.
    PhylomeDBi Q9VIS1.

    Miscellaneous databases

    GenomeRNAii 35267.
    NextBioi 792708.

    Gene expression databases

    Bgeei Q9VIS1.

    Family and domain databases

    Gene3Di 1.10.555.10. 1 hit.
    InterProi IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00620. RhoGAP. 1 hit.
    [Graphical view ]
    SMARTi SM00324. RhoGAP. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEi PS50238. RHOGAP. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Dynamic expression of d-CdGAPr, a novel Drosophila melanogaster gene encoding a GTPase activating protein."
      Sagnier T., Grienenberger A., Mariol M.-C., Berenger H., Pradel J., Graba Y.
      Mech. Dev. 94:267-270(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1062-1843.
      Strain: Berkeley.
      Tissue: Embryo.
    6. "Focal adhesion kinase controls morphogenesis of the Drosophila optic stalk."
      Murakami S., Umetsu D., Maeyama Y., Sato M., Yoshida S., Tabata T.
      Development 134:1539-1548(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
      Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
      Mol. Biosyst. 3:275-286(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1216, IDENTIFICATION BY MASS SPECTROMETRY.
    8. "Phosphoproteome analysis of Drosophila melanogaster embryos."
      Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
      J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166; SER-168; SER-180; SER-837; SER-840; THR-843; SER-851; SER-861; SER-872; SER-876; SER-1029; THR-1118; THR-1121; SER-1125; SER-1281; SER-1284; SER-1453; SER-1456 AND THR-1679, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.

    Entry informationi

    Entry nameiCDGAP_DROME
    AccessioniPrimary (citable) accession number: Q9VIS1
    Secondary accession number(s): Q6AWI4, Q8MSV9, Q9NCL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3