Q9VIM5 (ARPC2_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable actin-related protein 2/3 complex subunit 2

Alternative name(s):
Arp2/3 complex 34 kDa subunit
Short name=p34-ARC

Gene names

Name:	Arc-p34
ORF Names:	CG10954

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament By similarity.
Subunit structure	Component of the Arp2/3 complex By similarity.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Sequence similarities	Belongs to the ARPC2 family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	Actin-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell morphogenesis Inferred from mutant phenotype PubMed 21041442. Source: FlyBase cell projection assembly Inferred from mutant phenotype PubMed 14588242. Source: FlyBase cortical actin cytoskeleton organization Inferred from mutant phenotype PubMed 14588242. Source: FlyBase lateral inhibition Inferred from mutant phenotype PubMed 19363474. Source: FlyBase regulation of actin filament polymerization Inferred from electronic annotation. Source: InterPro regulation of cell shape Inferred from mutant phenotype PubMed 14527345PubMed 14588242. Source: FlyBase
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	actin binding Inferred from sequence or structural similarity PubMed 10908588. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Probable actin-related protein 2/3 complex subunit 2		PRO_0000124039

Sequences

	Sequence		Length	Mass (Da)
	Q9VIM5 [UniParc]. Last modified January 27, 2003. Version 2. Checksum: BD1C82C1343CA5AF	FASTA	301	35,104
	10 20 30 40 50 60 MILLEINNRI IEETLLVKYR NAQAGLKPES IDIRIADFDG VLYHISNVNG DKTKVRISIS 70 80 90 100 110 120 LKFYKQLQEH GADELLKREY GSLLTDTEEG YNVSVLINLE EIPEDCEQIA KRIGLLKRNC 130 140 150 160 170 180 FASVFEKYFD YQEQGEEGQK RAVINYRNDE TLYVEAKPDR VTVVFSTIFR DEDDVIIGKV 190 200 210 220 230 240 FMQELREGRR ASHTAPQVLF SHREPPLELA NTDARVGDNI GYVTFVLFPR HTNKETRDNT 250 260 270 280 290 300 INLIHMFRDY LHYHIKCSKA YIHSRMRAKT SDFLKVLNRA RPEPKNTEKK TITGRTFKRI D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014134 Genomic DNA. Translation: AAF53892.2. AY060391 mRNA. Translation: AAL25430.1.
RefSeq	NP_610033.1. NM_136189.3.
UniGene	Dm.4005.
3D structure databases
ProteinModelPortal	Q9VIM5.
SMR	Q9VIM5. Positions 1-283.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-19044N.
IntAct	Q9VIM5. 3 interactions.
MINT	MINT-980672.
Proteomic databases
PaxDb	Q9VIM5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0081358; FBpp0080890; FBgn0032859.
GeneID	35311.
KEGG	dme:Dmel_CG10954.
UCSC	CG10954-RA. d. melanogaster.
Organism-specific databases
CTD	10109.
FlyBase	FBgn0032859. Arc-p34.
Phylogenomic databases
eggNOG	NOG327379.
GeneTree	ENSGT00390000016794.
InParanoid	Q9VIM5.
KO	K05758.
OMA	LKFYKQL.
OrthoDB	EOG4J6Q6M.
PhylomeDB	Q9VIM5.
Gene expression databases
Bgee	Q9VIM5.
GermOnline	CG10954. Drosophila melanogaster.
Family and domain databases
InterPro	IPR007188. P34-arc. [Graphical view]
PANTHER	PTHR12058. PTHR12058. 1 hit.
Pfam	PF04045. P34-Arc. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	35311.
NextBio	792904.

Entry information

Entry name

ARPC2_DROME

Accession

Primary (citable) accession number: Q9VIM5
Secondary accession number(s): Q95T07

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 27, 2003
Last modified:	April 3, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project