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Protein

Actin-related protein 2/3 complex subunit 2

Gene

Arpc2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).By similarity

GO - Molecular functioni

  • actin binding Source: FlyBase
  • actin filament binding Source: GO_Central
  • structural constituent of cytoskeleton Source: FlyBase

GO - Biological processi

  • actin filament polymerization Source: InterPro
  • Arp2/3 complex-mediated actin nucleation Source: FlyBase
  • cell morphogenesis Source: FlyBase
  • cell projection assembly Source: FlyBase
  • cortical actin cytoskeleton organization Source: FlyBase
  • regulation of cell shape Source: FlyBase

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-DME-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DME-5663213 RHO GTPases Activate WASPs and WAVEs
R-DME-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 2
Alternative name(s):
Arp2/3 complex 34 kDa subunit
Short name:
p34-ARC
Gene namesi
Name:Arpc2
Synonyms:Arc-p34
ORF Names:CG10954
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi

Organism-specific databases

FlyBaseiFBgn0032859 Arpc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001240391 – 301Actin-related protein 2/3 complex subunit 2Add BLAST301

Proteomic databases

PaxDbiQ9VIM5
PRIDEiQ9VIM5

Expressioni

Gene expression databases

BgeeiFBgn0032859
ExpressionAtlasiQ9VIM5 baseline and differential
GenevisibleiQ9VIM5 DM

Interactioni

Subunit structurei

Component of the Arp2/3 complex.By similarity

GO - Molecular functioni

  • actin binding Source: FlyBase
  • actin filament binding Source: GO_Central

Protein-protein interaction databases

BioGridi61277, 15 interactors
DIPiDIP-19044N
IntActiQ9VIM5, 3 interactors
STRINGi7227.FBpp0080890

Structurei

3D structure databases

ProteinModelPortaliQ9VIM5
SMRiQ9VIM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC2 family.Curated

Phylogenomic databases

eggNOGiKOG2826 Eukaryota
ENOG410YKF6 LUCA
InParanoidiQ9VIM5
KOiK05758
OMAiVFIQEFV
OrthoDBiEOG091G0BUH
PhylomeDBiQ9VIM5

Family and domain databases

Gene3Di3.30.1460.20, 2 hits
InterProiView protein in InterPro
IPR007188 ARPC2
IPR034666 ARPC2/4
PANTHERiPTHR12058 PTHR12058, 1 hit
PfamiView protein in Pfam
PF04045 P34-Arc, 1 hit
SUPFAMiSSF69645 SSF69645, 2 hits

Sequencei

Sequence statusi: Complete.

Q9VIM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILLEINNRI IEETLLVKYR NAQAGLKPES IDIRIADFDG VLYHISNVNG
60 70 80 90 100
DKTKVRISIS LKFYKQLQEH GADELLKREY GSLLTDTEEG YNVSVLINLE
110 120 130 140 150
EIPEDCEQIA KRIGLLKRNC FASVFEKYFD YQEQGEEGQK RAVINYRNDE
160 170 180 190 200
TLYVEAKPDR VTVVFSTIFR DEDDVIIGKV FMQELREGRR ASHTAPQVLF
210 220 230 240 250
SHREPPLELA NTDARVGDNI GYVTFVLFPR HTNKETRDNT INLIHMFRDY
260 270 280 290 300
LHYHIKCSKA YIHSRMRAKT SDFLKVLNRA RPEPKNTEKK TITGRTFKRI

D
Length:301
Mass (Da):35,104
Last modified:January 27, 2003 - v2
Checksum:iBD1C82C1343CA5AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF53892.2
AY060391 mRNA Translation: AAL25430.1
RefSeqiNP_001286102.1, NM_001299173.1
NP_610033.1, NM_136189.4
UniGeneiDm.4005

Genome annotation databases

EnsemblMetazoaiFBtr0081358; FBpp0080890; FBgn0032859
FBtr0346418; FBpp0312086; FBgn0032859
GeneIDi35311
KEGGidme:Dmel_CG10954
UCSCiCG10954-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiARPC2_DROME
AccessioniPrimary (citable) accession number: Q9VIM5
Secondary accession number(s): Q95T07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 27, 2003
Last modified: May 23, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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