Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein MCM10 homolog

Gene

Mcm10

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Proposed to be involved in DNA replication and to participate in the activation of the pre-replication complex (pre-RC). May be involved in chromosome condensation.1 Publication

GO - Molecular functioni

GO - Biological processi

  • chromosome condensation Source: FlyBase
  • DNA endoreduplication Source: FlyBase
  • DNA replication Source: FlyBase
  • DNA replication initiation Source: GO_Central
  • eye-antennal disc development Source: FlyBase
  • female meiosis chromosome segregation Source: FlyBase
  • heterochromatin organization involved in chromatin silencing Source: FlyBase
  • negative regulation of compound eye retinal cell apoptotic process Source: FlyBase
  • positive regulation of mitotic cell cycle Source: FlyBase
  • positive regulation of R7 cell differentiation Source: FlyBase
  • pre-replicative complex assembly involved in nuclear cell cycle DNA replication Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-176187. Activation of ATR in response to replication stress.
R-DME-68962. Activation of the pre-replicative complex.
R-DME-69300. Removal of licensing factors from origins.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MCM10 homolog
Alternative name(s):
Sensitized chromosome inheritance modifier 19
Gene namesi
Name:Mcm10
Synonyms:Scim19
ORF Names:CG9241
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0032929. Mcm10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 776776Protein MCM10 homologPRO_0000278325Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei87 – 871Phosphoserine1 Publication
Modified residuei88 – 881Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9VIE6.
PRIDEiQ9VIE6.

PTM databases

iPTMnetiQ9VIE6.

Expressioni

Gene expression databases

BgeeiFBgn0032929.
ExpressionAtlasiQ9VIE6. differential.
GenevisibleiQ9VIE6. DM.

Interactioni

Subunit structurei

Self-associates. Interacts with Mcm2, dup, Orc2, CDC45L and Su(var)205.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC45LO969892EBI-91264,EBI-156880
dupQ7JVY22EBI-91264,EBI-164632
Mcm2P497352EBI-91264,EBI-138228
Orc2Q241682EBI-91264,EBI-179453
Su(var)205P052052EBI-91264,EBI-155532

Protein-protein interaction databases

BioGridi61343. 1 interaction.
DIPiDIP-20713N.
IntActiQ9VIE6. 7 interactions.
MINTiMINT-284647.
STRINGi7227.FBpp0081004.

Structurei

3D structure databases

ProteinModelPortaliQ9VIE6.
SMRiQ9VIE6. Positions 193-357, 659-740.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni331 – 35626Zinc finger-likeAdd
BLAST

Domaini

The zinc finger-like domain binds a zinc ion and is involved in self-association.By similarity

Sequence similaritiesi

Belongs to the MCM10 family.Curated

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3056. Eukaryota.
ENOG41100ZT. LUCA.
GeneTreeiENSGT00390000007134.
InParanoidiQ9VIE6.
KOiK10736.
OMAiKHCSNCG.
OrthoDBiEOG091G053R.
PhylomeDBiQ9VIE6.

Family and domain databases

InterProiIPR015411. Rep_factor_Mcm10_C.
IPR015408. Znf_Mcm10/DnaG.
[Graphical view]
PfamiPF09332. Mcm10. 1 hit.
PF09329. zf-primase. 1 hit.
[Graphical view]
SMARTiSM01280. Mcm10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VIE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPAQKSGTD ISIDDEEEIL ALEKLLGAAE NENTKSAESE KAKPTAPILV
60 70 80 90 100
PKLREDNSFA NAFTFEKIVK PEKQKNAAII KEPELDSSDD EEVKNFLERK
110 120 130 140 150
YNEYGSDINK RLKQQQENAY ESKVAREVDQ ELKKSIHVVT STPQPLKNPH
160 170 180 190 200
NPIKRQSAVS TTFQRPPPVA AAVASTSQSS APVSAVFTDP VFGLRMINPL
210 220 230 240 250
VSSSLLQERM TGRKPVPFSG VAYHIERGDL AKDWVIAGAL VSKNPVKNTK
260 270 280 290 300
KGDPYSTWKL SDLRGEVKTI SLFLFKEAHK SLWKTAEGLC LAVLNPTIFE
310 320 330 340 350
RRAGSSDVAC LSIDSSQKVM ILGQSKDLGT CRATKKNGDK CTSVVNLTDC
360 370 380 390 400
DYCIFHVKQE YGKMSRRSEL QSATAGRGIN ELRNKVLGKN EVFYGGQTFT
410 420 430 440 450
AVPARKSAKL ITKERDRLSM LAGYDVSPFA HTANHTSKPK TAEPTKIPYA
460 470 480 490 500
ERGGPVSRLA GGVEASRKQR VQDLERLRLL KEENERFEKK KQAEGHVLGS
510 520 530 540 550
DNKKESEAGT PAVSMPTTPV PDKFKNRGFS FDASLTPKLS GSENFSFEIN
560 570 580 590 600
VGSRQAQNAK LKAAALLKKK PLEKINPNST RGSESGKRRA IDELNEKFSS
610 620 630 640 650
SAKRQKIDED DRELMRKSRI EKIMAATSSH TNLVEMRERE AQEEYFNKLE
660 670 680 690 700
RKEAMEEKML TTYKMPCKAV ICQVCKYTAF SASDRCKEQK HPLKVVDAEK
710 720 730 740 750
RFFQCKDCGN RTTTVFKLPK QSCKNCKGSR WQRTAMIREK KILTGRETLS
760 770
VRGDEETFMG CLAGSANLNL LVPDEE
Length:776
Mass (Da):86,524
Last modified:October 1, 2002 - v2
Checksum:i2076F7C06FCDAD9C
GO

Sequence cautioni

The sequence AAL29025 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF53976.2.
AY061477 mRNA. Translation: AAL29025.1. Different initiation.
RefSeqiNP_610097.2. NM_136253.4.

Genome annotation databases

EnsemblMetazoaiFBtr0081475; FBpp0081004; FBgn0032929.
GeneIDi35390.
KEGGidme:Dmel_CG9241.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF53976.2.
AY061477 mRNA. Translation: AAL29025.1. Different initiation.
RefSeqiNP_610097.2. NM_136253.4.

3D structure databases

ProteinModelPortaliQ9VIE6.
SMRiQ9VIE6. Positions 193-357, 659-740.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi61343. 1 interaction.
DIPiDIP-20713N.
IntActiQ9VIE6. 7 interactions.
MINTiMINT-284647.
STRINGi7227.FBpp0081004.

PTM databases

iPTMnetiQ9VIE6.

Proteomic databases

PaxDbiQ9VIE6.
PRIDEiQ9VIE6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0081475; FBpp0081004; FBgn0032929.
GeneIDi35390.
KEGGidme:Dmel_CG9241.

Organism-specific databases

CTDi55388.
FlyBaseiFBgn0032929. Mcm10.

Phylogenomic databases

eggNOGiKOG3056. Eukaryota.
ENOG41100ZT. LUCA.
GeneTreeiENSGT00390000007134.
InParanoidiQ9VIE6.
KOiK10736.
OMAiKHCSNCG.
OrthoDBiEOG091G053R.
PhylomeDBiQ9VIE6.

Enzyme and pathway databases

ReactomeiR-DME-176187. Activation of ATR in response to replication stress.
R-DME-68962. Activation of the pre-replicative complex.
R-DME-69300. Removal of licensing factors from origins.

Miscellaneous databases

GenomeRNAii35390.
PROiQ9VIE6.

Gene expression databases

BgeeiFBgn0032929.
ExpressionAtlasiQ9VIE6. differential.
GenevisibleiQ9VIE6. DM.

Family and domain databases

InterProiIPR015411. Rep_factor_Mcm10_C.
IPR015408. Znf_Mcm10/DnaG.
[Graphical view]
PfamiPF09332. Mcm10. 1 hit.
PF09329. zf-primase. 1 hit.
[Graphical view]
SMARTiSM01280. Mcm10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCM10_DROME
AccessioniPrimary (citable) accession number: Q9VIE6
Secondary accession number(s): Q95RC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.