Unreviewed, UniProtKB/TrEMBL Q9VHS8 (Q9VHS8_DROME)

Names and origin

Protein names

Submitted name:
    eIF4AIII EMBL AAF54221.1
    EC=3.6.1.3

Gene names

Name:	eIF4AIII EMBL AAF54221.1
ORF Names:	Dmel_CG7483 EMBL AAF54221.1

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the DEAD box helicase family. RuleBase RU000492V4

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Helicase RuleBase RU000492V4 Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro ATP-dependent helicase activity Inferred from electronic annotation. Source: InterPro ATPase activity, uncoupled Inferred from electronic annotation. Source: EC nucleic acid binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q9VZV9	1	EBI-159053,EBI-125137

Sequences

	Sequence		Length	Mass (Da)
	Q9VHS8-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: B07BD3EF9276918B	FASTA	399	45,645
	10 20 30 40 50 60 MARKNAQAED LSNVEFETSE DVEVIPTFNA MNLKEELLRG IYAYGFEKPS AIQQRSITPI 70 80 90 100 110 120 VKGRDVIAQA QSGTGKTATF SISILQSLDT TLRETQVLCL SPTRELAVQI QKVILALGDM 130 140 150 160 170 180 MNVQCHVCIG GTNLGEDIRK LDYGQHIVSG TPGRVFDMIK RRVLRTRAIK MLVLDEADEM 190 200 210 220 230 240 LNKGFKEQIY DVYRYLPPAT QVVLISATLP HEILEMTSKF MTDPIRILVK RDELTLEGIK 250 260 270 280 290 300 QFFVAVEREE WKFDTLCDLY DTLTITQAVI FCNTKRKVDW LTEKMREANF TVSSMHGDMP 310 320 330 340 350 360 QKERDEIMKE FRAGQSRVLI TTDVWARGID VQQVSLVINY DLPNNRELYI HRIGRSGRFG 370 380 390 RKGVAINFVK SDDIRILRDI EQYYSTQIDE MPMNVADLI

References

[1]

"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.

[2]

"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014297 Genomic DNA. Translation: AAF54221.1.
RefSeq	NP_649788.2.
UniGene	Dm.4910
3D structure databases
HSSP	HSSP built from PDB template 1FUK based on UniProtKB P10081.
SMR	Q9VHS8. Positions 9-399.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VHS8. 3 interactions.
Proteomic databases
PRIDE	Q9VHS8.
Genome annotation databases
Ensembl	FBgn0037573. Drosophila melanogaster. [Contig view]
GeneID	40987.
KEGG	dme:Dmel_CG7483.
NMPDR	fig|7227.3.peg.11676.
Organism-specific databases
FlyBase	FBgn0037573. eIF4AIII.
Phylogenomic databases
OMA	Q9VHS8. PIVKGRD.
Gene expression databases
ArrayExpress	Q9VHS8.
Family and domain databases
InterPro	IPR014001. DEAD-like_N. IPR001650. DNA/RNA_helicase_C. IPR011545. DNA/RNA_helicase_DEAD/DEAH_N. IPR014021. Helicase_SF1/SF2_ATP-bd. IPR000629. RNA-helicase_DEAD-box_CS. IPR014014. RNA_helicase_DEAD_Q_motif. [Graphical view]
Pfam	PF00270. DEAD. 1 hit. PF00271. Helicase_C. 1 hit. [Graphical view]
SMART	SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. [Graphical view]
PROSITE	PS00039. DEAD_ATP_HELICASE. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS51195. Q_MOTIF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	821610.

Entry information

Entry name

Q9VHS8_DROME

Accession

Primary (citable) accession number: Q9VHS8

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	July 7, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)