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Q9VHS4 (OR85A_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative odorant receptor 85a
Gene names
Name:Or85a
ORF Names:CG7454
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide By similarity.

Subunit structure

Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Miscellaneous

The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

Sequence similarities

Belongs to the heteromeric odorant receptor channel (TC 1.A.69) family. [View classification]

Binary interactions

With

Entry

#Exp.

IntAct

Notes

yellow-bQ9VJI51EBI-183787,EBI-196229

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 397397Putative odorant receptor 85a
PRO_0000174274

Regions

Topological domain1 – 4646Cytoplasmic Potential
Transmembrane47 – 6721Helical; Name=1; Potential
Topological domain68 – 8316Extracellular Potential
Transmembrane84 – 10421Helical; Name=2; Potential
Topological domain105 – 14238Cytoplasmic Potential
Transmembrane143 – 16321Helical; Name=3; Potential
Topological domain164 – 19229Extracellular Potential
Transmembrane193 – 21321Helical; Name=4; Potential
Topological domain214 – 26249Cytoplasmic Potential
Transmembrane263 – 28321Helical; Name=5; Potential
Topological domain284 – 29411Extracellular Potential
Transmembrane295 – 31521Helical; Name=6; Potential
Topological domain316 – 34732Cytoplasmic Potential
Transmembrane348 – 36821Helical; Name=7; Potential
Topological domain369 – 39729Extracellular Potential

Amino acid modifications

Glycosylation751N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9VHS4 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 4ED07645226497C2

FASTA39745,820
        10         20         30         40         50         60 
MIFKYIQEPV LGSLFRSRDS LIYLNRSIDQ MGWRLPPRTK PYWWLYYIWT LVVIVLVFIF 

        70         80         90        100        110        120 
IPYGLIMTGI KEFKNFTTTD LFTYVQVPVN TNASIMKGII VLFMRRRFSR AQKMMDAMDI 

       130        140        150        160        170        180 
RCTKMEEKVQ VHRAAALCNR VVVIYHCIYF GYLSMALTGA LVIGKTPFCL YNPLVNPDDH 

       190        200        210        220        230        240 
FYLATAIESV TMAGIILANL ILDVYPIIYV VVLRIHMELL SERIKTLRTD VEKGDDQHYA 

       250        260        270        280        290        300 
ELVECVKDHK LIVEYGNTLR PMISATMFIQ LLSVGLLLGL AAVSMQFYNT VMERVVSGVY 

       310        320        330        340        350        360 
TIAILSQTFP FCYVCEQLSS DCESLTNTLF HSKWIGAERR YRTTMLYFIH NVQQSILFTA 

       370        380        390 
GGIFPICLNT NIKMAKFAFS VVTIVNEMDL AEKLRRE

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014297 Genomic DNA. Translation: AAF54225.1.
RefSeqNP_524277.1. NM_079553.1.
UniGeneDm.27235.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP-22791N.
IntActQ9VHS4. 1 interaction.
MINTMINT-865244.
STRINGQ9VHS4.

Proteomic databases

PRIDEQ9VHS4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0081836; FBpp0081326; FBgn0037576.
GeneID40991.
KEGGdme:Dmel_CG7454.
NMPDRfig|7227.3.peg.11681.

Organism-specific databases

CTD40991.
FlyBaseFBgn0037576. Or85a.

Phylogenomic databases

GeneTreeEMGT00050000009319.
InParanoidQ9VHS4.
OMAWIDASPR.
OrthoDBEOG44B8HN.
PhylomeDBQ9VHS4.

Gene expression databases

BgeeQ9VHS4.
GermOnlineCG7454. Drosophila melanogaster.

Family and domain databases

InterProIPR004117. 7tm6_olfct_rcpt.
[Graphical view]
KOK08471.
PANTHERPTHR21137. 7tm6_olfct_rcpt. 1 hit.
PfamPF02949. 7tm_6. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio821630.

Entry information

Entry nameOR85A_DROME
AccessionPrimary (citable) accession number: Q9VHS4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents