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Q9VHS2

- COX7A_DROME

UniProt

Q9VHS2 - COX7A_DROME

Protein

Probable cytochrome c oxidase subunit 7A, mitochondrial

Gene

CG9603

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytochrome c oxidase subunit 7A, mitochondrial (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase subunit VIIa
    Gene namesi
    ORF Names:CG9603
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0040529. CG9603.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial respiratory chain Source: InterPro

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3131MitochondrionSequence AnalysisAdd
    BLAST
    Chaini32 – 8958Probable cytochrome c oxidase subunit 7A, mitochondrialPRO_0000006153Add
    BLAST

    Proteomic databases

    PaxDbiQ9VHS2.
    PRIDEiQ9VHS2.

    Expressioni

    Gene expression databases

    BgeeiQ9VHS2.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BcDNA.GH11688Q9Y1041EBI-105449,EBI-97789

    Protein-protein interaction databases

    BioGridi72497. 1 interaction.
    DIPiDIP-17309N.
    IntActiQ9VHS2. 1 interaction.
    MINTiMINT-744456.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VHS2.
    SMRiQ9VHS2. Positions 33-88.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c oxidase VIIa family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG118447.
    InParanoidiQ9VHS2.
    KOiK02270.
    OrthoDBiEOG7J182H.
    PhylomeDBiQ9VHS2.

    Family and domain databases

    Gene3Di4.10.91.10. 1 hit.
    InterProiIPR003177. Cyt_c_oxidase_su7a.
    [Graphical view]
    PANTHERiPTHR10510. PTHR10510. 1 hit.
    PfamiPF02238. COX7a. 1 hit.
    [Graphical view]
    SUPFAMiSSF81419. SSF81419. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9VHS2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMNLSRAVVR SFATTAGRRS AAVPKDQIEK GYFEIRKVQE HFQKKDGKPV   50
    FLKGSVVDNV LYRVTVALAL VGIGGMGKLF YELSVPKKE 89
    Length:89
    Mass (Da):9,902
    Last modified:May 1, 2000 - v1
    Checksum:i9220331ED2D07F20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014297 Genomic DNA. Translation: AAF54227.1.
    BT058048 mRNA. Translation: ACM78490.1.
    RefSeqiNP_652184.2. NM_143927.3.
    UniGeneiDm.6020.

    Genome annotation databases

    EnsemblMetazoaiFBtr0081855; FBpp0081344; FBgn0040529.
    GeneIDi50002.
    KEGGidme:Dmel_CG9603.
    UCSCiCG9603-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014297 Genomic DNA. Translation: AAF54227.1 .
    BT058048 mRNA. Translation: ACM78490.1 .
    RefSeqi NP_652184.2. NM_143927.3.
    UniGenei Dm.6020.

    3D structure databases

    ProteinModelPortali Q9VHS2.
    SMRi Q9VHS2. Positions 33-88.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 72497. 1 interaction.
    DIPi DIP-17309N.
    IntActi Q9VHS2. 1 interaction.
    MINTi MINT-744456.

    Proteomic databases

    PaxDbi Q9VHS2.
    PRIDEi Q9VHS2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0081855 ; FBpp0081344 ; FBgn0040529 .
    GeneIDi 50002.
    KEGGi dme:Dmel_CG9603.
    UCSCi CG9603-RA. d. melanogaster.

    Organism-specific databases

    FlyBasei FBgn0040529. CG9603.

    Phylogenomic databases

    eggNOGi NOG118447.
    InParanoidi Q9VHS2.
    KOi K02270.
    OrthoDBi EOG7J182H.
    PhylomeDBi Q9VHS2.

    Miscellaneous databases

    ChiTaRSi CG9603. drosophila.
    GenomeRNAii 50002.
    NextBioi 840015.

    Gene expression databases

    Bgeei Q9VHS2.

    Family and domain databases

    Gene3Di 4.10.91.10. 1 hit.
    InterProi IPR003177. Cyt_c_oxidase_su7a.
    [Graphical view ]
    PANTHERi PTHR10510. PTHR10510. 1 hit.
    Pfami PF02238. COX7a. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81419. SSF81419. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
      Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Ovary.

    Entry informationi

    Entry nameiCOX7A_DROME
    AccessioniPrimary (citable) accession number: Q9VHS2
    Secondary accession number(s): B9EQX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3