Reviewed, UniProtKB/Swiss-Prot Q9VHQ2 (OR85D_DROME)

Names and origin

Protein names

Recommended name:
    Putative odorant receptor 85d

Gene names

Name:	Or85d
ORF Names:	CG11742

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	412 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Complexes with Or83b to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide By similarity.
Subunit structure	Interacts with Or83b. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Miscellaneous	The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Or83b complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Sequence similarities	Belongs to the odorant-gated ionic channel family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of smell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	odorant binding Inferred from electronic annotation. Source: InterPro olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 412	412	Putative odorant receptor 85d		PRO_0000174277
Regions
	Topological domain	1 – 56	56	Cytoplasmic Potential
	Transmembrane	57 – 77	21	1 Potential
	Topological domain	78 – 84	7	Extracellular Potential
	Transmembrane	85 – 105	21	2 Potential
	Topological domain	106 – 152	47	Cytoplasmic Potential
	Transmembrane	153 – 173	21	3 Potential
	Topological domain	174 – 219	46	Extracellular Potential
	Transmembrane	220 – 240	21	4 Potential
	Topological domain	241 – 282	42	Cytoplasmic Potential
	Transmembrane	283 – 303	21	5 Potential
	Topological domain	304 – 314	11	Extracellular Potential
	Transmembrane	315 – 335	21	6 Potential
	Topological domain	336 – 382	47	Cytoplasmic Potential
	Transmembrane	383 – 403	21	7 Potential
	Topological domain	404 – 412	9	Extracellular Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9VHQ2-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 0E4E8EA5FC14A9EC	FASTA	412	47,987
	10 20 30 40 50 60 MLTKKDTQSA KEQEKLKAIP LHSFLKYANV FYLSIGMMAY DHKYSQKWKE VLLHWTFIAQ 70 80 90 100 110 120 MVNLNTVLIS ELIYVFLAIG KGSNFLEATM NLSFIGFVIV GDFKIWNISR QRKRLTQVVS 130 140 150 160 170 180 RLEELHPQGL AQQEPYNIGH HLSGYSRYSK FYFGMHMVLI WTYNLYWAVY YLVCDFWLGM 190 200 210 220 230 240 RQFERMLPYY CWVPWDWSTG YSYYFMYISQ NIGGQACLSG QLAADMLMCA LVTLVVMHFI 250 260 270 280 290 300 RLSAHIESHV AGIGSFQHDL EFLQATVAYH QSLIHLCQDI NEIFGVSLLS NFVSSSFIIC 310 320 330 340 350 360 FVGFQMTIGS KIDNLVMLVL FLFCAMVQVF MIATHAQRLV DASEQIGQAV YNHDWFRADL 370 380 390 400 410 RYRKMLILII KRAQQPSRLK ATMFLNISLV TVSDLLQLSY KFFALLRTMY VN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014297 Genomic DNA. Translation: AAF54249.1.
RefSeq	NP_524281.1.
UniGene	Dm.27239
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q9VHQ2.
Genome annotation databases
Ensembl	FBgn0037594. Drosophila melanogaster. [Contig view]
GeneID	41011.
KEGG	dme:Dmel_CG11742.
NMPDR	fig|7227.3.peg.11706.
Organism-specific databases
FlyBase	FBgn0037594. Or85d.
Phylogenomic databases
HOGENOM	Q9VHQ2.
OMA	Q9VHQ2. INEIFGV.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-010558-MON.
Gene expression databases
ArrayExpress	Q9VHQ2.
GermOnline	CG11742. Drosophila melanogaster.
Family and domain databases
InterPro	IPR004117. 7tm6_olfct_rcpt. [Graphical view]
PANTHER	PTHR21137. 7tm6_olfct_rcpt. 1 hit.
Pfam	PF02949. 7tm_6. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	821721.

Entry information

Entry name

OR85D_DROME

Accession

Primary (citable) accession number: Q9VHQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project