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Protein
Submitted name:

IP11374p

Gene

Task7

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • potassium channel activity Source: FlyBase
  • potassium ion leak channel activity Source: GO_Central
  • protein heterodimerization activity Source: FlyBase

GO - Biological processi

  • potassium ion transmembrane transport Source: FlyBase
  • stabilization of membrane potential Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-DME-1299316. TWIK-releated acid-sensitive K+ channel (TASK).
R-DME-5576886. Phase 4 - resting membrane potential.

Names & Taxonomyi

Protein namesi
Submitted name:
IP11374pImported
Submitted name:
TWIK-related acid-sensitive K[+] channel 7Imported
Gene namesi
Name:Task7Imported
ORF Names:CG9361Imported, Dmel_CG9361Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0037690. Task7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei79 – 9719HelicalSequence analysisAdd
BLAST
Transmembranei109 – 12921HelicalSequence analysisAdd
BLAST
Transmembranei160 – 17920HelicalSequence analysisAdd
BLAST
Transmembranei191 – 20919HelicalSequence analysisAdd
BLAST
Transmembranei221 – 24727HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: FlyBase
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0037690.

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase

Protein-protein interaction databases

MINTiMINT-864780.
STRINGi7227.FBpp0081523.

Structurei

3D structure databases

SMRiQ9VHE0. Positions 23-243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 13357Ion_trans_2InterPro annotationAdd
BLAST
Domaini170 – 24879Ion_trans_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00760000118858.
KOiK04919.
OMAiPEDYHMI.
OrthoDBiEOG091G08DH.
PhylomeDBiQ9VHE0.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01095. TASKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q9VHE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKRQNVRTL SLVVCTFTYL LIGAAVFDSL ESPTEAKRWE FLQTVKNNFV
60 70 80 90 100
RKYNVTDEDF RVMEIVIIEN KPHKAGPQWK FAGAFYFSTV VLAMIGYGHS
110 120 130 140 150
TPVTIPGKAF CMGYAMVGIP LGLVMFQSIG ERLNKFASVI IRRAKRASGA
160 170 180 190 200
RCTDATEMNL MLATGMLSSI IITTGAAVFS RYEGWSYFDS FYYCFVTLTT
210 220 230 240 250
IGFGDYVALQ NDQALTNKPG YVALSLVFIL FGLAVVAASI NLLVLRFMTM
260 270 280 290 300
QAEDAKRDEQ DAQNLAGNAQ PVTFDDESTY NMHGKLLENN YTTENDETAS
310 320 330 340
LCSCTCMGGT RCLNHEQFVD PDFQPTDIIE STLCLKRASV
Length:340
Mass (Da):37,841
Last modified:May 1, 2000 - v1
Checksum:i018D756D21F8D57A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF54374.1.
BT024313 mRNA. Translation: ABC86375.1.
RefSeqiNP_649891.1. NM_141634.2.
UniGeneiDm.27247.

Genome annotation databases

EnsemblMetazoaiFBtr0082045; FBpp0081523; FBgn0037690.
GeneIDi41125.
KEGGidme:Dmel_CG9361.
UCSCiCG9361-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF54374.1.
BT024313 mRNA. Translation: ABC86375.1.
RefSeqiNP_649891.1. NM_141634.2.
UniGeneiDm.27247.

3D structure databases

SMRiQ9VHE0. Positions 23-243.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-864780.
STRINGi7227.FBpp0081523.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0082045; FBpp0081523; FBgn0037690.
GeneIDi41125.
KEGGidme:Dmel_CG9361.
UCSCiCG9361-RA. d. melanogaster.

Organism-specific databases

CTDi41125.
FlyBaseiFBgn0037690. Task7.

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00760000118858.
KOiK04919.
OMAiPEDYHMI.
OrthoDBiEOG091G08DH.
PhylomeDBiQ9VHE0.

Enzyme and pathway databases

ReactomeiR-DME-1299316. TWIK-releated acid-sensitive K+ channel (TASK).
R-DME-5576886. Phase 4 - resting membrane potential.

Miscellaneous databases

GenomeRNAii41125.

Gene expression databases

BgeeiFBgn0037690.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01095. TASKCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9VHE0_DROME
AccessioniPrimary (citable) accession number: Q9VHE0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.