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Q9VHD3

- MAAI1_DROME

UniProt

Q9VHD3 - MAAI1_DROME

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Protein
Probable maleylacetoacetate isomerase 1
Gene
GstZ1, CG9362
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid in vitro. Possesses low glutathione thioltransferase activity toward 4-hydroxynonenal (4-HNE). Has no glutathione thioltransferase activity with adrenochrome, phenethyl isothiocyanate (PEITC), 5-hydroperoxyeicosatetraenoic acid ((5S)-HpETE), prostaglandin A2 (PGA2) or 2-hydroxyethyldisulfide (HED).1 Publication

Catalytic activityi

4-maleylacetoacetate = 4-fumarylacetoacetate.1 Publication
RX + glutathione = HX + R-S-glutathione.1 Publication

Cofactori

Glutathione. Required for the MAAI activity.1 Publication

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei88 – 881Glutathione; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei140 – 1401Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: FlyBase
  2. maleylacetoacetate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-UniPathway
  2. glutathione metabolic process Source: FlyBase
  3. tyrosine catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Transferase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Enzyme and pathway databases

ReactomeiREACT_203229. Phenylalanine and tyrosine catabolism.
UniPathwayiUPA00139; UER00340.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable maleylacetoacetate isomerase 1 (EC:5.2.1.2)
Short name:
MAAI 1
Alternative name(s):
Glutathione S-transferase zeta 1 (EC:2.5.1.18)
Gene namesi
Name:GstZ1
ORF Names:CG9362
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0037696. GstZ1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Probable maleylacetoacetate isomerase 1
PRO_0000186026Add
BLAST

Proteomic databases

PaxDbiQ9VHD3.
PRIDEiQ9VHD3.

Expressioni

Developmental stagei

Expressed during embryogenesis.1 Publication

Gene expression databases

BgeeiQ9VHD3.

Interactioni

Protein-protein interaction databases

BioGridi66293. 2 interactions.
STRINGi7227.FBpp0081522.

Structurei

3D structure databases

ProteinModelPortaliQ9VHD3.
SMRiQ9VHD3. Positions 33-243.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 11685GST N-terminal
Add
BLAST
Domaini121 – 241121GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni42 – 476Glutathione binding By similarity
Regioni100 – 1012Glutathione binding By similarity
Regioni144 – 1463Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Zeta family.

Phylogenomic databases

eggNOGiCOG0625.
GeneTreeiENSGT00390000006580.
InParanoidiQ9VHD3.
KOiK01800.
OMAiRVRTFLM.
OrthoDBiEOG7TF79P.
PhylomeDBiQ9VHD3.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005955. Mal_ac_isom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01262. maiA. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VHD3-1 [UniParc]FASTAAdd to Basket

« Hide

MASATQLTHR GIHLAGLYRS SWSKPLFRHL ATKPILYSYW PSSCSWRVRV    50
ALAIKKIDYD IKPTSLLKTV SGHAYTDEYR EVNPMQKVPS LKIDGHTLCD 100
SVAIIHYLEE TRPQPALLPQ DPVKRAKIRE IVELICSGIQ PLQNVSVLDH 150
IGKDQSLQWA QHWISRGFQG LEKVLSHSAG KFCVGDELSM ADICLVPQVR 200
NARRYKADLT PYPTIVRLNQ ELQELDVFKA THPSTQPDCP PEFAKK 246
Length:246
Mass (Da):27,890
Last modified:May 1, 2000 - v1
Checksum:i9DEBC10717E380E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: AAF54381.1.
AY061527 mRNA. Translation: AAL29075.1.
RefSeqiNP_649894.1. NM_141637.3.
UniGeneiDm.3568.

Genome annotation databases

EnsemblMetazoaiFBtr0082044; FBpp0081522; FBgn0037696.
GeneIDi41132.
KEGGidme:Dmel_CG9362.
UCSCiCG9362-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: AAF54381.1 .
AY061527 mRNA. Translation: AAL29075.1 .
RefSeqi NP_649894.1. NM_141637.3.
UniGenei Dm.3568.

3D structure databases

ProteinModelPortali Q9VHD3.
SMRi Q9VHD3. Positions 33-243.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 66293. 2 interactions.
STRINGi 7227.FBpp0081522.

Proteomic databases

PaxDbi Q9VHD3.
PRIDEi Q9VHD3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0082044 ; FBpp0081522 ; FBgn0037696 .
GeneIDi 41132.
KEGGi dme:Dmel_CG9362.
UCSCi CG9362-RA. d. melanogaster.

Organism-specific databases

CTDi 2954.
FlyBasei FBgn0037696. GstZ1.

Phylogenomic databases

eggNOGi COG0625.
GeneTreei ENSGT00390000006580.
InParanoidi Q9VHD3.
KOi K01800.
OMAi RVRTFLM.
OrthoDBi EOG7TF79P.
PhylomeDBi Q9VHD3.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00340 .
Reactomei REACT_203229. Phenylalanine and tyrosine catabolism.

Miscellaneous databases

GenomeRNAii 41132.
NextBioi 822330.

Gene expression databases

Bgeei Q9VHD3.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005955. Mal_ac_isom.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR01262. maiA. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A preliminary characterization of the cytosolic glutathione transferase proteome from Drosophila melanogaster."
    Saisawang C., Wongsantichon J., Ketterman A.J.
    Biochem. J. 442:181-190(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, COFACTOR, DEVELOPMENTAL STAGE.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiMAAI1_DROME
AccessioniPrimary (citable) accession number: Q9VHD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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