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Q9VHD3

- MAAI1_DROME

UniProt

Q9VHD3 - MAAI1_DROME

Protein

Probable maleylacetoacetate isomerase 1

Gene

GstZ1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid in vitro. Possesses low glutathione thioltransferase activity toward 4-hydroxynonenal (4-HNE). Has no glutathione thioltransferase activity with adrenochrome, phenethyl isothiocyanate (PEITC), 5-hydroperoxyeicosatetraenoic acid ((5S)-HpETE), prostaglandin A2 (PGA2) or 2-hydroxyethyldisulfide (HED).1 Publication

    Catalytic activityi

    4-maleylacetoacetate = 4-fumarylacetoacetate.1 Publication
    RX + glutathione = HX + R-S-glutathione.1 Publication

    Cofactori

    Glutathione. Required for the MAAI activity.1 Publication

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei88 – 881Glutathione; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei140 – 1401GlutathioneBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: FlyBase
    2. maleylacetoacetate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutathione metabolic process Source: FlyBase
    2. L-phenylalanine catabolic process Source: UniProtKB-UniPathway
    3. tyrosine catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Transferase

    Keywords - Biological processi

    Phenylalanine catabolism, Tyrosine catabolism

    Enzyme and pathway databases

    ReactomeiREACT_203229. Phenylalanine and tyrosine catabolism.
    UniPathwayiUPA00139; UER00340.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable maleylacetoacetate isomerase 1 (EC:5.2.1.2)
    Short name:
    MAAI 1
    Alternative name(s):
    Glutathione S-transferase zeta 1 (EC:2.5.1.18)
    Gene namesi
    Name:GstZ1
    ORF Names:CG9362
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0037696. GstZ1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246Probable maleylacetoacetate isomerase 1PRO_0000186026Add
    BLAST

    Proteomic databases

    PaxDbiQ9VHD3.
    PRIDEiQ9VHD3.

    Expressioni

    Developmental stagei

    Expressed during embryogenesis.1 Publication

    Gene expression databases

    BgeeiQ9VHD3.

    Interactioni

    Protein-protein interaction databases

    BioGridi66293. 2 interactions.
    STRINGi7227.FBpp0081522.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VHD3.
    SMRiQ9VHD3. Positions 33-243.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 11685GST N-terminalAdd
    BLAST
    Domaini121 – 241121GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni42 – 476Glutathione bindingBy similarity
    Regioni100 – 1012Glutathione bindingBy similarity
    Regioni144 – 1463Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Zeta family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0625.
    GeneTreeiENSGT00390000006580.
    InParanoidiQ9VHD3.
    KOiK01800.
    OMAiRVRTFLM.
    OrthoDBiEOG7TF79P.
    PhylomeDBiQ9VHD3.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR005955. Mal_ac_isom.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR01262. maiA. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9VHD3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASATQLTHR GIHLAGLYRS SWSKPLFRHL ATKPILYSYW PSSCSWRVRV    50
    ALAIKKIDYD IKPTSLLKTV SGHAYTDEYR EVNPMQKVPS LKIDGHTLCD 100
    SVAIIHYLEE TRPQPALLPQ DPVKRAKIRE IVELICSGIQ PLQNVSVLDH 150
    IGKDQSLQWA QHWISRGFQG LEKVLSHSAG KFCVGDELSM ADICLVPQVR 200
    NARRYKADLT PYPTIVRLNQ ELQELDVFKA THPSTQPDCP PEFAKK 246
    Length:246
    Mass (Da):27,890
    Last modified:May 1, 2000 - v1
    Checksum:i9DEBC10717E380E4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014297 Genomic DNA. Translation: AAF54381.1.
    AY061527 mRNA. Translation: AAL29075.1.
    RefSeqiNP_649894.1. NM_141637.3.
    UniGeneiDm.3568.

    Genome annotation databases

    EnsemblMetazoaiFBtr0082044; FBpp0081522; FBgn0037696.
    GeneIDi41132.
    KEGGidme:Dmel_CG9362.
    UCSCiCG9362-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014297 Genomic DNA. Translation: AAF54381.1 .
    AY061527 mRNA. Translation: AAL29075.1 .
    RefSeqi NP_649894.1. NM_141637.3.
    UniGenei Dm.3568.

    3D structure databases

    ProteinModelPortali Q9VHD3.
    SMRi Q9VHD3. Positions 33-243.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 66293. 2 interactions.
    STRINGi 7227.FBpp0081522.

    Proteomic databases

    PaxDbi Q9VHD3.
    PRIDEi Q9VHD3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0082044 ; FBpp0081522 ; FBgn0037696 .
    GeneIDi 41132.
    KEGGi dme:Dmel_CG9362.
    UCSCi CG9362-RA. d. melanogaster.

    Organism-specific databases

    CTDi 2954.
    FlyBasei FBgn0037696. GstZ1.

    Phylogenomic databases

    eggNOGi COG0625.
    GeneTreei ENSGT00390000006580.
    InParanoidi Q9VHD3.
    KOi K01800.
    OMAi RVRTFLM.
    OrthoDBi EOG7TF79P.
    PhylomeDBi Q9VHD3.

    Enzyme and pathway databases

    UniPathwayi UPA00139 ; UER00340 .
    Reactomei REACT_203229. Phenylalanine and tyrosine catabolism.

    Miscellaneous databases

    GenomeRNAii 41132.
    NextBioi 822330.

    Gene expression databases

    Bgeei Q9VHD3.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR005955. Mal_ac_isom.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR01262. maiA. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A preliminary characterization of the cytosolic glutathione transferase proteome from Drosophila melanogaster."
      Saisawang C., Wongsantichon J., Ketterman A.J.
      Biochem. J. 442:181-190(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, COFACTOR, DEVELOPMENTAL STAGE.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.

    Entry informationi

    Entry nameiMAAI1_DROME
    AccessioniPrimary (citable) accession number: Q9VHD3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3