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Protein

Mannose-6-phosphate isomerase

Gene

Dmel\CG8417

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Mannose-6-phosphate isomerase (Dmel\CG8417)
  2. Probable phosphomannomutase (CG10688)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi86ZincUniRule annotation1
Metal bindingi88ZincUniRule annotation1
Metal bindingi113ZincUniRule annotation1
Metal bindingi241ZincUniRule annotation1
Active sitei260UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationImported
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-DME-446205. Synthesis of GDP-mannose.
UniPathwayiUPA00126; UER00423.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.8UniRule annotation)
Gene namesi
Name:Dmel\CG8417Imported
ORF Names:CG8417Imported, Dmel_CG8417Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0037744. CG8417.

Subcellular locationi

Expressioni

Gene expression databases

BgeeiFBgn0037744.

Interactioni

Protein-protein interaction databases

IntActiQ9VH77. 16 interactors.
MINTiMINT-310398.
STRINGi7227.FBpp0081609.

Family & Domainsi

Sequence similaritiesi

Belongs to the mannose-6-phosphate isomerase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2757. Eukaryota.
COG1482. LUCA.
GeneTreeiENSGT00390000016075.
KOiK01809.
OMAiLCYEKLM.
OrthoDBiEOG091G078D.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiView protein in InterPro
IPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
PANTHERiPTHR10309. PTHR10309. 1 hit.
PfamiView protein in Pfam
PF01238. PMI_typeI. 1 hit.
PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSiPR00714. MAN6PISMRASE.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR00218. manA. 1 hit.
PROSITEiView protein in PROSITE
PS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VH77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELTGWVKNY GWGRKGINSA VAQLAMANDP DFRLNEEETY AEMWMGTHVC
60 70 80 90 100
GVSVVKETGE TLDRVLKKDL SYLFKVLSIN KALSIQVHPN KCEAERLHKE
110 120 130 140 150
RPDIYKDPNH KPELAIALTP FLALVGFMSA EDIRDYIDEF QPLSKLIGKE
160 170 180 190 200
AVDQLHDSTN SESVKLCYEK LMKTEEPVIA KCISEIAKDY QNELKSNDLL
210 220 230 240 250
EVFTKVNKDF PGDVGVLSLF FLNLIRLQPG QAIYLGANEI HAYLDGDCVE
260 270 280 290 300
CMACSDNVIR AGLTPKYKDV DQLLESVIFE SSYKDRKEFI PYRIDDQVQV
310 320 330 340 350
YIPPVSDFAV INVNIEHSLE SYKLEIQAFG SILIVLKGSR ILKLKTQQGD
360 370 380 390
KEILVTRGSI VYIPVEAAPE IEFAQSDDCD EDFSGYIATS NYFRVP
Length:396
Mass (Da):44,774
Last modified:May 1, 2000 - v1
Checksum:i1EB1176951903C2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF54442.1.
AY059444 mRNA. Translation: AAL13350.1.
AY075552 mRNA. Translation: AAL68359.1.
RefSeqiNP_649940.1. NM_141683.3.
UniGeneiDm.4351.

Genome annotation databases

EnsemblMetazoaiFBtr0082131; FBpp0081609; FBgn0037744.
GeneIDi41192.
KEGGidme:Dmel_CG8417.
UCSCiCG8417-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ9VH77_DROME
AccessioniPrimary (citable) accession number: Q9VH77
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 27, 2017
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported