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Protein

NAD-dependent protein deacetylase Sirt6

Gene

Sirt6

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span.By similarity1 Publication

Catalytic activityi

NAD+ + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.PROSITE-ProRule annotation

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei133Proton acceptorPROSITE-ProRule annotation1
Metal bindingi141ZincPROSITE-ProRule annotation1
Metal bindingi144ZincPROSITE-ProRule annotation1
Metal bindingi166ZincPROSITE-ProRule annotation1
Metal bindingi177ZincPROSITE-ProRule annotation1
Binding sitei259NAD; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi52 – 71NADBy similarityAdd BLAST20
Nucleotide bindingi113 – 116NADBy similarity4
Nucleotide bindingi215 – 217NADBy similarity3
Nucleotide bindingi241 – 243NADBy similarity3

GO - Molecular functioni

  • histone deacetylase activity Source: FlyBase
  • metal ion binding Source: UniProtKB-KW
  • NAD+ binding Source: InterPro

GO - Biological processi

  • determination of adult lifespan Source: FlyBase
  • histone deacetylation Source: FlyBase
  • positive regulation of chromatin silencing Source: FlyBase

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
NAD-dependent protein deacetylase Sirt6 (EC:3.5.1.-)
Alternative name(s):
Regulatory protein SIR2 homolog 6
SIR2-like protein 6
Gene namesi
Name:Sirt6
ORF Names:CG6284
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0037802 Sirt6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

Causes lethality during development. Induced silencing shortens life span.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004173621 – 317NAD-dependent protein deacetylase Sirt6Add BLAST317

Proteomic databases

PaxDbiQ9VH08
PRIDEiQ9VH08

Expressioni

Gene expression databases

BgeeiFBgn0037802
GenevisibleiQ9VH08 DM

Interactioni

Protein-protein interaction databases

BioGridi66403, 3 interactors
STRINGi7227.FBpp0293897

Structurei

3D structure databases

ProteinModelPortaliQ9VH08
SMRiQ9VH08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 275Deacetylase sirtuin-typePROSITE-ProRule annotationAdd BLAST241

Sequence similaritiesi

Belongs to the sirtuin family. Class IV subfamily.Curated

Phylogenomic databases

eggNOGiKOG1905 Eukaryota
COG0846 LUCA
GeneTreeiENSGT00530000063706
InParanoidiQ9VH08
KOiK11416
OrthoDBiEOG091G0FOW
PhylomeDBiQ9VH08

Family and domain databases

InterProiView protein in InterPro
IPR029035 DHS-like_NAD/FAD-binding_dom
IPR003000 Sirtuin
IPR026590 Ssirtuin_cat_dom
PfamiView protein in Pfam
PF02146 SIR2, 2 hits
SUPFAMiSSF52467 SSF52467, 1 hit
PROSITEiView protein in PROSITE
PS50305 SIRTUIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VH08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCNYADGLS AYDNKGILGA PESFDSDEVV AEKCQELAEL IKKSGHVVLH
60 70 80 90 100
TGAGISTSAG IPDFRGPKGV WTLEEKGEKP DFNVSFDEAR PTKTHMAIIA
110 120 130 140 150
LIESGYVQYV ISQNIDGLHL KSGLDRKYLS ELHGNIYIEQ CKKCRRQFVS
160 170 180 190 200
PSAVETVGQK SLQRACKSSM DSKGRSCRSG ILYDNVLDWE HDLPENDLEM
210 220 230 240 250
GVMHSTVADL NIALGTTLQI VPSGDLPLKN LKCGGKFVIC NLQPTKHDKK
260 270 280 290 300
ANLIISSYVD VVLSKVCKLL GVEIPEYSEA SDPTKQSKPM EWTIPTSNVN
310
TFHRQYKKYV YFIYYLL
Length:317
Mass (Da):35,204
Last modified:May 1, 2000 - v1
Checksum:i660B59F0EB3E3BAC
GO

Sequence cautioni

The sequence AAF54513 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AEB33520 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54513.2 Sequence problems.
BT126234 mRNA Translation: AEB33520.1 Different initiation.
RefSeqiNP_649990.2, NM_141733.3
UniGeneiDm.24872

Genome annotation databases

EnsemblMetazoaiFBtr0305358; FBpp0293897; FBgn0037802
GeneIDi41254
KEGGidme:Dmel_CG6284
UCSCiCG6284-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiSIR6_DROME
AccessioniPrimary (citable) accession number: Q9VH08
Secondary accession number(s): F3YD73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2012
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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