Unreviewed, UniProtKB/TrEMBL Q9VH01 (Q9VH01_DROME)

Names and origin

Protein names

Submitted name:
    Bruce EMBL AAF54520.3
    EC=6.3.2.19
Submitted name:
    BIR-containing ubiquitin-conjugating enzyme EMBL AAM77747.1

Gene names

Name:	Bruce EMBL AAF54520.3
ORF Names:	CG6303 FlyBase FBgn0037808, Dmel_CG6303 EMBL AAF54520.3

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	4876 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family. RuleBase RU004027V3

Ontologies

Keywords
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	post-translational protein modification Inferred from electronic annotation. Source: InterPro programmed cell death Ref.4 Inferred from genetic interaction. Source: FlyBase regulation of protein metabolic process Inferred from electronic annotation. Source: InterPro spermatid development Inferred from mutant phenotype. Source: FlyBase
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9VH01-1 [UniParc]. Last modified July 5, 2004. Version 3. Checksum: DD858A2584BB3A73	FASTA	4,876	539,214
	10 20 30 40 50 60 MATEQHHQQR VLKQDGYLDL GDCNSAPSRP FEMRNVVYHP QLNVLLLFDN GSTVKVLDAN 70 80 90 100 110 120 SGVILQTYHL SSNGDSIVHG RYMPLQDKIL FWDGHNLGLR GDYNGVLLLD TILQAPIGQN 130 140 150 160 170 180 DDYIKLEIIL SEAIIFQNCI TELESEGLEC PCDISNELTQ KINQAQLKAK KGIKAQRWNT 190 200 210 220 230 240 ICLEVPYSSL KLVSNNMVIL LKRLERHIPV LAIASAINER LTDMMMGSRV PDFGWNFSNF 250 260 270 280 290 300 QRVLMHSEAV RRQTFEKWPH MDYKWALPDQ MAQAGFYHQP SSSGEDRAMC FTCSVCLVCW 310 320 330 340 350 360 EKTDEPWSEH ERHSPLCPFV KGEYTQNVPL SITYATNPAL PAPGLGFDII SNSDYANVLC 370 380 390 400 410 420 TSCSQTGELS VWSIERHLKL MHTFHVPTLL NYIFEESFEW ARVTAICVLP NARARTKVNY 430 440 450 460 470 480 VYSAANYGGS GSSNGAGCNS GLNAVSGGKF GSVNAQHITS TSTLRAGVVG SKIVLGVSVR 490 500 510 520 530 540 QSSGELALRM VVLNIVEVDR NSESSTSVSN DSGSVSSGGG QLMKSSSPMV NVSAENNATV 550 560 570 580 590 600 TQVNLESKDD DNKAMTPYEK FADGFDSNGF VSALMTYNKN NGVSQNTDDA SALYDFDLCT 610 620 630 640 650 660 LSQILDHNLE EPLSLMVGSS NTVNVSNIGM GNEINKLVVD VEISHQNNNN NNNNNNEASS 670 680 690 700 710 720 LGGNSSNNNN NIMINGGTNS SIDKMTAIEE IDCVVESWTS VKRMNALDGA SSGVNGVNHM 730 740 750 760 770 780 DQEVIEIAEI LPTTPKCNQL LVKLLRTKAP EAEGSKIIMA TVAKEEEEED EEQRTDESME 790 800 810 820 830 840 TDNNAEGNVA AQLLVFDYDD TEISNDYTLA MTFSRAKFPK QLCILPHFNS SPEHKDAGSI 850 860 870 880 890 900 CVVCADGTVE IYSLADFQGT MVIEEEGEHF ESVVYCRNLD RLCCCSRQGG LLFYSLSDGE 910 920 930 940 950 960 NDSGDELLEM DDDCSTTLTQ AADVSVTDGG RQLARTDLLG KTLLANESIC MDAGSEAAAI 970 980 990 1000 1010 1020 PNSSSAAQGA HVQTSPSASS APSTNANLLA YKTADLTLED LKVFYALTQF DDKLTVYSAE 1030 1040 1050 1060 1070 1080 VPSCWNDIGQ VQNQRKQSQN MRHGGDERDF TRTWRLHNDA TTWDEHIIEL NLAQPVSLGH 1090 1100 1110 1120 1130 1140 IDLKFTVYQQ CSNPAAIQVT LLKQNNNGFG YRMKGPHSSY KPNVIDDNID LSYIANENPV 1150 1160 1170 1180 1190 1200 LSEEYLLAHN AEVLAGPIEL SSCIDLCDQG GTATLTSPKL FKTRTRNFLL HIKTVSDPSK 1210 1220 1230 1240 1250 1260 DGQNKTRGCD WLHEISISVR AVKSHSRISN GRMQRIAMLE SNVLLVQLLR IASDPASSSL 1270 1280 1290 1300 1310 1320 AKNLSLDILN WICFIRLNRF RSPKSERLKD QINKQTAANI QDLLAQQFEC ISLAEKHIEQ 1330 1340 1350 1360 1370 1380 LLRNCVIYSE RSTAHKCVKL LIMLTEGATN LPAEVQDHTT LDYSFKAAIA NTFPELPRAQ 1390 1400 1410 1420 1430 1440 CGSVVRWYMM LTCATSTAES HNSISEQAIS LLKEIAAEID KRWDPHCALL CTRFGLYGYP 1450 1460 1470 1480 1490 1500 FEPEIFDFDF PNVSRQGPGS SVANVIRSSP TILPVTGLDI KRLSSIDGVD FRTFPYLIRG 1510 1520 1530 1540 1550 1560 KSISNQLRGL LEVVQLHFNC VQTSEATRID NIDSVGGNTG ANVIIEDVMM MPKQVVAKEK 1570 1580 1590 1600 1610 1620 GEEMLNDLVN DVECLVEEMK VDENEKQEKV DYDAFGLVNG FKDKTLSSLN SVKQTLKEEV 1630 1640 1650 1660 1670 1680 KKEKADIMDK LTIAKFLPKL SLLESYMQKK INEHISFDDF GKLDNWDGNT TPPFNLEVEA 1690 1700 1710 1720 1730 1740 PIVCSEATSE SNMSQQATSA GGNILDDAAD SEKITESLNA NPCQPIAWHK LITPPPKQMI 1750 1760 1770 1780 1790 1800 VIDRMHSGAR RFVVLDFGQH ILLTDLVIPS CDELTSLNID IWCFDEETDC TRLVQVNDIQ 1810 1820 1830 1840 1850 1860 TKTLVLSDIQ PAPICRYLKL TIIGRIGMSA TKCKVPLGRF FGHPVVLEHD GYGDQLMKYI 1870 1880 1890 1900 1910 1920 KHPTHSLQSQ IKSLNALYED VHCRYSLASS KLMDLLAPMR NSELSNVAHL QAFINKQREE 1930 1940 1950 1960 1970 1980 ELSGLENNNK VVSLYDECML LQYQINVIRN VVLRLERALS PNSPTTTLLP GQSIPLTEDI 1990 2000 2010 2020 2030 2040 LRAASRDKLR VLSLSLVEVL LHFSIEYGIK NILPVHQRFN AATAKALFNA LVVYGDAQLQ 2050 2060 2070 2080 2090 2100 LATCSLLVRM CCFQPWWGDF LADTFCSLFS AQNCKAFPQD RIFFLLTYLG RRSIAMGACR 2110 2120 2130 2140 2150 2160 SIVIDAVLKT LVKLLAPISP HYKFQSEQPS TSANAADRNA AMGTTSDLQL ITWLLLFLSV 2170 2180 2190 2200 2210 2220 CLDDNERKDK SAARWDFMSC EGDFTKARPS ATPNIKQLRC FKKRIIQQNK YLAQPYADWG 2230 2240 2250 2260 2270 2280 KKIYMIQNEH PGIFMELSTK SKGAGPTKST STGGKINMGS SGLCVGGPSS SSGNTSKSAA 2290 2300 2310 2320 2330 2340 SSSSPKNQAV PGTDGERDSN FDKGLKSLRM DNIKVVIRGL FALLLEMDFD CNMDQFLLTC 2350 2360 2370 2380 2390 2400 KVIARLVAAC RPSVQLCKIV TIAQLQQLVR LSVWNDQQHP WAVHAITCLL QDLLDADKQF 2410 2420 2430 2440 2450 2460 RDNDVTPTND TPRTMEAAIQ ETRDLFSDYT STASSCTEAL FETLMPTARE FYQEAVKYNY 2470 2480 2490 2500 2510 2520 LPSLIECDDT EFDEMLNDID MIERTKPVTK KESNALSKNT FNFFCKSISI ALDSRLDVGL 2530 2540 2550 2560 2570 2580 ELHVETQLRR LTNRTSLDLY SSLPQVLTNE FVSPPPEAAP WPEYLTQLWS GTEYNGDNTY 2590 2600 2610 2620 2630 2640 VMFKRVFDSI LAELHLEDTW VHLEQVLQMW LTLNCELSDK PYTSGITHSD VPKIPFGANA 2650 2660 2670 2680 2690 2700 VQGLLLALAW HSDIKLRTWC LGFQCLFLAC NSLPIGDDAD CTRINEAIVN DENFEKVLLR 2710 2720 2730 2740 2750 2760 FFSGYGMSSS IITNRCAGPT ICKHLHELLL WLHSKSETSG IPCKRRLKDI LLHVVLQLVQ 2770 2780 2790 2800 2810 2820 PGGSISNQQG PIDAQNQLVR DLLMMPNDKG DLNIALKITE SVSFLVYNNI SNGERLQCQR 2830 2840 2850 2860 2870 2880 GNENSPVGNN FSNLFANVLG SENPNKQNAA ICDNSLIINL LKLSSHMVLT EMPRQPSEVT 2890 2900 2910 2920 2930 2940 IPEEEELSNQ SQTDETKAEQ LNTEGHRSKV PCIADWVLRH FPTMKRLFGT LSQCSTNTFT 2950 2960 2970 2980 2990 3000 MMSSGCFFSP KSNMILDDPQ TIADAVFSLM ITLNDKASHP RLVVVPICRY LEETTIPRNA 3010 3020 3030 3040 3050 3060 TLPRLPHSEP FLWYISKVLE VPAAVQTFTQ LGGIQIICHS LVRLNKTIIN MQPGLISLIM 3070 3080 3090 3100 3110 3120 QHLTRNTRFK RNNHVAASSA CKKTTTGTGT TCPTSAQPPR SAAQYDGLIN FAPFSHIVSE 3130 3140 3150 3160 3170 3180 NDATQSAEVL ISNPNNSHRR PRSPAWTYMF YPNETHVDLT ITLPTAILLK EVQLVPHTTS 3190 3200 3210 3220 3230 3240 LASCPSAVAL ELSRDYGLGS IPVGAPMATT GLTCIRLKLA KAEVATSIVL RLYKPKDCGN 3250 3260 3270 3280 3290 3300 VGLVQIAVLG QTIFGNRMHG LRSPSPFIDS LATCSSPVQT AVLAAMDADS MLEDDAFAKT 3310 3320 3330 3340 3350 3360 SIGWVRILSR CFHVAALQPD SKLADLIAAY PAAYPGFLEA CCSLLNIMPM IPSLAQQHLE 3370 3380 3390 3400 3410 3420 TILLKLSAYN HEISLQLLRT LLWHTTPQVF KLSSDSVCDL IYEVVTGSTE HLLDKLRVLI 3430 3440 3450 3460 3470 3480 DWVMQLHDNY SKQARCNNPQ SGFVKVIASI LWKVHTQQQL PELPLLISSS LFETCFEWVS 3490 3500 3510 3520 3530 3540 SLEHDEPLKS SFDSLLCALC FIKPELFNQL LVKLGVKLEP PARGQTDDSK VQSGSAWFRR 3550 3560 3570 3580 3590 3600 EGSENLSVLL QRPTFLKTLA LACQSPAAVY QMLDSGLPKL LAHAIYEYCM HLMPGSEPVA 3610 3620 3630 3640 3650 3660 SASTVPEDEP LANNQAAAAA DDEDSSLTDF DKAEANVVYN TPLLSSSNVP KVLDFFAECC 3670 3680 3690 3700 3710 3720 AEGPMRDWLG TMQGSVFWKP LLQLLCNTHA AQFSKTLPKE QSFIRLERAT INFFTRVSAC 3730 3740 3750 3760 3770 3780 HPGNQENLTS LLIGAIICKP LRFSHGVRPT ISGFTRQMVL QLLLENEHIT VSVRSQQPLQ 3790 3800 3810 3820 3830 3840 RRDTLSAVLG GISSGASTSL PVAAVNNHPA RRSSAHHMLF TVTTSTTCQE IMQNCVSVFS 3850 3860 3870 3880 3890 3900 NLVYQQPTDQ RAGETSASSS GVSSATAKSS ESKMEKSSFL NFNNVEAGSM EFLTVGAAVA 3910 3920 3930 3940 3950 3960 AKDKRIKDAK NQAAMNKDKE TQTSSTNLAS NIFNVDEFLL QSANAVNGNQ LVIPEYSDIV 3970 3980 3990 4000 4010 4020 LAGDATISQV LASLQNAGHS LSTPCISFDL VLQQRSDDTS EAKKTKAACT EPLPSPLQRF 4030 4040 4050 4060 4070 4080 SSSGGLSLLA HYLPTVYPEH SGRKTTLVFS EKEKSPPLSD WVKLEPNDEI YEDLEDTLCE 4090 4100 4110 4120 4130 4140 PAAKLATVSS VPQHSLAAFG LFLRLPAYSD VLLRDKMRAQ CLLRLVLGVT GDGDGNDIYS 4150 4160 4170 4180 4190 4200 LSLAPSLPTL PFEVFRQLLD SVPLSTDDGV LLRRVVIEVG AMHLVLNCLG IFSHQSHNNR 4210 4220 4230 4240 4250 4260 IGAPISEPSP SGTSSGSGTI GNGSGNGSVS GTKTNAPEEA TPSATSDDKS HMYWAKGTGF 4270 4280 4290 4300 4310 4320 GTGSTTQSWN VEQALLRQKS EEEHVTVLLL VLASYINPGD CIPSEMCGED ILAYHDVRDV 4330 4340 4350 4360 4370 4380 TGELPPIFQT LLQQSCLIPA LSSYLRNDSV LDITRHIPLY RAILKLLRAL SLSKMLVSLL 4390 4400 4410 4420 4430 4440 QPSASGSGDS TPPIVELLTS MKTCVDTYAK RLKVNKKSNI KGQTHQLTFN IDDGDDEGLA 4450 4460 4470 4480 4490 4500 LLIPDIHETS VLVQKTTDAD ALINMLHTNE DGSAQLEPQS KSIEQRYLEL MKKRQFDTFD 4510 4520 4530 4540 4550 4560 MIVESDNNSF RFVVSHHFEK MVRLAGDRYH PSRVKRLAQE AVTLSTSLPL SFSSSVFVRC 4570 4580 4590 4600 4610 4620 DTDRLDIMKV LITGPADTPY ANGCFEFDVF FPPDYPNQPM LINLETTGRH SVRFNPNLYN 4630 4640 4650 4660 4670 4680 DGKVCLSVLN TWHGRPEEKW NAQTSSFLQV LVSIQSLILV PEPYFNEPGF ERSRGSPSGT 4690 4700 4710 4720 4730 4740 NSSREYNSNI YQACVRWAML EQIRSPSQCF KDVIHKHFWL KREEICAQIE GWIEELGKPQ 4750 4760 4770 4780 4790 4800 YTERASRTIS FNSMVLRRHY RHLREELSKL KPPRGLEDLD APFNPVATLP PMDVSAVAPS 4810 4820 4830 4840 4850 4860 LAATNTVQAQ PDDAIVTDIT LLGENADECE ADGDAEGDGE VDDGFKGFPQ EEGLLTGEEE 4870 VVEILSDTEN ESSMWQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Drosophila Bruce can potently suppress Rpr- and Grim-dependent but not Hid-dependent cell death." Vernooy S.Y., Chow V., Su J., Verbrugghe K., Yang J., Cole S., Olson M.R., Hay B.A. Curr. Biol. 12:1164-1168(2002) [PubMed: 12121627] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014297 Genomic DNA. Translation: AAF54520.3. AF517634 mRNA. Translation: AAM77747.1.
RefSeq	NP_649995.2.
UniGene	Dm.13678
3D structure databases
HSSP	HSSP built from PDB template 1I3O based on UniProtKB P98170.
ModBase	Search...
Genome annotation databases
Ensembl	FBgn0037808. Drosophila melanogaster. [Contig view]
GeneID	41260.
KEGG	dme:Dmel_CG6303.
NMPDR	fig|7227.3.peg.12060.
Organism-specific databases
FlyBase	FBgn0037808. Bruce.
Phylogenomic databases
HOGENOM	Q9VH01.
OMA	Q9VH01. IPALSSY.
Gene expression databases
ArrayExpress	Q9VH01.
Family and domain databases
InterPro	IPR001370. Prot_inh_I32_IAP. IPR016135. UBQ-conjugat/RWD-like. IPR000608. UBQ-conjugat_E2. [Graphical view]
Gene3D	G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.
Pfam	PF00653. BIR. 1 hit. PF00179. UQ_con. 1 hit. [Graphical view]
ProDom	PD000461. UBQ_conjugat. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00238. BIR. 1 hit. SM00212. UBCc. 1 hit. [Graphical view]
PROSITE	PS50143. BIR_REPEAT_2. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	822968.

Entry information

Entry name

Q9VH01_DROME

Accession

Primary (citable) accession number: Q9VH01
Secondary accession number(s): Q8MUM9

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 62 of the entry and version 3 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)