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Q9VGY5 (MET15_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable methyltransferase-like protein 15 homolog
EC=2.1.1.-
Gene names
ORF Names:CG14683
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable S-adenosyl-L-methionine-dependent methyltransferase By similarity.

Sequence similarities

Belongs to the methyltransferase superfamily. RsmH family.

Ontologies

Keywords
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functionmethyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356Probable methyltransferase-like protein 15 homolog
PRO_0000308335

Regions

Region55 – 573S-adenosyl-L-methionine binding By similarity

Sites

Binding site741S-adenosyl-L-methionine By similarity
Binding site1031S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding site1261S-adenosyl-L-methionine By similarity
Binding site1331S-adenosyl-L-methionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9VGY5 [UniParc].

Last modified March 1, 2001. Version 2.
Checksum: 70C7890DB11190A5

FASTA35639,703
        10         20         30         40         50         60 
MKRLLNPTRL RLDWLRRSSI DVTTAPHVPV LCDTAIEYLQ PVPGGTYFDM TFGAGGHTRR 

        70         80         90        100        110        120 
LLEKCPEAKV YALDRDPLAH QLARDMSESE EFKGRLIPLL GKFSDLPKLF KEHGLAKNSV 

       130        140        150        160        170        180 
DGMLFDFGCS SMQFDEAVRG FSISRDGPLD MRMDGGHSGG VTAADVLANV EEGDLVKILR 

       190        200        210        220        230        240 
MYGEEKAAKK IARGLVDARN ALFKIETTKQ LADIIENIMD GGTRKDKLRR PAHSATKTFQ 

       250        260        270        280        290        300 
AIRIFVNNEL NEINYGMVLA NEILRVDGRL VTITFHSLED TIVKRHINGN VLAGAANALP 

       310        320        330        340        350 
LKYSSHYAID EPDILESLTK KSWKQLHRHV IVPDADEVAR NTRSRSAKLR AAVKTN

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[3]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Head.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014297 Genomic DNA. Translation: AAO41540.1.
AE014297 Genomic DNA. Translation: AAX52945.1.
AY051437 mRNA. Translation: AAK92861.1.
RefSeqNP_001014615.1. NM_001014615.1.
NP_788632.1. NM_176455.1.
UniGeneDm.14326.

3D structure databases

HSSPHSSP built from PDB template 1M6Y based on UniProtKB Q9WZX6.
ProteinModelPortalQ9VGY5.
SMRQ9VGY5. Positions 26-356.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-310100.
STRINGQ9VGY5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0082267; FBpp0081744; FBgn0037822.
GeneID41278.
KEGGdme:Dmel_CG14683.
NMPDRfig|7227.3.peg.12093.
UCSCCG14683-RA. d. melanogaster.

Organism-specific databases

FlyBaseFBgn0037822. CG14683.

Phylogenomic databases

eggNOGinNOG06984.
GeneTreeEMGT00050000014332.
InParanoidQ9VGY5.
OMANPATRAF.
OrthoDBEOG4XSJ5J.
PhylomeDBQ9VGY5.

Family and domain databases

InterProIPR002903. SAM-dep_MeTrfase_MraW.
IPR023397. SAM-dep_MeTrfase_MraW_recog.
[Graphical view]
Gene3DG3DSA:1.10.150.170. G3DSA:1.10.150.170. 1 hit.
PANTHERPTHR11265. Bact_methyltrans. 1 hit.
PfamPF01795. Methyltransf_5. 1 hit.
[Graphical view]
PIRSFPIRSF004486. MraW. 1 hit.
SUPFAMSSF81799. SSF81799. 1 hit.
TIGRFAMsTIGR00006. TIGR00006. 1 hit.
ProtoNetSearch...

Other

NextBio823057.

Entry information

Entry nameMET15_DROME
AccessionPrimary (citable) accession number: Q9VGY5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2001
Last modified: January 25, 2012
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents