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Q9VGX3

- FAU_DROME

UniProt

Q9VGX3 - FAU_DROME

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Protein

Protein anoxia up-regulated

Gene

fau

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of tissue responsiveness to oxygen deprivation.

GO - Biological processi

  1. response to anoxia Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Protein anoxia up-regulated
Gene namesi
Name:fau
ORF Names:CG6544
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0020439. fau.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619Protein anoxia up-regulatedPRO_0000087203Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei79 – 791Phosphoserine1 Publication
Modified residuei81 – 811Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9VGX3.

Expressioni

Tissue specificityi

Concentrated in lamina neurons, first optic lobe neurons and cortical neurons of central brain.

Inductioni

By anoxia.

Gene expression databases

BgeeiQ9VGX3.
ExpressionAtlasiQ9VGX3. differential.

Interactioni

Protein-protein interaction databases

BioGridi66435. 17 interactions.
DIPiDIP-18797N.
IntActiQ9VGX3. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9VGX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi88 – 14356Thr-richAdd
BLAST
Compositional biasi305 – 619315Ala/Glu-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG242396.
InParanoidiQ9VGX3.
OMAiRILSMVR.
OrthoDBiEOG7F24SQ.
PhylomeDBiQ9VGX3.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform E (identifier: Q9VGX3-5) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVYESGFTTR RTYSSRPVTT SYAVTYPSVE KVTRVYKSSY PIYSSYSVPR
60 70 80 90 100
RVYGATRVVT SPIRVVTSPA RVVSRVIHSP SPVRVVRTTT RVISSPERTT
110 120 130 140 150
YSYTTPSTYY SPSYLPSTYT STYIPTSYTT YTPSYAYSPT TVTRVYAPRS
160 170 180 190 200
SLSPLRITPS PVRVITSPVR SVPSYLKRLP PGYGARALTN YLNTEPFTTF
210 220 230 240 250
SEETSRIRNR AQSLIRDLHT PVVRRARSCT PFPVTGYTYE PASQLALDAY
260 270 280 290 300
VARVTNPVRH IAKEVHNISH YPRPAVKYVD AELDPNRPSR KFSAPRPLED
310 320 330 340 350
PLDVEAKEKQ RLRQERLLTV NEEALDEVDL EKKRAQKADE AKRREERALK
360 370 380 390 400
EERDRLTAEA EKQAAAKAKK AAEEAAKIAA EEALLAEAAA QKAAEEAKAL
410 420 430 440 450
KAAEDAAQKA AEEARLAEEA AAQKVAEEAA QKAAEEARLA EEAAAQKAAE
460 470 480 490 500
EAAQKAAEEA ALKAAEEARL AEEAAQKAAE EAALKAVEEA RAAEEAAQKA
510 520 530 540 550
AEEARVAEEA RLEEEQRVRE QELERLAEIE KESEGELARQ AAELAEIARQ
560 570 580 590 600
ESELAAQELQ AIQKNENETS EPVVEEPVTP VEEQEPIIEL GSNVTPTGGN
610
SYEEDLDAEE EEDEEEEEE

Note: No experimental confirmation available.

Length:619
Mass (Da):68,642
Last modified:July 19, 2004 - v3
Checksum:i7DDCB26AD1AB9CEE
GO
Isoform B (identifier: Q9VGX3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-163: YPSVEKVTRV...PLRITPSPVR → RTKRTPIDWE...SGAMVTKYSY
     164-619: Missing.

Note: No experimental confirmation available.

Show »
Length:163
Mass (Da):18,836
Checksum:i5871581843CB6030
GO
Isoform C (identifier: Q9VGX3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-131: YPSVEKVTRV...TYIPTSYTTY → TPRLDLCTDR...TKYRHFSYHV
     132-619: Missing.

Show »
Length:131
Mass (Da):14,371
Checksum:i58EF580B0F90570D
GO
Isoform D (identifier: Q9VGX3-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-98: YKSSYPIYSS...TTRVISSPER → SIWFSSLSPT...HIIVLFRLKH
     99-619: Missing.

Note: No experimental confirmation available.

Show »
Length:98
Mass (Da):11,304
Checksum:i0DBFBEFF66AE6398
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei26 – 163138YPSVE…PSPVR → RTKRTPIDWEKVPFVPRPSL ISDPVTAFGVRRPDLERRQR SILDPINRASIKPDYKLAYE PIEPYVSTRDKNRTRILGMV RQHIDTVEAGGNTAGRTFRD SLDAQLPRLHRAVSESLPVR RETYRNERSGAMVTKYSY in isoform B. CuratedVSP_004048Add
BLAST
Alternative sequencei26 – 131106YPSVE…SYTTY → TPRLDLCTDRPGSHRSRASS DYSYTSKSSVEKSSYDSSNP HSYRPERSTYTSTVEKTSRS GPGGSYNYSTERTSTTGAGP GGYSYSSTTSGNLPGGTKYR HFSYHV in isoform C. 2 PublicationsVSP_004046Add
BLAST
Alternative sequencei36 – 9863YKSSY…SSPER → SIWFSSLSPTSLVIIHLSMD YYYSFLLTYITHCSITSITS SSLEKQIRLVISPHIIVLFR LKH in isoform D. CuratedVSP_004050Add
BLAST
Alternative sequencei99 – 619521Missing in isoform D. CuratedVSP_004051Add
BLAST
Alternative sequencei132 – 619488Missing in isoform C. 2 PublicationsVSP_004047Add
BLAST
Alternative sequencei164 – 619456Missing in isoform B. CuratedVSP_004049Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF154418 mRNA. Translation: AAD38397.1.
AE014297 Genomic DNA. Translation: AAF54549.3.
AE014297 Genomic DNA. Translation: AAF54550.1.
AE014297 Genomic DNA. Translation: AAF54551.1.
AE014297 Genomic DNA. Translation: AAF54552.1.
AY060997 mRNA. Translation: AAL28545.1.
AY119569 mRNA. Translation: AAM50223.1.
RefSeqiNP_650015.3. NM_141758.5. [Q9VGX3-5]
NP_731505.1. NM_169361.3. [Q9VGX3-3]
NP_731506.1. NM_169362.4. [Q9VGX3-2]
UniGeneiDm.19238.

Genome annotation databases

EnsemblMetazoaiFBtr0082307; FBpp0081783; FBgn0020439. [Q9VGX3-5]
GeneIDi19834760.
19836061.
41291.
KEGGidme:Dmel_CG6544.
UCSCiCG6544-RA. d. melanogaster. [Q9VGX3-5]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF154418 mRNA. Translation: AAD38397.1 .
AE014297 Genomic DNA. Translation: AAF54549.3 .
AE014297 Genomic DNA. Translation: AAF54550.1 .
AE014297 Genomic DNA. Translation: AAF54551.1 .
AE014297 Genomic DNA. Translation: AAF54552.1 .
AY060997 mRNA. Translation: AAL28545.1 .
AY119569 mRNA. Translation: AAM50223.1 .
RefSeqi NP_650015.3. NM_141758.5. [Q9VGX3-5 ]
NP_731505.1. NM_169361.3. [Q9VGX3-3 ]
NP_731506.1. NM_169362.4. [Q9VGX3-2 ]
UniGenei Dm.19238.

3D structure databases

ProteinModelPortali Q9VGX3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 66435. 17 interactions.
DIPi DIP-18797N.
IntActi Q9VGX3. 3 interactions.

Proteomic databases

PaxDbi Q9VGX3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0082307 ; FBpp0081783 ; FBgn0020439 . [Q9VGX3-5 ]
GeneIDi 19834760.
19836061.
41291.
KEGGi dme:Dmel_CG6544.
UCSCi CG6544-RA. d. melanogaster. [Q9VGX3-5 ]

Organism-specific databases

CTDi 2197.
FlyBasei FBgn0020439. fau.

Phylogenomic databases

eggNOGi NOG242396.
InParanoidi Q9VGX3.
OMAi RILSMVR.
OrthoDBi EOG7F24SQ.
PhylomeDBi Q9VGX3.

Miscellaneous databases

ChiTaRSi FAU. drosophila.
GenomeRNAii 41291.
NextBioi 823138.

Gene expression databases

Bgeei Q9VGX3.
ExpressionAtlasi Q9VGX3. differential.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene regulation by O2 deprivation: an anoxia-regulated novel gene in Drosophila melanogaster."
    Ma E., Xu T., Haddad G.G.
    Brain Res. Mol. Brain Res. 63:217-224(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C).
    Strain: Canton-S.
    Tissue: Head.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS C AND E).
    Strain: Berkeley.
    Tissue: Head.
  5. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79 AND SER-81, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiFAU_DROME
AccessioniPrimary (citable) accession number: Q9VGX3
Secondary accession number(s): Q95S18
, Q9VGX1, Q9VGX2, Q9Y0F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: July 19, 2004
Last modified: October 29, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase

External Data

Dasty 3