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Q9VGX3

- FAU_DROME

UniProt

Q9VGX3 - FAU_DROME

Protein

Protein anoxia up-regulated

Gene

fau

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 3 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Plays an important role in the regulation of tissue responsiveness to oxygen deprivation.

    GO - Biological processi

    1. response to anoxia Source: UniProtKB

    Keywords - Biological processi

    Stress response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein anoxia up-regulated
    Gene namesi
    Name:fau
    ORF Names:CG6544
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0020439. fau.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 619619Protein anoxia up-regulatedPRO_0000087203Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei79 – 791Phosphoserine1 Publication
    Modified residuei81 – 811Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9VGX3.

    Expressioni

    Tissue specificityi

    Concentrated in lamina neurons, first optic lobe neurons and cortical neurons of central brain.

    Inductioni

    By anoxia.

    Gene expression databases

    BgeeiQ9VGX3.

    Interactioni

    Protein-protein interaction databases

    BioGridi66435. 17 interactions.
    DIPiDIP-18797N.
    IntActiQ9VGX3. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VGX3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi88 – 14356Thr-richAdd
    BLAST
    Compositional biasi305 – 619315Ala/Glu-richAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG242396.
    InParanoidiQ9VGX3.
    OMAiRILSMVR.
    OrthoDBiEOG7F24SQ.
    PhylomeDBiQ9VGX3.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform E (identifier: Q9VGX3-5) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVYESGFTTR RTYSSRPVTT SYAVTYPSVE KVTRVYKSSY PIYSSYSVPR    50
    RVYGATRVVT SPIRVVTSPA RVVSRVIHSP SPVRVVRTTT RVISSPERTT 100
    YSYTTPSTYY SPSYLPSTYT STYIPTSYTT YTPSYAYSPT TVTRVYAPRS 150
    SLSPLRITPS PVRVITSPVR SVPSYLKRLP PGYGARALTN YLNTEPFTTF 200
    SEETSRIRNR AQSLIRDLHT PVVRRARSCT PFPVTGYTYE PASQLALDAY 250
    VARVTNPVRH IAKEVHNISH YPRPAVKYVD AELDPNRPSR KFSAPRPLED 300
    PLDVEAKEKQ RLRQERLLTV NEEALDEVDL EKKRAQKADE AKRREERALK 350
    EERDRLTAEA EKQAAAKAKK AAEEAAKIAA EEALLAEAAA QKAAEEAKAL 400
    KAAEDAAQKA AEEARLAEEA AAQKVAEEAA QKAAEEARLA EEAAAQKAAE 450
    EAAQKAAEEA ALKAAEEARL AEEAAQKAAE EAALKAVEEA RAAEEAAQKA 500
    AEEARVAEEA RLEEEQRVRE QELERLAEIE KESEGELARQ AAELAEIARQ 550
    ESELAAQELQ AIQKNENETS EPVVEEPVTP VEEQEPIIEL GSNVTPTGGN 600
    SYEEDLDAEE EEDEEEEEE 619

    Note: No experimental confirmation available.

    Length:619
    Mass (Da):68,642
    Last modified:July 19, 2004 - v3
    Checksum:i7DDCB26AD1AB9CEE
    GO
    Isoform B (identifier: Q9VGX3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         26-163: YPSVEKVTRV...PLRITPSPVR → RTKRTPIDWE...SGAMVTKYSY
         164-619: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:163
    Mass (Da):18,836
    Checksum:i5871581843CB6030
    GO
    Isoform C (identifier: Q9VGX3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         26-131: YPSVEKVTRV...TYIPTSYTTY → TPRLDLCTDR...TKYRHFSYHV
         132-619: Missing.

    Show »
    Length:131
    Mass (Da):14,371
    Checksum:i58EF580B0F90570D
    GO
    Isoform D (identifier: Q9VGX3-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         36-98: YKSSYPIYSS...TTRVISSPER → SIWFSSLSPT...HIIVLFRLKH
         99-619: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:98
    Mass (Da):11,304
    Checksum:i0DBFBEFF66AE6398
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei26 – 163138YPSVE…PSPVR → RTKRTPIDWEKVPFVPRPSL ISDPVTAFGVRRPDLERRQR SILDPINRASIKPDYKLAYE PIEPYVSTRDKNRTRILGMV RQHIDTVEAGGNTAGRTFRD SLDAQLPRLHRAVSESLPVR RETYRNERSGAMVTKYSY in isoform B. CuratedVSP_004048Add
    BLAST
    Alternative sequencei26 – 131106YPSVE…SYTTY → TPRLDLCTDRPGSHRSRASS DYSYTSKSSVEKSSYDSSNP HSYRPERSTYTSTVEKTSRS GPGGSYNYSTERTSTTGAGP GGYSYSSTTSGNLPGGTKYR HFSYHV in isoform C. 2 PublicationsVSP_004046Add
    BLAST
    Alternative sequencei36 – 9863YKSSY…SSPER → SIWFSSLSPTSLVIIHLSMD YYYSFLLTYITHCSITSITS SSLEKQIRLVISPHIIVLFR LKH in isoform D. CuratedVSP_004050Add
    BLAST
    Alternative sequencei99 – 619521Missing in isoform D. CuratedVSP_004051Add
    BLAST
    Alternative sequencei132 – 619488Missing in isoform C. 2 PublicationsVSP_004047Add
    BLAST
    Alternative sequencei164 – 619456Missing in isoform B. CuratedVSP_004049Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF154418 mRNA. Translation: AAD38397.1.
    AE014297 Genomic DNA. Translation: AAF54549.3.
    AE014297 Genomic DNA. Translation: AAF54550.1.
    AE014297 Genomic DNA. Translation: AAF54551.1.
    AE014297 Genomic DNA. Translation: AAF54552.1.
    AY060997 mRNA. Translation: AAL28545.1.
    AY119569 mRNA. Translation: AAM50223.1.
    RefSeqiNP_650015.3. NM_141758.5. [Q9VGX3-5]
    NP_731504.1. NM_169360.3. [Q9VGX3-4]
    NP_731505.1. NM_169361.3. [Q9VGX3-3]
    NP_731506.1. NM_169362.4. [Q9VGX3-2]
    UniGeneiDm.19238.

    Genome annotation databases

    EnsemblMetazoaiFBtr0082307; FBpp0081783; FBgn0020439. [Q9VGX3-5]
    GeneIDi41291.
    KEGGidme:Dmel_CG6544.
    UCSCiCG6544-RA. d. melanogaster. [Q9VGX3-5]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF154418 mRNA. Translation: AAD38397.1 .
    AE014297 Genomic DNA. Translation: AAF54549.3 .
    AE014297 Genomic DNA. Translation: AAF54550.1 .
    AE014297 Genomic DNA. Translation: AAF54551.1 .
    AE014297 Genomic DNA. Translation: AAF54552.1 .
    AY060997 mRNA. Translation: AAL28545.1 .
    AY119569 mRNA. Translation: AAM50223.1 .
    RefSeqi NP_650015.3. NM_141758.5. [Q9VGX3-5 ]
    NP_731504.1. NM_169360.3. [Q9VGX3-4 ]
    NP_731505.1. NM_169361.3. [Q9VGX3-3 ]
    NP_731506.1. NM_169362.4. [Q9VGX3-2 ]
    UniGenei Dm.19238.

    3D structure databases

    ProteinModelPortali Q9VGX3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 66435. 17 interactions.
    DIPi DIP-18797N.
    IntActi Q9VGX3. 3 interactions.

    Proteomic databases

    PaxDbi Q9VGX3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0082307 ; FBpp0081783 ; FBgn0020439 . [Q9VGX3-5 ]
    GeneIDi 41291.
    KEGGi dme:Dmel_CG6544.
    UCSCi CG6544-RA. d. melanogaster. [Q9VGX3-5 ]

    Organism-specific databases

    CTDi 2197.
    FlyBasei FBgn0020439. fau.

    Phylogenomic databases

    eggNOGi NOG242396.
    InParanoidi Q9VGX3.
    OMAi RILSMVR.
    OrthoDBi EOG7F24SQ.
    PhylomeDBi Q9VGX3.

    Miscellaneous databases

    ChiTaRSi FAU. drosophila.
    GenomeRNAii 41291.
    NextBioi 823138.

    Gene expression databases

    Bgeei Q9VGX3.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Gene regulation by O2 deprivation: an anoxia-regulated novel gene in Drosophila melanogaster."
      Ma E., Xu T., Haddad G.G.
      Brain Res. Mol. Brain Res. 63:217-224(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C).
      Strain: Canton-S.
      Tissue: Head.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS C AND E).
      Strain: Berkeley.
      Tissue: Head.
    5. "Phosphoproteome analysis of Drosophila melanogaster embryos."
      Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
      J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79 AND SER-81, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.

    Entry informationi

    Entry nameiFAU_DROME
    AccessioniPrimary (citable) accession number: Q9VGX3
    Secondary accession number(s): Q95S18
    , Q9VGX1, Q9VGX2, Q9Y0F9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 98 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase

    External Data

    Dasty 3