Q9VGW1 (CAD86_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cadherin-86C

Gene names

Name:	Cad86C
ORF Names:	CG4509

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	1943 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells By similarity.
Subcellular location	Cell membrane; Single-pass type I membrane protein Potential.
Tissue specificity	As cell intercalation proceeds, a row of stigmatophore cells surrounding the spiracular chamber show expression of Cad86C. Expression is regulated by the Abd-B cascade, requiring sal. Expressed in a broad region of the morphogenetic furrow and in clusters of cells posterior to the morphogenetic furrow. Weakly expressed in the epithelium of wing imaginal disks. In eye imaginal disk cells within the morphogenetic furrow, expression is localized to the apical region. Ref.1 Ref.5
Induction	By hedgehog (hh) and dpp signal transduction in the morphogenetic furrow. Ref.1
Domain	Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.
Sequence similarities	Contains 5 cadherin domains.
Sequence caution	The sequence AAM29379.1 differs from that shown. Reason: Erroneous termination at position 1331. Translated as Arg.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	calcium-dependent cell-cell adhesion Non-traceable author statement. Source: UniProtKB homophilic cell adhesion Inferred from electronic annotation. Source: InterPro regulation of cell shape Inferred from mutant phenotype Ref.1. Source: FlyBase
Cellular_component	integral to plasma membrane Inferred from sequence or structural similarity PubMed 10908592. Source: FlyBase subapical complex Inferred from direct assay Ref.1. Source: FlyBase
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – ?		Potential
	Chain	? – 1943		Cadherin-86C		PRO_0000004010
Regions
	Topological domain	1 – 934	934	Extracellular Potential
	Transmembrane	935 – 955	21	Helical; Potential
	Topological domain	956 – 1943	988	Cytoplasmic Potential
	Domain	238 – 366	129	Cadherin 1
	Domain	367 – 483	117	Cadherin 2
	Domain	484 – 600	117	Cadherin 3
	Domain	601 – 708	108	Cadherin 4
	Domain	709 – 832	124	Cadherin 5
Amino acid modifications
	Glycosylation	12	1	N-linked (GlcNAc...) Potential
	Glycosylation	244	1	N-linked (GlcNAc...) Potential
	Glycosylation	419	1	N-linked (GlcNAc...) Potential
	Glycosylation	531	1	N-linked (GlcNAc...) Potential
	Glycosylation	579	1	N-linked (GlcNAc...) Potential
	Glycosylation	585	1	N-linked (GlcNAc...) Potential
	Glycosylation	612	1	N-linked (GlcNAc...) Potential
	Glycosylation	645	1	N-linked (GlcNAc...) Potential
	Glycosylation	912	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	926	1	D → DTLTPLQ in AAM29379. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q9VGW1 [UniParc]. Last modified October 19, 2011. Version 3. Checksum: 16ADFDBB8C0EED30	FASTA	1,943	220,408
	10 20 30 40 50 60 MASTSSSQPE KNRSHVPLCR LGTEPVSRTG AAEEPSGQRE CYYYAPATSP HHHHHHHHQH 70 80 90 100 110 120 HHHHRLKQHH RHHHHHHRLQ HHHHHHQQQH NHQNQQMQHH WPSRLGPIGP WLGAMTAYRL 130 140 150 160 170 180 LTISLLIGIL CPHHVQGADP KFDPTTRMRL VLVPADAQVN SVIYRLRATD EEFDYPLTFE 190 200 210 220 230 240 FVGDASASTV KVESLPCTKY NSVCQANIVL QRRLEPGRYY DFQVSVKDTK GGMTTQLCSI 250 260 270 280 290 300 TATNFTTPHD LIFPHKPGII MIPEDAKRGT ELDYVIARKN PLFQKPVYLE LWGSPLFAIR 310 320 330 340 350 360 QKIVSSETTE GTVFLLGPLD FEKQAMYHLT ILANDAYAEP GQDSRNIAGM EIVVIVQDVQ 370 380 390 400 410 420 DQPPVFTSAP PVTKLPPGIL PGDKILQVHA EDGDKGNPRE VRYGLVSENN PFTSFFDINE 430 440 450 460 470 480 TSGEIFLMRP LEDIAFITHV GDPVLLTVIA EEVKVGRDEP PALASTVQLA FFLPDRTNSP 490 500 510 520 530 540 PYFENDHYVS RVDENAPQGT ALTFVDPYVP RVYDDDTGKN GVFSLTLLNN NGTFEISPNV 550 560 570 580 590 600 AERSAGFLIR VRDNSMLDYE QQQSVQFQIL AQELGPATNL SALVNVTVYI NDVNDNAPVF 610 620 630 640 650 660 EQPAYSVELP ENMTAGTKVV QVLATDPDSG LGGKVRYTAI LGYLNTSLNL DAETGLITVS 670 680 690 700 710 720 TNKHGFDREV MPEYHLYVEA RDMDGEGNRA QVPLIIKLID VNDETPIFDK DLYEFILTHD 730 740 750 760 770 780 LMGFTTTAVI HAEDKDATAP NNEVRYEIIN GNYDNQFVLD KVTGELTVRE KIHLRSKKNA 790 800 810 820 830 840 KTRRRRQAGS DDEDTDIFIL TARAYDLGVP VRFSTTTIRV YPPESRKRSV KFVVPGHNPD 850 860 870 880 890 900 KAKTEETLSA LSGGKVYIHN IRPLSPDEPG AKDIPAGNPG IKERSVVTAT VIYDSSSVVD 910 920 930 940 950 960 ISEIQQRLSH HNNSYAIMPQ DTSSTDTQYK AENKVLFWLL ILLATLVALT ILILLLCCIC 970 980 990 1000 1010 1020 SWCPLYGAAT KRIVNISRTE DDVHLVHREM ANGKQTKSVQ VAEWMGRRDA WSAEKPPDTR 1030 1040 1050 1060 1070 1080 TKPTRWEFHD GREQLDEDVG RGQDIGEGDR RHIQSAEEQQ RRVRIKHNRT AKDDLHLNFH 1090 1100 1110 1120 1130 1140 NSRTNLINDR DVYMEDVIEN RDLAGDREHI TRTRVNRQEY ARRKQYDSEV RHIDDDSMRR 1150 1160 1170 1180 1190 1200 HEIDRGSDID FNTAHNSLKS KRELFIKDGN VEILQLMTRD KTRDGLNLDD DNIYVNVPLK 1210 1220 1230 1240 1250 1260 PAGNLSHPQL LMVDNTGKEI LMRRFIEEQP DGKQIIREHY QIVPGATYIQ SMPNEVQQGS 1270 1280 1290 1300 1310 1320 TLKGDTFPLG KSGPNSIVYS QLEPEVKVIH TQPVQAGEGV SLDQQMQPAV SNQSLTHELE 1330 1340 1350 1360 1370 1380 HSLKQQNALL RQILMEKEKL ENAYTQHEVA LETQSLPGQS MAIGTQTDCD AGTQTEGFDG 1390 1400 1410 1420 1430 1440 VLDPEISLAK PSRRRARSEN DESMSEDGYE YVRFNPPNSP EGVYWIKRRR TKKRPRQPRK 1450 1460 1470 1480 1490 1500 RIVMVEEVKR KIRTPIKEEE EVQERKKRVP PKKPLRETKT SILRKQLSDE SRKDQSRNGE 1510 1520 1530 1540 1550 1560 SQTGNRHRSE SDSHNRDMFM EITDSMDELA SPGSHSIRKI QVEKYYKHSD GDFDEDDTEY 1570 1580 1590 1600 1610 1620 SIDSDGDEIV IRTNYPSRAQ ENERYRRQER TYAEPENPVD RKRPARKSSP TDSQPEAMPR 1630 1640 1650 1660 1670 1680 LSRRDSSKRG SRKQTSSEPP HNRVSISKYE STVTENGRKL MSTSTEIVGS KRSLTDRSYQ 1690 1700 1710 1720 1730 1740 SETELAGLEH EERNVPKYME WYYNKKKSSV SGRTSTESSK SQPSSKKKVG AAEKRVSKTR 1750 1760 1770 1780 1790 1800 ITAQPKDVEE YDETGGRYKP EPAPRKSPPK GSRLLKEDRA LNKQHKPKIE TDTNHPLLQH 1810 1820 1830 1840 1850 1860 SEHRFERENA LEVPAAPTKL PHYMYPETPP HAAAGGKESK SGRESKTSKE AKPKPSPIRE 1870 1880 1890 1900 1910 1920 NEVKVSNSKI YVEHRGTGHP TQKQLNASTL EDDHDSGIAM NSLLNSLGRR NPIAEKKSVF 1930 1940 SIAYDDVSRV KKINSGGESP QYS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Hedgehog and Dpp signaling induce cadherin Cad86C expression in the morphogenetic furrow during Drosophila eye development." Schlichting K., Dahmann C. Mech. Dev. 125:712-728(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 726-1943. Strain: Berkeley. Tissue: Larva and Pupae.
[5]	"Coordinated control of cell adhesion, polarity, and cytoskeleton underlies Hox-induced organogenesis in Drosophila." Lovegrove B., Simoes S., Rivas M.L., Sotillos S., Johnson K., Knust E., Jacinto A., Hombria J.C. Curr. Biol. 16:2206-2216(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EU707853 mRNA. Translation: ACD79974.1. AE014297 Genomic DNA. Translation: AAF54562.5. AY113374 mRNA. Translation: AAM29379.1. Sequence problems.
RefSeq	NP_001247031.1. NM_001260102.1. NP_788635.3. NM_176458.4.
3D structure databases
ProteinModelPortal	Q9VGW1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VGW1. 1 interaction.
MINT	MINT-892952.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	41302.
KEGG	dme:Dmel_CG42601.
Organism-specific databases
CTD	41302.
FlyBase	FBgn0261053. Cad86C.
Phylogenomic databases
eggNOG	NOG260805.
InParanoid	Q9VGW1.
OrthoDB	EOG473N6K.
Gene expression databases
Bgee	Q9VGW1.
GermOnline	CG4509. Drosophila melanogaster.
Family and domain databases
Gene3D	2.60.40.60. 6 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. [Graphical view]
Pfam	PF00028. Cadherin. 3 hits. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 5 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 5 hits.
PROSITE	PS00232. CADHERIN_1. 1 hit. PS50268. CADHERIN_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	41302.
NextBio	823209.

Entry information

Entry name

CAD86_DROME

Accession

Primary (citable) accession number: Q9VGW1
Secondary accession number(s): B3GN10, Q8MZ37

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
Last sequence update:	October 19, 2011
Last modified:	April 3, 2013
This is version 98 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project