Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9VGW1

- CAD86_DROME

UniProt

Q9VGW1 - CAD86_DROME

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cadherin-86C

Gene

Cad86C

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells By similarity.By similarity

GO - Molecular functioni

  1. calcium ion binding Source: FlyBase

GO - Biological processi

  1. calcium-dependent cell-cell adhesion Source: FlyBase
  2. cell-cell adhesion mediated by cadherin Source: FlyBase
  3. homophilic cell adhesion Source: InterPro
  4. regulation of cell shape Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-86C
Gene namesi
Name:Cad86C
ORF Names:CG4509
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0261053. Cad86C.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: FlyBase
  2. subapical complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 1943Cadherin-86CPRO_0000004010
Signal peptidei1 – ?Sequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi244 – 2441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi531 – 5311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi579 – 5791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi585 – 5851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi612 – 6121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi645 – 6451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi912 – 9121N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

As cell intercalation proceeds, a row of stigmatophore cells surrounding the spiracular chamber show expression of Cad86C. Expression is regulated by the Abd-B cascade, requiring sal. Expressed in a broad region of the morphogenetic furrow and in clusters of cells posterior to the morphogenetic furrow. Weakly expressed in the epithelium of wing imaginal disks. In eye imaginal disk cells within the morphogenetic furrow, expression is localized to the apical region.2 Publications

Inductioni

By hedgehog (hh) and dpp signal transduction in the morphogenetic furrow.1 Publication

Gene expression databases

BgeeiQ9VGW1.

Interactioni

Protein-protein interaction databases

BioGridi66446. 2 interactions.
IntActiQ9VGW1. 1 interaction.
MINTiMINT-892952.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 934934ExtracellularSequence AnalysisAdd
BLAST
Topological domaini956 – 1943988CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei935 – 95521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini238 – 366129Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini367 – 483117Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini484 – 600117Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini601 – 708108Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini709 – 832124Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG260805.
InParanoidiQ9VGW1.
OrthoDBiEOG7CVPWS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 3 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 1 hit.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VGW1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASTSSSQPE KNRSHVPLCR LGTEPVSRTG AAEEPSGQRE CYYYAPATSP
60 70 80 90 100
HHHHHHHHQH HHHHRLKQHH RHHHHHHRLQ HHHHHHQQQH NHQNQQMQHH
110 120 130 140 150
WPSRLGPIGP WLGAMTAYRL LTISLLIGIL CPHHVQGADP KFDPTTRMRL
160 170 180 190 200
VLVPADAQVN SVIYRLRATD EEFDYPLTFE FVGDASASTV KVESLPCTKY
210 220 230 240 250
NSVCQANIVL QRRLEPGRYY DFQVSVKDTK GGMTTQLCSI TATNFTTPHD
260 270 280 290 300
LIFPHKPGII MIPEDAKRGT ELDYVIARKN PLFQKPVYLE LWGSPLFAIR
310 320 330 340 350
QKIVSSETTE GTVFLLGPLD FEKQAMYHLT ILANDAYAEP GQDSRNIAGM
360 370 380 390 400
EIVVIVQDVQ DQPPVFTSAP PVTKLPPGIL PGDKILQVHA EDGDKGNPRE
410 420 430 440 450
VRYGLVSENN PFTSFFDINE TSGEIFLMRP LEDIAFITHV GDPVLLTVIA
460 470 480 490 500
EEVKVGRDEP PALASTVQLA FFLPDRTNSP PYFENDHYVS RVDENAPQGT
510 520 530 540 550
ALTFVDPYVP RVYDDDTGKN GVFSLTLLNN NGTFEISPNV AERSAGFLIR
560 570 580 590 600
VRDNSMLDYE QQQSVQFQIL AQELGPATNL SALVNVTVYI NDVNDNAPVF
610 620 630 640 650
EQPAYSVELP ENMTAGTKVV QVLATDPDSG LGGKVRYTAI LGYLNTSLNL
660 670 680 690 700
DAETGLITVS TNKHGFDREV MPEYHLYVEA RDMDGEGNRA QVPLIIKLID
710 720 730 740 750
VNDETPIFDK DLYEFILTHD LMGFTTTAVI HAEDKDATAP NNEVRYEIIN
760 770 780 790 800
GNYDNQFVLD KVTGELTVRE KIHLRSKKNA KTRRRRQAGS DDEDTDIFIL
810 820 830 840 850
TARAYDLGVP VRFSTTTIRV YPPESRKRSV KFVVPGHNPD KAKTEETLSA
860 870 880 890 900
LSGGKVYIHN IRPLSPDEPG AKDIPAGNPG IKERSVVTAT VIYDSSSVVD
910 920 930 940 950
ISEIQQRLSH HNNSYAIMPQ DTSSTDTQYK AENKVLFWLL ILLATLVALT
960 970 980 990 1000
ILILLLCCIC SWCPLYGAAT KRIVNISRTE DDVHLVHREM ANGKQTKSVQ
1010 1020 1030 1040 1050
VAEWMGRRDA WSAEKPPDTR TKPTRWEFHD GREQLDEDVG RGQDIGEGDR
1060 1070 1080 1090 1100
RHIQSAEEQQ RRVRIKHNRT AKDDLHLNFH NSRTNLINDR DVYMEDVIEN
1110 1120 1130 1140 1150
RDLAGDREHI TRTRVNRQEY ARRKQYDSEV RHIDDDSMRR HEIDRGSDID
1160 1170 1180 1190 1200
FNTAHNSLKS KRELFIKDGN VEILQLMTRD KTRDGLNLDD DNIYVNVPLK
1210 1220 1230 1240 1250
PAGNLSHPQL LMVDNTGKEI LMRRFIEEQP DGKQIIREHY QIVPGATYIQ
1260 1270 1280 1290 1300
SMPNEVQQGS TLKGDTFPLG KSGPNSIVYS QLEPEVKVIH TQPVQAGEGV
1310 1320 1330 1340 1350
SLDQQMQPAV SNQSLTHELE HSLKQQNALL RQILMEKEKL ENAYTQHEVA
1360 1370 1380 1390 1400
LETQSLPGQS MAIGTQTDCD AGTQTEGFDG VLDPEISLAK PSRRRARSEN
1410 1420 1430 1440 1450
DESMSEDGYE YVRFNPPNSP EGVYWIKRRR TKKRPRQPRK RIVMVEEVKR
1460 1470 1480 1490 1500
KIRTPIKEEE EVQERKKRVP PKKPLRETKT SILRKQLSDE SRKDQSRNGE
1510 1520 1530 1540 1550
SQTGNRHRSE SDSHNRDMFM EITDSMDELA SPGSHSIRKI QVEKYYKHSD
1560 1570 1580 1590 1600
GDFDEDDTEY SIDSDGDEIV IRTNYPSRAQ ENERYRRQER TYAEPENPVD
1610 1620 1630 1640 1650
RKRPARKSSP TDSQPEAMPR LSRRDSSKRG SRKQTSSEPP HNRVSISKYE
1660 1670 1680 1690 1700
STVTENGRKL MSTSTEIVGS KRSLTDRSYQ SETELAGLEH EERNVPKYME
1710 1720 1730 1740 1750
WYYNKKKSSV SGRTSTESSK SQPSSKKKVG AAEKRVSKTR ITAQPKDVEE
1760 1770 1780 1790 1800
YDETGGRYKP EPAPRKSPPK GSRLLKEDRA LNKQHKPKIE TDTNHPLLQH
1810 1820 1830 1840 1850
SEHRFERENA LEVPAAPTKL PHYMYPETPP HAAAGGKESK SGRESKTSKE
1860 1870 1880 1890 1900
AKPKPSPIRE NEVKVSNSKI YVEHRGTGHP TQKQLNASTL EDDHDSGIAM
1910 1920 1930 1940
NSLLNSLGRR NPIAEKKSVF SIAYDDVSRV KKINSGGESP QYS
Length:1,943
Mass (Da):220,408
Last modified:October 19, 2011 - v3
Checksum:i16ADFDBB8C0EED30
GO

Sequence cautioni

The sequence AAM29379.1 differs from that shown. Reason: Erroneous termination at position 1331. Translated as Arg.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti926 – 9261D → DTLTPLQ in AAM29379. (PubMed:12537569)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU707853 mRNA. Translation: ACD79974.1.
AE014297 Genomic DNA. Translation: AAF54562.5.
AY113374 mRNA. Translation: AAM29379.1. Sequence problems.
RefSeqiNP_001247031.1. NM_001260102.1.
NP_788635.3. NM_176458.4.
UniGeneiDm.1141.

Genome annotation databases

GeneIDi41302.
KEGGidme:Dmel_CG42601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU707853 mRNA. Translation: ACD79974.1 .
AE014297 Genomic DNA. Translation: AAF54562.5 .
AY113374 mRNA. Translation: AAM29379.1 . Sequence problems.
RefSeqi NP_001247031.1. NM_001260102.1.
NP_788635.3. NM_176458.4.
UniGenei Dm.1141.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 66446. 2 interactions.
IntActi Q9VGW1. 1 interaction.
MINTi MINT-892952.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 41302.
KEGGi dme:Dmel_CG42601.

Organism-specific databases

CTDi 41302.
FlyBasei FBgn0261053. Cad86C.

Phylogenomic databases

eggNOGi NOG260805.
InParanoidi Q9VGW1.
OrthoDBi EOG7CVPWS.

Miscellaneous databases

GenomeRNAii 41302.
NextBioi 823209.

Gene expression databases

Bgeei Q9VGW1.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view ]
Pfami PF00028. Cadherin. 3 hits.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 5 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 5 hits.
PROSITEi PS00232. CADHERIN_1. 1 hit.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Hedgehog and Dpp signaling induce cadherin Cad86C expression in the morphogenetic furrow during Drosophila eye development."
    Schlichting K., Dahmann C.
    Mech. Dev. 125:712-728(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 726-1943.
    Strain: Berkeley.
    Tissue: Larva and Pupae.
  5. "Coordinated control of cell adhesion, polarity, and cytoskeleton underlies Hox-induced organogenesis in Drosophila."
    Lovegrove B., Simoes S., Rivas M.L., Sotillos S., Johnson K., Knust E., Jacinto A., Hombria J.C.
    Curr. Biol. 16:2206-2216(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCAD86_DROME
AccessioniPrimary (citable) accession number: Q9VGW1
Secondary accession number(s): B3GN10, Q8MZ37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: October 19, 2011
Last modified: October 29, 2014
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3