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Q9VGW1

- CAD86_DROME

UniProt

Q9VGW1 - CAD86_DROME

Protein

Cadherin-86C

Gene

Cad86C

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 3 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. calcium-dependent cell-cell adhesion Source: FlyBase
    2. homophilic cell adhesion Source: InterPro
    3. regulation of cell shape Source: FlyBase

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin-86C
    Gene namesi
    Name:Cad86C
    ORF Names:CG4509
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0261053. Cad86C.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: FlyBase
    2. subapical complex Source: FlyBase

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 1943Cadherin-86CPRO_0000004010
    Signal peptidei1 – ?Sequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi244 – 2441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi531 – 5311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi579 – 5791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi585 – 5851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi612 – 6121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi645 – 6451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi912 – 9121N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    As cell intercalation proceeds, a row of stigmatophore cells surrounding the spiracular chamber show expression of Cad86C. Expression is regulated by the Abd-B cascade, requiring sal. Expressed in a broad region of the morphogenetic furrow and in clusters of cells posterior to the morphogenetic furrow. Weakly expressed in the epithelium of wing imaginal disks. In eye imaginal disk cells within the morphogenetic furrow, expression is localized to the apical region.2 Publications

    Inductioni

    By hedgehog (hh) and dpp signal transduction in the morphogenetic furrow.1 Publication

    Gene expression databases

    BgeeiQ9VGW1.

    Interactioni

    Protein-protein interaction databases

    BioGridi66446. 2 interactions.
    IntActiQ9VGW1. 1 interaction.
    MINTiMINT-892952.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 934934ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini956 – 1943988CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei935 – 95521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini238 – 366129Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini367 – 483117Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini484 – 600117Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini601 – 708108Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini709 – 832124Cadherin 5PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 5 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG260805.
    InParanoidiQ9VGW1.
    OrthoDBiEOG7CVPWS.

    Family and domain databases

    Gene3Di2.60.40.60. 6 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    [Graphical view]
    PfamiPF00028. Cadherin. 3 hits.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 5 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 5 hits.
    PROSITEiPS00232. CADHERIN_1. 1 hit.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9VGW1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASTSSSQPE KNRSHVPLCR LGTEPVSRTG AAEEPSGQRE CYYYAPATSP     50
    HHHHHHHHQH HHHHRLKQHH RHHHHHHRLQ HHHHHHQQQH NHQNQQMQHH 100
    WPSRLGPIGP WLGAMTAYRL LTISLLIGIL CPHHVQGADP KFDPTTRMRL 150
    VLVPADAQVN SVIYRLRATD EEFDYPLTFE FVGDASASTV KVESLPCTKY 200
    NSVCQANIVL QRRLEPGRYY DFQVSVKDTK GGMTTQLCSI TATNFTTPHD 250
    LIFPHKPGII MIPEDAKRGT ELDYVIARKN PLFQKPVYLE LWGSPLFAIR 300
    QKIVSSETTE GTVFLLGPLD FEKQAMYHLT ILANDAYAEP GQDSRNIAGM 350
    EIVVIVQDVQ DQPPVFTSAP PVTKLPPGIL PGDKILQVHA EDGDKGNPRE 400
    VRYGLVSENN PFTSFFDINE TSGEIFLMRP LEDIAFITHV GDPVLLTVIA 450
    EEVKVGRDEP PALASTVQLA FFLPDRTNSP PYFENDHYVS RVDENAPQGT 500
    ALTFVDPYVP RVYDDDTGKN GVFSLTLLNN NGTFEISPNV AERSAGFLIR 550
    VRDNSMLDYE QQQSVQFQIL AQELGPATNL SALVNVTVYI NDVNDNAPVF 600
    EQPAYSVELP ENMTAGTKVV QVLATDPDSG LGGKVRYTAI LGYLNTSLNL 650
    DAETGLITVS TNKHGFDREV MPEYHLYVEA RDMDGEGNRA QVPLIIKLID 700
    VNDETPIFDK DLYEFILTHD LMGFTTTAVI HAEDKDATAP NNEVRYEIIN 750
    GNYDNQFVLD KVTGELTVRE KIHLRSKKNA KTRRRRQAGS DDEDTDIFIL 800
    TARAYDLGVP VRFSTTTIRV YPPESRKRSV KFVVPGHNPD KAKTEETLSA 850
    LSGGKVYIHN IRPLSPDEPG AKDIPAGNPG IKERSVVTAT VIYDSSSVVD 900
    ISEIQQRLSH HNNSYAIMPQ DTSSTDTQYK AENKVLFWLL ILLATLVALT 950
    ILILLLCCIC SWCPLYGAAT KRIVNISRTE DDVHLVHREM ANGKQTKSVQ 1000
    VAEWMGRRDA WSAEKPPDTR TKPTRWEFHD GREQLDEDVG RGQDIGEGDR 1050
    RHIQSAEEQQ RRVRIKHNRT AKDDLHLNFH NSRTNLINDR DVYMEDVIEN 1100
    RDLAGDREHI TRTRVNRQEY ARRKQYDSEV RHIDDDSMRR HEIDRGSDID 1150
    FNTAHNSLKS KRELFIKDGN VEILQLMTRD KTRDGLNLDD DNIYVNVPLK 1200
    PAGNLSHPQL LMVDNTGKEI LMRRFIEEQP DGKQIIREHY QIVPGATYIQ 1250
    SMPNEVQQGS TLKGDTFPLG KSGPNSIVYS QLEPEVKVIH TQPVQAGEGV 1300
    SLDQQMQPAV SNQSLTHELE HSLKQQNALL RQILMEKEKL ENAYTQHEVA 1350
    LETQSLPGQS MAIGTQTDCD AGTQTEGFDG VLDPEISLAK PSRRRARSEN 1400
    DESMSEDGYE YVRFNPPNSP EGVYWIKRRR TKKRPRQPRK RIVMVEEVKR 1450
    KIRTPIKEEE EVQERKKRVP PKKPLRETKT SILRKQLSDE SRKDQSRNGE 1500
    SQTGNRHRSE SDSHNRDMFM EITDSMDELA SPGSHSIRKI QVEKYYKHSD 1550
    GDFDEDDTEY SIDSDGDEIV IRTNYPSRAQ ENERYRRQER TYAEPENPVD 1600
    RKRPARKSSP TDSQPEAMPR LSRRDSSKRG SRKQTSSEPP HNRVSISKYE 1650
    STVTENGRKL MSTSTEIVGS KRSLTDRSYQ SETELAGLEH EERNVPKYME 1700
    WYYNKKKSSV SGRTSTESSK SQPSSKKKVG AAEKRVSKTR ITAQPKDVEE 1750
    YDETGGRYKP EPAPRKSPPK GSRLLKEDRA LNKQHKPKIE TDTNHPLLQH 1800
    SEHRFERENA LEVPAAPTKL PHYMYPETPP HAAAGGKESK SGRESKTSKE 1850
    AKPKPSPIRE NEVKVSNSKI YVEHRGTGHP TQKQLNASTL EDDHDSGIAM 1900
    NSLLNSLGRR NPIAEKKSVF SIAYDDVSRV KKINSGGESP QYS 1943
    Length:1,943
    Mass (Da):220,408
    Last modified:October 19, 2011 - v3
    Checksum:i16ADFDBB8C0EED30
    GO

    Sequence cautioni

    The sequence AAM29379.1 differs from that shown. Reason: Erroneous termination at position 1331. Translated as Arg.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti926 – 9261D → DTLTPLQ in AAM29379. (PubMed:12537569)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU707853 mRNA. Translation: ACD79974.1.
    AE014297 Genomic DNA. Translation: AAF54562.5.
    AY113374 mRNA. Translation: AAM29379.1. Sequence problems.
    RefSeqiNP_001247031.1. NM_001260102.1.
    NP_788635.3. NM_176458.4.
    UniGeneiDm.1141.

    Genome annotation databases

    GeneIDi41302.
    KEGGidme:Dmel_CG42601.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU707853 mRNA. Translation: ACD79974.1 .
    AE014297 Genomic DNA. Translation: AAF54562.5 .
    AY113374 mRNA. Translation: AAM29379.1 . Sequence problems.
    RefSeqi NP_001247031.1. NM_001260102.1.
    NP_788635.3. NM_176458.4.
    UniGenei Dm.1141.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 66446. 2 interactions.
    IntActi Q9VGW1. 1 interaction.
    MINTi MINT-892952.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 41302.
    KEGGi dme:Dmel_CG42601.

    Organism-specific databases

    CTDi 41302.
    FlyBasei FBgn0261053. Cad86C.

    Phylogenomic databases

    eggNOGi NOG260805.
    InParanoidi Q9VGW1.
    OrthoDBi EOG7CVPWS.

    Miscellaneous databases

    GenomeRNAii 41302.
    NextBioi 823209.

    Gene expression databases

    Bgeei Q9VGW1.

    Family and domain databases

    Gene3Di 2.60.40.60. 6 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    [Graphical view ]
    Pfami PF00028. Cadherin. 3 hits.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 5 hits.
    PROSITEi PS00232. CADHERIN_1. 1 hit.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hedgehog and Dpp signaling induce cadherin Cad86C expression in the morphogenetic furrow during Drosophila eye development."
      Schlichting K., Dahmann C.
      Mech. Dev. 125:712-728(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 726-1943.
      Strain: Berkeley.
      Tissue: Larva and Pupae.
    5. "Coordinated control of cell adhesion, polarity, and cytoskeleton underlies Hox-induced organogenesis in Drosophila."
      Lovegrove B., Simoes S., Rivas M.L., Sotillos S., Johnson K., Knust E., Jacinto A., Hombria J.C.
      Curr. Biol. 16:2206-2216(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCAD86_DROME
    AccessioniPrimary (citable) accession number: Q9VGW1
    Secondary accession number(s): B3GN10, Q8MZ37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 27, 2003
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 106 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3