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Protein

Neither inactivation nor afterpotential protein G

Gene

ninaG

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Oxidoreductase involved in biosynthesis of 3-hydroxyretinal, a chromophore for rhodopsin Rh1. Not responsible for the initial hydroxylation of the retinal ring but rather acts in a subsequent step in chromophore production. May catalyze the conversion of (3R)-3-hydroxyretinol to the 3S enantiomer.2 Publications

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei516Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi48 – 77FADBy similarityAdd BLAST30

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: InterPro
  • oxidoreductase activity Source: UniProtKB
  • oxidoreductase activity, acting on CH-OH group of donors Source: InterPro

GO - Biological processi

  • oxidation-reduction process Source: FlyBase
  • protein localization to rhabdomere Source: UniProtKB
  • response to stimulus Source: UniProtKB-KW
  • retinoid metabolic process Source: UniProtKB
  • rhabdomere morphogenesis Source: UniProtKB
  • rhodopsin metabolic process Source: UniProtKB
  • visual perception Source: UniProtKB

Keywordsi

Molecular functionOxidoreductase
Biological processSensory transduction, Vision
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17371
ReactomeiR-DME-6798163 Choline catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Neither inactivation nor afterpotential protein G (EC:1.-.-.-)
Gene namesi
Name:ninaG
ORF Names:CG6728
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0037896 ninaG

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000023529527 – 581Neither inactivation nor afterpotential protein GAdd BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi404N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi464N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9VGP2
PRIDEiQ9VGP2

Expressioni

Gene expression databases

BgeeiFBgn0037896
ExpressionAtlasiQ9VGP2 baseline and differential
GenevisibleiQ9VGP2 DM

Interactioni

Protein-protein interaction databases

IntActiQ9VGP2, 1 interactor
STRINGi7227.FBpp0081880

Structurei

3D structure databases

ProteinModelPortaliQ9VGP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1238 Eukaryota
COG2303 LUCA
GeneTreeiENSGT00530000063260
InParanoidiQ9VGP2
OrthoDBiEOG091G033B
PhylomeDBiQ9VGP2

Family and domain databases

Gene3Di3.50.50.60, 4 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR012132 GMC_OxRdtase
IPR000172 GMC_OxRdtase_N
IPR007867 GMC_OxRtase_C
PfamiView protein in Pfam
PF05199 GMC_oxred_C, 1 hit
PF00732 GMC_oxred_N, 2 hits
PIRSFiPIRSF000137 Alcohol_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VGP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMKFQKILV LAGIVIGFLS IIVVLAGTLL KNSVPNVLAP VERHFAFDYV
60 70 80 90 100
IVGGGTGGST LTSLLAKNSN GSVLLIEAGG QFGLLSRIPL LTTFQQKGIN
110 120 130 140 150
DWSFLSVPQK HSSRGLIERR QCLPRGKGLG GSANLNYMLH FDGHGPDFDS
160 170 180 190 200
WRDHHNLSDW SWAQMRSFMA AAKPKNPDML EIPRRYSKLT EALEEAQAQF
210 220 230 240 250
AYKDWIFRRS LYNIRNGLRH SVVQQFLNPV IHHSNLRLLP DALVKRIQLA
260 270 280 290 300
PSPFLQATSI LVGIKDEENR EKEFSIELLM ASGIGDVSAL KKLGIPAQHS
310 320 330 340 350
LPLVGHNLHD HFNLPLFVSM GVTGPTLNQN TLLNPMTLIN YLSSGSGPLG
360 370 380 390 400
NFGVLGNVVS YGGLGAPPYG ITFFGAGAID ESALMSISNF KGPAFRALFP
410 420 430 440 450
RYYNSSQEGF VVISSCLQPK SRGSVGLLNR HMRRNPLIDP NYLSSEEDVA
460 470 480 490 500
CTISAIRSAV ELVNSTAFAA LHPRIHWPRV QECSNFGPFE RDFFDNRPSD
510 520 530 540 550
QYLECLMRHV GLGSHHPGGT CALGSVVDSQ LRLKGVSNVR VVDASVLPRP
560 570 580
ISGNPNSVVV AIALRAASWI LKSELQAGDS K
Length:581
Mass (Da):63,475
Last modified:May 16, 2006 - v2
Checksum:iA2F13BEBC25E496D
GO

Sequence cautioni

The sequence AAF54634 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF54634.1 Sequence problems.
AY118818 mRNA Translation: AAM50678.1
RefSeqiNP_001247047.1, NM_001260118.1
NP_650070.1, NM_141813.2
UniGeneiDm.13684

Genome annotation databases

EnsemblMetazoaiFBtr0301146; FBpp0290369; FBgn0037896
GeneIDi41369
KEGGidme:Dmel_CG6728
UCSCiCG6728-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiNINAG_DROME
AccessioniPrimary (citable) accession number: Q9VGP2
Secondary accession number(s): Q8MSH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: May 23, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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