Q9VGK8 (Q9VGK8_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
C-terminal Src kinase, isoform H EMBL AAF54668.3
EC=2.7.10.- EMBL AAF54668.3
EC=2.7.10.2 EMBL AAF54668.3

Gene names

Name:	Csk FlyBase FBgn0086688 FlyBase FBgn0086903 FlyBase FBgn0259217 FlyBase FBgn0262081
ORF Names:	Dmel_CG42317 EMBL AAF54668.3

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	805 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS020635
Sequence similarities	Contains 1 protein kinase domain. SAAS SAAS020635

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS020635 RuleBase RU000304 Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase SAAS SAAS020635
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9VGK8 [UniParc]. Last modified July 5, 2004. Version 3. Checksum: 1CD585A522567F2E	FASTA	805	87,172
	10 20 30 40 50 60 MSESIAIGFL QYIITINYDD EEAQARKTSH EKSQKPKPKP EENHKEKEAI SRKASGEGDL 70 80 90 100 110 120 ITVEIKQGLL RKQTATTTTG QAMNSHATAT QNGQTTVVGH HRGFSQPSVT VAAAAATGST 130 140 150 160 170 180 AGDPWFLQTT GHQMPPTAPL RHNKRPAPQP NAVLGAGSSG TAPGSAVGAV LLHQQQLSQS 190 200 210 220 230 240 QPHIVPPSIP PHHHHHRENN VHPIQAGAAA ALHLSSHALN SHNLISSASN HSPKSPSQTQ 250 260 270 280 290 300 QQQQTTNQQQ QQQQQQASHS ILSTFAPAPT VAAVQPAGSQ SVAGTAAAVA AVAQQQQQQH 310 320 330 340 350 360 LQLLANCPPG GAGLMSSSLN AAQMGMHGAE RALPPKSLAL SGSQHGSNML LHTAPQPPQA 370 380 390 400 410 420 SQPAAVVGVS GSGSAGMSTS LHSFDINGVT AGSGVNASSA WSSGSTTAMN HASLSPTALA 430 440 450 460 470 480 PQQGRSRCEV KLNAMPWFHG SITRDEAEHL LQPREDGLFL VRESTNFPGD YTLCVCFQSK 490 500 510 520 530 540 VEHYRVKYLE NKLTIDDEEY FENLGQLVAH YEADADGLCT QLIKCLPKLG KQEFCINSKD 550 560 570 580 590 600 FVDKGWVIPE AELQLRESIG KGEFGDVMLG ILRNEKVAVK MLKDEGAVQK FLAEASVMTT 610 620 630 640 650 660 LEHDNLVKFI GLVFTSKHLY LVTEYMSKGS LVDYLRSRGR QHITKKDQII FAYDTASGME 670 680 690 700 710 720 YLEAKKVVHR DLAARNVLIS EDCVAKVSDF GLAREECYNL DVGKLPIKWT APEALKNGRF 730 740 750 760 770 780 SNKSDMWSFG ILLWEIYSFG RVPYPRIPLA DVVKHVEVGY KMEAPEGCPP EIYEMMRQAW 790 800 DLNPAKRPTF AELKVKLQLL NNATA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014297 Genomic DNA. Translation: AAF54668.3.
RefSeq	NP_650097.2. NM_141840.1.
UniGene	Dm.37763.
3D structure databases
HSSP	HSSP built from PDB template 1BYG based on UniProtKB P41240.
ProteinModelPortal	Q9VGK8.
SMR	Q9VGK8. Positions 397-803.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VGK8. 16 interactions.
MINT	MINT-871725.
STRING	Q9VGK8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0300546; FBpp0289773; FBgn0262081.
GeneID	41398.
KEGG	dme:Dmel_CG42317.
Organism-specific databases
CTD	1445.
FlyBase	FBgn0262081. Csk.
Phylogenomic databases
GeneTree	EMGT00050000002730.
InParanoid	Q9VGK8.
OMA	HQMPPTA.
PhylomeDB	Q9VGK8.
Gene expression databases
ArrayExpress	Q9VGK8.
Bgee	Q9VGK8.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase. IPR000980. SH2. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
Gene3D	G3DSA:3.30.505.10. SH2. 1 hit.
KO	K05728.
Pfam	PF07714. Pkinase_Tyr. 1 hit. PF00017. SH2. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00109. TYRKINASE.
SMART	SM00252. SH2. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	823661.

Entry information

Entry name

Q9VGK8_DROME

Accession

Primary (citable) accession number: Q9VGK8
Secondary accession number(s): Q9VGK9

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 100 of the entry and version 3 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)