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Protein

Bloom syndrome protein homolog

Gene

Blm

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi759 – 7668ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent 3'-5' DNA helicase activity Source: FlyBase
  • ATP-dependent DNA helicase activity Source: FlyBase
  • DNA-dependent ATPase activity Source: FlyBase
  • DNA helicase activity Source: FlyBase
  • helicase activity Source: FlyBase
  • Y-form DNA binding Source: FlyBase

GO - Biological processi

  • cellular response to DNA damage stimulus Source: FlyBase
  • DNA duplex unwinding Source: FlyBase
  • DNA repair Source: FlyBase
  • DNA replication Source: UniProtKB-KW
  • DNA strand renaturation Source: FlyBase
  • DNA synthesis involved in DNA repair Source: FlyBase
  • double-strand break repair Source: FlyBase
  • double-strand break repair via homologous recombination Source: FlyBase
  • double-strand break repair via nonhomologous end joining Source: FlyBase
  • double-strand break repair via synthesis-dependent strand annealing Source: FlyBase
  • negative regulation of double-strand break repair via single-strand annealing Source: FlyBase
  • reciprocal meiotic recombination Source: FlyBase
  • strand displacement Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-3108214. SUMOylation of DNA damage response and repair proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Bloom syndrome protein homolog (EC:3.6.4.12)
Short name:
Dmblm
Alternative name(s):
Bloom syndrome helicase ortholog
Mutagen-sensitive protein 309
RecQ helicase homolog
Gene namesi
Name:Blm
Synonyms:mus309
ORF Names:CG6920
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0002906. Blm.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14871487Bloom syndrome protein homologPRO_0000205044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei52 – 521Phosphoserine1 Publication
Modified residuei53 – 531Phosphoserine1 Publication
Modified residuei92 – 921Phosphoserine1 Publication
Modified residuei94 – 941Phosphoserine1 Publication
Modified residuei108 – 1081Phosphoserine1 Publication
Modified residuei113 – 1131Phosphothreonine1 Publication
Modified residuei118 – 1181Phosphoserine1 Publication
Modified residuei120 – 1201Phosphoserine1 Publication
Modified residuei130 – 1301Phosphoserine1 Publication
Modified residuei151 – 1511Phosphoserine1 Publication
Modified residuei153 – 1531Phosphoserine1 Publication
Modified residuei180 – 1801Phosphoserine1 Publication
Modified residuei182 – 1821Phosphoserine1 Publication
Modified residuei197 – 1971Phosphoserine1 Publication
Modified residuei203 – 2031Phosphoserine1 Publication
Modified residuei328 – 3281Phosphoserine1 Publication
Modified residuei506 – 5061Phosphoserine1 Publication
Modified residuei509 – 5091Phosphoserine1 Publication
Modified residuei510 – 5101Phosphoserine1 Publication
Modified residuei535 – 5351Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9VGI8.
PRIDEiQ9VGI8.

PTM databases

iPTMnetiQ9VGI8.

Expressioni

Gene expression databases

BgeeiQ9VGI8.
ExpressionAtlasiQ9VGI8. differential.
GenevisibleiQ9VGI8. DM.

Interactioni

Protein-protein interaction databases

BioGridi66499. 14 interactions.
DIPiDIP-23386N.
IntActiQ9VGI8. 7 interactions.
MINTiMINT-784091.
STRINGi7227.FBpp0081910.

Structurei

3D structure databases

ProteinModelPortaliQ9VGI8.
SMRiQ9VGI8. Positions 714-1357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati89 – 1122411 PublicationAdd
BLAST
Repeati115 – 1382421 PublicationAdd
BLAST
Domaini746 – 921176Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini944 – 1093150Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini1283 – 136381HRDCPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni89 – 138502 X 24 AA repeats of L-D-L-S-V-S-P-L-A-E-L-[SP]-A-K-K-K-[YS]-[AD]-R-D-[SP]-P-P-K-PAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi865 – 8684DEAH box
Motifi1416 – 143217Nuclear localization signalBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi225 – 2306Poly-Pro
Compositional biasi464 – 4674Poly-Ser
Compositional biasi1369 – 13724Poly-Glu

Sequence similaritiesi

Belongs to the helicase family. RecQ subfamily.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 1 HRDC domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0351. Eukaryota.
COG0514. LUCA.
GeneTreeiENSGT00550000074520.
InParanoidiQ9VGI8.
KOiK10901.
OMAiDLCGEPD.
OrthoDBiEOG72NRPB.
PhylomeDBiQ9VGI8.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.80. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR004589. DNA_helicase_ATP-dep_RecQ.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR010997. HRDC-like.
IPR002121. HRDC_dom.
IPR027417. P-loop_NTPase.
IPR032284. RecQ_Zn-bd.
IPR018982. RQC_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00570. HRDC. 1 hit.
PF16124. RecQ_Zn_bind. 1 hit.
PF09382. RQC. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00341. HRDC. 1 hit.
SM00956. RQC. 1 hit.
[Graphical view]
SUPFAMiSSF47819. SSF47819. 1 hit.
SSF52540. SSF52540. 4 hits.
TIGRFAMsiTIGR00614. recQ_fam. 1 hit.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50967. HRDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VGI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKPVAQRK QLTLSSFIGL DGNSQSQPKS RAASVRSKPP AVYNPIFLDA
60 70 80 90 100
SSSDDETTEI SSQSNNGTIA TKKSSRDPRT AKLKKHTYLD LSVSPLAKLS
110 120 130 140 150
AKKYARDSPK KPTSLDLSVS PLAELLAKKS DRDSPKKPVQ NENSYTYRGL
160 170 180 190 200
SESPVENKSI GDTLRKPPQK ERKTSIVWLS DSPEKKVTQN ERKILDSPLQ
210 220 230 240 250
RFSFEDFPNK ENGNRHHLLT LPDSPPPPQP VKKPEKTMWQ NETKTIQDKD
260 270 280 290 300
SPANPLVSNN LASISTLLDS SRAPNTYKGS SRNLFEDSPE KSGSGEQGYK
310 320 330 340 350
LGSAKENEIP TKPATASLER NSVTSSPSPA APLKPRYSVA FDNSLADYLK
360 370 380 390 400
DLAQNDNFSI DPNKQNTETL KSTLGFFRNT YVELMEKYCS LIDQIPAMHF
410 420 430 440 450
NEIAGFQPNT FLKLKVMRQK FKARTQLVQN SLDKKESQLK AEQEALEKEE
460 470 480 490 500
IEMQAEQAQQ TVLSSSSPEK SRPIMPLPKV QEIKDEKIPN RNQLIHDLCG
510 520 530 540 550
EPDNFSPPSS PRDTQLIPKR QQLINDLCGE PDDFSPPSKQ NDPHLLRKCE
560 570 580 590 600
ELVHDLCEEP DDYLAQSMML DGDLEEEQLN GPTQGTTTSG MDDDEDDLEG
610 620 630 640 650
LLAEIEDEHQ KMQGRRSEFN GYSYKELEAV KVKEKHKETP INISLDDDGF
660 670 680 690 700
PEYDEAMFEQ MHSQAAANKS RVSSAGPSTS KSVVPTKQTS ALHSQKLSGN
710 720 730 740 750
FHANVHNDGI TGEFDGQKFE HSTRLMHGLS YSFGLKSFRP NQLQVINATL
760 770 780 790 800
LGNDCFVLMP TGGGKSLCYQ LPAILTEGVT IVISPLKSLI FDQINKLASL
810 820 830 840 850
DICAKSLSGE QKMADVMAIY RDLESQPPMV KLLYVTPEKI SSSARFQDTL
860 870 880 890 900
DTLNSNNYIS RFVIDEAHCV SQWGHDFRPD YKKLGVLKKR FPNVPTIALT
910 920 930 940 950
ATATPRVRLD ILAQLNLKNC KWFLSSFNRS NLRYRVLPKK GVSTLDDISR
960 970 980 990 1000
YIRSKPQHFS GIIYCLSRKE CDETSKKMCK DGVRAVSYHA GLTDTDRESR
1010 1020 1030 1040 1050
QKDWLTGKMR VICATVAFGM GIDKPDVRFV LHYSLPKSIE GYYQEAGRAG
1060 1070 1080 1090 1100
RDGDVADCIL YYNYSDMLRI KKMLDSDKAL QYNVKKIHVD NLYRIVGYCE
1110 1120 1130 1140 1150
NLTDCRRAQQ LDYFGEHFTS EQCLENRETA CDNCINKRAY KAVDALEHAR
1160 1170 1180 1190 1200
KAARAVKDLC SGRSRFTLLH IADVLKGSKI KKIIDFNHHK TPHHGVLKDW
1210 1220 1230 1240 1250
DKNDVHRLLR KMVIDGFLRE DLIFTNDFPQ AYLYLGNNIS KLMEGTPNFE
1260 1270 1280 1290 1300
FAVTKNAKEA KAAVGSVSDG ATSSTADGQS GMREIHERCY TDLLDLCRTI
1310 1320 1330 1340 1350
ASQRNVTMAS IMNIQALKSM AETLPITEKD MCSIPHVTKA NFDKYGAKLL
1360 1370 1380 1390 1400
EITSNYASEK LLMQAVLDEE EEQAAAKQRP STSGWNNESV DWDMAVASQG
1410 1420 1430 1440 1450
NANTSGASGF NSFRAGKRKK IYKSGASKRY KTSTTSPAAR KTTSARGRGG
1460 1470 1480
RAGAKRAESS ASSASGWKSK KTGNSFGFDL MPLPGSK
Length:1,487
Mass (Da):166,079
Last modified:May 1, 2000 - v1
Checksum:i07361B8005E29432
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti98 – 981K → E in AAD41441 (PubMed:10049920).Curated
Sequence conflicti110 – 1101K → P in AAD41441 (PubMed:10049920).Curated
Sequence conflicti126 – 1261L → P in AAD41441 (PubMed:10049920).Curated
Sequence conflicti134 – 1363SPK → PPP in AAD41441 (PubMed:10049920).Curated
Sequence conflicti169 – 1691Q → P in AAD41441 (PubMed:10049920).Curated
Sequence conflicti222 – 2221P → S in AAD41441 (PubMed:10049920).Curated
Sequence conflicti299 – 2991Y → N in AAD41441 (PubMed:10049920).Curated
Sequence conflicti417 – 4171M → V in AAD41441 (PubMed:10049920).Curated
Sequence conflicti459 – 4591Q → R in AAD41441 (PubMed:10049920).Curated
Sequence conflicti471 – 4711S → C in AAD41441 (PubMed:10049920).Curated
Sequence conflicti496 – 4961H → P in AAD41441 (PubMed:10049920).Curated
Sequence conflicti594 – 5941D → G in AAD41441 (PubMed:10049920).Curated
Sequence conflicti614 – 6141G → A in AAD41441 (PubMed:10049920).Curated
Sequence conflicti805 – 8051K → E in AAD41441 (PubMed:10049920).Curated
Sequence conflicti1116 – 11161E → G in AAD41441 (PubMed:10049920).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92536 mRNA. Translation: AAD41441.1.
AE014297 Genomic DNA. Translation: AAF54691.1.
RefSeqiNP_524319.2. NM_079595.3.
UniGeneiDm.2444.

Genome annotation databases

EnsemblMetazoaiFBtr0082434; FBpp0081910; FBgn0002906.
GeneIDi41366.
KEGGidme:Dmel_CG6920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92536 mRNA. Translation: AAD41441.1.
AE014297 Genomic DNA. Translation: AAF54691.1.
RefSeqiNP_524319.2. NM_079595.3.
UniGeneiDm.2444.

3D structure databases

ProteinModelPortaliQ9VGI8.
SMRiQ9VGI8. Positions 714-1357.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66499. 14 interactions.
DIPiDIP-23386N.
IntActiQ9VGI8. 7 interactions.
MINTiMINT-784091.
STRINGi7227.FBpp0081910.

PTM databases

iPTMnetiQ9VGI8.

Proteomic databases

PaxDbiQ9VGI8.
PRIDEiQ9VGI8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0082434; FBpp0081910; FBgn0002906.
GeneIDi41366.
KEGGidme:Dmel_CG6920.

Organism-specific databases

CTDi641.
FlyBaseiFBgn0002906. Blm.

Phylogenomic databases

eggNOGiKOG0351. Eukaryota.
COG0514. LUCA.
GeneTreeiENSGT00550000074520.
InParanoidiQ9VGI8.
KOiK10901.
OMAiDLCGEPD.
OrthoDBiEOG72NRPB.
PhylomeDBiQ9VGI8.

Enzyme and pathway databases

ReactomeiR-DME-3108214. SUMOylation of DNA damage response and repair proteins.

Miscellaneous databases

ChiTaRSiBlm. fly.
GenomeRNAii41366.
NextBioi823498.
PROiQ9VGI8.

Gene expression databases

BgeeiQ9VGI8.
ExpressionAtlasiQ9VGI8. differential.
GenevisibleiQ9VGI8. DM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.80. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR004589. DNA_helicase_ATP-dep_RecQ.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR010997. HRDC-like.
IPR002121. HRDC_dom.
IPR027417. P-loop_NTPase.
IPR032284. RecQ_Zn-bd.
IPR018982. RQC_domain.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00570. HRDC. 1 hit.
PF16124. RecQ_Zn_bind. 1 hit.
PF09382. RQC. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00341. HRDC. 1 hit.
SM00956. RQC. 1 hit.
[Graphical view]
SUPFAMiSSF47819. SSF47819. 1 hit.
SSF52540. SSF52540. 4 hits.
TIGRFAMsiTIGR00614. recQ_fam. 1 hit.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50967. HRDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Evolution of the RECQ family of helicases: a Drosophila homolog, Dmblm, is similar to the human Bloom syndrome gene."
    Kusano K., Berres M.E., Engels W.R.
    Genetics 151:1027-1039(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], REPEATS.
    Strain: Canton-S.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52; SER-53; SER-92; SER-94; SER-108; THR-113; SER-118; SER-120; SER-130; SER-151; SER-153; SER-180; SER-182; SER-197; SER-203; SER-328; SER-506; SER-509; SER-510 AND SER-535, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiBLM_DROME
AccessioniPrimary (citable) accession number: Q9VGI8
Secondary accession number(s): Q9Y062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.