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Protein

Cadherin-87A

Gene

Cad87A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-87A
Gene namesi
Name:Cad87A
ORF Names:CG6977
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0037963. Cad87A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 17751758ExtracellularSequence analysisAdd
BLAST
Transmembranei1776 – 179621HelicalSequence analysisAdd
BLAST
Topological domaini1797 – 1975179CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 19751958Cadherin-87APRO_0000004007Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence analysis
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence analysis
Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence analysis
Glycosylationi424 – 4241N-linked (GlcNAc...)1 Publication
Glycosylationi730 – 7301N-linked (GlcNAc...)Sequence analysis
Glycosylationi761 – 7611N-linked (GlcNAc...)Sequence analysis
Glycosylationi1039 – 10391N-linked (GlcNAc...)Sequence analysis
Glycosylationi1049 – 10491N-linked (GlcNAc...)Sequence analysis
Glycosylationi1111 – 11111N-linked (GlcNAc...)Sequence analysis
Glycosylationi1163 – 11631N-linked (GlcNAc...)Sequence analysis
Glycosylationi1217 – 12171N-linked (GlcNAc...)Sequence analysis
Glycosylationi1325 – 13251N-linked (GlcNAc...)Sequence analysis
Glycosylationi1349 – 13491N-linked (GlcNAc...)Sequence analysis
Glycosylationi1492 – 14921N-linked (GlcNAc...)Sequence analysis
Glycosylationi1576 – 15761N-linked (GlcNAc...)1 Publication
Glycosylationi1691 – 16911N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9VGG5.
PRIDEiQ9VGG5.

Expressioni

Gene expression databases

BgeeiQ9VGG5.
GenevisibleiQ9VGG5. DM.

Interactioni

Protein-protein interaction databases

IntActiQ9VGG5. 2 interactions.
STRINGi7227.FBpp0081987.

Structurei

3D structure databases

ProteinModelPortaliQ9VGG5.
SMRiQ9VGG5. Positions 20-568, 582-1662.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 132105Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini133 – 245113Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini246 – 358113Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini359 – 472114Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini473 – 669197Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini670 – 774105Cadherin 6PROSITE-ProRule annotationAdd
BLAST
Domaini775 – 878104Cadherin 7PROSITE-ProRule annotationAdd
BLAST
Domaini879 – 998120Cadherin 8PROSITE-ProRule annotationAdd
BLAST
Domaini999 – 1103105Cadherin 9PROSITE-ProRule annotationAdd
BLAST
Domaini1104 – 1211108Cadherin 10PROSITE-ProRule annotationAdd
BLAST
Domaini1212 – 1318107Cadherin 11PROSITE-ProRule annotationAdd
BLAST
Domaini1319 – 1431113Cadherin 12PROSITE-ProRule annotationAdd
BLAST
Domaini1432 – 1553122Cadherin 13PROSITE-ProRule annotationAdd
BLAST
Domaini1554 – 1677124Cadherin 14PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 14 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
InParanoidiQ9VGG5.
OMAiEEVYQEQ.
OrthoDBiEOG7BP81N.
PhylomeDBiQ9VGG5.

Family and domain databases

Gene3Di2.60.40.60. 15 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 9 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 14 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 14 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VGG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLPLGLLMI CLGLTLAKGE TNLPPVFTQT LNNIILYENV TVGTVVFRLE
60 70 80 90 100
AYDPEGSPVT YGAIGADHFS VDPVSGNITL IKPLDREEKD TLKFLVSIRD
110 120 130 140 150
RVDPEGESER DNVVEVPITF IILDLNDNPP EFQNTPYEAD VNEDAAVGTT
160 170 180 190 200
IFDKITVKDR DIVGESLDLK CLPQQQSPEA CRKFRLHIIK RDATILEAAV
210 220 230 240 250
VLNDTLNYNQ RMVYHFQIEA TDGPHKTQTT FEARVKDVQD KPPVFQGSLS
260 270 280 290 300
TVIDEDSPIN TLVLTVHARD GDTGEPRKIV YDLRTNPNDY FLLDAQTGEL
310 320 330 340 350
RTAKPLDREA LEDSTGIISL VIRARELVNG VPSDDPLTSA TAKATVTIRD
360 370 380 390 400
VNDSPPVFNH KEYSVSLLEN TLPGTPLALD MSVSDADVGI NSKFALRLDD
410 420 430 440 450
VSGVFDVEPK LVTGYSQVNI RVANGTLDYE NPNQRKFIVL VVAEETDTNP
460 470 480 490 500
RLSSTATITV SVLDANDNKP VFEQESYSAS VSEAALPGQY IATITARDVD
510 520 530 540 550
SGSYGDSGIR YSLSGTGAEL FHVNEQTGVI SLANCHDNGE SNRRERRDLN
560 570 580 590 600
EDEHVEEDDG EGHLEMLSME AATREIGTEP TVQYTLITQA PEEQASSVPL
610 620 630 640 650
PAPVPHAAPS GVPAATANDD KAPQTCLDYE SETTYFLSYK ATDDNGRGSA
660 670 680 690 700
SVVSLRISVT DANDSPPVCE SPLYRASVDE GAVVFDSPLI VKARDADTMS
710 720 730 740 750
RISYRIRGSE QVESIFDIDR ETGQIIIRPN ATLDVTNLNS DQLIFAVEAN
760 770 780 790 800
DGLFTAHCGV NITVRDVNNH VPNFEQQSYS AVVEENSEIG TSVERVHATD
810 820 830 840 850
LDTGKNAELR YRIQQGSFDD FGIVETTGEV FVSRKLDFDR RNTYQLQIQA
860 870 880 890 900
SDQGTPSLTG TATLTINVQN SNDKDPYFVP ATQHAEVRAD APPGQLVYTL
910 920 930 940 950
IALDPDVANH NALEFAGTDD ITAIDKEGKE LPHYDQFKEY FKISRNGKVS
960 970 980 990 1000
VNKQLDRNLF AVMRINVLVT DSTAPNVQQG RGLLIIQIID VNKNPPRFNA
1010 1020 1030 1040 1050
PWSVEQPQIK LQMVEEQPVG TVLTTLQAND EDSSIGEFNI SDNDYFAINQ
1060 1070 1080 1090 1100
TSGMIYTIAR LDYEVVKEVK FQVTVSDTGV PALTATADVV VDIINLNDND
1110 1120 1130 1140 1150
PKFSQSDYYF NVTENSPRGT VAGKVEAHDG DVGVFGEITY TLIGENNKYF
1160 1170 1180 1190 1200
SIDAYTGNVM VANSSILDRE QIKELTLSVV AQDKAPAAVQ KSATATIHIN
1210 1220 1230 1240 1250
ILDVNDNAPV FTRDVYNSTV AENAAYQPPA ALLQVQAIDQ DEGLYGDVRY
1260 1270 1280 1290 1300
IITAGNEMGL FKLDAQSGIV YPAQSLSGKH GAYELTISAR DTQGSGTMES
1310 1320 1330 1340 1350
TTKAIITVLR VNRHKPEFVI PALSNATIEI PGDIVQPDYL LLTVRAMDND
1360 1370 1380 1390 1400
TEENGKVSYH LQVNNRNEQQ TGEFKIDEVT GELRAKTQLN RKNRANYDII
1410 1420 1430 1440 1450
LVARDAGNPP FESLRLLSVS IVDANENRPE FPDASNPYKV SINENSGRDV
1460 1470 1480 1490 1500
KIGHIQAASR SKHNRDIFYY MLLGNEDGAF YVDKLTGDIY TNKSLDREET
1510 1520 1530 1540 1550
DVYTLYILAS IKADLHISEE ERASFSIKTL NRDNTVAKVA ITVLDVNDNP
1560 1570 1580 1590 1600
PVFEKPIYYA GVNANAKMGA AITLVNATDA DQGKNAKIEF MIVASNLYKF
1610 1620 1630 1640 1650
GATKSTGSIV PSPFAISQDG RISANTIMAE YNQDRFELEI VARELEQPQS
1660 1670 1680 1690 1700
SASTKVNIWV FDGTQLVRVI LSRPPEEVYQ EQEEIIAELR NATQHRIIVD
1710 1720 1730 1740 1750
EIRFHLDSIG RIRMDWCDLY FHAVDPQTQQ IAPVDEILKD IDRNYDYLKD
1760 1770 1780 1790 1800
YYAGFAIENV VPAYIAIVQD EFDLAVAGLV ALVIVLFVGV ISFIVLCCCL
1810 1820 1830 1840 1850
KHWNLSVPVE TRRKEALIKK QIIEDLNTTE NPLWIEQKLK LYEEQELTMQ
1860 1870 1880 1890 1900
VFSEPDHISN SEAPGHLDHR SSLEQVHHVG QTVDNTYATI QPRNNQNRLT
1910 1920 1930 1940 1950
GGGGAGGGSM RSGGGASAGG VGGAGLLLAR VDPHMNEFAD YATLRNNRAP
1960 1970
SLYEFTGSTF QAPIRDGDDA VAELI
Length:1,975
Mass (Da):217,557
Last modified:May 10, 2004 - v4
Checksum:i91BF71B0461D6E4F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti771 – 7711V → M in AAM75098 (PubMed:12537569).Curated
Sequence conflicti1110 – 11101F → S in AAM75098 (PubMed:12537569).Curated
Sequence conflicti1650 – 16501S → R in AAM75098 (PubMed:12537569).Curated
Sequence conflicti1690 – 16901R → C in AAM75098 (PubMed:12537569).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF54717.4.
AY128505 mRNA. Translation: AAM75098.1.
RefSeqiNP_731649.2. NM_169440.3.
UniGeneiDm.10799.

Genome annotation databases

EnsemblMetazoaiFBtr0082513; FBpp0081987; FBgn0037963.
GeneIDi41441.
KEGGidme:Dmel_CG6977.
UCSCiCG6977-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF54717.4.
AY128505 mRNA. Translation: AAM75098.1.
RefSeqiNP_731649.2. NM_169440.3.
UniGeneiDm.10799.

3D structure databases

ProteinModelPortaliQ9VGG5.
SMRiQ9VGG5. Positions 20-568, 582-1662.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9VGG5. 2 interactions.
STRINGi7227.FBpp0081987.

Proteomic databases

PaxDbiQ9VGG5.
PRIDEiQ9VGG5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0082513; FBpp0081987; FBgn0037963.
GeneIDi41441.
KEGGidme:Dmel_CG6977.
UCSCiCG6977-RA. d. melanogaster.

Organism-specific databases

CTDi41441.
FlyBaseiFBgn0037963. Cad87A.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
InParanoidiQ9VGG5.
OMAiEEVYQEQ.
OrthoDBiEOG7BP81N.
PhylomeDBiQ9VGG5.

Miscellaneous databases

GenomeRNAii41441.
PROiQ9VGG5.

Gene expression databases

BgeeiQ9VGG5.
GenevisibleiQ9VGG5. DM.

Family and domain databases

Gene3Di2.60.40.60. 15 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 9 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 14 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 14 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. "A Drosophila full-length cDNA resource."
    Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
    Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 443-1975.
    Strain: Berkeley.
    Tissue: Embryo.
  4. "Identification of N-glycosylated proteins from the central nervous system of Drosophila melanogaster."
    Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L., Panin V.
    Glycobiology 17:1388-1403(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-424 AND ASN-1576, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Oregon-R.
    Tissue: Head.

Entry informationi

Entry nameiCAD87_DROME
AccessioniPrimary (citable) accession number: Q9VGG5
Secondary accession number(s): Q8MQL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: May 10, 2004
Last modified: June 8, 2016
This is version 113 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.