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Protein

Phospholipid-transporting ATPase

Gene

ATP8B

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).UniRule annotationSAAS annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-UniRule
  • magnesium ion binding Source: UniProtKB-UniRule
  • phospholipid-translocating ATPase activity Source: FlyBase

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of smell Source: FlyBase
  • Golgi organization Source: GO_Central
  • phospholipid translocation Source: FlyBase
  • regulation of protein localization Source: FlyBase

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-6798695. Neutrophil degranulation.
R-DME-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPaseUniRule annotation (EC:3.6.3.1UniRule annotation)
Gene namesi
Name:ATP8BImported
ORF Names:CG14741Imported, Dmel_CG14741Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0037989. ATP8B.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei453 – 482HelicalUniRule annotationAdd BLAST30
Transmembranei502 – 531HelicalUniRule annotationAdd BLAST30
Transmembranei1388 – 1408HelicalUniRule annotationAdd BLAST21
Transmembranei1438 – 1460HelicalUniRule annotationAdd BLAST23
Transmembranei1466 – 1487HelicalUniRule annotationAdd BLAST22
Transmembranei1499 – 1522HelicalUniRule annotationAdd BLAST24
Transmembranei1542 – 1565HelicalUniRule annotationAdd BLAST24

GO - Cellular componenti

  • cilium Source: FlyBase
  • Golgi apparatus Source: GO_Central
  • integral component of membrane Source: FlyBase
  • plasma membrane Source: GO_Central
  • sensory dendrite Source: FlyBase

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ9VGD4.
PRIDEiQ9VGD4.

Expressioni

Gene expression databases

BgeeiFBgn0037989.
ExpressionAtlasiQ9VGD4. differential.
GenevisibleiQ9VGD4. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0289580.

Structurei

3D structure databases

ProteinModelPortaliQ9VGD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini196 – 261PhoLip_ATPase_NInterPro annotationAdd BLAST66
Domaini1324 – 1570PhoLip_ATPase_CInterPro annotationAdd BLAST247

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00870000136387.
InParanoidiQ9VGD4.
OMAiGFGELIM.
OrthoDBiEOG091G0139.
PhylomeDBiQ9VGD4.

Family and domain databases

Gene3Di3.40.1110.10. 2 hits.
3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
PANTHERiPTHR24092. PTHR24092. 1 hit.
PfamiView protein in Pfam
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81653. SSF81653. 2 hits.
SSF81660. SSF81660. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VGD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGGRRCSEA ARRLRRRPDT LELSVLGGQP IETELQEDNE RTPTKGAGNV
60 70 80 90 100
DEPGIEAPEA SCSAPSKRTR WFQFARSSKN RRKRLHCNED EDVKQPERRN
110 120 130 140 150
SDLEGSPRAC LAQPEGMNIG SSTQTIATPL MIGDSFYSLA PGGGNPPPNK
160 170 180 190 200
SDDQELYKQR DPSVTSESKS VPSLRRLSQI RRRRSSYYFS ENERRIRAND
210 220 230 240 250
KEFNAQFKYH NNYIKTSKYS LFTFLPFNLL EQFQRLANFY FLCLLVLQLI
260 270 280 290 300
PAISSLTPVT TAIPLIGVLT LTAVKDAYDD IQRHISDSQV NNRKSKTLRN
310 320 330 340 350
GKLVEAKWSE VQVGDVIRLD NNQFVAADTL LLSTSEPNGL CFIETAELDG
360 370 380 390 400
ETNLKAKQCL TETIELGDRH DSLWNFNGEI ICERPNNLLN KFDGTLIWRG
410 420 430 440 450
QRFALDNEKI LLRGCVLRNT QWCYGVVVFA GVDTKLMQNS GKTQFKSTGV
460 470 480 490 500
DRLLNFIIIG IVLFLVSICA LFAIGCAIWE GLIGQHFQLY LPWEHIIPKD
510 520 530 540 550
YIPTGATVIG LLVFFSYAIV LNTVVPISLY VSVEVIRFVQ SFLINWDEEM
560 570 580 590 600
YYPTTNTYAK ARTTTLNEEL GQIQYIFSDK TGTLTQNIMT FNKCSINGRS
610 620 630 640 650
YGDVIDLRTG ELVEITEQQT IFQNSNTNNR PSPLSGAIVA PPAAPPPIIL
660 670 680 690 700
VHKAEVHAKK TSMVVTSSGE AQVLPDRPRS DIERSAPPMD ASEKRPGLKH
710 720 730 740 750
VRYSAPSRSQ DADAGRLSPR LDGSGGLSPP VGNEERRISG GFKRSGAGCM
760 770 780 790 800
QRQLSRTSSC DKVKILHDSQ QTETHNMHHS SHNRKRLVKI RFKKAPSTAT
810 820 830 840 850
LGVVISQLEH HLDEEPQSTS TLSTTKHHHH RSKAFATNWS SSPHRVHALQ
860 870 880 890 900
SVDFSANPHH ESDFRWYDRT LLDAVRSDEE HSHVFFRLLA LCHTVMAETV
910 920 930 940 950
DGKLEYQAQS PDEAALVSAA RNFGFVFRTR TPNSITIEVM GQTEEYELLN
960 970 980 990 1000
ILDFNNVRKR MSVILRRGDS MVLYCKGADN VIYDRLHGGQ EDLKARTQDH
1010 1020 1030 1040 1050
LNKFAGEGLR TLALAERRLT EQYYNDWRSR QQEAALSMDS REQKLNAIYE
1060 1070 1080 1090 1100
EIESEMQLVG VTAIEDKLQD GVPKSIANLQ NAGIKIWVLT GDKQETAINI
1110 1120 1130 1140 1150
GYSCQLLTDE LADVFIVDGN SVEEVEKQLR QFKESIKIYN RFRPGGFDPF
1160 1170 1180 1190 1200
DRLNSDSNMD PLSVTMTQTS AFMQETNLPP TPPPPPAISV VTFRWDEKNK
1210 1220 1230 1240 1250
DNKGGPDSAE CNNLFGDEKG SEDGGTASIV VDENTGFALV VNGHSLVHCL
1260 1270 1280 1290 1300
SPELENKFLD IASQCKAVIC CRVTPLQKAL VVELIKRAKN AVTLAIGDGA
1310 1320 1330 1340 1350
NDVSMIKAAH IGVGISGQEG LQAVLSSDYS IAQFRYLERL LLVHGRWSYY
1360 1370 1380 1390 1400
RMCKFLRYFF YKNFAFTLCH CWYSLFCGFS AQTVFDPMFI SVYNLFYTSL
1410 1420 1430 1440 1450
PVLALGVFEQ DVSDKNSLEF PRLYTPGLKS ELFNIREFIY SVLHGAFTSL
1460 1470 1480 1490 1500
VLFLIPYGVY KDGVSANGFV VSDHMTLGAV VATILIVDNT AQISLYTSYW
1510 1520 1530 1540 1550
TVVNHVTIWG SLVWYFVLDY FYNYVIGGPY VGSLTQAMKD LTFWVTMLIT
1560 1570 1580 1590 1600
VMALVAPVLA YKFYLLDVHP SLSDKIRQKS LKKIHSRASS DVRRTASSRR
1610 1620 1630 1640 1650
GRRSVRSGYA FAHQEGFGRL ITSGKIMHKL PQDFAFPLGL GTKKTQVLHN
1660 1670 1680 1690 1700
NLNSADGPNS KGNNVTGHHM VNNNTNMRHN QNQNHSSMAD ITADGRGNGG
1710 1720
DDGRGSGGSD DMSPRAPCQD LDTINL
Length:1,726
Mass (Da):193,368
Last modified:November 30, 2010 - v2
Checksum:i27B6C90D191FEF55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF54749.2.
RefSeqiNP_731669.2. NM_169450.4.

Genome annotation databases

EnsemblMetazoaiFBtr0300351; FBpp0289580; FBgn0037989.
GeneIDi41469.
UCSCiCG14741-RB. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ9VGD4_DROME
AccessioniPrimary (citable) accession number: Q9VGD4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: November 30, 2010
Last modified: July 5, 2017
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported