Reviewed, UniProtKB/Swiss-Prot Q9VGC3 (COG1_DROME)

Names and origin

Protein names

Recommended name:
    Conserved oligomeric Golgi complex subunit 1
      Short name=COG complex subunit 1
Alternative name(s):
    Component of oligomeric Golgi complex 1

Gene names

ORF Names:

CG4848

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	886 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Required for normal Golgi function By similarity.
Subunit structure	Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization By similarity.
Subcellular location	Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side By similarity.
Sequence similarities	Belongs to the COG1 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Golgi apparatus Membrane
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CG6488	Q9VKH0	1	EBI-195650,EBI-88610

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 886	886	Conserved oligomeric Golgi complex subunit 1		PRO_0000213493
Amino acid modifications
	Modified residue	839	1	Phosphoserine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q9VGC3-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 2DE97D584476FBC8	FASTA	886	99,716
	10 20 30 40 50 60 MTANLLNLNV DTLFEQHSVS EIDEVHKKIQ SVVENKREEL RTHVGERYRD LLQAADTIAA 70 80 90 100 110 120 MQTSAGTLME QVRHVQANCR SLNEQQLLGF QSTANASAKD AALKERNAGK KLQTYYGTMA 130 140 150 160 170 180 QIKLLTALPE LIWTHLDNDR FYAATELFIF SRHISTGLQL DGQSALMQKL PVARKQWEIL 190 200 210 220 230 240 RPFHVTIKQA ILTALEREEL LQEMTVDCLQ SLLLLDKSDL STVLKSFLNL RSSAFLNCLQ 250 260 270 280 290 300 SGPSEPRRVK DRILASLNVL NSTVELLDKC LLGYSLLFSR LEECASSTCP PSINRMESSE 310 320 330 340 350 360 RQLVHLLPEI IAGFKPQFDV PQLTPEQLGS SLQQWLDKMN ALAAAHLQQV FALVTNMQTI 370 380 390 400 410 420 QDIKSAARTN GRPDFVRLEQ QLHLKRSQLD FYARKYVPLI NARVREIIRS SWASAMKLTY 430 440 450 460 470 480 EQVLLLIEAG QSQPPLQIWR EQSDDLPLSL AAALSDQPKR LANRTKGYDG ATIELCKRFD 490 500 510 520 530 540 SHLADIVQEL NVMLQEQTTR AEDKVSLIEF LRETAEEQLT EYLSNLKGLE LRERPALLLA 550 560 570 580 590 600 LRNSLALVEL CPNLKLCFCQ PSSWRQWTDN SAGLGIEHWQ RICGLIEKEM LSFWLVIVDD 610 620 630 640 650 660 VLAGHNCEEK LPKVINHEVV LSDFALWQTL TLEQRDEDQE QSVQSTIRIP SQPRLSLQTY 670 680 690 700 710 720 LHQLIQALNS VVPQTLPPKV LQAFIQRLIG KLLCHYEGLA HAECTKASQN IALQLYFDLK 730 740 750 760 770 780 FLERVFAISR EERTLYDQIH AQQNQLRDYI DPFDFELFAE HITAHVSRAA SRLQGELGVL 790 800 810 820 830 840 TPSAAAPSQG AAAASSLAHE ADPNVLCLSS SGSTSLWFPL LPIVMPQAAG RVTSAERKSP 850 860 870 880 IQEPVEKTAT TTPTRKSGGN GARKGDSSKS KSSAASFFGM SQEWFR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Head.
[4]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-839, MASS SPECTROMETRY. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014297 Genomic DNA. Translation: AAF54760.1. AY058448 mRNA. Translation: AAL13677.1.
RefSeq	NP_650162.1.
UniGene	Dm.4266
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:23267N.
IntAct	Q9VGC3. 2 interactions.
Proteomic databases
PRIDE	Q9VGC3.
Genome annotation databases
Ensembl	FBgn0037998. Drosophila melanogaster. [Contig view]
GeneID	41479.
KEGG	dme:Dmel_CG4848.
NMPDR	fig|7227.3.peg.12381.
Organism-specific databases
FlyBase	FBgn0037998. CG4848.
Phylogenomic databases
HOGENOM	Q9VGC3.
OMA	Q9VGC3. FLWSESP.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-011220-MON.
Gene expression databases
ArrayExpress	Q9VGC3.
GermOnline	CG4848. Drosophila melanogaster.
Family and domain databases
InterPro	IPR014812. Vps51. [Graphical view]
Pfam	PF08700. Vps51. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	824083.

Entry information

Entry name

COG1_DROME

Accession

Primary (citable) accession number: Q9VGC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project