Q9VGA1 (Q9VGA1_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Glutathione S transferase D10 EMBL AAF54784.1
EC=2.5.1.18 EMBL AAF54784.1

Submitted name:
IP02193p EMBL ABE01241.1
Submitted name:
IP02196p EMBL ABK57060.1

Gene names

Name:	GstD10 EMBL ABE01241.1 FlyBase FBgn0042206
ORF Names:	Dmel_CG18548 EMBL AAF54784.1

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 GST C-terminal domain. SAAS SAAS004045 Contains 1 GST N-terminal domain. SAAS SAAS004045

Ontologies

Keywords
Molecular function	Transferase EMBL AAF54784.1
Technical term	3D-structure PDB 3GH6 PDB 3F6F Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glutathione metabolic process Inferred from direct assay PubMed 22082028. Source: FlyBase
Molecular_function	glutathione transferase activity Inferred from direct assay PubMed 12443531PubMed 22082028. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	51 – 53	3	Glutathione binding PDB 3GH6
	Region	65 – 67	3	Glutathione binding PDB 3GH6
Sites
	Binding site	9	1	Glutathione PDB 3GH6
	Binding site	39	1	Glutathione PDB 3GH6

Sequences

	Sequence		Length	Mass (Da)
	Q9VGA1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: C47BB348D6AC34B3	FASTA	210	24,593
	10 20 30 40 50 60 MDLYYRPGSA PCRSVLMTAK ALGVEFDKKT IINTRAREQF TPEYLKINPQ HTIPTLHDHG 70 80 90 100 110 120 FALWESRAIM VYLVEKYGKD DKLFPKDVQK QALINQRLYF DMGTLYKSFS EYYYPQIFLK 130 140 150 160 170 180 KPANEENYKK IEVAFEFLNT FLEGQTYSAG GDYSLADIAF LATVSTFDVA GFDFKRYANV 190 200 210 ARWYENAKKL TPGWEENWAG CQEFRKYFDN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[3]	Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J., Park S., Wan K., Yu C., Celniker S. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Stapleton M., Carlson J., Frise E., Kapadia B., Park S., Wan K., Yu C., Celniker S. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[5]	"Crystal Structure of Glutathione Transferase dmGSTD10 from Drosophila melanogaster." Wongsantichon J., Robinson R.C., Ketterman A.J. Submitted (NOV-2008) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).
[6]	"Crystal Structure of Glutathione Transferase dmGSTD10 from Drosophila melanogaster." Wongsantichon J., Robinson R.C., Ketterman A.J. Submitted (MAR-2009) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) IN COMPLEX WITH GLUTATHIONE.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE014297 Genomic DNA. Translation: AAF54784.1.
BT025011 mRNA. Translation: ABE01241.1.
BT029403 mRNA. Translation: ABK57060.1.

RefSeq

NP_652713.1. NM_144456.2.

UniGene

Dm.24889.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3F6F	X-ray	1.60	A	1-210	[»]
3GH6	X-ray	1.65	A	1-210	[»]

SMR

Q9VGA1. Positions 1-209.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-1018146.

STRING

7227.FBpp0082079.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblMetazoa

FBtr0082609; FBpp0082079; FBgn0042206.

GeneID

59240.

KEGG

dme:Dmel_CG18548.

UCSC

CG18548-RA. d. melanogaster.

Organism-specific databases

CTD

59240.

FlyBase

FBgn0042206. GstD10.

Phylogenomic databases

eggNOG

COG0625.

GeneTree

ENSGT00540000069741.

InParanoid

Q9VGA1.

KO

K00799.

OMA

FRKYFDN.

OrthoDB

EOG441NTC.

Family and domain databases

Gene3D

1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.

InterPro

IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR017933. Glutathione_S_Trfase/Cl_chnl_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]

SUPFAM

SSF47616. GST_C_like. 1 hit.
SSF52833. Thiordxn-like_fd. 1 hit.

PROSITE

PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9VGA1.

GenomeRNAi

59240.

NextBio

841731.

Entry information

Entry name

Q9VGA1_DROME

Accession

Primary (citable) accession number: Q9VGA1

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)