Reviewed, UniProtKB/Swiss-Prot Q9VG98 (GSTT2_DROME)

Names and origin

Protein names

Recommended name:
    Glutathione S-transferase D2
      Short name=DmGST21
    EC=2.5.1.18

Gene names

Name:	GstD2
Synonyms:	gstD21
ORF Names:	CG4181

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the GST superfamily. Theta family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	glutathione peroxidase activity Traceable author statement. Source: FlyBase glutathione transferase activity Inferred from direct assay. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 215	215	Glutathione S-transferase D2		PRO_0000185954
Regions
	Domain	1 – 80	80	GST N-terminal
	Domain	86 – 212	127	GST C-terminal

Sequences

	Sequence		Length	Mass (Da)
	Q9VG98-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 221A9961BBF0E5B5	FASTA	215	24,535
	10 20 30 40 50 60 MDFYYMPGGG GCRTVIMVAK ALGLELNKKL LNTMEGEQLK PEFVKLNPQH TIPTLVDNGF 70 80 90 100 110 120 SIWESRAIAV YLVEKYGKDD YLLPNDPKKR AVINQRLYFD MGTLYESFAK YYYPLFRTGK 130 140 150 160 170 180 PGSDEDLKRI ETAFGFLDTF LEGQEYVAGD QLTVADIAIL STVSTFEVSE FDFSKYSNVS 190 200 210 RWYDNAKKVT PGWDENWEGL MAMKALFDAR KLAAK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The glutathione S-transferase D genes. A divergently organized, intronless gene family in Drosophila melanogaster." Toung Y.-P.S., Hsieh T.-S., Tu C.-P.D. J. Biol. Chem. 268:9737-9746(1993) [PubMed: 7683659] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M97702 Genomic DNA. No translation available. AE014297 Genomic DNA. Translation: AAF54787.1.
PIR	D46681.
RefSeq	NP_524912.1.
UniGene	Dm.1756
3D structure databases
HSSP	HSSP built from PDB template 1JLV based on UniProtKB Q9GNE9.
ModBase	Search...
Proteomic databases
PRIDE	Q9VG98.
Genome annotation databases
Ensembl	FBgn0010038. Drosophila melanogaster. [Contig view]
GeneID	48335.
KEGG	dme:Dmel_CG4181.
Organism-specific databases
FlyBase	FBgn0010038. GstD2.
Phylogenomic databases
HOGENOM	Q9VG98.
OMA	Q9VG98. FRTGKPG.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-011247-MON.
BRENDA	2.5.1.18. 48.
Gene expression databases
ArrayExpress	Q9VG98.
GermOnline	CG4181. Drosophila melanogaster.
Family and domain databases
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. [Graphical view]
Gene3D	G3DSA:1.20.1050.10. GST_C_like. 1 hit.
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	839325.

Entry information

Entry name

GSTT2_DROME

Accession

Primary (citable) accession number: Q9VG98
Secondary accession number(s): Q9TX91

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project