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Q9VG96

- GSTT4_DROME

UniProt

Q9VG96 - GSTT4_DROME

Protein

Glutathione S-transferase D4

Gene

GstD4

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei9 – 91GlutathioneBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: FlyBase
    2. protein binding Source: IntAct

    GO - Biological processi

    1. glutathione metabolic process Source: FlyBase

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase D4 (EC:2.5.1.18)
    Short name:
    DmGST23
    Gene namesi
    Name:GstD4
    Synonyms:gstD23
    ORF Names:CG11512
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0010040. GstD4.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 215215Glutathione S-transferase D4PRO_0000185956Add
    BLAST

    Proteomic databases

    PaxDbiQ9VG96.
    PRIDEiQ9VG96.

    Expressioni

    Gene expression databases

    BgeeiQ9VG96.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GstD6Q9VG943EBI-117276,EBI-152218

    Protein-protein interaction databases

    BioGridi71334. 8 interactions.
    DIPiDIP-19902N.
    IntActiQ9VG96. 5 interactions.
    MINTiMINT-793961.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VG96.
    SMRiQ9VG96. Positions 1-207.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8080GST N-terminalAdd
    BLAST
    Domaini86 – 207122GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni50 – 523Glutathione bindingBy similarity
    Regioni64 – 663Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Theta family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0625.
    GeneTreeiENSGT00540000069741.
    InParanoidiQ9VG96.
    KOiK00799.
    OMAiNGFAIWE.
    OrthoDBiEOG7V1FRJ.
    PhylomeDBiQ9VG96.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9VG96-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFYYSPRSS GSRTIIMVAK ALGLELNKKQ LRITEGEHLK PEFLKLNPQH    50
    TIPTLVDNGF AIWESRAIAV YLVEKYGKDD SLFPNDPQKR ALINQRLYFD 100
    MGTLHDSFMK YYYPFIRTGQ LGNAENYKKV EAAFEFLDIF LEGQDYVAGS 150
    QLTVADIAIL SSVSTFEVVE FDISKYPNVA RWYANAKKIT PGWDENWKGL 200
    LQMKTMYEAQ KASLK 215
    Length:215
    Mass (Da):24,736
    Last modified:May 1, 2000 - v1
    Checksum:i9556E0A1A54BBE1F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti142 – 1421E → V in M97702. (PubMed:7683659)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M97702 Genomic DNA. No translation available.
    AE014297 Genomic DNA. Translation: AAF54789.1.
    AY071648 mRNA. Translation: AAL49270.1.
    PIRiE46681.
    RefSeqiNP_524913.1. NM_080174.3.
    UniGeneiDm.1754.

    Genome annotation databases

    EnsemblMetazoaiFBtr0082571; FBpp0082043; FBgn0010040.
    GeneIDi48337.
    KEGGidme:Dmel_CG11512.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M97702 Genomic DNA. No translation available.
    AE014297 Genomic DNA. Translation: AAF54789.1 .
    AY071648 mRNA. Translation: AAL49270.1 .
    PIRi E46681.
    RefSeqi NP_524913.1. NM_080174.3.
    UniGenei Dm.1754.

    3D structure databases

    ProteinModelPortali Q9VG96.
    SMRi Q9VG96. Positions 1-207.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 71334. 8 interactions.
    DIPi DIP-19902N.
    IntActi Q9VG96. 5 interactions.
    MINTi MINT-793961.

    Proteomic databases

    PaxDbi Q9VG96.
    PRIDEi Q9VG96.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0082571 ; FBpp0082043 ; FBgn0010040 .
    GeneIDi 48337.
    KEGGi dme:Dmel_CG11512.

    Organism-specific databases

    CTDi 48337.
    FlyBasei FBgn0010040. GstD4.

    Phylogenomic databases

    eggNOGi COG0625.
    GeneTreei ENSGT00540000069741.
    InParanoidi Q9VG96.
    KOi K00799.
    OMAi NGFAIWE.
    OrthoDBi EOG7V1FRJ.
    PhylomeDBi Q9VG96.

    Miscellaneous databases

    GenomeRNAii 48337.
    NextBioi 839335.

    Gene expression databases

    Bgeei Q9VG96.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The glutathione S-transferase D genes. A divergently organized, intronless gene family in Drosophila melanogaster."
      Toung Y.-P.S., Hsieh T.-S., Tu C.-P.D.
      J. Biol. Chem. 268:9737-9746(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.

    Entry informationi

    Entry nameiGSTT4_DROME
    AccessioniPrimary (citable) accession number: Q9VG96
    Secondary accession number(s): Q541F8, Q9TX90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3