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Protein

Glutathione S-transferase D5

Gene

GstD5

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in detoxification (PubMed:22082028).1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.1 Publication

Kineticsi

  1. KM=1.43 mM for glutathione1 Publication
  2. KM=2.98 mM for 1-chloro-2,4-dinitrobenzene1 Publication
  1. Vmax=9.9 µmol/min/mg enzyme with 1-chloro-2,4-dinitrobenzene as substrate1 Publication
  2. Vmax=1.48 µmol/min/mg enzyme with 4-hydroxy-2-nonenal as substrate1 Publication
  3. Vmax=3.5 nmol/min/mg enzyme with adrenochrome as substrate1 Publication
  4. Vmax=0.203 µmol/min/mg enzyme with phenethyl isothiocyanate as substrate1 Publication
  5. Vmax=0.165 µmol/min/mg enzyme with 2-hydroxyethyl disulfide as substrate1 Publication

GO - Molecular functioni

  • glutathione transferase activity Source: FlyBase

GO - Biological processi

  • glutathione metabolic process Source: FlyBase
  • response to toxic substance Source: UniProtKB-KW

Keywordsi

Molecular functionTransferase
Biological processDetoxification

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase D51 Publication (EC:2.5.1.181 Publication)
Gene namesi
Name:GstD5Imported
Synonyms:gstD24, GSTD5-5Imported
ORF Names:CG12242Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0010041. GstD5.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859571 – 216Glutathione S-transferase D5Add BLAST216

Proteomic databases

PaxDbiQ9VG95.
PRIDEiQ9VG95.

Expressioni

Gene expression databases

BgeeiFBgn0010041.
ExpressionAtlasiQ9VG95. differential.
GenevisibleiQ9VG95. DM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi71335. 5 interactors.
STRINGi7227.FBpp0082044.

Structurei

3D structure databases

ProteinModelPortaliQ9VG95.
SMRiQ9VG95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 80GST N-terminalAdd BLAST80
Domaini86 – 207GST C-terminalAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 52Glutathione bindingBy similarity3
Regioni64 – 66Glutathione bindingBy similarity3

Sequence similaritiesi

Belongs to the GST superfamily. Delta family.1 Publication

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
COG0625. LUCA.
GeneTreeiENSGT00540000069741.
InParanoidiQ9VG95.
KOiK00799.
OMAiWDENWNG.
OrthoDBiEOG091G0MS3.
PhylomeDBiQ9VG95.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VG95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFYYSPRGS GCRTVIMVAK ALGVKLNMKL LNTLEKDQLK PEFVKLNPQH
60 70 80 90 100
TIPTLVDNGF SIWESRAIAV YLVEKYGKDD TLFPKDPKKQ ALVNQRLYFD
110 120 130 140 150
MGTLYDSFAK YYYPLFHTGK PGSDEDFKKI ESSFEYLNIF LEGQNYVAGD
160 170 180 190 200
HLTVADIAIL STVSTFEIFD FDLNKYPNVA RWYANAKKVT PGWEENWKGA
210
VELKGVFDAR QAAAKQ
Length:216
Mass (Da):24,713
Last modified:December 1, 2000 - v2
Checksum:i9136816534D39A18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97702 Genomic DNA. No translation available.
AE014297 Genomic DNA. Translation: AAF54790.3.
PIRiC46681.
RefSeqiNP_524914.3. NM_080175.3.

Genome annotation databases

EnsemblMetazoaiFBtr0082572; FBpp0082044; FBgn0010041.
GeneIDi48338.
KEGGidme:Dmel_CG12242.

Similar proteinsi

Entry informationi

Entry nameiGSTD5_DROME
AccessioniPrimary (citable) accession number: Q9VG95
Secondary accession number(s): Q9TX92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: August 30, 2017
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families