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Protein

Glutathione S-transferase D7

Gene

GstD7

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in detoxification (PubMed:22082028).1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.1 Publication

Kineticsi

  1. KM=1.68 mM for glutathione1 Publication
  2. KM=1.16 mM for 1-chloro-2,4-dinitrobenzene1 Publication
  1. Vmax=9.76 µmol/min/mg enzyme with 1-chloro-2,4-dinitrobenzene as substrate1 Publication
  2. Vmax=0.66 µmol/min/mg enzyme with 4-hydroxy-2-nonenal as substrate1 Publication
  3. Vmax=41.5 nmol/min/mg enzyme with adrenochrome as substrate1 Publication
  4. Vmax=0.16 µmol/min/mg enzyme with phenethyl isothiocyanate as substrate1 Publication

GO - Molecular functioni

  • glutathione transferase activity Source: FlyBase

GO - Biological processi

  • glutathione metabolic process Source: FlyBase
  • response to toxic substance Source: UniProtKB-KW

Keywordsi

Molecular functionTransferase
Biological processDetoxification

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase D71 Publication (EC:2.5.1.181 Publication)
Gene namesi
Name:GstD7Imported
Synonyms:gstD26, GSTD7-7Imported
ORF Names:CG4371Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0010043. GstD7.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859591 – 224Glutathione S-transferase D7Add BLAST224

Proteomic databases

PaxDbiQ9VG93.
PRIDEiQ9VG93.

Expressioni

Gene expression databases

BgeeiFBgn0010043.
GenevisibleiQ9VG93. DM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi71337. 5 interactors.
IntActiQ9VG93. 11 interactors.
STRINGi7227.FBpp0082046.

Structurei

3D structure databases

ProteinModelPortaliQ9VG93.
SMRiQ9VG93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 83GST N-terminalAdd BLAST82
Domaini90 – 210GST C-terminalAdd BLAST121

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni53 – 55Glutathione bindingBy similarity3
Regioni67 – 69Glutathione bindingBy similarity3

Sequence similaritiesi

Belongs to the GST superfamily. Delta family.1 Publication

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
COG0625. LUCA.
GeneTreeiENSGT00540000069741.
InParanoidiQ9VG93.
KOiK00799.
OMAiYADFRMA.
OrthoDBiEOG091G0MS3.
PhylomeDBiQ9VG93.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR036282. Glutathione-S-Trfase_C_sf.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR036249. Thioredoxin-like_sf.
PfamiView protein in Pfam
PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VG93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNLDLYNFP MAPASRAIQM VAKALGLELN SKLINTMEGD QLKPEFVRIN
60 70 80 90 100
PQHTIPTLVD NGFVIWESRA IAVYLVEKYG KPDSPLYPND PQKRALINQR
110 120 130 140 150
LYFDMGTLYD ALTKYFFLIF RTGKFGDQEA LDKVNSAFGF LNTFLEGQDF
160 170 180 190 200
VAGSQLTVAD IVILATVSTV EWFSFDLSKF PNVERWLKNA PKVTPGWEQN
210 220
LESLQQGKKF LQDLQAAKEK EVKA
Length:224
Mass (Da):25,419
Last modified:May 1, 2000 - v1
Checksum:iD4478B93C59E565A
GO

Sequence cautioni

The sequence M97702 differs from that shown. Reason: Frameshift at several positions.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97702 Genomic DNA. No translation available.
AE014297 Genomic DNA. Translation: AAF54792.1.
BT023285 mRNA. Translation: AAY55701.1.
PIRiH46681.
RefSeqiNP_525114.1. NM_080375.3.
UniGeneiDm.27472.

Genome annotation databases

EnsemblMetazoaiFBtr0082574; FBpp0082046; FBgn0010043.
GeneIDi48340.
KEGGidme:Dmel_CG4371.

Similar proteinsi

Entry informationi

Entry nameiGSTD7_DROME
AccessioniPrimary (citable) accession number: Q9VG93
Secondary accession number(s): Q4V3S1, Q9TX87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families