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Protein

Palmitoyltransferase

Gene

CG5196-RA

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.UniRule annotation

GO - Molecular functioni

  • protein-cysteine S-palmitoyltransferase activity Source: FlyBase

GO - Biological processi

  • Golgi organization Source: FlyBase
  • protein palmitoylation Source: FlyBase

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
PalmitoyltransferaseUniRule annotation (EC:2.3.1.225UniRule annotation)
Gene namesi
Name:CG5196-RAImported
ORF Names:CG5196Imported, Dmel_CG5196Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0038039. CG5196.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32HelicalUniRule annotationAdd BLAST21
Transmembranei44 – 66HelicalUniRule annotationAdd BLAST23
Transmembranei135 – 159HelicalUniRule annotationAdd BLAST25
Transmembranei180 – 208HelicalUniRule annotationAdd BLAST29

GO - Cellular componenti

  • endomembrane system Source: FlyBase
  • endoplasmic reticulum Source: FlyBase
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0038039.
ExpressionAtlasiQ9VG80. differential.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0082056.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 223zf-DHHCInterPro annotationAdd BLAST134

Domaini

The DHHC domain is required for palmitoyltransferase activity.UniRule annotation

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1314. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00870000136467.
KOiK20031.
OMAiWFPRRCV.
OrthoDBiEOG091G0HOK.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VG80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPEISGFRR FLHWGPITAL SIIKCITLTT LYMNSMWWPP NKSFAGFAHQ
60 70 80 90 100
ALFLLLSTLA TFNYVMATLT GPGLMPKQWH PKDPKDAQFL QYCKKCEGYK
110 120 130 140 150
APRSHHCRKC DRCVKKMDHH CPWINHCVGW ANHAYFTYFL LFSILGSLQG
160 170 180 190 200
TVVLCCSFWR GIYRYYYLTH GLAHLASVQF TLLSIIMCIL GMGLAIGVVI
210 220 230 240 250
GLSMLLFIQL KTIVNNQTGI EIWIVEKAIY RRYRNADCDD EFLYPYDLGW
260 270 280 290 300
RANLRLVFND ECQKRGDGIE WPVVEGCDQY TLTREQLAQK EEKRARTRTF
310 320 330 340 350
KCTRPVTGRW LPIFSQGWRV CVAAPCSDEP RISLRPNDMI KVTRFRNHWL
360 370 380 390 400
FGERVLSEQE LAGVKKRQRK GPIRGWFPRR SAVEVIEAVH EGSGDGNSET
410 420
PAPAAQNGNA HSHLKQQQRN GHAKKYM
Length:427
Mass (Da):49,200
Last modified:May 1, 2000 - v1
Checksum:iC90A9F98BE2B8D9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF54805.1.
BT082042 mRNA. Translation: ACO72879.1.
RefSeqiNP_650191.1. NM_141934.2.
UniGeneiDm.7090.

Genome annotation databases

EnsemblMetazoaiFBtr0082584; FBpp0082056; FBgn0038039.
GeneIDi41522.
KEGGidme:Dmel_CG5196.
UCSCiCG5196-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF54805.1.
BT082042 mRNA. Translation: ACO72879.1.
RefSeqiNP_650191.1. NM_141934.2.
UniGeneiDm.7090.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0082056.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0082584; FBpp0082056; FBgn0038039.
GeneIDi41522.
KEGGidme:Dmel_CG5196.
UCSCiCG5196-RA. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0038039. CG5196.

Phylogenomic databases

eggNOGiKOG1314. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00870000136467.
KOiK20031.
OMAiWFPRRCV.
OrthoDBiEOG091G0HOK.

Miscellaneous databases

ChiTaRSiCG5196. fly.
GenomeRNAii41522.

Gene expression databases

BgeeiFBgn0038039.
ExpressionAtlasiQ9VG80. differential.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9VG80_DROME
AccessioniPrimary (citable) accession number: Q9VG80
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: April 12, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.