Reviewed, UniProtKB/Swiss-Prot Q9VG73 (ILF2_DROME)

Names and origin

Protein names

Recommended name:
    Interleukin enhancer-binding factor 2 homolog

Gene names

ORF Names:

CG5641

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May regulate transcription of undefined genes By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 1 DZF domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	positive regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: UniProtKB transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleolus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	DNA binding Inferred from sequence or structural similarity. Source: UniProtKB double-stranded RNA binding Inferred from sequence or structural similarity. Source: UniProtKB protein binding Inferred from physical interaction. Source: IntAct transcription regulator activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Zn72D	Q9VUY6	1	EBI-151485,EBI-166432

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Interleukin enhancer-binding factor 2 homolog		PRO_0000126069
Regions
	Domain	105 – 345	241	DZF

Sequences

	Sequence		Length	Mass (Da)
	Q9VG73-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 3E6583A9A88ED34E	FASTA	396	43,657
	10 20 30 40 50 60 MVRGALRGGR PMRGGIRPPF KKTFVPRHPF DLTLAEVFFP KVPSAGAVDD SALTAALLKR 70 80 90 100 110 120 NQDLSPTPSE QTAIGNLVTK VQAVLDNLVV APGDLTTCQL EEVRQVGSFK KGTILTGNNV 130 140 150 160 170 180 ADVVVILKTL PTKEAVDALA KKVEADLKAS MKTEVLTKGD QHTVQIHERG FDIANVHAKV 190 200 210 220 230 240 RILIATLPQN LRKLEPEIHL DHKLMQSHLA AIRHTRWFEE NAHHSSIKVL IRILKDLTRR 250 260 270 280 290 300 FDAFSPLSAW MLDLIAHLAI MNNPSRQALP INLAFRRVFQ LLSAGLFLPG SAGITDPTEP 310 320 330 340 350 360 GHIRVHTAMT LEQQDVCCYT SQTLLRVLAH GGYKHILGLE GNTSVVREMS VWNGVCISPL 370 380 390 TAVYEKPTDK KEGDLEEDID MIENENEEEG SDDGAE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Head.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014297 Genomic DNA. Translation: AAF54812.1. AY051610 mRNA. Translation: AAK93034.1.
RefSeq	NP_650196.1.
UniGene	Dm.1170
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VG73. 7 interactions.
Proteomic databases
PRIDE	Q9VG73.
Genome annotation databases
Ensembl	FBgn0038046. Drosophila melanogaster. [Contig view]
GeneID	41529.
KEGG	dme:Dmel_CG5641.
NMPDR	fig|7227.3.peg.12439.
Organism-specific databases
FlyBase	FBgn0038046. CG5641.
Phylogenomic databases
HOGENOM	Q9VG73.
OMA	Q9VG73. QVGSFKK.
Gene expression databases
ArrayExpress	Q9VG73.
GermOnline	CG5641. Drosophila melanogaster.
Family and domain databases
InterPro	IPR006561. DZF. [Graphical view]
Pfam	PF07528. DZF. 1 hit. [Graphical view]
SMART	SM00572. DZF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	824267.

Entry information

Entry name

ILF2_DROME

Accession

Primary (citable) accession number: Q9VG73

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project