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Protein

Major heat shock 70 kDa protein Bbb

Gene

Hsp70Bbb

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Miscellaneous

Most strains have three copies of the gene coding for this protein at chromosome locus 87C1; two tandemly repeated Hsp70 genes (Hsp70Bb and Hsp70Bc) and one in reverse orientation (Hsp70Ba). Some strains, including that sequenced in the Drosophila genome project have three tandemly repeated Hsp70 genes (Hsp70Bb, Hsp70Bbb and Hsp70Bc).1 Publication

GO - Molecular functioni

GO - Biological processi

  • heat shock-mediated polytene chromosome puffing Source: FlyBase
  • response to heat Source: FlyBase
  • response to hypoxia Source: FlyBase

Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Major heat shock 70 kDa protein Bbb
Short name:
Heat shock protein 70Bbb
Alternative name(s):
HSP70-87C1
Gene namesi
ORF Names:CG5834
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0051354. Hsp70Bbb.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000783341 – 641Major heat shock 70 kDa protein BbbAdd BLAST641

Proteomic databases

PaxDbiQ9VG58.
PRIDEiQ9VG58.

Expressioni

Inductioni

Heat shock induces the synthesis of seven proteins at five otherwise inactive sites in the polytene chromosomes of fruit fly larvae. Two separate sites, producing two and three copies, respectively, code for the 70 kDa protein.Curated

Gene expression databases

BgeeiFBgn0051354.
GenevisibleiQ9VG58. DM.

Interactioni

Protein-protein interaction databases

BioGridi72503. 45 interactors.
STRINGi7227.FBpp0082105.

Structurei

3D structure databases

ProteinModelPortaliQ9VG58.
SMRiQ9VG58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.UniRule annotationCurated

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00890000139357.
InParanoidiQ9VG58.
KOiK03283.
OMAiRVMARNQ.
OrthoDBiEOG091G03SF.
PhylomeDBiQ9VG58.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiView protein in InterPro
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
PfamiView protein in Pfam
PF00012. HSP70. 1 hit.
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiView protein in PROSITE
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VG58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAIGIDLGT TYSCVGVYQH GKVEIIANDQ GNRTTPSYVA FTDSERLIGD
60 70 80 90 100
PAKNQVAMNP RNTVFDAKRL IGRKYDDPKI AEDMKHWPFK VVSDGGKPKI
110 120 130 140 150
GVEYKGESKR FAPEEISSMV LTKMKETAEA YLGESITDAV ITVPAYFNDS
160 170 180 190 200
QRQATKDAGH IAGLNVLRII NEPTAAALAY GLDKNLKDER NVLIFDLGGG
210 220 230 240 250
TFDVSILTID EGSLFEVRST AGDTHLGGED FDNRLVTHLA EEFKRKYKKD
260 270 280 290 300
LRSNPRALRR LRTAAERAKR TLSSSTEATI EIDALFEGQD FYTKVSRARF
310 320 330 340 350
EELCADLFRN TLQPVEKALN DAKMDKGQIH DIVLVGGSTR IPKVQSLLQE
360 370 380 390 400
FFHGKNLNLS INPDEAVAYG AAVQAAILSG DQSGKIQDVL LVDVAPLSLG
410 420 430 440 450
IETAGGVMTK LIERNCRIPC KQTKTFSTYS DNQPGVSIQV YEGERAMTKD
460 470 480 490 500
NNALGTFDLS GIPPAPRGVP QIEVTFDLDA NGILNVSAKE MSTGKAKNIT
510 520 530 540 550
IKNDKGRLSQ AEIDRMVNEA EKYADEDEKH RQRITSRNAL ESYVFNVKQS
560 570 580 590 600
VEQAPAGKLD EADKNSVLDK CNETIRWLDS NTTAEKEEFD HKMEELTRHC
610 620 630 640
SPIMTKMHQQ GAGAAGGPGA NCGQQAGGFG GYSGPTVEEV D
Length:641
Mass (Da):70,253
Last modified:October 1, 2002 - v2
Checksum:i9C889F367BEF97D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF54830.2.
RefSeqiNP_788663.1. NM_176486.2.
UniGeneiDm.33563.

Genome annotation databases

EnsemblMetazoaiFBtr0082636; FBpp0082105; FBgn0051354.
GeneIDi50022.
KEGGidme:Dmel_CG5834.
UCSCiCG5834-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiHSP74_DROME
AccessioniPrimary (citable) accession number: Q9VG58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families