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Protein

Protein hugin

Gene

Hug

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably has a role in larval molting.

GO - Molecular functioni

  • ecdysis-triggering hormone activity Source: FlyBase
  • hormone activity Source: FlyBase
  • myostimulatory hormone activity Source: FlyBase
  • neuropeptide receptor binding Source: FlyBase
  • receptor binding Source: FlyBase

GO - Biological processi

  • ecdysis, chitin-based cuticle Source: UniProtKB
  • larval feeding behavior Source: FlyBase
  • neuropeptide signaling pathway Source: FlyBase

Keywordsi

Molecular functionNeuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Protein hugin
Cleaved into the following 3 chains:
Alternative name(s):
Drm-PK-2
Myotrophin-2
Short name:
Drm-MT2
Short name:
MT-2
Pyrokinin-2
Gene namesi
Name:Hug
ORF Names:CG6371
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0028374. Hug.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • extracellular space Source: FlyBase

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000029911? – 1711 Publication
Signal peptidei1 – 241 PublicationAdd BLAST24
PropeptideiPRO_000002990825 – 1191 PublicationAdd BLAST95
PeptideiPRO_0000029909121 – 137Hug-gammaSequence analysisAdd BLAST17
PeptideiPRO_0000029910140 – ?Hug-peptideSequence analysis
PeptideiPRO_0000029912174 – 181PK-21 Publication8
PropeptideiPRO_0000029913185 – 1911 Publication7

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei137Leucine amideSequence analysis1
Modified residuei181Leucine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ9VG55.
PRIDEiQ9VG55.

Expressioni

Tissue specificityi

Expressed in a subgroup of neurosecretory cells in the subesophageal ganglion from embryonic stage 9 to larval stages.1 Publication

Developmental stagei

Expressed during embryogenesis through to adult stages with highest expression at later half of embryogenesis and during larval stages.1 Publication

Gene expression databases

BgeeiFBgn0028374.
GenevisibleiQ9VG55. DM.

Interactioni

GO - Molecular functioni

  • ecdysis-triggering hormone activity Source: FlyBase
  • hormone activity Source: FlyBase
  • myostimulatory hormone activity Source: FlyBase
  • neuropeptide receptor binding Source: FlyBase
  • receptor binding Source: FlyBase

Protein-protein interaction databases

BioGridi66642. 1 interactor.
DIPiDIP-17451N.
IntActiQ9VG55. 1 interactor.
MINTiMINT-1601192.
STRINGi7227.FBpp0082108.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyrokinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KBU4. Eukaryota.
ENOG4110MXQ. LUCA.
InParanoidiQ9VG55.
OMAiYRVRTPR.
OrthoDBiEOG091G0RVY.
PhylomeDBiQ9VG55.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VG55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGPSYCTLL LIAASCYILV CSHAKSLQGT SKLDLGNHIS AGSARGSLSP
60 70 80 90 100
ASPALSEARQ KRAMGDYKEL TDIIDELEEN SLAQKASATM QVAAMPPQGQ
110 120 130 140 150
EFDLDTMPPL TYYLLLQKLR QLQSNGEPAY RVRTPRLGRS IDSWRLLDAE
160 170 180 190
GATGMAGGEE AIGGQFMQRM VKKSVPFKPR LGKRAQVCGG D
Length:191
Mass (Da):20,623
Last modified:May 1, 2000 - v1
Checksum:i78F4A9811C57D932
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133105 Genomic DNA. Translation: CAB88005.1.
AE014297 Genomic DNA. Translation: AAF54833.1.
AY047528 mRNA. Translation: AAK77260.1.
RefSeqiNP_524329.1. NM_079605.2.
UniGeneiDm.2437.

Genome annotation databases

EnsemblMetazoaiFBtr0082639; FBpp0082108; FBgn0028374.
GeneIDi41547.
KEGGidme:Dmel_CG6371.

Similar proteinsi

Entry informationi

Entry nameiHUGIN_DROME
AccessioniPrimary (citable) accession number: Q9VG55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 2000
Last modified: May 10, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families