Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable cytochrome P450 304a1

Gene

Cyp304a1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.By similarity

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi454 – 4541Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome P450 304a1 (EC:1.14.-.-)
Alternative name(s):
CYPCCCIVA1
Gene namesi
Name:Cyp304a1
ORF Names:CG7241
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0038095. Cyp304a1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Probable cytochrome P450 304a1PRO_0000052313Add
BLAST

Proteomic databases

PaxDbiQ9VG17.

Expressioni

Gene expression databases

BgeeiQ9VG17.
GenevisibleiQ9VG17. DM.

Interactioni

Protein-protein interaction databases

BioGridi66675. 1 interaction.
DIPiDIP-23993N.
IntActiQ9VG17. 2 interactions.
MINTiMINT-1701446.
STRINGi7227.FBpp0082159.

Structurei

3D structure databases

ProteinModelPortaliQ9VG17.
SMRiQ9VG17. Positions 29-510.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118992.
InParanoidiQ9VG17.
OMAiERNFMDV.
OrthoDBiEOG77M8NM.
PhylomeDBiQ9VG17.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VG17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITETLLTIC AAVFLCLSYR YAVGRPSGFP PGPPKIPLFG SYLFMLIINF
60 70 80 90 100
KYLHKAALTL SRWYKSDIIG LHVGPFPVAV VHSADGVREI LNNQVFDGRP
110 120 130 140 150
QLFVAAMRDP GQDVRGIFFQ DGPLWKEQRR FILRYLRDFG FGRRFDQLEL
160 170 180 190 200
VIQEQLNDML DLIRNGPKYP HEHEMVKSGG YRVLLPLLFN PFSANAHFYI
210 220 230 240 250
VYNECLSREE MGKLVKLCQM GIQFQRNADD YGKMLSIIPW IRHIWPEWSG
260 270 280 290 300
YNKLNESNLF VRQFFADFVD KYLDSYEEGV ERNFMDVYIA EMRRGPGYGF
310 320 330 340 350
NRDQLIMGLV DFSFPAFTAI GVQLSLLVQY LMLYPAVLRR VQNEIDEVVG
360 370 380 390 400
CGRLPNLEDR KNLPFTEATI REGLRIETLV PSDVPHKALE DTELLGYRIP
410 420 430 440 450
KDTIVVPSLY AFHSDARIWS DPEQFRPERF LDADGKLCLK LDVSLPFGAG
460 470 480 490 500
KRLCAGETFA RNMLFLVTAT MCQHFDFVLG PNDRLPDLSQ NLNGLIISPP
510
DFWLQLQDRH
Length:510
Mass (Da):58,790
Last modified:December 1, 2000 - v2
Checksum:i3E20A106ADEF3BF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAG22150.1.
AY113430 mRNA. Translation: AAM29435.1.
RefSeqiNP_731751.1. NM_169484.2.
UniGeneiDm.10031.

Genome annotation databases

EnsemblMetazoaiFBtr0082691; FBpp0082159; FBgn0038095.
GeneIDi41586.
KEGGidme:Dmel_CG7241.
UCSCiCG7241-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAG22150.1.
AY113430 mRNA. Translation: AAM29435.1.
RefSeqiNP_731751.1. NM_169484.2.
UniGeneiDm.10031.

3D structure databases

ProteinModelPortaliQ9VG17.
SMRiQ9VG17. Positions 29-510.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66675. 1 interaction.
DIPiDIP-23993N.
IntActiQ9VG17. 2 interactions.
MINTiMINT-1701446.
STRINGi7227.FBpp0082159.

Proteomic databases

PaxDbiQ9VG17.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0082691; FBpp0082159; FBgn0038095.
GeneIDi41586.
KEGGidme:Dmel_CG7241.
UCSCiCG7241-RA. d. melanogaster.

Organism-specific databases

CTDi41586.
FlyBaseiFBgn0038095. Cyp304a1.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118992.
InParanoidiQ9VG17.
OMAiERNFMDV.
OrthoDBiEOG77M8NM.
PhylomeDBiQ9VG17.

Miscellaneous databases

GenomeRNAii41586.
PROiQ9VG17.

Gene expression databases

BgeeiQ9VG17.
GenevisibleiQ9VG17. DM.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiCP304_DROME
AccessioniPrimary (citable) accession number: Q9VG17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: July 6, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.