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Protein

Probable cytochrome P450 304a1

Gene

Cyp304a1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.By similarity

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi454Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome P450 304a1 (EC:1.14.-.-)
Alternative name(s):
CYPCCCIVA1
Gene namesi
ORF Names:CG7241
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0038095. Cyp304a1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000523131 – 510Probable cytochrome P450 304a1Add BLAST510

Proteomic databases

PaxDbiQ9VG17.
PRIDEiQ9VG17.

Expressioni

Gene expression databases

BgeeiFBgn0038095.
GenevisibleiQ9VG17. DM.

Interactioni

Protein-protein interaction databases

BioGridi66675. 1 interactor.
DIPiDIP-23993N.
IntActiQ9VG17. 2 interactors.
MINTiMINT-1701446.
STRINGi7227.FBpp0082159.

Structurei

3D structure databases

ProteinModelPortaliQ9VG17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00880000137854.
InParanoidiQ9VG17.
OMAiYLHKAAL.
OrthoDBiEOG091G0BT8.
PhylomeDBiQ9VG17.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VG17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITETLLTIC AAVFLCLSYR YAVGRPSGFP PGPPKIPLFG SYLFMLIINF
60 70 80 90 100
KYLHKAALTL SRWYKSDIIG LHVGPFPVAV VHSADGVREI LNNQVFDGRP
110 120 130 140 150
QLFVAAMRDP GQDVRGIFFQ DGPLWKEQRR FILRYLRDFG FGRRFDQLEL
160 170 180 190 200
VIQEQLNDML DLIRNGPKYP HEHEMVKSGG YRVLLPLLFN PFSANAHFYI
210 220 230 240 250
VYNECLSREE MGKLVKLCQM GIQFQRNADD YGKMLSIIPW IRHIWPEWSG
260 270 280 290 300
YNKLNESNLF VRQFFADFVD KYLDSYEEGV ERNFMDVYIA EMRRGPGYGF
310 320 330 340 350
NRDQLIMGLV DFSFPAFTAI GVQLSLLVQY LMLYPAVLRR VQNEIDEVVG
360 370 380 390 400
CGRLPNLEDR KNLPFTEATI REGLRIETLV PSDVPHKALE DTELLGYRIP
410 420 430 440 450
KDTIVVPSLY AFHSDARIWS DPEQFRPERF LDADGKLCLK LDVSLPFGAG
460 470 480 490 500
KRLCAGETFA RNMLFLVTAT MCQHFDFVLG PNDRLPDLSQ NLNGLIISPP
510
DFWLQLQDRH
Length:510
Mass (Da):58,790
Last modified:December 1, 2000 - v2
Checksum:i3E20A106ADEF3BF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAG22150.1.
AY113430 mRNA. Translation: AAM29435.1.
RefSeqiNP_731751.1. NM_169484.2.
UniGeneiDm.10031.

Genome annotation databases

EnsemblMetazoaiFBtr0082691; FBpp0082159; FBgn0038095.
GeneIDi41586.
KEGGidme:Dmel_CG7241.
UCSCiCG7241-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiCP304_DROME
AccessioniPrimary (citable) accession number: Q9VG17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: August 30, 2017
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families