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Q9VFX1

- WNT8_DROME

UniProt

Q9VFX1 - WNT8_DROME

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Protein

Wnt inhibitor of Dorsal protein

Gene
wntD, Wnt8, CG8458
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus.

GO - Molecular functioni

  1. frizzled binding Source: UniProtKB

GO - Biological processi

  1. cell fate commitment Source: RefGenome
  2. defense response to Gram-positive bacterium Source: FlyBase
  3. neuron differentiation Source: RefGenome
  4. pole cell migration Source: FlyBase
  5. regulation of embryonic development Source: FlyBase
  6. ventral furrow formation Source: FlyBase
  7. Wnt signaling pathway Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_184324. WNT ligand biogenesis and trafficking.
REACT_207070. TCF dependent signaling in response to WNT.

Names & Taxonomyi

Protein namesi
Recommended name:
Wnt inhibitor of Dorsal protein
Alternative name(s):
Protein Wnt-8
dWnt-8
Gene namesi
Name:wntD
Synonyms:Wnt8
ORF Names:CG8458
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0038134. wntD.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: FlyBase
  2. extracellular space Source: RefGenome
  3. proteinaceous extracellular matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed predictionAdd
BLAST
Chaini17 – 309293Wnt inhibitor of Dorsal proteinPRO_0000041480Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 62
Disulfide bondi102 ↔ 110
Disulfide bondi112 ↔ 121
Disulfide bondi162 ↔ 179
Disulfide bondi164 ↔ 174
Disulfide bondi232 ↔ 269 By similarity
Disulfide bondi248 ↔ 262 By similarity
Disulfide bondi266 ↔ 308 By similarity
Disulfide bondi284 ↔ 299 By similarity
Disulfide bondi286 ↔ 296 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

BgeeiQ9VFX1.

Interactioni

Protein-protein interaction databases

BioGridi66717. 8 interactions.
IntActiQ9VFX1. 2 interactions.
MINTiMINT-767524.
STRINGi7227.FBpp0082243.

Structurei

Secondary structure

1
309
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi36 – 5419
Beta strandi58 – 603
Helixi64 – 729
Helixi81 – 10323
Helixi125 – 13511
Helixi141 – 15515
Beta strandi158 – 1669
Turni171 – 1733
Beta strandi177 – 1837
Helixi186 – 19813
Beta strandi208 – 2103
Turni214 – 2163

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KRRX-ray2.12A31-240[»]
ProteinModelPortaliQ9VFX1.
SMRiQ9VFX1. Positions 33-232.

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG258743.
GeneTreeiENSGT00690000101857.
InParanoidiQ9VFX1.
KOiK00714.
OMAiERRCNCK.
OrthoDBiEOG7SFHZX.
PhylomeDBiQ9VFX1.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026540. WntD.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF79. PTHR12027:SF79. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VFX1-1 [UniParc]FASTAAdd to Basket

« Hide

MIFAITFFMG ITSTLAAVLE PMSYYQYTQF QAPLSWEDIT GKGLKQALDS    50
CQQSFQWQRW NCPSQDFVQK NSKPEENSPN REDVYVAAIS MAAIVHTLTK 100
DCANGVIAGC GCTENALNVP CAHEPTKALE QYEKHFGSGS GAIGHNRRVV 150
GALLQRSLEQ ECRCKQPGAV QGECQEEECV AVLKPFEAIA QDLLQMYDDA 200
IQLEGASSNL KIMWQNIPLD SLVFMQDSPN YCERDATGLW KGTRGRQCSK 250
DGSGSLEERL SCQQLCRVCG YRVRSQHVRT ERRCNCKLVW GFRLQCDVCV 300
QLERQYSCY 309
Length:309
Mass (Da):34,777
Last modified:March 1, 2001 - v2
Checksum:iBA6AC2F3198B4DAD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: AAF54924.2.
AY071538 mRNA. Translation: AAL49160.1.
RefSeqiNP_650272.1. NM_142015.2.
UniGeneiDm.5874.

Genome annotation databases

EnsemblMetazoaiFBtr0082775; FBpp0082243; FBgn0038134.
GeneIDi41633.
KEGGidme:Dmel_CG8458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: AAF54924.2 .
AY071538 mRNA. Translation: AAL49160.1 .
RefSeqi NP_650272.1. NM_142015.2.
UniGenei Dm.5874.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4KRR X-ray 2.12 A 31-240 [» ]
ProteinModelPortali Q9VFX1.
SMRi Q9VFX1. Positions 33-232.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 66717. 8 interactions.
IntActi Q9VFX1. 2 interactions.
MINTi MINT-767524.
STRINGi 7227.FBpp0082243.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0082775 ; FBpp0082243 ; FBgn0038134 .
GeneIDi 41633.
KEGGi dme:Dmel_CG8458.

Organism-specific databases

CTDi 41633.
FlyBasei FBgn0038134. wntD.

Phylogenomic databases

eggNOGi NOG258743.
GeneTreei ENSGT00690000101857.
InParanoidi Q9VFX1.
KOi K00714.
OMAi ERRCNCK.
OrthoDBi EOG7SFHZX.
PhylomeDBi Q9VFX1.

Enzyme and pathway databases

Reactomei REACT_184324. WNT ligand biogenesis and trafficking.
REACT_207070. TCF dependent signaling in response to WNT.

Miscellaneous databases

GenomeRNAii 41633.
NextBioi 824739.

Gene expression databases

Bgeei Q9VFX1.

Family and domain databases

InterProi IPR005817. Wnt.
IPR026540. WntD.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
PTHR12027:SF79. PTHR12027:SF79. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  4. "Wnt proteins are lipid-modified and can act as stem cell growth factors."
    Willert K., Brown J.D., Danenberg E., Duncan A.W., Weissman I.L., Reya T., Yates J.R. III, Nusse R.
    Nature 423:448-452(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY PALMITOYLATION.
  5. "Lipid-independent secretion of a Drosophila Wnt protein."
    Ching W., Hang H.C., Nusse R.
    J. Biol. Chem. 283:17092-17098(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: ABSENCE OF PALMITOYLATION.
  6. "structural Studies of Wnts and identification of an LRP6 binding site."
    Chu M.L., Ahn V.E., Choi H.J., Daniels D.L., Nusse R., Weis W.I.
    Structure 21:1235-1242(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.12 ANGSTROMS) OF 31-240, DISULFIDE BONDS.

Entry informationi

Entry nameiWNT8_DROME
AccessioniPrimary (citable) accession number: Q9VFX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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