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Q9VFX1

- WNT8_DROME

UniProt

Q9VFX1 - WNT8_DROME

Protein

Wnt inhibitor of Dorsal protein

Gene

wntD

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus.Curated

    GO - Molecular functioni

    1. frizzled binding Source: UniProtKB

    GO - Biological processi

    1. cell fate commitment Source: RefGenome
    2. defense response to Gram-positive bacterium Source: FlyBase
    3. neuron differentiation Source: RefGenome
    4. pole cell migration Source: FlyBase
    5. regulation of embryonic development Source: FlyBase
    6. ventral furrow formation Source: FlyBase
    7. Wnt signaling pathway Source: FlyBase

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_184324. WNT ligand biogenesis and trafficking.
    REACT_207070. TCF dependent signaling in response to WNT.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Wnt inhibitor of Dorsal protein
    Alternative name(s):
    Protein Wnt-8
    dWnt-8
    Gene namesi
    Name:wntD
    Synonyms:Wnt8
    ORF Names:CG8458
    OrganismiDrosophila melanogaster (Fruit fly)Imported
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0038134. wntD.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: FlyBase
    2. extracellular space Source: RefGenome
    3. proteinaceous extracellular matrix Source: UniProtKB

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 309293Wnt inhibitor of Dorsal proteinPRO_0000041480Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi51 ↔ 621 Publication
    Disulfide bondi102 ↔ 1101 Publication
    Disulfide bondi112 ↔ 1211 Publication
    Disulfide bondi162 ↔ 1791 Publication
    Disulfide bondi164 ↔ 1741 Publication
    Disulfide bondi232 ↔ 269By similarity
    Disulfide bondi248 ↔ 262By similarity
    Disulfide bondi266 ↔ 308By similarity
    Disulfide bondi284 ↔ 299By similarity
    Disulfide bondi286 ↔ 296By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Gene expression databases

    BgeeiQ9VFX1.

    Interactioni

    Protein-protein interaction databases

    BioGridi66717. 8 interactions.
    IntActiQ9VFX1. 2 interactions.
    MINTiMINT-767524.
    STRINGi7227.FBpp0082243.

    Structurei

    Secondary structure

    1
    309
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi36 – 5419
    Beta strandi58 – 603
    Helixi64 – 729
    Helixi81 – 10323
    Helixi125 – 13511
    Helixi141 – 15515
    Beta strandi158 – 1669
    Turni171 – 1733
    Beta strandi177 – 1837
    Helixi186 – 19813
    Beta strandi208 – 2103
    Turni214 – 2163

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4KRRX-ray2.12A31-240[»]
    ProteinModelPortaliQ9VFX1.
    SMRiQ9VFX1. Positions 33-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG258743.
    GeneTreeiENSGT00690000101857.
    InParanoidiQ9VFX1.
    KOiK00714.
    OMAiERRCNCK.
    OrthoDBiEOG7SFHZX.
    PhylomeDBiQ9VFX1.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR026540. WntD.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF79. PTHR12027:SF79. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9VFX1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIFAITFFMG ITSTLAAVLE PMSYYQYTQF QAPLSWEDIT GKGLKQALDS    50
    CQQSFQWQRW NCPSQDFVQK NSKPEENSPN REDVYVAAIS MAAIVHTLTK 100
    DCANGVIAGC GCTENALNVP CAHEPTKALE QYEKHFGSGS GAIGHNRRVV 150
    GALLQRSLEQ ECRCKQPGAV QGECQEEECV AVLKPFEAIA QDLLQMYDDA 200
    IQLEGASSNL KIMWQNIPLD SLVFMQDSPN YCERDATGLW KGTRGRQCSK 250
    DGSGSLEERL SCQQLCRVCG YRVRSQHVRT ERRCNCKLVW GFRLQCDVCV 300
    QLERQYSCY 309
    Length:309
    Mass (Da):34,777
    Last modified:March 1, 2001 - v2
    Checksum:iBA6AC2F3198B4DAD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014297 Genomic DNA. Translation: AAF54924.2.
    AY071538 mRNA. Translation: AAL49160.1.
    RefSeqiNP_650272.1. NM_142015.2.
    UniGeneiDm.5874.

    Genome annotation databases

    EnsemblMetazoaiFBtr0082775; FBpp0082243; FBgn0038134.
    GeneIDi41633.
    KEGGidme:Dmel_CG8458.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014297 Genomic DNA. Translation: AAF54924.2 .
    AY071538 mRNA. Translation: AAL49160.1 .
    RefSeqi NP_650272.1. NM_142015.2.
    UniGenei Dm.5874.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4KRR X-ray 2.12 A 31-240 [» ]
    ProteinModelPortali Q9VFX1.
    SMRi Q9VFX1. Positions 33-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 66717. 8 interactions.
    IntActi Q9VFX1. 2 interactions.
    MINTi MINT-767524.
    STRINGi 7227.FBpp0082243.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0082775 ; FBpp0082243 ; FBgn0038134 .
    GeneIDi 41633.
    KEGGi dme:Dmel_CG8458.

    Organism-specific databases

    CTDi 41633.
    FlyBasei FBgn0038134. wntD.

    Phylogenomic databases

    eggNOGi NOG258743.
    GeneTreei ENSGT00690000101857.
    InParanoidi Q9VFX1.
    KOi K00714.
    OMAi ERRCNCK.
    OrthoDBi EOG7SFHZX.
    PhylomeDBi Q9VFX1.

    Enzyme and pathway databases

    Reactomei REACT_184324. WNT ligand biogenesis and trafficking.
    REACT_207070. TCF dependent signaling in response to WNT.

    Miscellaneous databases

    GenomeRNAii 41633.
    NextBioi 824739.

    Gene expression databases

    Bgeei Q9VFX1.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR026540. WntD.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF79. PTHR12027:SF79. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley1 Publication.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley1 Publication.
      Tissue: Embryo1 Publication.
    4. "Wnt proteins are lipid-modified and can act as stem cell growth factors."
      Willert K., Brown J.D., Danenberg E., Duncan A.W., Weissman I.L., Reya T., Yates J.R. III, Nusse R.
      Nature 423:448-452(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY PALMITOYLATION.
    5. "Lipid-independent secretion of a Drosophila Wnt protein."
      Ching W., Hang H.C., Nusse R.
      J. Biol. Chem. 283:17092-17098(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: ABSENCE OF PALMITOYLATION.
    6. "structural Studies of Wnts and identification of an LRP6 binding site."
      Chu M.L., Ahn V.E., Choi H.J., Daniels D.L., Nusse R., Weis W.I.
      Structure 21:1235-1242(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.12 ANGSTROMS) OF 31-240, DISULFIDE BONDS.

    Entry informationi

    Entry nameiWNT8_DROME
    AccessioniPrimary (citable) accession number: Q9VFX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3