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Protein

Wnt inhibitor of Dorsal protein

Gene

wntD

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus.Curated

GO - Molecular functioni

  • frizzled binding Source: UniProtKB

GO - Biological processi

  • cell fate commitment Source: GO_Central
  • defense response to Gram-positive bacterium Source: FlyBase
  • neuron differentiation Source: GO_Central
  • pole cell migration Source: FlyBase
  • regulation of embryonic development Source: FlyBase
  • ventral furrow formation Source: FlyBase
  • Wnt signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-DME-3238698. WNT ligand biogenesis and trafficking.
R-DME-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Wnt inhibitor of Dorsal protein
Alternative name(s):
Protein Wnt-8
dWnt-8
Gene namesi
Name:wntD
Synonyms:Wnt8
ORF Names:CG8458
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0038134. wntD.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: FlyBase
  • extracellular space Source: GO_Central
  • proteinaceous extracellular matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000004148017 – 309Wnt inhibitor of Dorsal proteinAdd BLAST293

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 621 Publication
Disulfide bondi102 ↔ 1101 Publication
Disulfide bondi112 ↔ 1211 Publication
Disulfide bondi162 ↔ 1791 Publication
Disulfide bondi164 ↔ 1741 Publication
Disulfide bondi232 ↔ 269By similarity
Disulfide bondi248 ↔ 262By similarity
Disulfide bondi266 ↔ 308By similarity
Disulfide bondi284 ↔ 299By similarity
Disulfide bondi286 ↔ 296By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9VFX1.
PRIDEiQ9VFX1.

Expressioni

Gene expression databases

BgeeiFBgn0038134.
GenevisibleiQ9VFX1. DM.

Interactioni

GO - Molecular functioni

  • frizzled binding Source: UniProtKB

Protein-protein interaction databases

BioGridi66717. 8 interactors.
IntActiQ9VFX1. 2 interactors.
MINTiMINT-767524.
STRINGi7227.FBpp0082243.

Structurei

Secondary structure

1309
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi36 – 54Combined sources19
Beta strandi58 – 60Combined sources3
Helixi64 – 72Combined sources9
Helixi81 – 103Combined sources23
Helixi125 – 135Combined sources11
Helixi141 – 155Combined sources15
Beta strandi158 – 166Combined sources9
Turni171 – 173Combined sources3
Beta strandi177 – 183Combined sources7
Helixi186 – 198Combined sources13
Beta strandi208 – 210Combined sources3
Turni214 – 216Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KRRX-ray2.12A31-240[»]
ProteinModelPortaliQ9VFX1.
SMRiQ9VFX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00690000101857.
InParanoidiQ9VFX1.
KOiK00714.
OMAiERRCNCK.
OrthoDBiEOG091G0YJI.
PhylomeDBiQ9VFX1.

Family and domain databases

InterProiIPR005817. Wnt.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VFX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFAITFFMG ITSTLAAVLE PMSYYQYTQF QAPLSWEDIT GKGLKQALDS
60 70 80 90 100
CQQSFQWQRW NCPSQDFVQK NSKPEENSPN REDVYVAAIS MAAIVHTLTK
110 120 130 140 150
DCANGVIAGC GCTENALNVP CAHEPTKALE QYEKHFGSGS GAIGHNRRVV
160 170 180 190 200
GALLQRSLEQ ECRCKQPGAV QGECQEEECV AVLKPFEAIA QDLLQMYDDA
210 220 230 240 250
IQLEGASSNL KIMWQNIPLD SLVFMQDSPN YCERDATGLW KGTRGRQCSK
260 270 280 290 300
DGSGSLEERL SCQQLCRVCG YRVRSQHVRT ERRCNCKLVW GFRLQCDVCV

QLERQYSCY
Length:309
Mass (Da):34,777
Last modified:March 1, 2001 - v2
Checksum:iBA6AC2F3198B4DAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF54924.2.
AY071538 mRNA. Translation: AAL49160.1.
RefSeqiNP_650272.1. NM_142015.2.
UniGeneiDm.5874.

Genome annotation databases

EnsemblMetazoaiFBtr0082775; FBpp0082243; FBgn0038134.
GeneIDi41633.
KEGGidme:Dmel_CG8458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF54924.2.
AY071538 mRNA. Translation: AAL49160.1.
RefSeqiNP_650272.1. NM_142015.2.
UniGeneiDm.5874.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KRRX-ray2.12A31-240[»]
ProteinModelPortaliQ9VFX1.
SMRiQ9VFX1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi66717. 8 interactors.
IntActiQ9VFX1. 2 interactors.
MINTiMINT-767524.
STRINGi7227.FBpp0082243.

Proteomic databases

PaxDbiQ9VFX1.
PRIDEiQ9VFX1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0082775; FBpp0082243; FBgn0038134.
GeneIDi41633.
KEGGidme:Dmel_CG8458.

Organism-specific databases

CTDi41633.
FlyBaseiFBgn0038134. wntD.

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00690000101857.
InParanoidiQ9VFX1.
KOiK00714.
OMAiERRCNCK.
OrthoDBiEOG091G0YJI.
PhylomeDBiQ9VFX1.

Enzyme and pathway databases

ReactomeiR-DME-3238698. WNT ligand biogenesis and trafficking.
R-DME-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.

Miscellaneous databases

GenomeRNAii41633.
PROiQ9VFX1.

Gene expression databases

BgeeiFBgn0038134.
GenevisibleiQ9VFX1. DM.

Family and domain databases

InterProiIPR005817. Wnt.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWNT8_DROME
AccessioniPrimary (citable) accession number: Q9VFX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Caution

In contrast to other members of the family, it is not lipidated.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.