Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Acid-sensitive two pore domain K+ channel dTASK-6

Gene

Task6

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • potassium channel activity Source: FlyBase
  • potassium ion leak channel activity Source: GO_Central
  • protein heterodimerization activity Source: FlyBase

GO - Biological processi

  • potassium ion transmembrane transport Source: FlyBase
  • stabilization of membrane potential Source: GO_Central

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotationImported
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-DME-1299316. TWIK-releated acid-sensitive K+ channel (TASK).
R-DME-5576886. Phase 4 - resting membrane potential.

Names & Taxonomyi

Protein namesi
Submitted name:
Acid-sensitive two pore domain K+ channel dTASK-6Imported
Submitted name:
TWIK-related acid-sensitive K[+] channel 6, isoform CImported
Submitted name:
TWIK-related acid-sensitive K[+] channel 6, isoform FImported
Gene namesi
Name:Task6Imported
Synonyms:K2P-TASK6Imported
ORF Names:CG9637Imported, Dmel_CG9637Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0038165. Task6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 29HelicalSequence analysisAdd BLAST24
Transmembranei108 – 125HelicalSequence analysisAdd BLAST18
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Transmembranei189 – 208HelicalSequence analysisAdd BLAST20
Transmembranei220 – 247HelicalSequence analysisAdd BLAST28

GO - Cellular componenti

  • integral component of membrane Source: FlyBase
  • integral component of plasma membrane Source: GO_Central

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0038165.

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase

Protein-protein interaction databases

MINTiMINT-958012.
STRINGi7227.FBpp0290868.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 132Ion_trans_2InterPro annotationAdd BLAST58
Domaini169 – 246Ion_trans_2InterPro annotationAdd BLAST78

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00760000118858.
OMAiEINLICV.
OrthoDBiEOG091G08DH.

Family and domain databases

InterProiView protein in InterPro
IPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR013099. K_chnl_dom.
PfamiView protein in Pfam
PF07885. Ion_trans_2. 2 hits.
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01095. TASKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q9VFS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKQNVRTIS LIVCTFTYLL VGAAVFDALE SETEKRRWEA LQDAEDMIIR
60 70 80 90 100
KYNISQEDFK VMETVVLKSE SHKAGQQWKF TGAFYYATTV LTTIGYGHST
110 120 130 140 150
PSTVGGKLFT MCYAIVGIPL GLVMFQSIGE RVNRLSSYVI KAVRSSLRCK
160 170 180 190 200
RTVASEVDLI CVVTTLSSLT IAGGAAAFSK FEGWSYFDSV YYCFITLTTI
210 220 230 240 250
GFGDMVALQR DNALNRKPEY VMFALIFILF GLAIVAASLN LLVLRFVTMN
260 270 280 290 300
TEDERRDEAQ AMQALQVAVK LEGDVITSNG SILSGYEGHD GQSLNGSNTS
310 320 330 340 350
SMCSCHCICL NGNRHKKSSN LEKNNDAENQ YKLRQSPTHI RHLLPEVVPM
360 370 380 390 400
QDLNYDYDTQ SLHTLADRGT MDSSYMGVDM ADMGDTGSME LRPHTLLKRN

VSLLSIRI
Length:408
Mass (Da):45,430
Last modified:November 30, 2010 - v2
Checksum:i3F26D326C5B3D9AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF54970.2.
AE014297 Genomic DNA. Translation: AGB95923.1.
AJ920330 mRNA. Translation: CAI72672.1.
RefSeqiNP_001262541.1. NM_001275612.1.
NP_650300.2. NM_142043.3.
UniGeneiDm.24060.

Genome annotation databases

EnsemblMetazoaiFBtr0301654; FBpp0290868; FBgn0038165.
FBtr0334494; FBpp0306561; FBgn0038165.
GeneIDi41671.
UCSCiCG9637-RA. d. melanogaster.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ9VFS9_DROME
AccessioniPrimary (citable) accession number: Q9VFS9
Secondary accession number(s): Q3ZZY1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: November 30, 2010
Last modified: July 5, 2017
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported