Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA replication licensing factor REC

Gene

rec

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for meiotic DNA recombination in females. Probably not involved in DNA repair and recombination in somatic cells.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri281 – 308C4-typeSequence analysisAdd BLAST28
Nucleotide bindingi473 – 480ATPSequence analysis8

GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • ATP-dependent DNA helicase activity Source: UniProtKB
  • DNA binding Source: UniProtKB-KW
  • DNA-dependent ATPase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • DNA replication initiation Source: UniProtKB
  • reciprocal meiotic recombination Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, DNA recombination, Meiosis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-176187 Activation of ATR in response to replication stress
R-DME-68689 CDC6 association with the ORC:origin complex
R-DME-68827 CDT1 association with the CDC6:ORC:origin complex
R-DME-68867 Assembly of the pre-replicative complex
R-DME-68949 Orc1 removal from chromatin
R-DME-68962 Activation of the pre-replicative complex
R-DME-69300 Removal of licensing factors from origins

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication licensing factor REC
Alternative name(s):
Protein mini chromosome maintenance-related
Protein recombination-defective
Gene namesi
Name:rec
ORF Names:CG31293
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0003227 rec

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi455S → F in rec3; temperature-sensitive allele. Recombination-defective. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001941271 – 885DNA replication licensing factor RECAdd BLAST885

Proteomic databases

PaxDbiQ9VF30
PRIDEiQ9VF30

Expressioni

Gene expression databases

BgeeiFBgn0003227
ExpressionAtlasiQ9VF30 differential
GenevisibleiQ9VF30 DM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
mei-217Q86B502EBI-99278,EBI-15133128

Protein-protein interaction databases

BioGridi721084 interactors.
DIPiDIP-61892N
IntActiQ9VF30 4 interactors.
STRINGi7227.FBpp0082647

Structurei

3D structure databases

ProteinModelPortaliQ9VF30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini430 – 627MCMAdd BLAST198

Sequence similaritiesi

Belongs to the MCM family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri281 – 308C4-typeSequence analysisAdd BLAST28

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0480 Eukaryota
COG1241 LUCA
GeneTreeiENSGT00910000144163
InParanoidiQ9VF30
OMAiFYFRRNG
OrthoDBiEOG091G082T
PhylomeDBiQ9VF30

Family and domain databases

InterProiView protein in InterPro
IPR031327 MCM
IPR001208 MCM_dom
IPR033762 MCM_OB
IPR012340 NA-bd_OB-fold
IPR027417 P-loop_NTPase
PANTHERiPTHR11630 PTHR11630, 1 hit
PfamiView protein in Pfam
PF00493 MCM, 1 hit
PF17207 MCM_OB, 1 hit
PRINTSiPR01657 MCMFAMILY
SMARTiView protein in SMART
SM00350 MCM, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50051 MCM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VF30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPTLSRGGA PSRFVRGRGR GGGAYRPYFY FRRNGRVIPA GGNRQPNQGE
60 70 80 90 100
PGAPDAPSVP PATRQPRGWS RTAGKRGRNA HLDCSFLRPE NYAAPEDGLQ
110 120 130 140 150
VQSIAVDNPR AYSGWRLYFL REKYEEGNEL ATRIMAVEAY YQRNPHTFDF
160 170 180 190 200
VMIRDRGFFP LCAAGIKSDA QLKEVWPSLS EDIREHPLRT LGTLSLAMHT
210 220 230 240 250
VVVNHQLDCN DSTTAMVSTP EQYVLPTPRV RKIYARPDDF VPVESIEGIS
260 270 280 290 300
HSRVDTLFSI RGFVSNVGEP SYSLTWQAFR CSRCQMEIAM RQRGTFQPRP
310 320 330 340 350
YQCKRSECVA RDEFVPLRSS PYTRLSIRQI IRVEESSLNL VHDFETSMPA
360 370 380 390 400
EMDVELRHDL VDAVRVGQEV VVTGILKLQE LGDDTTTGDT SNQMQPYLKA
410 420 430 440 450
VSIRDASSIK REFSERDLEA IVMINAEPNS FKLLVQSIAP EVYGHELPKA
460 470 480 490 500
ACLLSLLGGK GAETEAINVL LVGDPGIGKT KILQSCAQIA ERGAHVSGKR
510 520 530 540 550
GAQSAQQLGV TFAGRNKRVL QAGSLMMASG GGHCTLDDVD KLASKQAVLL
560 570 580 590 600
QCLQSEEVNL PLAGAFASFP AQPSVIACAN PQRGQYDEGR YLLQNINISP
610 620 630 640 650
SLLREFHLVY ILLDKPSERD MSLTAHVRAL HAGARKRARI AARYALKPKM
660 670 680 690 700
SDSMCEVSLN VPAAGKDDDT IKTEDDNDSI MQQDYDLDKR LEVLPEEGDL
710 720 730 740 750
DLLPPILIKK FLSYARQELN PVLNEDASNA VLRYFLELKG SCNLDEDVSS
760 770 780 790 800
QIGAGQLLAI IHLSQARARL DLSHVVSPQH VRDVIALLTE SITQTSLKEG
810 820 830 840 850
SSRQGTRGGG GAGGGAGKSA QLRNFLELTK RRSAALGRRI FEFDELKEIG
860 870 880
TRAGILTGFS QLVEMANLGG YLLMKGANMY EVVPD
Length:885
Mass (Da):97,585
Last modified:October 1, 2002 - v2
Checksum:i9CDC8D6CF91C21C6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti118Y → H1 Publication1
Natural varianti422V → A1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB120941 mRNA Translation: BAC92698.1
AB120942 mRNA Translation: BAC92699.1
AB120943 mRNA Translation: BAC92700.1
AB120944 Genomic DNA Translation: BAC92701.1
AB120945 Genomic DNA Translation: BAC92702.1
AB120946 Genomic DNA Translation: BAC92703.1
AB120947 Genomic DNA Translation: BAC92704.1
AB120948 Genomic DNA Translation: BAC92705.1
AB120949 Genomic DNA Translation: BAC92706.1
AB120950 Genomic DNA Translation: BAC92707.1
AB120951 mRNA Translation: BAC92708.1
AB120952 Genomic DNA Translation: BAC92709.1
AB120953 mRNA Translation: BAC92710.1
AE014297 Genomic DNA Translation: AAF55231.2
RefSeqiNP_001262615.1, NM_001275686.1
NP_732072.1, NM_169674.2
UniGeneiDm.31313

Genome annotation databases

EnsemblMetazoaiFBtr0083193; FBpp0082647; FBgn0003227
FBtr0334595; FBpp0306662; FBgn0003227
GeneIDi49241
KEGGidme:Dmel_CG31293

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMCMR_DROME
AccessioniPrimary (citable) accession number: Q9VF30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome