Q9VEN5 (Q9VEN5_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Keap1, isoform A EMBL AAF55386.1

Submitted name:
Keap1, isoform C EMBL AAO41571.1

Gene names

Name:	Keap1 EMBL AAF55386.1 FlyBase FBgn0038475
ORF Names:	Dmel_CG3962 EMBL AAF55386.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	744 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 BTB (POZ) domain. SAAS SAAS015916 RuleBase RU004401

Ontologies

Keywords
Domain	Kelch repeat SAAS SAAS015916 Repeat SAAS SAAS015916
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to oxidative stress Inferred from mutant phenotype. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9VEN5 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 6F7A4EB69DF482E9	FASTA	744	83,605
	10 20 30 40 50 60 MSNTSESCSI SCGGRFGSAH STLDDHDATD DDMTFCMSNY AKEALKMMYM MRSHGMLTDV 70 80 90 100 110 120 VLEVKKELFP AHKVVLSAAS PYFKAMFTGG LKESEMSRVQ LQGVCPTAMS RILYFMYTGQ 130 140 150 160 170 180 IRVTEVTVCQ LLPAATMFQV PNVIDACCAF LERQLDPTNA IGIAHFAEQH GCVELQKKAN 190 200 210 220 230 240 VFIERNFTQV CQEEEFLQLS AYQLIALIRR DELNVQEERE VYNAVLKWVK YDEDNRHCKM 250 260 270 280 290 300 EHILGAVRCQ FLTPNFLKEQ MKNCDVLRKV PACREYLAKI FKDLTLHKCP GVKERTPNTT 310 320 330 340 350 360 RMIFVAGGFF RHSLDILEAY NVDDMTWTTL ANLRIPRSGL GAAFLKGKFY AVGGRNNNIG 370 380 390 400 410 420 SSYDSDWVDR YSAVTETWRP CAPMSVPRHR VGVAVMDELM YAVGGSAGME YHNTVEYYDP 430 440 450 460 470 480 DLDRWTLVQP MHAKRLGVGV VVVNRLLYAI GGFDGNERLA SVECYHPENN EWSFLPPLQT 490 500 510 520 530 540 GRSGAGVAAI NQYIYVVGGF DGTRQLATVE RYDTENDTWD MVAPIQIARS ALSLTPLDEK 550 560 570 580 590 600 LYAIGGFDGN NFLSIVEVYD PRTNTWTTGT PLKSGRSGHA SAVIYQPACS TTFMDYEDSD 610 620 630 640 650 660 APHPDGSNNG ERNAHTPQNT YGSGSPHYPG TASNMQFHTS YGMSGCNNCD SEMDIKPYIP 670 680 690 700 710 720 AEHHSFQIPA IRSEELVNPN CPWSRMQERF RRTPPASFTD DERNANDMRH KLKKAQKECL 730 740 FSTAAKVFHH HIEGRLRKLT SAAT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014297 Genomic DNA. Translation: AAF55386.1. AE014297 Genomic DNA. Translation: AAO41571.1.
RefSeq	NP_650594.1. NM_142337.2. NP_788685.1. NM_176508.2.
UniGene	Dm.1228.
3D structure databases
HSSP	HSSP built from PDB template 1R2B based on UniProtKB P41182.
ProteinModelPortal	Q9VEN5.
SMR	Q9VEN5. Positions 38-269, 301-587.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VEN5. 3 interactions.
MINT	MINT-297590.
STRING	Q9VEN5.
Proteomic databases
PRIDE	Q9VEN5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0083422; FBpp0082863; FBgn0038475. FBtr0083424; FBpp0082865; FBgn0038475.
GeneID	42062.
KEGG	dme:Dmel_CG3962.
UCSC	CG3962-RA. d. melanogaster.
Organism-specific databases
CTD	9817.
FlyBase	FBgn0038475. Keap1.
Phylogenomic databases
GeneTree	EMGT00050000004073.
InParanoid	Q9VEN5.
Gene expression databases
ArrayExpress	Q9VEN5.
Bgee	Q9VEN5.
Family and domain databases
InterPro	IPR011705. BACK. IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR015916. Gal_Oxidase_b-propeller. IPR006652. Kelch_1. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. G3DSA:2.130.10.80. Gal_Oxidase_b-propeller. 1 hit.
KO	K10456.
Pfam	PF07707. BACK. 1 hit. PF00651. BTB. 1 hit. PF01344. Kelch_1. 5 hits. [Graphical view]
SMART	SM00875. BACK. 1 hit. SM00225. BTB. 1 hit. SM00612. Kelch. 6 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	826982.

Entry information

Entry name

Q9VEN5_DROME

Accession

Primary (citable) accession number: Q9VEN5

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)