Q9VEN1 (Q9VEN1_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cheerio, isoform A EMBL AAF55390.4

Submitted name:
Filamin A EMBL AAF04108.1

Gene names

Name:	cher EMBL AAF55390.4 FlyBase FBgn0014141
ORF Names:	CG3937 FlyBase FBgn0014141, Dmel_CG3937 EMBL AAF55390.4

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	2210 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Domain	Repeat SAAS SAAS001589
Ligand	Actin-binding SAAS SAAS001589
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	determination of adult lifespan Inferred from mutant phenotype. Source: FlyBase female germline ring canal formation, actin assembly Inferred from mutant phenotype Ref.2. Source: FlyBase germarium-derived female germ-line cyst encapsulation Inferred from mutant phenotype. Source: FlyBase mitosis Inferred from mutant phenotype. Source: FlyBase negative regulation of lamellocyte differentiation Inferred from mutant phenotype. Source: FlyBase olfactory learning Inferred from mutant phenotype. Source: FlyBase protein localization Inferred from mutant phenotype. Source: FlyBase
Cellular component	female germline ring canal inner rim Inferred from direct assay Ref.2. Source: FlyBase female germline ring canal outer rim Inferred from direct assay Ref.2. Source: FlyBase
Molecular function	actin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9VEN1 [UniParc]. Last modified April 26, 2005. Version 2. Checksum: A600974971A3FD84	FASTA	2,210	239,181
	10 20 30 40 50 60 MEAERDLAED AQWKKIQQNT FTRWANEHLK TIDRSINNLE TDLSDGLRLI ALIEVLSQKR 70 80 90 100 110 120 MPKYNKRPTF RSQKLENVSV ALKFLQDEGI KIVNIDSSDI VDCKLKLILG LIWTLILHYS 130 140 150 160 170 180 ISMPMWDGED DKQLNGSGHT PKQRLLNWIH AKIPDLPINN FTNDWTTGKA VGALVDACAP 190 200 210 220 230 240 GLCPDWELWD PKDAVQNASE AMGLADDWLN VRQLIKPEEL VNPNVDEQSM MTYLSQYPNS 250 260 270 280 290 300 KLKTGAPLRP KTNPNRVRAY GPGIEPIGPV VGAPANFTVE TFSAGKGSVD VDIQGPNGEI 310 320 330 340 350 360 EKADVRFNND KNLTYTVSYI PKSEGSHKVA VKFSGRDIPK SPFPVKVEGH AGDASKVKVT 370 380 390 400 410 420 GPGIQPNGVT IKKPTFFDIL AKDAGRGVPE VIIIDPANHK TSVAAKVRQL ENDTWRCEYV 430 440 450 460 470 480 TALQGLHSVN VFYAGTPIPN SPFPVKVAPL SDARKVRASG RGLQATGVRV GDDADFKIYT 490 500 510 520 530 540 EGAGEGEPEV RVIGPGGMNQ NVMQSKVDGN TYECHYYPTK EGRYVIMVTF AGQEVAKSPF 550 560 570 580 590 600 EVKVGPKKES SIVAYGPGLS SGVIGYPAAF VVETNGETGA LGFTVAGPSQ AEIECHDNGD 610 620 630 640 650 660 GSALVKYHPT AVGEYAVHIL CDNEDIPKSP FIAQILPRTD FHPELVKASG PGLEKNGVTI 670 680 690 700 710 720 NQPTSFTVDP SKAGNAPLDV VVQDVFGTKL PVELKNNPDG TKKVTYTPTS GVPHTVEVNY 730 740 750 760 770 780 GGVSTPNSPH RVYVGVPVDA AKVQAFGPWL QPGVRPNAAT HFNVDAREAG DAELKVKIIH 790 800 810 820 830 840 EETKIEVPCR IIDNEDNTYS VEVIPPSKGA YTTTMTYGGQ RVPLGEKVVV EQTVDVSKIK 850 860 870 880 890 900 VDGLEPSVIM NAATDFMVDM SKVGSNIDSG KLSCAIFDPM GHVLPSKIVQ GPTDDIFRIM 910 920 930 940 950 960 YTPFEAGRHT IELMYDNIPV PGSPFVVNVK SGCDPARCKA YGPGLEKGLT NQKNKFTVET 970 980 990 1000 1010 1020 KGAGNGGLSL AIEGPSEAKM TCTDNRDGSC DVDYLATDPG EYDITIRFAD KHIPGSPFRV 1030 1040 1050 1060 1070 1080 LVEETVDPSK VKVYGPGIEH GQVRESVPTF FNVDVGEAGP GRIAVKLTNS EGIPVDNLRV 1090 1100 1110 1120 1130 1140 EDKGNCIYAV HYVPPKAGSV LTCQVKFSEV EVPCSPFVMT VFPKSEPTKV KVKGVNEKKK 1150 1160 1170 1180 1190 1200 TPASLPAEFE IDTKQAGQAD INVAIKNPKG KAMQPRLEEV STGTYVVSFV PDECGTYQCS 1210 1220 1230 1240 1250 1260 IKYGDKEIEG SPFKLEAFPT GEAKKCKLVE QAPKIQTSGS QSHLKVDARE AGDGAVTCKI 1270 1280 1290 1300 1310 1320 TNKAGSEIVD IDVIEKDGFF DILYALNDPG DYDINVKFGG KDIPNGSFSI KAVESIEQYS 1330 1340 1350 1360 1370 1380 HSEYIEEHTT KVVQQTTQSE LVNGKSEITY RSVAFEKLPL PTTGGNVTAE VRMPSGKVDK 1390 1400 1410 1420 1430 1440 PVIQDNRDGT VSVKYDPREE GSHELVVKYN GEPVQGSPFK FHVDSITSGY VTAYGPGLTH 1450 1460 1470 1480 1490 1500 GVTGEPANFT ISTKGASAGG LTMAVEGPSK ADINYHDNKD GTVSVQYLPT APGEYQVSVR 1510 1520 1530 1540 1550 1560 FGDKHIKGSP YFAKITGEGR KRNQISVGSC SEVTMPGDIT DDDLRALNAS IQAPSGLEEP 1570 1580 1590 1600 1610 1620 CFLKRMPTGN IGISFTPREI GEHLVSVKRL GKHINNSPFK VTVCEREVGD AKKVKVSGTG 1630 1640 1650 1660 1670 1680 LKEGQTHADN IFSVDTRNAG FGGLSVSIEG PSKAEIQCTD KDDGTLNISY KPTEPGYYIV 1690 1700 1710 1720 1730 1740 NLKFADHHVE GSPFTVKVAG EGSNRKREKI QRERDAVPIT EIGSQCKLTF KMPGITSFDL 1750 1760 1770 1780 1790 1800 AACVTSPSNV TEDAEIQEVE DGLYAVHFVP KELGVHTVSV RYSEMHIPGS PFQFTVGPLR 1810 1820 1830 1840 1850 1860 DSGSHLVKAG GSGLERGVVG EAAEFNVWTR EAGGGSLAIS VEGPSKADIE FKDRKDGSCD 1870 1880 1890 1900 1910 1920 VSYKVTEPGE YRVGLKFNDR HIPDSPFKVY VSPDAGDAHK LEVQQFPQGN IQADAPYQFM 1930 1940 1950 1960 1970 1980 VRKNGAKGEL DAKIVAPSGT DDDCFIQVID GEMYSVRFYP RENGIHAIHV KFNGVHIPDS 1990 2000 2010 2020 2030 2040 PFRIKVGKDV ADPAAVHASG NGLDEVKTGH KADFIINTCN AGVGTLAVSI DGPSKVAMDC 2050 2060 2070 2080 2090 2100 TEVEEGYKVR YTPLLPGEHY ITVKYNNMHI VGSPFKVNAT GDKLADEGAQ ETSTVIVETV 2110 2120 2130 2140 2150 2160 QKVAKGGKNT GVHLPTFKSD ASKVVSKGMG LKKAYIGKQN QFSISATDAG NNILYVGMYG 2170 2180 2190 2200 2210 PKGPCEEFHV KHAGHNNYNV QYLVRDRGQY VLLIKWGEEH IPGSPFQIDV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Drosophila filamin encoded by the cheerio locus is a component of ovarian ring canals." Sokol N.S., Cooley L. Curr. Biol. 9:1221-1230(1999) [PubMed: 10556087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF188360 mRNA. Translation: AAF04108.1. AE014297 Genomic DNA. Translation: AAF55390.4.
RefSeq	NP_524383.3. NM_079659.4.
3D structure databases
HSSP	HSSP built from PDB template 1AA2 based on UniProtKB Q01082.
ProteinModelPortal	Q9VEN1.
SMR	Q9VEN1. Positions 4-242, 252-2210.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-804035.
STRING	Q9VEN1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0089471; FBpp0088478; FBgn0014141.
GeneID	42066.
KEGG	dme:Dmel_CG3937.
NMPDR	fig|7227.3.peg.13252.
UCSC	CG3937-RA. d. melanogaster.
Organism-specific databases
CTD	42066.
FlyBase	FBgn0014141. cher.
Phylogenomic databases
GeneTree	EMGT00050000003241.
InParanoid	Q9VEN1.
Gene expression databases
ArrayExpress	Q9VEN1.
Bgee	Q9VEN1.
Family and domain databases
InterPro	IPR001589. Actinin_actin-bd_CS. IPR001715. CH-domain. IPR001298. Filamin. IPR017868. Filamin/ABP280_repeat-like. IPR013783. Ig-like_fold. IPR014756. Ig_E-set. [Graphical view]
Gene3D	G3DSA:1.10.418.10. Calponin-homology. 2 hits. G3DSA:2.60.40.10. Ig-like_fold. 20 hits.
KO	K04437.
Pfam	PF00307. CH. 2 hits. PF00630. Filamin. 19 hits. [Graphical view]
SMART	SM00033. CH. 2 hits. SM00557. IG_FLMN. 20 hits. [Graphical view]
SUPFAM	SSF47576. Calponin-homology. 1 hit. SSF81296. Ig_E-set. 20 hits.
PROSITE	PS00019. ACTININ_1. 1 hit. PS00020. ACTININ_2. 1 hit. PS50021. CH. 2 hits. PS50194. FILAMIN_REPEAT. 20 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	827008.

Entry information

Entry name

Q9VEN1_DROME

Accession

Primary (citable) accession number: Q9VEN1
Secondary accession number(s): Q7KJX2 , Q9U4I3, Q9U6C0, Q9U6C1

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	April 26, 2005
Last modified:	January 25, 2012
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)