Q9VEG9 (NRM_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nurim homolog

Alternative name(s):
Nuclear envelope membrane protein
Nuclear rim protein

Gene names

Name:	nrm
ORF Names:	CG7655

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the nurim family.

Ontologies

Keywords
Cellular component	Membrane Nucleus
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nuclear inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
nos	P25724	1	EBI-139317,EBI-106556

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	Nurim homolog		PRO_0000299403
Regions
	Topological domain	1 – 2	2	Nuclear Potential
	Transmembrane	3 – 30	28	Helical; Potential
	Topological domain	31 – 56	26	Perinuclear space Potential
	Transmembrane	57 – 78	22	Helical; Potential
	Topological domain	79 – 96	18	Nuclear Potential
	Transmembrane	97 – 113	17	Helical; Potential
	Topological domain	114 – 132	19	Perinuclear space Potential
	Transmembrane	133 – 161	29	Helical; Potential
	Topological domain	162 – 188	27	Nuclear Potential
	Transmembrane	189 – 207	19	Helical; Potential
	Topological domain	208 – 213	6	Perinuclear space Potential
	Transmembrane	214 – 231	18	Helical; Potential
	Topological domain	232 – 253	22	Nuclear Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9VEG9 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: CE25BDC208DDA8D7	FASTA	253	28,570
	10 20 30 40 50 60 MTSIAKSIVL LASLATFAYS LYVVGSLMMF LSTPRSISKA HTWIFNLLDN KSRLQTAYGP 70 80 90 100 110 120 VVFDTLYLIG FIFQHSFLKS AVVKKLLAKL GLSGAERTIY SLTSSLCLHY LIVNWLPAQS 130 140 150 160 170 180 IVLWQIDVEQ SAPLWWTFVI THGICWVVIF GGSLVMDLPE LLGVKQAYYD LKAYGPPISY 190 200 210 220 230 240 KSGELRNLYA HVRHPSFVGL SVILFATNVM SVDRLVMALL LTTYMYLAWS TDQKDVAYQK 250 IQLQRKKLEL KAK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Head.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014297 Genomic DNA. Translation: AAF55455.1. AY060774 mRNA. Translation: AAL28322.1. BT003593 mRNA. Translation: AAO39596.1.
RefSeq	NP_650646.1. NM_142389.2.
UniGene	Dm.1232.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VEG9. 1 interaction.
MINT	MINT-815425.
Proteomic databases
PRIDE	Q9VEG9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0083479; FBpp0082912; FBgn0038536.
GeneID	42128.
KEGG	dme:Dmel_CG7655.
NMPDR	fig|7227.3.peg.13329.
UCSC	CG7655-RA. d. melanogaster.
Organism-specific databases
FlyBase	FBgn0038536. CG7655.
Phylogenomic databases
eggNOG	inNOG09948.
GeneTree	EMGT00050000017533.
InParanoid	Q9VEG9.
OMA	HPLMLGF.
OrthoDB	EOG4PK0RC.
PhylomeDB	Q9VEG9.
Gene expression databases
ArrayExpress	Q9VEG9.
Bgee	Q9VEG9.
Family and domain databases
ProtoNet	Search...
Other
NextBio	827304.

Entry information

Entry name

NRM_DROME

Accession

Primary (citable) accession number: Q9VEG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project