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Protein
Submitted name:

Cadmus, isoform A

Gene

cdm

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • modulation of synaptic transmission Source: FlyBase
  • neuron-neuron synaptic transmission Source: FlyBase
  • phototaxis Source: FlyBase
  • protein import into nucleus Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cadmus, isoform AImported
Submitted name:
Cadmus, isoform BImported
Submitted name:
LD35896pImported
Gene namesi
Name:cdmImported
ORF Names:CG7212Imported, Dmel_CG7212Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0261532. cdm.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

MINTiMINT-834899.
STRINGi7227.FBpp0083039.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2X1GX-ray3.35F/G1-971[»]
3ZKVX-ray3.00A1-971[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 9367Importin N-terminalInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG2022. Eukaryota.
ENOG410XT8Y. LUCA.
GeneTreeiENSGT00530000063347.
OMAiQMYSTIP.
OrthoDBiEOG718KC9.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VEC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPIDIARLE EAVVSFYRSN SQNQAITHEW LTDAEASPQA WQFSWQLMQL
60 70 80 90 100
GKSQEVQFFG AITLHSKLMK HWHEVPPENR EELKQKILES IVRFAGGPKI
110 120 130 140 150
VLNRLCISLG AYIVHMLGEW PGAIEEVINT FQNQRMPNVS ADVQLWIMLE
160 170 180 190 200
VLTAIPEEAQ VIHTSVKRVV LRAEIAKRVQ LVIHTVERYL KLQMNRVWDA
210 220 230 240 250
EAYSNMNRAV KCVGTWIKNI GYTIEGCVTI TAVLLEVVHK CYWPCIHAGD
260 270 280 290 300
GCMTADENEL AESCLKTMVN IIIQPDCHNY PKTAFVLIKM FLDSLSEITK
310 320 330 340 350
TEWKRENDNE DIIVHIYMLF VSSVERHSTL LLSGITSADP ELSILVHRIV
360 370 380 390 400
QEILHCTDKP GIYPVEESCS TMALAFWYML QDEVFAMSND EQKHKCWEYI
410 420 430 440 450
KPLYAHLTRI LVRKSEQPDE KSLAKWSSDD LECFRCYRQD ISDTFMYCYD
460 470 480 490 500
VLNDYILEIL AAMLDEAIAD LQRHPTHWTK LEACIYSFQS VAEHFGGEEK
510 520 530 540 550
RQIPRLMRVL AEIPYEKLNV KLLGTALETM GSYCNWLMEN PAYIPPAINL
560 570 580 590 600
LVRGLNSSMS AQATLGLKEL CRDCQLQLKP YADPLLNACH ASLNTGRMKN
610 620 630 640 650
SDSVRLMFSI GKLMSLLRPE EIPKYLDIIV SPCFEELQAI CQADSKTPAA
660 670 680 690 700
RIRTIFRLNM ISTLFSSLNT DVDEQATDQP IVQPVLLVMQ RTMPIFKRIA
710 720 730 740 750
EMWVEEIDVL EAACSAMKHA ITNLRSSFQP MLQDLCLFIV ASFQTRCCAP
760 770 780 790 800
TLEISKTAIV MFFKDEGCKP LMQQLLREFI QHSFKLFEST PEQNFSNISD
810 820 830 840 850
TMETFFGCLT QIIKKIPQVL EDKTLAYDRL VFYAQRGMTL PESGAIRNSI
860 870 880 890 900
QFLTHFVMQS RNHAHVTEVV LATGEQTLYT AMMCVGYLTP RSQVDKFADI
910 920 930 940 950
LLAMNRKYAA EMAVWMKSLM STPNFPTQLI TDADKTRYTA LIIKEKVNKR
960 970
LLQQHLSEMA MKTRGLTEKF Q
Length:971
Mass (Da):111,313
Last modified:May 1, 2000 - v1
Checksum:i79479AC06DCCF35E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF55502.1.
AY061428 mRNA. Translation: AAL28976.1.
AE014297 Genomic DNA. Translation: AGB96076.1.
RefSeqiNP_001262696.1. NM_001275767.1.
NP_650682.1. NM_142425.3.
UniGeneiDm.7262.

Genome annotation databases

EnsemblMetazoaiFBtr0083619; FBpp0083039; FBgn0261532.
FBtr0336472; FBpp0307575; FBgn0261532.
GeneIDi42171.
KEGGidme:Dmel_CG7212.
UCSCiCG7212-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF55502.1.
AY061428 mRNA. Translation: AAL28976.1.
AE014297 Genomic DNA. Translation: AGB96076.1.
RefSeqiNP_001262696.1. NM_001275767.1.
NP_650682.1. NM_142425.3.
UniGeneiDm.7262.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2X1GX-ray3.35F/G1-971[»]
3ZKVX-ray3.00A1-971[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-834899.
STRINGi7227.FBpp0083039.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0083619; FBpp0083039; FBgn0261532.
FBtr0336472; FBpp0307575; FBgn0261532.
GeneIDi42171.
KEGGidme:Dmel_CG7212.
UCSCiCG7212-RA. d. melanogaster.

Organism-specific databases

CTDi12582.
FlyBaseiFBgn0261532. cdm.

Phylogenomic databases

eggNOGiKOG2022. Eukaryota.
ENOG410XT8Y. LUCA.
GeneTreeiENSGT00530000063347.
OMAiQMYSTIP.
OrthoDBiEOG718KC9.

Miscellaneous databases

GenomeRNAii42171.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013598. Exportin-1/Importin-b-like.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
PF08389. Xpo1. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  5. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  12. "Nuclear import mechanism of the EJC component Mago-Y14 revealed by structural studies of importin 13."
    Bono F., Cook A.G., Grunwald M., Ebert J., Conti E.
    Mol. Cell 37:211-222(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.35 ANGSTROMS).
  13. "Structural basis for the nuclear export activity of Importin13."
    Grunwald M., Lazzaretti D., Bono F.
    EMBO J. 32:899-913(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS).
  14. FlyBase
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9VEC5_DROME
AccessioniPrimary (citable) accession number: Q9VEC5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.