Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribosome production factor 2 homolog

Gene

Non3

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for normal assembly of the mitotic spindle. May be involved in both centrosome-dependent and centrosome-independent spindle assembly programs.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome production factor 2 homolog
Alternative name(s):
Brix domain-containing protein 1 homolog
Novel nucleolar protein 31 Publication
Ribosome biogenesis protein RPF2 homolog
Gene namesi
Name:Non3Imported
ORF Names:CG7993Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0038585. Non3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202261 – 320Ribosome production factor 2 homologAdd BLAST320

Proteomic databases

PaxDbiQ9VEB3.
PRIDEiQ9VEB3.

Expressioni

Gene expression databases

BgeeiFBgn0038585.
ExpressionAtlasiQ9VEB3. differential.
GenevisibleiQ9VEB3. DM.

Interactioni

Protein-protein interaction databases

BioGridi67204. 4 interactors.
IntActiQ9VEB3. 2 interactors.
STRINGi7227.FBpp0082984.

Structurei

3D structure databases

ProteinModelPortaliQ9VEB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 234BrixPROSITE-ProRule annotationAdd BLAST205

Sequence similaritiesi

Belongs to the RPF2 family.Curated

Phylogenomic databases

eggNOGiKOG3031. Eukaryota.
COG5106. LUCA.
GeneTreeiENSGT00390000007279.
InParanoidiQ9VEB3.
KOiK14847.
OMAiKIYMRSY.
OrthoDBiEOG091G0EYG.
PhylomeDBiQ9VEB3.

Family and domain databases

InterProiView protein in InterPro
IPR007109. Brix.
PfamiView protein in Pfam
PF04427. Brix. 1 hit.
SMARTiView protein in SMART
SM00879. Brix. 1 hit.
PROSITEiView protein in PROSITE
PS50833. BRIX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VEB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLRIRKPK TRKGKKVLLA REPQLIESAR TMLFLDGRKC GGNVKLCMKD
60 70 80 90 100
LQALKKPLVK VLNRKNDITP FDDPSSLEFL TMKNDAALFT FGSTSKKRPD
110 120 130 140 150
NIILGRIFEN EVLDMFELGI KRYQAISEFK NEKIGACVKP CLVFNGPKWA
160 170 180 190 200
QTEELRRLRN LFIDTFQREK VDSIRLQGIE HVLSFTVTDD MNILMRSYRI
210 220 230 240 250
LLKKSGQRTP RIELEEIGPS ADFSIRRTKI ASEDLYKQAR KQPKQLKVGK
260 270 280 290 300
KKNISTDALG NTKGRVHLGK QQTGSIQTRR VKALRKTPEE KKENRQRKKV
310 320
ALKAAAAEAL ASQGNNPFSS
Length:320
Mass (Da):36,498
Last modified:August 4, 2003 - v3
Checksum:iEE988944DD5226F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188T → I in AAL13477 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF55514.2.
AY058248 mRNA. Translation: AAL13477.1.
RefSeqiNP_650694.2. NM_142437.3.
UniGeneiDm.4339.

Genome annotation databases

EnsemblMetazoaiFBtr0083562; FBpp0082984; FBgn0038585.
GeneIDi42183.
KEGGidme:Dmel_CG7993.
UCSCiCG7993-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiRPF2_DROME
AccessioniPrimary (citable) accession number: Q9VEB3
Secondary accession number(s): Q95U84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: August 4, 2003
Last modified: September 27, 2017
This is version 104 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families